• The Journal of Dong Guk Oriental Medicine
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• v.6 no.1
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• pp.163-176
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• 1997

This study was undertaken to determine whether Juglandis Semen extraction(JS) has a protective effect against the lung cell injury caused by oxidant, t-butythydroperoxide(t-BHP) and $H_2O_2$ in rabbit lung slices. JS significantly prevented an increase in water content induced by t-BHP. Similarly, JS significantly prevented the lipid peroxidation induced by t-BHP. Cellular concentration of glutathione, and the activities of catalase and superoxide dismutase were significantly not altered by 5% JS. However, JS at 5% concentration significantly increased the glutathione peroxidase activity in oxidant-treated and control tissues. JS decreased directly the production of superoxide or hydroxyl radical. These results indicate that JS prevents the cell injury and lipid peroxidation induced by oxidants in the lung. Such an antioxidant effect is attributed to enhancement of major endogenous antioxidant defence systems such as glutathione peroxidase and direct inhibition of oxygen free radical production.

• The Journal of Dong Guk Oriental Medicine
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• v.7 no.2
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• pp.141-148
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• 1999

A simple and rapid FoLT(formamide low temperature)-PCR, whereby human genomic DNA from blood can be amplified without DNA preparative stps, is described using human insulin genes. By applicatin of FoLT-PCR in human insulin genes, intragenic polymorphism in non-coding regions of the human insulin gene was shown after amplification and analysis by restriction enzyme digestion. All nucleotide sequences were the same as the reported, and four necleotides, at 4 different positions were polymorphic, and polymorphic alleles ${\alpha}4$, ${\alpha}5$, ${\alpha}6$, and ${\beta}2$ were identified. The new alleles were originated from homologous recombination between the ${\alpha}1$ and ${\beta}1$ alleles, and the alleles were founded in heterozygotes only. Although allele ${\alpha}1$ was dominant, the new alleles and ${\beta}1$ were recessive. From the results, it was suggested that the new method of FoLT-PCR was highly applicable in genetic variation analysis.

• The Journal of Korean Medicine
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• v.30 no.2
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• pp.30-45
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• 2009

Background: The safety of herbal products is an important issue in Korea. It is more complicated because of the concomitant use of conventional western drugs and herbal medicine, including prescribed medicine, folk herbs and food supplements. Although both western and traditional Korean medical doctors have studied on the safety of HMP, their results did not show relevant or consistent conclusions because of the poor quality of studies, including bias. Objectives: The aim of this study was to review the studies in Korea related to drug induced liver injury (DILI) systematically. We tried to estimate the proportion of causative materials of DILI and evaluate the clinical difference of DILIs from different materials. Methods: Systematic searches were performed on MedRIC and MEDLIS in Korea. The extraction of data as well as selective screening of the studies was carried out independently by two of the authors. There were no restrictions on the types of publication, including grey literature. Results: Twenty-one articles were included. Of them only 7 adapted prospective design and only 6 were published in peer-reviewed journals. The proportion of conventional drugs associated with hepatotoxic injuries in all DILI ranged from 15.8% to 83.3% and that of herbal medicine was from 28.9% to 44.7%. However, the criteria for herbal medicine were not clearly defined and concomitant medications were not fully investigated in most studies. There were limited objective data in the clinical differences of liver injuries from different materials and their results were conflicting. Conclusions: The causality assessments regarding DILI of herbal medicine were not performed properly and causative materials were misclassified in most of the studies published in Korea. These make the safety issue still ambiguous because of the limitations and lack of objectivity of the studies. More rigorous studies are required for clearly addressing these conflicting issues with cooperative investigation between traditional Korean and western medicine.

• Journal of Korean Society for Geospatial Information Science
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• v.23 no.3
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• pp.49-55
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• 2015

Current medical delivery system in Korea has been distinguished into three types; primary medical facilities, secondary facilities, and tertiary facilities since 1989. This system prevents the waste of medical resources along with the maintenance of balance according to the medical treatment subjects. However, it is inevitable that the imbalance of the medical services among regions has been generated due to the concentration of the medical facilities on large cities. In this regard, this study attempted to evaluate the quality of the primary medical services, emphasizing accessibility and convenience targeting Jinju city, a small and medium-sized city, based on the distribution characteristics of the space. The study results show that cohesion index about the spatial distribution of the primary care facilities was 0~0.25. It conducted a correlation analysis between the location of the hospitals and users, based on the study results. Finally, it is demonstrated the correlation between the location of the hospitals and users tended to be low, while, the cohesion of the Oriental medicine clinics was high in other treatment subjects, and the accessibility to the Oriental medicine clinics was the highest because most Oriental medicine clinics were distributed to the places where users were many. However, on account that the locations of the medical facilities and users were varied in other treatment subjects except for the Oriental medicine clinics, problems were generated in terms of the accessibility. Therefore, it is judged that the preparation of the measures to improve the selection of lots in consideration of users, who use the primary medical services, is required.

• Journal of Acupuncture Research
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• v.22 no.1
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• pp.165-176
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• 2005

Objective : This study was to vertify the effect of Semen Sinapsis Albae Pressing at Sanyinjiao(SP6), Umnungchon(SP9) and Shinnsu(B23) on dysmenorrhea of Women's University Students. This study was an one group pretest-posttest experimental design. Methods : The subjects were 50 patients who was suffering for dysmenorrhea visited to D University Health center located in B city, from January to May, 2004. They had agreed to take part in this experiment, with didn't take any anodyne drugs. Results : The results of the study are as follows 1. Hypothesis 1 that "Semen Sinapsis Albae pressing in SP6, SP9 and B23 is decreased dysmenorrhea" is adapted(t=12.777, p=0.000). 2. Semen Sinapsis Albae pressing is more fast manifested in alleviation of pain, longer in duration of alleviation of pain, and had a less dysmenorrhea than anodyne drugs. Semen Sinapsis Albae pressing is probably more effective than who are dosed anodyne instead of pressing.

