• 축산식품과학과 산업
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• v.8 no.1
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• pp.8-13
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• 2019

• Food Science and Industry
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• v.45 no.1
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• pp.39-47
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• 2012

• KOREAN POULTRY JOURNAL
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• v.33 no.7 s.381
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• pp.84-87
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• 2001

우리나라에서는 어린이 설사, 위염을 치료하고 충치를 예방할 수 있는 달걀이 지난해말 개발되어 시중에 시판되고 있다. 이러한 기능성 계란은 한국식품개발연구원과 에그바이오텍, 시트리 등 바이오 업체 중심으로 개발되어 다한영농법인, 강남농장, 에그원, 가농바이오 등 농장에서 생산하여 소비자에게 공급하고 있다. 그러나 이러한 기능성계란은 인체용으로 사용되어 왔고 가축 질병 치료제로 사용되지는 못했다. ㈜단$\cdot$바이오텍(대표 김정우)은 첨단 생물공학기술을 이용하여 동물생체에 친화적인 고품질의 신생물질(면역항체, lgY)의 생산을 산업화함으로써 동물과 사람의 치료시 화학제제 및 항생제의 장기복용 및 오$\cdot$남용으로 인해 발생되는 제반 문제점을 해결한다는 사명감을 가지고 지난해 10월 출범하여 업계의 관심이 집중되고 있다.

• Journal of Korea Far Infrared Association
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• s.20
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• pp.20-29
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• 2004

• Microbiology and Biotechnology Letters
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• v.50 no.3
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• pp.395-403
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• 2022

In this study, we identified that the fermentation of Korean indigenous probiotics and red ginseng produced ginsenoside compound K (CK) from major ginsenosides. Based on whole genome sequencing of 19 probiotics species, β-glucosidase, α-arabinofuranosidase, β-xylosidase, and α-rhamnosidase related to bioconversion of ginsenosides are identified in the genome of 19 species, 3 species, 6 species, and 8 species, respectively. Among the 19 probiotics species, Bifidobacterium longum CBT BG7 converted from ginsenoside Rb1 to CK, and both B. breve CBT BR3 and B. lactis CBT BL3 converted ginsenoside Rb1 to Rd. The final concentration and yield of ginsenoside F2 and CK were higher in the fermentation with the nondisrupted cells than with disrupted cells. The combination of both CBT BG7 and BL3, and CBT BG7 and BR3 showed higher amounts of F2 than CBT BG7 only. CBT BG7 with adding α-amylase increased the amounts of F2. In this study, we identified that the fermentation of both Korean indigenous probiotic bacteria CBT BG7, BR3 and BL3, and red gingseng is able to produce CK, a bioactive compound that promotes health benefits.

• Proceedings of the Korean Society of Crop Science Conference
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• 2019.09a
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• pp.28-28
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• 2019

• The Science & Technology
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• v.34 no.4 s.383
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• pp.20-21
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• 2001

리젠바이오텍은 배ㆍ피부 등 생체조직을 파괴시키거나 이에 필요한 생리활성물질 및 촉진제를 개발하는 조직공학분야의 바이오벤처기업이다. 이 회사의 연구팀은 지난 5년동안 키토산을 이용해 각종 세포배양 연구를 하던중 최근 3차원 세포배양을 용이하게 할 수 있는 '다공성 키토산 구슬'을 개발하는데 성공했으며 지난해에는 자연치아 특성을 살린 혁신적인 인공치아 제조기술을 개발하기도 했다.

• The Korean Journal of Food And Nutrition
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• v.32 no.2
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• pp.106-113
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• 2019

The objective of this study was to evaluate the effect of fermented Kalopanax pictus (KP-F) on macrophage activation and its effect as a competitive inhibitor of LPS and inhibitory effect on endotoxemia. The results showed that KP-F could activate macrophage in a dose-dependent manner, and KP-F was confirmed to act as a ligand for TLR4. Also, it was found that KP-F did not exhibit the same biotoxicity as LPS in intraperitoneal injection, and that it could suppress the neutrophil migration induced by LPS administration. In normal mice, the body weight, tissue weight, and amount of nitrite and pro-inflammatory cytokines in serum showed no significant changes with KP-F diet for 2 weeks, confirming that administration of KP-F in normal mice did not lead to over activation of immune response and biotoxicity. In the mouse model of endotoxemia induced by LPS and D-galactosamine(D-GalN) in sub-lethal dose, the diet of KP-F effectively inhibited the amount of nitrite and cytokines in the blood, and thus was found to be able to relieve the hepatic and kidney injury. In addition, in the endotoxemia mouse model induced by LPS and D-GalN of lethal dose, the survival rate was increased by KP-F diet in a dose-dependent manner.

• The Korean Journal of Food And Nutrition
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• v.32 no.2
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• pp.148-154
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• 2019

The aim of this study was to select compounds for the standardization of fermented Kalopanax pictus Nakai (KP-F), to develop the analysis method using HPLC-PDA and to perform method validation. KP-F is a fermented powder developed to improve the original physiological activities and create a new functionality. Eleutheroside E, Acanthoside B, and Syringaresinol were selected as the standard compounds and developed our own method for simultaneous analysis. The analyte was isolated using C18 column with a gradient elution of 0.05 M phosphoric acid in water and methanol as the mobile phase at a flow rate of 1 mL/min and detected at 210 nm. As a result, all standard compounds showed good linearity with an $R^2$ (coefficient of correlation) of 1.000 and for the limit of detection range of $0.710{\sim}0.831{\mu}g/mL$, and the limit of quantification as $2.150{\sim}2.520{\mu}g/mL$. The precision was RSD (%) of less than 4.80%, while the accuracy was 4.70%>RSD (%) for the range 102.44~110.48%. In conclusion, the developed analysis method is suitable for the detection of Eleutheroside E, Acanthoside B, and Syringaresinol in KP-F.

• Journal of Korea Far Infrared Association
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• s.19
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• pp.22-31
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• 2003