• The Journal of Internal Korean Medicine
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• v.26 no.3
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• pp.720-724
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• 2005

Objective : Skin scale(皮膚甲錯) refers to an excessive dryness of skin which can be found under such conditions as blood deficiency(血虛), blood heat(血熱), damp heat(濕熱), the weakness of stomach(脾胃虛) and blood stasis(瘀血). Method : A sensitive and nervous patient showed symptoms of insomnia and chest discomfort as well as skin scale. He had great anxiety over his illness. He, therefore, was diagnosed as blood stasis caused by outburst of emotions and was prescribed Hyulbuchukeotang(血府逐瘀湯) to remove blood stasis in chest. Result and Conclusion : After taking Hyulbuchukeotang, insomnia, chest discomfort and skin scale eased off. Since not only blood stasis but also other factors may cause skin scale, more research on such cases must be done to determine the efficacy of Hyulbuchukeotang for skin scale.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.315-321
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• 2016

Objective: This study reports on the clinical effects of combinatorial Hyulbuchuko-tang on a deep-vein thrombosis patient.Method: The deep-vein thrombosis patient was treated using combinatorial Hyulbuchuko-tang and pharmacopuncture (water-soluble carthami flos, WCF) three times a day for 33 days. The effects of deep-vein thrombosis were measured using a 0-10 numerical rating scale (NRS) and external appearance.Result: Improvements in the NRS from 7 to 2 were observed after the combinatorial Hyulbuchuko-tang treatment.Conclusions: From these results, combinatorial Hyulbuchuko-tang may be considered to show improvement for patients with deep-vein thrombosis.

• The Journal of Internal Korean Medicine
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• v.30 no.2
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• pp.438-449
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• 2009

Objectives: Deep vein thrombosis (DVT) is a common complication among stroke patients. The implication of DVT progressing into a fatal pulmonary embolism is one of the main reasons treatment cannot be delayed. However, when there is a contradiction for anticoagulants, such intracranial hemorrhage (ICH), it is difficult to determine the course of treatment. Our team reports a case with both acute DVT and ICH who improved with herbal medicine Hyulbuchuko-tang. Methods : A patient with a variety of thrombosis risk factors (atrial fibrillation, DVT, Cb-inf with intracranial hemorrhage due to thrombolytic complications) showed classic symptoms of DVT (pain, edema, discoloration), disorientation and chest discomfort. The patient was administered Hyulbuchuko-tang three times a day for 24 days without any anticoagulants. Conservative therapy including elastic stocking and leg elevation was co-administered. Laboratory tests and extremity vascular Doppler sonography were carried out 3 times during the treatment period. Results : After our treatment period, both popliteal vein DVT and calf vein DVT were not discovered by sonography, and thrombosis derived factors (eg. D-dimer, fibrinogen) decreased. There was no sign of edema or discoloration after treatment, and the patient no longer complained of leg pain, disorientation or chest discomfort. Conclusion : From these results, we suggest that there is a positive effect of Hyulbuchuko-tang on DVT. Hyulbuchuko-tang should be considered as a treatment option when western medical procedures are unavailable.

• The Journal of Korean Medicine
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• v.18 no.2
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• pp.273-282
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• 1997

To observe the effect of Heulbuchuketang on endometriosis, surgically induced endometriosis in rats was treated with Heulbuchuketang for l00days. The result are as follows: 1. Fragments of right uterine horn were implanted at the serosal wall of small intestine and its adjacent aterial suppling branch. After 4 weeks later endometriosis was observed at the area of implantation of small intestine. 2. After l00-day-treatment, the size of the endometriosis of treated group was much smaller compared to those of the untreated group. Especially the result of the later 60-day-treatment was much better than that of the early 40-day-treatment. 3. In case of inflammation or pustula induced from endometriosis, the size of abnormal endometriosis tissue showed no change after the total treatment and fibrotic change was often founded there, which was not responding to Heulbuchuketang. 4. In the ovary of untreated group, primordial follicle, primary follicle, maturing primary follicle were easily founded and there was no difference in shape and size between the ovary of Heulbuchuketang treated group. From the upper 1 to 4 laboratory result it can be suggested that Heulbuchuketang can be specially effective to mild endometriosis with conservating the ability of fertility.

• The Journal of Korean Medicine
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• v.26 no.3 s.63
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• pp.162-175
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• 2005

Backgrounds : Two stress pathways, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, regulate immune system responses through release of corticosteroids, norepinephrine and epinephrine. respectively. These neuromediators act on immune cells via specific receptors on their surface to modulate the production of key regulatory cytokines. Objectives : To evaluate the preventive effects of oriental medicine Hyeolbuchukyeo-tang (HC) on stress. Methods : Mice were divided into three groups: nounal group, control group under immobilization stress and HC group which received Hyeolbuchukyeo-tang (HC) under immobilization stress. following sacrifice, their splenocytes were isolated and splenocyte surface markers were determined. The brains were removed and mRNA determined. In vivo, we separated RNA Iron cultured macrophages (RAW264.7). Results : In our study, immune functions were decreased in stress due mainly to changes of various neuromediators, cytokines and macrophage activities, and the treatment of HC increased those expressions. Conclusions : In summary, the present study documents the anti-stress effects of HC through stress-immune regulation.

