• Biomolecules & Therapeutics
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• 제5권2호
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• pp.110-116
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• 1997

The present study was designed to evaluate the effects of a recombinant human granulocyte-colony stimulating factor (G-CSF) on leukopenia and tumor growth in mice treated with DA-125, an adri-amycin (ADM) derivative. In normal mice, single intravenous injection of DA-125 produced transient leukopenia accompanied with weight loss and splenic atrophy in a dose-related manner. However, subcutane-ous administration of G-CSF (5$\mu$g/head) for 5 consecutive days after DA-125 resulted in a significantly elevated nadir of leukocyte counts and facilitation of recovery from the leukopenia. To investigate the effect of G-CSF on antitumor effects of DA-125, ADM (12 mg/kg) or DA-125 (40 mg/kg) was administered to Colon-26 murine adenocarcinoma-bearing Balb/c mice with G-CSF. Regardless of treatment with G-CSF, DA-125 and ADM markedly retarded the growth of implanted tumor, though they failed to increase mean survival time of tumor-bearing mice. These results suggest that G-CSF is able to not only ameliorate, but reconstitute DA-125-induced myelosuppression without affecting its antitumor potential.

• 논리연구
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• 제18권1호
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• pp.39-64
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• 2015

수학적 플라톤주의자가 해결해야 할 가장 큰 문제는 바로 베나세라프가 제기하고 필드가 재정식화한 인식론적 문제라고 할 수 있다. 최근에 밸러궈는 자신의 독특한 형태의 수학적 플라톤주의인 FBP 즉 "혈기 왕성한 플라톤주의"는 이 인식론적 문제를 해결할 수 있다는 논의를 전개했다. 필자는 이 논문에서 그런 논의가 얼마나 성공적인가를 평가하면서 그의 논변이 지닌 문제점들을 살핀다. 우선 필자는 밸러궈 특유의 수학적 플라톤주의가 인식론적 문제를 해결한다는 논변을 형식적 측면에서 비판적으로 분석한다. 그리고 밸러궈의 논변과 전략에 대해 마녀주의의 사례를 통해 보다 본격적 반론을 전개한다. 마지막으로 밸러궈가 유비 논변에 기초해 자기 입장을 옹호하려는 대응을 무력화시키기 위한 논의를 펼친다.

• Journal of Trauma and Injury
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• 제22권2호
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• pp.161-166
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• 2009

Purpose: This study was conducted to analyze chest-trauma patients and the old-aged patients with a traumatic hemopneumothorax. Methods: We reviewed the medical records of 101 chest-trauma patients admitted to the department of cardiovascular and thoracic surgery from June 1999 to November 2008. We evaluated the general characteristics of the chest-trauma patient, especially those of old-aged patients with a traumatic hemopneumothorax. Results: Rib fracture was observed in 99 of the cases, the location distribution was right: left =261: 255, with right being dominant. Rib fractures commonly involved the 4th and the 7th rib. The average number of rib fractures was 5.1, and the average number of rib fractures in the old-aged patients was significantly higher than that in the non-old-aged patients (p=0.04). There were 17 cases of a hemopnuemothorax in old-aged patients, 52 cases in non-old-aged patients. The blood loss through the chest tube for old-aged patients was significantly more than that for the non-old-aged patients, and the initial hemoglobin level was lower in the old-aged patients. Conclusion: Elderly trauma patients are more likely to die after trauma than other age groups. Even with relatively stable vital signs, invasive hemodynamic monitoring and intensive treatment are recommended.

• 한국어병학회지
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• 제31권1호
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• pp.1-8
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• 2018

Causative agent of infectious hematopoietic necrosis (IHN) belonging to genus Novirhabdovirus (Rhabdoviridae). Economic losses caused by IHNV are serious in mainly Oncorhynchus spp. including rainbow trout O. mykiss and Atrantic salmon Salmo salar. IHNV was initially found by endemic presence in U.S. West Coast for sockeye salmon fry O. nerka and chinook salmon fry O. tshawytscha in the 1950s, and it has spread to Japan, Korea and Taiwan in the 1970s, and also to Italy and France in the 1990s. Currently, IHNV is detectable in many parts of the world, including Russia and South America. Mortality due to IHNV infection in fish with ${\leq}0.5g$ of body weight reaches 60% to 100%, while the mortality reduces by fish growing. In recent years, onset of IHNV infection has increased also in fish with large sizes. Here, we introduce molecular epidemiology and virulence changes of IHNV in East Asia, furthermore, we discuss on future prospects in IHNV researches.