• Journal of Digital Convergence
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• v.13 no.9
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• pp.439-444
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• 2015

This study analyzes the chicken-related prescription shown in the literature summarized by standing tradition deliberate aims to investigate the clinical efficacy of native chickens. Therefore, The old traditional medicine books of native chickens translate and organize the relevant prescriptions. The manuscript old documents is prescribed by the old central documents sourced directly from generation to generation descendants technical publishing contemporary situation sake of the development of this unique formulation not only contemporary who established himself through numerous trials and errors. Browse almost circular in traditional medicine prescription, which is scattered throughout the country is difficult, and because of the loss can not be confirmed even its existence. This study is to establish the analysis and separated by organized to establish a database on the basis of prescription and mixed herbs in a variety of functional foods developed through usability evaluation methods of treatment. Therefore, the management systems of native chickens related to lack of knowledge and information to foster the continued expansion and specialized training and knowledge of the future growth engine industry through the added value of cultural projects of national knowledge resources. Finally, convergence research and evaluate the usefulness of native chickens through interdisciplinary research systems, and practical measures of functional foods and alternative medicine are presented as well.

• KIPS Transactions on Software and Data Engineering
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• v.8 no.11
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• pp.433-440
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• 2019

Recently, machine learning and data mining have been used for many disease prediction and diagnosis. Chronic diseases account for about 80% of the total mortality rate and are increasing gradually. In previous studies, the predictive model for chronic diseases use data such as blood glucose, blood pressure, and insulin levels. In this paper, world's first research, verifies the relationship between dyslipidemia and facial characteristics, and develops the predictive model using machine learning based facial characteristics. Clinical data were obtained from 5390 adult Korean men, and using hypertriglyceridemia and facial characteristics data. Hypertriglyceridemia is a measure of dyslipidemia. The result of this study, find the facial characteristics that highly correlated with hypertriglyceridemia. FD_43_143_aD (p<0.0001, Area Under the receiver operating characteristics Curve(AUC)=0.652) is the best indicator of this study. FD_43_143_aD means distance between mandibular. The model based on this result obtained AUC value of 0.662. These results will provide a basis for predicting various diseases with only facial characteristics in the screening stage of disease epidemiology and public health in the future.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.533-536
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• 2019

Recombinant baculoviruses are widely used to express heterologous genes in cultured insect cells. Recombinant baculoviruses can serve as gene-transfer vectors for expression of recombinant proteins in a wide range of mammalian cell types. Baculovirus system has significant benefits in view of safety, large-scale, and high level of gene expression. In this study, baculoviral vectors which were reconstructed from pOPINEneo-3C-GFP vector, were recombined with cytomegalovirus (CMV) promoter, green fluorescent protein (GFP), and p53 with NcoI and XhoI. These recombinant vectors were infected with various cells and cell lines. The baculovirus vector thus developed was analyzed by comparing the metastasis and expression of the recombinant genes with conventional vectors. These results suggest that the baculovirus vector has higher efficiency in metastasis and expression than the control vector. This work was supported by a grant from Mid-Career Researcher Program(NRF-2016R1A2B4016552) through the National Research Foundation of Korea(NRF) funded by the Ministry of Science, ICT & Future Planning(MSIP).

• Science of Emotion and Sensibility
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• v.6 no.2
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• pp.29-35
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• 2003

In the oriental medicine, the illness of a human being is treated properly according to the strength and weakness of his/her physical constitution. In other words, the treatment principle of the oriental medicine is to balance the functions of the weak and strong inner parts of the physical constitution which can be classified into five characteristic elements: that is, the wood, fire, earth, mental, and water. An aroma therapy, one of traditional oriental medicine, uses pertinent perfumes to strengthen weak inner parts of the body, too. Although the remedy based on the five elements (in short, five element remedy) has revealed excellent clinical effects so far, it is still believed that the remedy is rather statistical and subjective than scientific. Thus, more systematic research needs to be done to prove it. In this paper, the correlation between perfume and physical constitutions has been formulated by grasping results of EEG through stimulation of lavender oil to both mental-type and fire-type persons. Also, the possibility of application for the five element remedy has been investigated. As a result, we found that the lavender oil helped to make strong gallbladder soften for fire-type individuals and to balance weak liver and strong gallbladder for mental-type persons. This agrees well with the results of the five element remedy practiced in the oriental medicine.

• Journal of Mushroom
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• v.19 no.4
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• pp.279-284
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• 2021

Flammulina velutipes is the representative edible mushroom in Korea. It makes up around 18% of the total mushroom production and accounts for about 36% of the total mushroom export. Despite being one of the most industrially important mushroom in Korea, the distribution rate of domestic cultivar was low (~31.6%) in 2020. Therefore, we need a new domestic cultivar with high quality as the main export mushroom. We developed a new white domestic cultivar, 'Seolhan', bred by mating two monokaryotic strains isolated from Baekseung and Woori-1ho. The optimum mycelial growth temperature was 25℃ and Seolhan had higher mycelial growth than the control at 20 and 25℃. In bottle cultivation, the optimum temperature of incubation was from 15℃ to 17℃ and the growth temperature of Seolhan was 7-8℃, which was slightly higher than that of the control. The yield of Seolan was 226.5±8.0 g, an increase of 18.4% compared to the control. The period of primodia formation also was a couple of days ahead. In morphological traits, the pileus of Seolhan was smaller than that of the control, the stipe was thicker, and the color brighter. As the results of replacement culture and genetic diversity test, it was confirmed that Seolhan was genetically different from other white varieties.