• The Journal of Korean Medicine
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• v.28 no.2 s.70
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• pp.44-53
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• 2007

Objectives : This study examined the neuroprotective effect of Hyulbuchookau-tang (血府逐瘀湯, HBCAT) against neural damage following global cerebral infarction. Methods : Sprague-Dawley rats were induced with global cerebral infarction by occlusion of the bilateral common carotid artery with hypotension (CCAO). The rats were divided into 3 groups. We treated extract of HBCAT to one group after operation (sample group), one group wasn't induced with ischemic damage after operation (sham group), and one group was induced with ischemic damage after operation (control group) but not treated. We observed neurological scores and cresyl violet-stained hippocampus CAl area, TUNEL-positive neurons, and Bax-positive neurons in brain regions. Results : HBCAT treatment after CCAO increased pyramidal neurons in CAl hippocampus induced by CCAO. HBCAT treatment after CCAO reduced Bax-positive neurons in CAl hippocampus of brain regions induced by CCAO. HBCAT treatment after CCAO wasn't effective for HSP70-positive neurons in CAl hippocampus induced by CCAO. Conclusions : These results suggest that HBCAT has a neuroprotective effect against global cerebral ischemia.

• The Journal of Korean Medicine
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• v.17 no.1 s.31
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• pp.465-477
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• 1996

Inhibitory effects of Hyeulbuchuckeutang(H.B.T) On the peroxidations of lecithin-liposomes by active oxygens, hydroxyl radical and superoxide anion, derived from hydrogen $peroxidase-Fe^{2+}$ system and xanthine- xanthine oxidase system. These effects were similar to and stronger than those of catalase, mannitol, superoxide dismutase or $dl-{\alpha}-tocopherol$ as a scavenger or an antioxidant. H.B.T. inhibited the peroxidation of lecithin-liposome and active oxygens in concentration-dependent manner. H.B.T. also dose-dependently protected the cell death mduced by tert-butvlhydroperoxide(tBHP) and significantly increased cell viability in the rat normal liver cell (Ac2F). These results suggested that H.B.T might playa protective role in lipid peroxidation by free radicals and tBHP.

• Korean Journal of Pharmacognosy
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• v.31 no.4
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• pp.373-382
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• 2000

This study was performed to investigate the antithrombotic activity and protective effect of hexane fraction of Kamihyulbuchukeotang (KHCTH) on brain injury by KCN and MCA occlusion a prescription of HCT added with Lumbricus and Notoginseng Radix. Experiemental parameters are brain ischemia by MCA occlusion assay, KCN-induced brain injury, pulmonary thrombosis and platelet aggregation assay. The results were summarized as follows; 1. KHCTH extracts significantly inhibited the duration of KCN-induced coma (67%) and mortality (80%). 2. KHCTH extracts significantly suppressed brain ischemic area and edema following MCA occlusion and protected neuron cells as compared with control data. 3. KHCTH extracts inhibited pulmonary thrombosis induced by collagen and epinephrine. 4. KHCTH extracts inhibited platelet aggregation induced by collagen, ADP as agonist up to 76.9% and 32.3% respectivey at 1 mg/ml more effective than water extract of KHCT These data suggested that KHCTH could be applied as the protector of brain ischemia and injury and antithrombotic agent.

• Journal of Oriental Neuropsychiatry
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• v.20 no.3
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• pp.249-259
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• 2009

Objectives : Anxiety is a symptom that many psychiatric patients experience. And in the traditional Korean medicine, anxiety is often categorized as a Gyeong Gye(驚悸) and Jung Choong(怔忡). In this case report, we will show the effective method in treatment of anxiety. Methods : First, We treated the patient with anxiety by the differential diagnosis of blood stasis(瘀血) that is summarized as stasis of blood, pollutant of blood and external blood of vessel. And we gave him Hyeolbuchukyeo-tang(血府逐瘀湯) whose effect is to eliminate blood stasis. And Second, we treated the patient with anxiety in the viewpoint of analytic psychology that claims anxiety has a meaning that makes patient be aware of the problem of himself. Results : The patient's symptom improved significantly. And this patient also can insight himself via the symptom of anxiety. It also help the patient improve. Conclusions : In the treatment of anxiety, the approach by the differential diagnosis of blood stasis(瘀血) can be helpful to improve patient's symptom. And treatment should include the insight of patent by the meaning of anxiety.

• The Journal of Internal Korean Medicine
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• v.21 no.5
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• pp.819-827
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• 2000

Purpose : To investigate the inhibitory effect of HCE on platelet aggragation and erythrocyte deformiability, we performed following experiments. Methods : Concentrated Hyulbuchukotang (HCE) was fed to rats for 10days. We compare normal group with $500{\beta}{\Sigma}/{\beta}{\Sigma}$-high dose group and $100{\beta}{\Sigma}/{\beta}{\Pi}$-low dose group. Results : HCE enhanced the blood filtration rate, erythrocyte deformiability, reduced the platelet aggreablilty and inhibited granule release from collagen stimulated platelet, the prostaglandin synthesis in platelat. Conclusion : HCE should inhibit thrombos formation due to platelet hyperaggraeability and reduction of erythrocyte defonmiability.