• 한국의사학회지
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• 제35권2호
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• pp.83-88
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• 2022

In East Asian medicine, 'gihyeol(氣血)' and 'hyeolgi(血氣)' are basic terms that can be found everywhere. However, despite its importance, there is no clear definition of the terms. In this paper, we tried to distinguish between 'gihyeol(氣血)' and 'hyeolgi(血氣)' and looked at actual clinical examples that were judged to be consistent with this idea. The terms of East Asian medicine reflect its view of the human body and the origin of this view of the body can be seen as Han's theory of sensitivity. In addition, in East Asian medicine, the human body was understood as having a dualistic structure. Based on the theories of Asian medicine, energy can be understood as qi and blood. Therefore, 'gihyeol(氣血)' and 'hyeolgi(血氣)' are not similar or the same terms, but can be seen as terms to distinguish different internal flows of the human body. This organic view of the human body leads to the 'Hyeonggiron(形氣論)' of Donguibogam, and this 'Hyeonggiron(形氣論)' leads to the 'Hyeonggiron(形氣論)' of Hyungsang Medicine.

• 대한한의학원전학회지
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• 제19권4호
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• pp.113-125
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• 2006

주씨재(周氏在) "독의수필(讀醫隨筆) 기혈정신론(氣血精神論)" 중개괄정기신지총의위(中槪括精氣神之總義爲): 기자(氣者), 무형이유기자야(無形而有機者也). 이기기지소동(以基機之所動), 유삼초지분출야(有三焦之分出也). 정자(精子), 유형자야(有形者也). 유형칙유질(有形則有質), 이기질지소별(以其質之所別), 유사등지부동야(有四等之不同也). 신자(神者), 무형무기이유용자야(無形無機而有用者也). 이기용지소성(以其用之所成), 고추견오성지대본야(故推見五性之大本也). 개괄정기신지분류여소주위(槪括精氣神之分類與所主爲): 기유삼(氣有三), 왈종기야(曰宗氣也), 영기야(榮氣也), 위기야(衛氣也), 주어명문(主於命門); 정유사(精有四), 왈정야(曰精也), 혈야(血也), 진야(津也), 액야(液也), 주어신(主於腎); 신유오(神有五), 왈신야(曰神也), 혼야(魂也), 백야(魄也), 의여지야(意與智也), 지야(志也), 시오장소장야(是五臟所藏也), 주어심이복종어담(主於心而復從於膽). 개괄정기신삼자적상호관계위(槪括精氣神三者的相互關係爲): 대기자(大氣者), 정지어야(精之御也); 정자(精者), 신지택야(神之宅也); 신자(信者), 기여정지화야(氣與精之華也). 주씨인위(周氏認爲): 위기위열기(衛氣爲熱氣), 영기위습기(營氣僞濕氣), 종기위동기(宗氣爲動氣), 고위기유한열병(故衛氣有寒熱病), 영기유습병(營氣有濕病) 조병(燥病), 종기유욱결병(宗氣有郁結病), 유노권병(有勞倦病). 혈지질최중탁(血之質最重濁); 진지질최경청(津之質最經淸); 액지질청이정영(液之質淸而晶瑩), 후이응결(厚而凝結), 중이불탁(重而不濁); 정지질극청극후(精之質極淸極厚), 이우극령(而又極靈); 인신당중(人身當中), 혈위최다(血爲最多), 정위최중(精爲最重), 이진지용위최대(而津之用爲最大); 정혈진액지병변다표현위부족혹허탈(精血津液之病變多表現爲不足惑虛脫). 심장신(心藏神), 폐장백(肺藏魄), 간장혼(肝藏魂), 비장의여지(脾藏意與智), 신장지(腎藏志). 오신이혈기위용(五神以血氣爲用), 내장어오장(內藏於五臟), 외현위희(外顯爲喜) 노(怒) 사(思) 우(憂) 공지오지(恐之五志). 신지병변불가측(神之病變不可測), 차우최불역치(且又最不易治), 총이조신여안정위근본치신지법(總以調神與安靜爲根本治神之法).

