• 제목/요약/키워드: 한국원자력연구소

검색결과 616건 처리시간 0.021초

감마선 조사에 의한 LPS의 면역 독성 저감화 (Reduction of Immune Toxicity of LPS by Gamma Irradiation)

  • 박종흠;성낙윤;변의백;송두섭;송범석;김재경;이주운;박상현;김재훈;강근옥;유영춘
    • 방사선산업학회지
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    • 제6권3호
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    • pp.217-221
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    • 2012
  • The purpose of this study is to reduce the immune toxicity of lipopolysaccharide (LPS) by gamma irradiation. LPS was gamma-irradiated at the various doses of 20, 100 and 200 kGy and then evaluated on the immune toxicity through the cell proliferation, nitricoxide production and cytokine release. Cell proliferation significantly decreased in the intact LPS treated groups, whereas gamma-irradiated LPS treated group were not reduced the cell proliferation. Similarly, the production of nitric oxide and cytokine showed the high levels in the intact LPS treated group. However, gamma-irradiated LPS treated group remarkably decreased the production of nitric oxide and cytokine in dose-dependent manner. Therefore, gamma irradiation may effective method to reduce the immune toxicity of LPS.

감마선 조사 패턴에 따른 벼의 Lipid Transfer Protein Gene (LTP)의 발현 차이 (Differential Expression of Rice Lipid Transfer Protein Gene (LTP) Classes in Response to γ-irradiation Pattern)

  • 김선희;송미라;장덕수;강시용;김진백;김상훈;하보근;박용대;김동섭
    • 방사선산업학회지
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    • 제5권1호
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    • pp.47-54
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    • 2011
  • In this study, we investigated to evaluate differential expression of genes encoding lipid transfer proteins (LTP) by acute and chronic gamma irradiation in rice. After acute and chronic gamma irradiation by 100 Gy and 400 Gy to rice plant, necrotic lesion was observed in the leaf blade and anthocyanin contents were increased. We isolated a total of 21 rice lipid transfer protein (LTP) genes in the TIGR database, and these genes were divided into four different groups on the basis of nucleotide sequences. The LTP genes also were classified as different four classes according to expression pattern using RT-PCR. Group A, B contained genes with increased expression and decreased expression in acute and chronic, respectively. Group C contained genes with contrasted expression pattern. Group D wasn't a regular pattern. But the specific affinity was not obtained between two grouping.

감마선 조사에 의한 수산 자숙액의 생리활성에 대한 연구 (Study on the Physiological Activities of Gamma-irradiated Seafood Cooking Drips)

  • 조으리;김연주;최종일;성낙윤;정필문;김재훈;송범석;윤요한;이주연;이주운
    • 방사선산업학회지
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    • 제4권1호
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    • pp.25-31
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    • 2010
  • Cooking drips which were obtained as by-product after seafood processing in the food industries, still contain lots of proteins, carbohydrates, and other functional materials. This study was conducted to investigate the effect of gamma irradiation on the biological activities of seafood cooking drips. When the cooking drips of Hizikia fusiformis, Enteroctopus dofleini and Thunnus thynnus were irradiated, the antioxidant activities, whitening effect, and angiotensin I converting enzyme inhibition activity of the ethanol extract from seafood cooking drips were all increased by gamma irradiation. This was because of the increased extraction efficiency of available compounds by irradiation. These results suggested that the seafood cooking drips, wasted as by-products, can be used as functional compounds with gamma irradiation treatment.

시판 유제품 중에서 분리된 젖산균의 감마선 조사에 의한 생존 효과 (The Effect of Gamma Irradiation on the Survival of Lactic Acid Isolated from Commercial Daily Product)

  • 이지혜;김재경;조으리;성낙윤;최종일;김재훈;송범석;박종흠;육홍선;이주운
    • 방사선산업학회지
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    • 제5권2호
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    • pp.175-178
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    • 2011
  • This study was conducted with effect of lactic acid bacteria by gamma irradiation. Lactic acid bacteria were exposed to irradiation with a single absorbed dose of 1, 2, 3, 4, 5, 6, 8, and 10 kGy. Possible lactic acid bacteria, including Lactobacillus paracasei KCTC 13169, Lactobacillus casei KCTC 3109, Lactobacillus acidophilus KCTC 3140, Lactobacillus plantarum subsp plantarum KCTC 3103, Lactobacillus debruekii subsp bulgaricus KCTC 3635, Streptococcus thermophilus KCTC 3658 were selected. The radiation sesitivities of lactic acid bacteria were expressed as $D_{10}$ values. The $D_{10}$ values of Lactobacillus paracasei, Lactobacillus casei, Streptococcus thermophilus, Lactobacillus acidophilus, Lactobacillus plantarum, and Lactobacillus debruekii were calculated as 0.42, 0.51, 0.47, 0.90, 0.44, and 0.61 kGy, respectively. Results suggest that L. acidiphilus has the highly resistant to gamma irradiation.

단자엽 모델 식물의 이온화 에너지원에 따른 생리 활성 (Physiological Characterization of Mono-Cotyledonous Model Plant by Ionizing Irradiation)

  • 송미라;김선희;장덕수;강시용;김진백;김상훈;하보근;박용대;김동섭
    • 방사선산업학회지
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    • 제5권1호
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    • pp.7-13
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    • 2011
  • The present study has been performed to compare the physiological analysis of monocot model plant (rice) in response to ionizing irradiations (cosmic-ray, gamma-ray, and Ion beam). Ionizing radiations were implanted into monocot model plant (rice) seed. After irradiation, the seeds were planted in the plastic pots for a growth period of one month. Thereafter, the morphological and physiological characteristics including malondealdehyde (MDA) and chlorophyll content, activities of antioxidant enzymes in irradiation samples were investigated. We are confirmed that the activity level of MDA and chlorophyll content were not changed by ionizing irradiation samples. However, the free radical contents were increased in all irradiated plants. And the activities of SOD, POD, and APX were significantly increased by irradiation compared with non-irradiation plant.

방사선 유도 돌연변이체 블랙베리 발효음료의 알코올 대사 및 숙취 억제 효과 (Effect of Fermented Blackberry Drinks Formed from Radiation-induced Mutant on Alcohol Metabolism and Hangover in Rats)

  • 조병옥;소양강;이창욱;조정근;우현심;진창현;정일윤
    • 방사선산업학회지
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    • 제7권1호
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    • pp.75-80
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    • 2013
  • This study was designed to elucidate the effect of fermented blackberry drinks (BD) on alcohol metabolism and hangover in alcohol-treated rats. We showed that the administration of BD increased the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in alcohol-treated rats. Moreover, the administration of BD reduced the serum alcohol and acetaldehyde concentrations in alcohol-treated rats. Furthermore, the administration of BD attenuated the levels of serum aspartate aminotransferase and alanine aminotransferase in alcohol-treated rats. Taken together, these results suggest that BD plays an important role in alcohol metabolism and liver function by reducing blood alcohol and acetaldehyde through the activation of ADH and ALDH in alcohol-treated rats and could be used as a functional anti-hangover drinks.