• The Korean Journal of Nuclear Medicine
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• v.26 no.2
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• pp.346-354
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• 1992

Cancer cells have several tumor-associated antigens on the cell surfaces, and antibodies against these antigens have been developed by many investigators. Radiolabeled antibodies have been used as new methods to diagnose and treat malignant tumors. Especially anti-carcinoembryonic antigen (CEA) is the most popular antibody for these purposes. In this investigation, we tried to label $^{131}I$ and $^{99m}Tc $ to anti-CEA monoclonal antibodies which were developed in the Seoul National University College of Medicine. We found CEA-79 and CEA-92 antibodies had the better immunological characteristics among 8 anti-CEA monoclonal antibodies. And radioiodination of CEA-79 could be performed by chloramine-T method, while radioiodination of CEA-92 by iodogen method. To label these antibodies with $^{99m}Tc $, we used pretargeting transchelation as direct labeling method. At first, $^{99m}Tc $ was bound to glucaric acid, and monoclonal antibody was reduced by $\beta-mercaptoethanol$. When these were incubated together. $^{99m}Tc $ bound to glucarate was switched to monoclonal antibody because of higher affinity. We established conditions of several steps in this method. Anti-CEA monoclonal antibodies labeled with $^{131}I$ and $^{99m}Tc $ are expected to be used valuably in the detection and treatment of malignant tumors.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.20 no.6
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• pp.117-132
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• 2021

Due to the terrain in Korea, there are many road sections passing through mountainous areas. During the winter, there is a higher risk of traffic accidents, due to black ice caused by the lack of sunlight. Despite domestic road freezing safety measures, accidents caused by road freezing results in severe traffic accidents. Under these considerations, this study analyzed whether traffic safety signs that change in response to the external temperature help drivers recognize frozen road segments. The study was conducted through analysis of the effect of the signs on a driver's perspective. For the signs under development, out of the signs designed by experts, the sign design which received the highest visibility and effectiveness evaluation ratings from the general public was selected. The sign was implemented through Virtual Reality (VR) and installed on the right side of the road to analyze the effect on gazing and driving behavior. As a result of analyzing the driver's driving behavior, a speed reduction of about 7km/h or more was found in the sign section. Therefore, It was found that the existence of the sign had a strong relationship with the rate of the drivers' speed reduction.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.10
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• pp.4514-4522
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• 2012

In this study, we presented the improved plans for establishment of boundary monuments and management of records in cadastral resurvey project after examining the Special Act on Cadastral Resurvey which has some problems of them. As the result, we proposed that it is necessary to change the color of boundary monuments for distinguishing with the existing one. And also, they should be established at the confirmed boundary points which land owners have already accepted through the temporary boundary monuments. In addition, the register of boundary monuments has to be unified with present records because they are very similar. We hope that the government should adapt these proposals for the successful project.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.4
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• pp.933-939
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• 2015

If the Visual Aids(light wave signs) is not supplied the general power it is using solar power system. These power supply systems, the role of the charge/discharge control is very important. Introduction of IT(AIS etc.) for the effective management of the AtoN(Aids to Navigation) is a Visual Aids has been added to the device using the power to charge/discharge control, the need increases. The current charge/discharge controller is attached to the inside of the AtoN and checks on and verification of the maritime environment, depending on the difficulty. In order to resolve these issues in this paper, the Bluetooth module is mounted on the inside of the charge/discharge controller and proposed a possible system monitoring at close range. Advantage of the system implemented is a simple configuration and low installation cost. In addition, it can be applied to a variety of AtoN. Also, it has been able to check the real-time status information of the charge/discharge controller at a short distance in to reduce inspection costs, and reduce risk factors that might occur during check.

• The Korean Journal of Nuclear Medicine
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• v.27 no.2
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• pp.285-292
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• 1993

