• Journal of agriculture & life science
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• v.45 no.6
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• pp.183-191
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• 2011

We investigated characterization as cosmetic substances of chestnut inner skin extracts with in vitro antioxidant activity. Total phenolics of various extracts from chestnut inner skin were the highest 60% methanol (164.82 mg/g), and ethyl acetate fractions (191.14 mg/g). We found that the both samples from chestnut inner skin dose-dependently increased in vitro antioxidant activities (DPPH radical scavenging activity and inhibition of lipid peroxidation). In addition, the both samples also showed a strong UV absorption in the range of UV-B (290-320 nm). Especially the 60% ethanol extracts presented higher inhibitory effect on elastase (46.40% at $100{\mu}g/mL$) than that of the ethyl acetate fractions, so that it showed in vitro anti-wrinkle activity. Finally, the 60% methanol extracts and ethyl acetate fractions showed anti-bacterial activity against skin pathogenic bacteria. Consequently, these results suggest that the chestnut inner skin can be used for cosmetic industry.

• Korean Journal of Food Science and Technology
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• v.35 no.6
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• pp.1209-1215
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• 2003

This study was carried out to establish a quantitative analysis method of separating immuno-activating substance (EN-SP) from Acanthopanax senticosus (A. senticosus) by competitive direct ELISA. Mouse antiserum (anti-EN-SP) against EN-SP was generated by immunization (s.c.) of EN-SP purified from A. senticosus as an immunogen. The titer of anti-EN-SP was about 1 : 400, and the optimal dilution of EN-SP-HRP conjugate was 1 : 1,000. When the standard curve was constructed by ELISA, its sensitivity was about $0.2{\mu}g/mL$. The coefficient variation of intra- and inter-assay were $6.13{\sim}8.81%$ and $6.73{\sim}8.60%$, respectively. According to the standard curve, the concentration of EN-SP in various senticosus extracts was found to be only $59.85\;{\mu}g$ in 10mg of extract from the bark of A. senticosus. Similarly, the immunostimulating activity to produce $TNF-{\alpha}$ or IL-12 among the various extracts of Acanthopanax was shown to be correlated with the content of EN-SP. These results demonstrated that competitive ELISA was a convenient, fast, reproducible, and accurate method for the determination of EN-SP as an immunologically active standard substance in extract of A. senticosus.

• Proceedings of the KOR-BRONCHOESO Conference
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• 1972.03a
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• pp.5-6
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• 1972

Noise and air pollution, which accompany the development of industry and the increase of population, contribute to the deterioration of urban environment. The air pollution level of Seoul has gradually increased and the city residents are suffering from a high pollution of noise. If no measures were taken against pollution, the amount of emission of pollutant into air would be 36.7 thousand tons per year per square kilometer in 1975, three times more than that of 1970, and it would be the same level as that of United States in 1968. The main sources of air pollution in Seoul are the exhaust has from vehicles and the combustion of bunker-C oil for heating purpose. Thus, it is urgent that an exhaust gas cleaner should be instaled to every car and the fuel substituted by less sulfur-contained-oil to prevent the pollution. Transportation noise (vehicular noise and train noise) is the main component of urban noise problem. The average noise level in downtown area is about 75㏈ with maximum of 85㏈ and the vehicular homing was checked 100㏈ up and down. Therefore, the reduction of the number of bus-stop the strict regulation of homing in downtown area and a better maintenance of car should be an effective measures against noise pollution in urban areas. Within the distance of 200 metres from railroad, the train noise exceeds the limit specified by the pollution control law in Korea. Especially, the level of noise and steam-whistle of train as measured by the ISO evaluation can adversely affect the community activities of residents. To prevent environmental destruction, many developed countries have taken more positive action against worsening pollution and such an action is now urgently required in this country.

• Korean Journal of Psychosomatic Medicine
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• v.14 no.1
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• pp.8-17
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• 2006

Neurofeedback, also known as EEG biofeedback or neurotherapy, is a new therapy differentiated from biofeedback in that brain waves are monitored to study brain itself as well as its functions. Needless to say, it has originated from biofeedback, however it has established itself as an independent and specialized therapy in the field of neurotherapy. In order to have a better understanding of neurofeedback we are going to have a look into its historical and theoretical background first and then we will explain how it can be used clinically. Neurofeedback was clinically introduced for epilepsy for the first time and its effect was proved. Since then it has been used successfully for a number of psychiatric disorders, such as attention deficit hyperactivity disorder(ADHD), anxiety, anxiety and mood disorder, sleep disorder, substance dependency, etc. Furthermore, it has been used for non-psychiatric or psychosomatic symptoms, such as headache, chronic pains, chronic fatigue symptoms, etc. Recently, it has been also used for non-medical areas, such as improvement of peak performance for sports and art activities, enhancement of cognitive function, etc, making the neurofeedback a very promising field for its potential and effectiveness.

