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Maximum tolerated dose estimations using various stopping rules in phase I clinical trial (제 1상 임상시험에서 다양한 멈춤 규칙을 이용한 최대허용용량 추정법)

  • Jeon, Soyoung;Kim, Dongjae
    • The Korean Journal of Applied Statistics
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    • v.35 no.2
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    • pp.251-263
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    • 2022
  • Phase I clinical trial is called 'Dose finding study'. It is first step of experimenting on humans with new drugs developed through animal experiments or vitro experiments. The important area of interest in designing Phase I clinical trial is determining the dose that acceptable level to the patients and provides the greatest efficacy. In this paper, we explain about methods to determine the maximum tolerated dose using various stopping rules. The SM3, NM, Rim, J3, BSM methods are compared through simulation. And we consider how the methods might be reformed. As a result of the simulation, BSM estimated the MTD closest to the target toxicity probability. J3 method required the least number of subjects. These results are due to the feature of the stopping rules of both methods. The BSM adds 2 or 1 subject at the same dose level when there is a toxic reaction. In addition, the J3 method has a smaller number of subjects than the other methods. If the methods are improved by combining these features, MTD can be estimated more efficiently. If the total number of subjects can be reduced while using the stopping rule of the BSM, accurate estimation is possible for a small number of subjects.

The Effect of Resource Scarcity on Ageism in the Younger Generation: The Moderating Effect of Socioeconomic Status (자원 부족이 청년세대의 노인차별주의에 미치는 영향: 사회경제적 지위의 조절효과를 중심으로)

  • Lee, Inyeong;Park, Hyekyung
    • Korean Journal of Culture and Social Issue
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    • v.27 no.2
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    • pp.139-165
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    • 2021
  • In this study, we focused on the socio-structural factors that cause ageism, investigating whether the influence of the resource scarcity on ageism in the younger generation depends on socioeconomic status. To test this hypothesis, we conducted an online study of 219 adults in their 20s and 30s. Specifically, participants were randomly assigned to either the resource scarcity priming condition or the control condition, and completed a writing task. After this, participants responded to ageism and socioeconomic status items. As a result, the effect of resource scarcity on ageism was not significant. However, we found that socioeconomic status moderated the impact of resource scarcity on ageism. In other words, resource scarcity priming has been shown to significantly reduce ageism for individuals who have relatively lower socioeconomic status. This finding is in line with previous studies in which people of low socioeconomic status were found to be more sympathetic to socially disadvantaged individuals suffering deleterious situations such as resource scarcity. This work is significant in that we have looked at both the situational and personal factors influencing ageism, and in that we have attempted to examine the causal influence of resource scarcity on ageism through an experimental approach. However, since the alternative explanation of the findings has not been completely excluded, replication through further studies will be necessary.

The Effect of Teratainment Task Oriented Activity on the Hemiplegia Weight Shifting of Stroke Patients (테라테인먼트 과제 지향적 활동이 뇌졸중 환자의 마비측 체중이동 능력에 미치는 영향)

  • Jung, Sang-Mi;Choi, Won-Ho
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.3
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    • pp.455-462
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    • 2020
  • The purpose of this study was to investigate the effect of hemiplegia on weight shift when mediating task-oriented activities in stroke patients. To this end, from September to December 2019, 33 patients with stroke were randomly assigned and divided into 17 experimental groups and 16 control groups. The experimental group provided task-oriented activities, and the control group general occupational therapy was conducted 3 times a week, 35 minutes per session for a total of 4 weeks. The weight shift of the left and right body was evaluated by the MTD balance system, and an initial evaluation before intervention and a re-evaluation was performed after 4 weeks of intervention. The result were as follows: 1) When evaluating the pre- and post-intervention within the group, the weight shift to the hemiplegia side showed an improvement in the weight shift to the hemiplegia side in both the experimental group(p<.001), and control groups(p<.001, p<.05). 2) In the pre- and post-intervention evaluation between groups, the experimental group showed a statistically significant improvement in weight shift to the control group(p<.01, p<.05). Through future supplementary studies, it is thought that task-oriented activities in the treatment of stroke patients could be usefully applied to promote weight transfer to the paralysis side.