• 대한한의학원전학회지
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• 제20권2호
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• pp.269-288
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• 2007

"표유부(標幽賦)"포라료침구경락적기본이론화자오유주침법(包羅了鍼灸經絡的基本理論和子午流注鍼法) 유주팔법등침구임상이론(流注八法等鍼灸臨床理論), 역우기송(易于기송), 통과대차(通過對此)"표유부(標幽賦)"급역대주석가대(及歷代注釋家對) "표유부(標幽賦)" 주석적연구(注釋的硏究). 금득출여하결론(今得出如下結論): 1. "표유부(標幽賦)"중출현적두한경적학술사상(中出現的竇漢卿的學術思想), 시재계승(是在계承)"내경(內經)"화(和)"난경(難經)"적침구학(的鍼灸學), 이론적기본상(理論的基本上), 진일보발전이성적(進一步發展而成的). 대후세침구학적발전산생료중요적영향(對後世鍼灸學的發展産生了重要的影響). 2. 유우폐경적경기유운문혈수출(由于肺經的經氣由雲門穴輸出), 연경락순행체표(沿經絡循行體表), 우시사운문혈구유료통경행기적주치작용(于是使雲門穴具有了通經行氣的主治作用), 고이불설'혈출중부'(故而不說'穴出中府'), 이제출'혈출운문'(而提出'穴出雲門'), 저시두한경재침구이론방면적독도지외(抵是竇漢卿在鍼灸理論方面的獨到之外). 3. 소우침구보사(소于鍼灸補瀉), 인위수지보사법적작용중우호흡보사(인위手指補瀉法的作用重于呼吸補瀉), 제시료순(提示了循), 문, 제(堤), 안(按), 탄(彈), 염, 차, 반(盤), 추, 내(內), 동(動), 요(搖), 조(爪), 절적십사종침자보사수법(切的十四종鍼刺보瀉手法). 4. 제출침자전요관찰확인침구유무이상손상(提出鍼刺前要觀察確인鍼具有无이常損상), 시침전요냉침온난(施鍼前要냉鍼온暖), 시침시요예방절침화피부근육적손상(施鍼時要預防折鍼和皮膚筋肉的損傷), 제출좌수당중이다안침혈(提出左手當重而多按鍼穴), 우수경이서서염전자입적수법(右手경而徐徐捻轉자入的手法), 인위사용쌍수진침위호(인위使用쌍手進鍼위好). 5. 호침가관통경락기혈운행적통로(毫鍼可관通經絡氣血運行的通路), 여오행상응(與五行相應), 인이가평오장지한열(因而可平五臟之寒熱), 가조육부지허실(可調六腑之虛實), 유견사부정지공(有견邪扶正之功), 재구침중응용최위광범(在九鍼中응用最위광泛). 6. 제출침자시요관찰본신(提出鍼刺時要관察本神), 대우'본신'구체가간주시환자적'맥기'화'혈기'(對于'本神'具체可看做是患者的'脈氣'和'穴氣'), 종대적방면간가간주시환자적정신(종大的方面看可看做是患者的精神). 7. 제시료참조전후좌우지혈정확취혈적방법(提示了參照前後左右之血正確取穴的方法), 여참조주변경락확정경락적방법(여參照周邊經絡確定經絡的方法), 병강조요준조골도분촌화굴신수족관절적방법취혈재능취혈정확(병强調要遵照骨度分寸和屈伸手足關節的方法取穴才能取穴正確). 8. 소우두면오관(소于頭面五官).인후경항(咽喉頸項).흉복부(胸腹部), 요배부(腰背部), 부인(婦人) 소아(小兒) 사지등질환(四肢等疾患), 개소료침구치료적경험화심득(介沼了療鍼灸治療的經驗和心得), 제시료자오유주축일안시개혈침법여영구팔법등안시취혈침법(提示了子午流注逐日按時開穴鍼法여靈驅八法等按時取穴鍼法), 성위후세각종안시개혈침법적기초(成위後世各種按時開穴鍼法的基초).