• The Journal of the Korea Contents Association
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• v.16 no.11
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• pp.584-593
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• 2016

With the development of digital technology, people's lives are becoming increasingly comfortable and convenience. But with the rapid technological development, people feel tired of a modern society, so they became interested in basic human value and the design with human emotion This design is defined as the analog design concept to stimulate human emotions in previous studies, this approach considering the psychological and physical characteristics of the people has been attempted. This study is to consider about the concepts and consequent design elements for analog emotional expression through the prior analysis of the study In particular, understanding the architecture environment transformed into objects that interact and communicate with humans, this study focused on architectural space. The purpose of this study is to provide advice on the basic research of the field by analyzing the value and significance of the analog design in the digital society.

• YAKHAK HOEJI
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• v.41 no.3
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• pp.312-320
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• 1997

Pharmacokinetics and tissue distribution of DWP20349 and 20351, new quinolones, were examined in rats after a single intravenous and oral administration. Analyses of DWP20349 an d DWP20351 in plasma, tissue, and urine were determined by both HPLC and bioassay(microbiological assay). The plasma concentrations of the drugs declined biexponentially. The terminal half-lives ($t_{1/2\beta}$) of drugs were about 114 min (DWP20349) and 105 min (DWP20351) after intravenous dosing, and were 77 min (DWP20349) and 79 min (DWP20351) after oral dosing. The volume of distrbution at steady-state ($Vd_{ss}$) and total body clearances ($Cl_t$) of DWP20349 and DWP20351 were 760 ml/kg and 1126 ml/kg, and 5ml/min/kg and 10 ml/min/kg, respectively. The extents of bioavailability if DWP20349 and DWP20351 after oral administration were 29% and 28%, respectively. 24 h urinary recoveries measured by bioassay were 1.8% (DWP20349) and 1.3% (DWP20351) after oral dosing, and 2.4% (DWP20349) and 1.9% (DWP20351) after intravenous dosing. Plasma protein binding ratios ranged from 87%-90% (DWP20349) and 61%-68% (DWP20351). These drugs were highly distrbuted by the order of lung, kidney, liver and plasma (DWP20394), and lung, liver, kidney and plasma (DWP20351) after 1 hour orally administered.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2011.10a
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• pp.5-5
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• 2011

최근에 고령화 사회에 접어들면서 건강하게 활동하며 수명을 다하는 것이 중요한 연구과제가 되고 있다. 이 때문에 영양, 운동, 스트레스, 환경 등과 관련하여 암, 당뇨병, 고혈압, 비만, 동맥경화 등 생활습관병의 극복이 사회문제가 되고 있는 실정이다. 지금까지 고려인삼의 대표적인 동물실험 및 임상학적 연구결과를 종합하여 보면 성인의 난치성 만성질환에 대해서 치료제보다는 질병을 예방하고 회복촉진에 보다 큰 효과 있음을 확인할 수 있다. 이는 인삼이 식품과 의약품의 중간에 위치한 식품의약품(Nutraceutical)의 용도로 활용할 수 있음을 시사한다. 현재까지 인삼제품에 표시되는 기능성의 내용은 약 3,000여편 이상의 약리효능에 관련된 논문이 발표되었다 하더라도 "피로회복, 면역력 증진, 혈소판 응집 억제를 통한 혈액흐름에 도움이 됩니다"이며 이외의 기능성 표시는 현재로서 원칙적으로 불가한 것으로 되어 있다. 그러나 시험물질의 규격화 및 임상시험의 검토기준을 만족시키는 과학적 자료제출에 의한 개별 평가 후 표시내용의 확대가 가능하다. 고려인삼의 다양한 성분 중 ginsenoside는 주요 약효성분으로 인정을 받고 있으며 현재 품질관리의 지표성분으로 활용되고 있다. 이러한 개별 ginsenoside의 약리작용을 보면 서로 유사 또는 상반된 효과를 보여주는 성분들이 공존하고 있어 인삼의 다양한 약리효과와 일맥상통하는 것으로 보고되고 있다. 아울러, ginsenoside는 인삼의 부위 별로 현격한 차이를 보여주기 때문에 소재의 규격화는 매우 중요하다고 판단된다. 따라서, 인삼제품 개발의 가장 중요한 조건은 의약품에 가까운 기능성식품으로 세계적인 제품을 만들기 위해서는 표준화가 선행되어야 한다. 이와 같은 조건을 잘 충족시키는 제품이 스위스 "파마톤의 진사나(백삼추출물, G115)" 제품으로 생각할 수 있다. 따라서, 고려인삼의 수출시장 확대 및 세계적인 제품을 위해서는 진사나에 필적할 수 있는 새로운 홍삼의 표준화된 추출물을 도출하는 것이 무엇보다 급선무라 생각한다. 아울러 고려인삼의 특장점 발굴을 위한 표준화 된 추출분획물, 활성성분 및 효능과 연계한 새로운 고부가가치 창출제품(식품/의약품)개발에 주력해야 할 것이다.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.115-115
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• 2018