Stiffness Enhancement of Piecewise Integrated Composite Robot Arm using Machine Learning (머신 러닝을 이용한 PIC 로봇 암 강성 향상에 대한 연구)

  • Ji, Seungmin;Ham, Seokwoo;Cheon, Seong S.
    • Composites Research
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    • v.35 no.5
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    • pp.303-308
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    • 2022
  • PIC (Piecewise Integrated Composite) is a new concept for designing a composite structure with mosaically assigning various types of stacking sequences in order to improve mechanical properties of laminated composites. Also, machine learning is a sub-category of artificial intelligence, that refers to the process by which computers develop the ability to continuously learn from and make predictions based on data, then make adjustments without further programming. In the present study, the tapered box beam type PIC robot arm for carrying and transferring wide and thin LCD display was designed based on the machine learning in order to increase structural stiffness. Essential training data were collected from the reference elements, which were intentionally designated elements among finite element models, during preliminary FE analysis. Additionally, triaxiality values for each finite element were obtained for judging the dominant external loading type, such as tensile, compressive or shear. Training and evaluating machine learning model were conducted using the training data and loading types of elements were predicted in case the level accuracy was fulfilled. Three types of stacking sequences, which were to be known as robust toward specific loading types, were mosaically assigned to the PIC robot arm. Henceforth, the bending type FE analysis was carried out and its result claimed that the PIC robot arm showed increased stiffness compared to conventional uni-stacking sequence type composite robot arm.

Design and Implementation of Interface System for Swarm USVs Simulation Based on Hybrid Mission Planning (하이브리드형 임무계획을 고려한 군집 무인수상정 시뮬레이션 시스템의 연동 인터페이스 설계 및 구현)

  • Park, Hee-Mun;Joo, Hak-Jong;Seo, Kyung-Min;Choi, Young Kyu
    • Journal of the Korea Society for Simulation
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    • v.31 no.3
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    • pp.1-10
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    • 2022
  • Defense fields widely operate unmanned systems to lower vulnerability and enhance combat effectiveness. In the navy, swarm unmanned surface vehicles(USVs) form a cluster within communication range, share situational awareness information among the USVs, and cooperate with them to conduct military missions. This paper proposes an interface system, i.e., Interface Adapter System(IAS), to achieve inter-USV and intra-USV interoperability. We focus on the mission planning subsystem(MPS) for interoperability, which is the core subsystem of the USV to decide courses of action such as automatic path generation and weapon assignments. The central role of the proposed system is to exchange interface data between MPSs and other subsystems in real-time. To this end, we analyzed the operational requirements of the MPS and identified interface messages. Then we developed the IAS using the distributed real-time middleware. As experiments, we conducted several integration tests at swarm USVs simulation environment and measured delay time and loss ratio of interface messages. We expect that the proposed IAS successfully provides bridge roles between the mission planning system and other subsystems.

The meaning and challenges of the introduction of the Customized Care Services for Older Adults (노인맞춤돌봄서비스의 도입 의미와 과제)

  • Chon, Yongho
    • 한국노년학
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    • v.40 no.4
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    • pp.599-616
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    • 2020
  • The South Korean government has introduced a new Customized Care Service for Older Adults by eliminating the six existing care services for them since 2020. It is a significant change of care service system for older adults and the service would play a key role in providing preventive services for them. The aim of the study is to examine the meaning and tasks of the introduction of the Customized Care Services for Older Adults in South Korea by using the framework of Gilbert and Terrell. The study found that the new service was designed under the government's policy contexts of the establishments of public-based social service providers and the emphasis of community care, and it has brought about a number of significant institutional changes of care system in terms of allocation, benefits, delivery, and finance. The institutional coverage of the service was increased to lower 70% of older adults and a large number of kinds of health and social care services would be provided for them. The sphere of living was set in each local area and the new service providers are entirely in charge of providing the services in each sphere. The financing system was changed to support service providers by providing government subsidies. Although a number of positive results would be expected to occur for the elderly, it is likely that some challenging tasks would happen in the fields as follows: the inadequate coverage, the vagueness of the application of self-care principle and the decrease in the amounts of direct care services, the inappropriate area of service provision, and the supplier-oriented provision of services rather than user-oriented.

A study on the change in the perception of funeral culture among the elderly (노인의 장례문화 인식변화에 대한 연구)

  • Song, Hyeon-Dong;Kim, Seol-Hee;Kim, Kwang-Hwan;Ku, Jin-Hee
    • Journal of Digital Convergence
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    • v.20 no.5
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    • pp.671-680
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    • 2022
  • The purpose of this study is to suggest the direction of the funeral culture industry suitable for the age of longevity and well-aging through a study on changes in the perception of funeral culture among the elderly. The survey of this paper was conducted by Gallup Korea, and the survey method was a 1:1 individual interview using a structured questionnaire. The survey was conducted from October 1 to October 25, 2021, targeting 127 elderly people over the age of 65 living in Seoul, Incheon, and Gyeonggi-do. The number of valid subjects was 110, and the sampling method used was allocation by sex/age/income level/religion. As a result of the study, as for the change in the perception of funeral culture among the elderly, women preferred cremation to men (p=0.034). It was investigated that the level of income (p=0.004) and religious status (p=0.020) had an effect on funerals while alive. According to the presence or absence of thoughts about death, there was a significant difference in the membership of the mutual aid product (p=0.008) and the intention to return to a religious organization (p=0.004) when a memorial service was held. The results of this study are expected to be usefully utilized in presenting the direction and policy of the funeral culture industry suitable for the age of well-aging in the future.