• Journal of Chest Surgery
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• 제41권4호
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• pp.536-539
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• 2008

52세 여자는 승용차 조수석에 앉아가다가 타차와 충돌후 다발성 늑골골절과 혈기흉과 함께 다량의 출혈을 야기한 우측 전완의 절단에 가까운 손상을 입었다. 응급실에 도착시 명료하지 못한 의식과 저혈압의 소견을 보였다. 혈액량 감소 쇼크로 판단되어 다량의 혈액과 수액을 급속수액주입기(레벨 1)를 이용하여 좌측 쇄골하정맥관을 통해 주입하였다. 폐좌상의 소견이 호전되었을 때 일반 흉부 X선 사진의 좌폐야에 이물질이 확인되었다. 폐동맥조영술에서 15 cm 정도의 이물질이 좌측 폐기저동맥에 있었다. 경피적 중재시술을 통해 혈관 겸자로 잡아 제거할 수 있었다.

• 대한수의학회지
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• 제30권4호
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• pp.473-478
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• 1990

This survey was conducted to observe the prevalence of blood parasites in slaughtered cattle included Korean native cattle, Charolias, Hereford, Aberdeenangus and Holstein breeds in the Western area of Kyeongnam. The results obtained are summarized as follows: 1. The prevalence of T sergenti was shown 71.8% as 395 heads of a total of 550 heads examined and from Jaunary to November the monthly prevalence of T sergenti was shown the range of 61.1% to 84% except 38.5% in December. The other blood parasites included Babesia and Anaplasma were not detected from the blood samples except Setaria spp microfilariae. 2. The distribution of parasitaemia levels of T sergenti in positive cattle was shown 93.9% in the range of 1~10/1000 rbc, 4.1% in 11~20, 1.3% in 21~30 and 0.8% above the range of 31. 3. The pervalence of T sergenti by breeds of slaughtered cattle was shown 71.2% in Korean native cattle, 72.7% in Charolias, 78.3% in Hereford and 81. 8% in others (Aberdeen-angus and Holstein) respectively. Also the parasitaemia levels in these cattle were shown higher levels in imported cattle included Charolias, Hereford, Aberdeen-angus and Holstein breeds comparing with Korean native cattle. 4. The prevalence of Setaria spp microfilariae in slaughtered cattle was shown 6.9% and by monthly prevalence of the parasite was shown higher in March, April and May compared with June, July, August and October. But in the winter season included January, February, November and December the parasite was not detected from the blood samples. 5. The distribution of parasitaemia levels of Setaria spp microfilariae per ml of blood was shown 65.8% in the range of 1~50, 13.2% in 51~100 and 10.5% in 101~200 and above the range of 201, respectively.

• Journal of Chest Surgery
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• 제31권5호
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• pp.513-517
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• 1998

비디오 흉강경의 이용은 여러 흉부질환에서 개흉술을 대치해 나가는 경향이며, 오늘날 광범위한 적응증은 개흉술의 대치가 보다 안전하고 유용함을 보여준다. 본원에서는 1993년 6월부터 1995년 6월까지 비디오 흉강경을 이용해 치료한 33명의 환자를 대상으로 하였다. 이들의 진단명을 보면 재발성 기흉이 16례, 엑스레이상 기포가 보이는 경우가 6례, 7일 이상 공기유출이 지속되는 경우가 4례, 양측성 기흉이 3례, 다한증 2례, 반대측 기흉의 과거력이 1례, 원발성 혈기흉 1례 순이었다. 이들의 평균 흉관 삽관 기간은 2.1$\pm$0.4일 이었으며, 재원 기간은 3.4$\pm$0.6일 이었으며 합병증은 48시간이상 자속된 공기유출이 3례에서 있었다. 이상과 같이 비디오 흉강경을 이용한 흉부 수술은 안전하고, 통증이 적으며, 짧은 재원 기간을 보여준다.