매실나무(Prunus mume)의 풋과일인 매실은 피로회복, 소화촉진, 살균 및 항균작용 등 다양한 생리활성을 갖고 있다. 본 연구는 국내 수집 매실 유전자원 172점의 핵심 기능성 물질인 유기산의 함량 특성을 평가하고자 2017년과 2018년 2년간 청매실을 수확하여 옥살산(OA), 사과산(MA), 구연산(CA)의 함량을 HPLC를 이용하여 분석하고 그 연차 변이를 평가하였다. 전체 유전자원 매실의 2년간 총유기산(TA) 함량은 평균 5.5% (최소 3.9%-최대 7.8%)이었으며, MA와 CA 및 OA의 평균 함량은 각각 2.7%, 2.8%, 0.1%였다. 대상 자원 내 유기산별 함량 변이는 CA (RSD=30%)가 MA (RSD=21%)보다 높게 나타났다. 2018년산 매실은 2017년산에 비교할 때 MA와 OA는 함량이 낮아 연차 변이가 인정되었으나 CA는 차이가 없었다. 비록 연차 변이는 있었으나 유전자원별 함량은 MA와 CA 및 TA에서 모두 2017년산과 2018년산간 정의 상관이 인정되어 유기산 함량이 높고 낮은 자원의 특성은 유지됨을 알 수 있었다. 대상 유전자원 중 TA함량이 가장 높았던 자원은 구산매, 용흥흥매, 상금백옥매 등이었으며, 함량이 낮은 자원은 한산매, 지곡매 등이었다. 상기 결과를 통해 매실 유기산 함량관련 국내 매실 유전자원의 유전적 다양성과 연차 변이의 영향을 평가할 수 있었다.

• Journal of the Korean Chemical Society
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• v.42 no.6
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• pp.664-671
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• 1998

Poly pyrrole polymer(ppy) has an excellent electrical conductivity and can be easily polymerized on anode to give various morophology according to doped anion on electroactive sites. To improve the properties of brittleness, ageing and hydrophobisity, poly furan polymer(pfu) having a high initiation potential was anodically implanted in this porous ppy film matrix to get the Pt/ppy/pfu(x)type of polymer composite electrode. Cyclic voltammetry and electrochemical impedance methods were used to these electrode, where $PF_6^-,\; BF_4^-$, and $ClO_4^-$ ions were employed as dopants. The composition of the pfu(x) at the electrode was changed from 0 to 1.10, but the range was useful only at 0.1 to 0.2 as the redox electrode. The polymer composite electrode doped with $PF_6^-$ was better in charge transfer resistance by a factor of 40 times and in double layer capacitance by a factor of 20 times than others. The charge transfer in the polymer film of the electrode was influenced on frequency change and equivalent circuit of this electrode had Warburg impedance including mass transfer.

• Korean Journal of Food Science and Technology
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• v.19 no.2
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• pp.102-106
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• 1987

In order to examine the appropriateness of types of pigskin as a raw material for gelatin production, comparison was made on the quality of gelatins made from raw and scalded pigskins. Raw and scalded pigskins were acidified in 1.7% HCl solution for 15-18 hr and then washed by tap water for 10 hr. After washing, pigskins were extracted at $60^{\circ}C$, $70^{\circ}C$ and $80^{\circ}C$ to produce gelatins. Gelatins from raw pigskins appeared to be better in gel strength than those from scalded ones at all extraction temperatures. Gelatin yield was higher with raw than with scalded pigskins. With the increase of extraction temperature, the decrease in gel strength and viscosity was resulted in. More colored gelatins were produced with increasing extraction temperature in both raw materials. Electrophoretic pattern of gelatins showed that higher molecular weight fractions decreased with the increase of extraction temperature and pigskin gelatin had more complicated molecular composition than that of type B gelatin (alkali-treated gelatin).