A Comparative Study on Willingness to Manage Urban Parks by Age - Focusing on the Case of Incheon City Park - (연령별 시민참여형 도시공원 관리의지 비교 연구 -인천광역시 도시공원을 대상으로-)

  • Yoo, Jae Seop;Lee, Jae Ho
    • Journal of the Korean Institute of Landscape Architecture
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    • v.49 no.6
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    • pp.16-26
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    • 2021
  • For urban parks' rational and efficient management, research on creating green spaces in living area through citizen participation is continuously being conducted. However, in existing studies, citizens are recognized as a homogeneous group, and research on the intention to participate in park management according to user characteristics has not been conducted. A few studies have attempted to show differences through conceptual variables, such as user satisfaction and attachment to parks, but studies on sociodemographic factors, such as the users' age, have not been conducted. This study was conducted to ascertain the differences in preferred parks and park management participation methods by age, targeting various parks located in ten districts of Incheon Metropolitan City. Regression analysis was performed after collecting 1,226 questionnaires, applying a population-proportional allocation in the ten districts. As a result of the study, it was found that the difference according to the age of users has the most influence on the willingness to manage the park rather than the satisfaction or other factors. Also, a chi-square analysis was conducted to find the differences in preferred urban parks and management methods by age. The results showed that the choice to manage parks was statistically higher for those in their 50s or older, and the differences in preferred park types and desired park greening methods suggested implications for park management plans by age.

Effects of online academic coaching program for undergraduate student on self-directed learning, academic motivation, and time management (대학생 온라인 학습코칭 프로그램이 자기주도학습능력, 학습동기, 시간관리행동에 미치는 효과)

  • Cho, Youyong;Park, Junseong;Moon, Kwangsu
    • The Korean Journal of Coaching Psychology
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    • v.6 no.1
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    • pp.33-55
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    • 2022
  • This study examined the effects of 1:1 online coaching for college students on self-directed learning, learning motivation and time management. The coaching program consisted of motivation, behavior and cognitive control, which are sub-factors of self-directed learning. Total of 7 sessions(80 minutes per session) were progressed. Seven participants who wanted coaching, out of the total 16 participants, were assigned to the experimental group. A non-equal control group experimental design was applied. Dependent variables were measured by questionnaire before and after the coaching, and satisfaction survey and post-interview were also conducted after the coaching. ANCOVA was adopted to test the effectiveness of the program. The statistical results indicated that the learning coaching of this study has positive effect on self-directed learning and learning motivation of university students, and has partially positive effect on time management. In addition, the mean of satisfaction survey was 4.85 and participants showed positive responses on the program.

Case Study of Establishing and Operating Maker Space in A Developing Country - Focusing on iTEC Tech-shop in Tanzania - (개발도상국 메이커 스페이스 구축 및 운영 사례 - 탄자니아 iTEC 테크샵을 중심으로 -)

  • Im, Hyuck-Soon;Jung, Woo-Kyun;Ngajilo, Tunu Y.;Meena, Okuli;Lee, Ahnna;Ahn, Sung-Hoon;Rhee, Hyop-Seung
    • Journal of Appropriate Technology
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    • v.6 no.2
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    • pp.126-135
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    • 2020
  • Recently, with the development of the 4th Industrial Revolution era and the popularization of technologies the maker movement is spreading worldwide in various ways for education, entrepreneurship, and solving social problems. This paper introduces a case of establishing and operating a maker space in Tanzania, East Africa, one of the developing countries. iTEC Tech-shop was established in the first half of 2018 at the Nelson Mandela African Institution of Science and Technology (NM-AIST) in Arusha, Tanzania by Innovative Technology and Energy Center (iTEC), and has been operating for nearly two years. With the allocation of empty warehouse space from NM-AIST, physical facilities were established through the purchase and installation of equipment and hand tools. Based on the advice from Idea Factory of Seoul National University and Fab-Lab Seoul, iTEC Tech-shop operational system were established. Through a total of 7 technical workshops, iTEC Tech-shop provided training courses for about 180 local personnel. In addition, the smart Techshop test-bed project was promoted in order to improve the operation level along with securing sustainability of the Techshop. The case of the iTEC Tech-shop could be a useful case for institutions or organizations promoting the maker movement to developing countries.