Avidin과 biotin의 높은 결합력을 이용하여 종양 영상을 개선하는 방법이 많이 연구되고 있다. 본 실험에서는 이러한 목적으로 쓰기 위하여 적당한 $^{99m}Tc$ 표지 avidin을 제조하였다. Avidin을 표지하기 위하여 우선 $^{99m}Tc$과 안정한 킬레이트를 형성할 수 있는 benzoylmercaptoacetyltriglycine (Bz-MAG3)과 biocytin을 화학적으로 결합시킨 Bz-MAG3-biocytin을 합성하였다. 이 화합물을 Tc-99m으로 표지시켜 avidin 또는 streptavidin을 1:1로 섞어 줌으로서 Tc-99m으로 표지된 avidin과 streptavidin을 제조하였다. 이들의 생쥐 생체내 분포를 조사한 결과 avidin의 경우 높은 간(56.6%, 10min)과 신장(28.5%, 10min) 축적을 보였고 streptavidin의 경우 높은 신장 축적 (28.9%, 21hr)을 보였다. Avidin의 높은 정상 조직 축적을 줄이기 위하여 succinic acid를 결합시켜 등전점(pI)을 낮춘 다음 같은 실험을 하여 본 결과 신장 축적율은 pI가 $7.0{\sim}9.3,\;5.5{\sim}6.2,\;4.0{\sim}4.8$로 낮아졌을 경우 19.0%, 3.1%, 1.7%로 각각 떨어졌지만 간에의 축적은 pI 변화에 따른 상관성을 찾아 볼 수가 없었다. 체내 제거율을 측정하여 본 결과 pI를 변화시킨 avidin과 변화시키지 않은 avdin들은 반감기가 13.5에서 16.0시간 사이로 큰 차이점을 보이지 않았는데 streptavidin은 반감기 61.5시간 정도로 느리게 제거된다는 것을 알았다. 이 실험의 결과 1. Avidin을 $^{99m}Tc$-MAG3-biocytin으로 안정하게 표지할 수 있었고, 2. pI가 낮아진 avidin은 신장에의 축적율이 크게 감소되었으며, 3. $^{99m}Tc$으로 표지된 avidin과 streptavidin은 먼저 간으로 흡수된 후 대사된 다음 신장으로 배설된다는 사실을 알았다.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.18 no.6
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• pp.241-250
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• 2019

Road signs are guide facilities for road users, and the Ministry of Land, Infrastructure and Transport has established and operated a system to enhance the convenience of managing these road signs. The role of road signs will decrease in the future autonomous driving, but they will continue to be needed. For the accurate mechanical recognition of texts on road signs, automatic road sign recognition equipment has been developed and it has applied image-based text recognition technology. Yet there are many cases of misrecognition due to irregular specifications and external environmental factors such as manual manufacturing, illumination, light reflection, and rainfall. The purpose of this study is to derive location-based destination names for finding misrecognition errors that cannot be overcome by image analysis, and to improve the automatic recognition of road signs destination names by using Levenshtein similarity verification method based on phoneme separation.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.11 no.1
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• pp.13-27
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• 2012

According to the development of Intelligent Transportation System technology, VMS(Variable Message Signs) are operating on highway. But, VMS display information which don't reflect traffic condition and driver's human factor. So driver can't read VMS message during limited time, it makes to reduce VMS's reliability. This paper presents a model for VMS message reading time and distance considering traffic condition and human factor. We built driving simulator by Winroad package which is able to copy real driving condition. Subjects were comprised of 20 people who reflect domestic driver's condition such as sex. We did regression analysis with experiment results and draw the model. The model could be possible to develop message- set considering traffic condition and human factor.

• Archives of design research
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• v.13 no.1
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• pp.247-256
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• 2000

Recently, foreign tourists and car owners or motorists are increasing, so tourist sign boards are necessary to inform them. Unfortunately, tourist sign boards are difficult to understand because they are often written incorrectly. This paper has a thorough grasp of this problem and will present an ideal standard model which is precise and detailed. This paper includes research of tourist boards sign Seoul, Kyongju, Pusan, Kwangju, Yosu, Kwang reung in Korea. Also tourist sign boards in the U.K, France, Switzerland, Italy and Austria will be discussed. A survey was conducted of eight hundred people to determine tourist information is obtained. In conclusion, tourist sign board should convey accurate and useful information to people of all ages. Tourist information should be systematic and logical. An ideal standard model of tourist signs will render traveling easier for tourists all over the world. It will be more convenient for both kinds of tourist; domestic and foreign. Futhermore good tourist sign board will give an excellent and bright image.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.31 no.4
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• pp.293-300
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• 2013

Road signs are important infrastructures for safe and smooth traffic by providing useful information to drivers. It is necessary to establish road sign DB for managing road signs systematically. To provide such DB, manually detection and recognition from imagery can be done. However, it is time and cost consuming. In this study, we proposed algorithms for automatic recognition of direction information in road sign image. Also we developed algorithm code using OpenCV library, and applied it to road sign image. To automatically detect and recognize direction information, we developed program which is composed of various modules such as image enhancement, image binarization, arrow region extraction, interesting point extraction, and template image matching. As a result, we can confirm the possibility of automatic recognition of direction information in road sign image.

• Journal of Digital Convergence
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• v.14 no.1
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• pp.181-187
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• 2016

Typical Retro-reflectors installed on road have problems such as limiting a driver's visibility at night when it is foggy or rainy. On the other hand, LED illuminated studs, called cat's eye system, extends a driver's visibility under these conditions. In this paper, we present a design of the LED cat's eye system using solar energy that can sustain vehicles with about 30-ton weight and is compliant with the IP68 code for water proof as IEC standard 60529. In addition, we propose a scheme of designing a LED driving circuit consuming low power to take into accounts cold weather or rainy season with limited sunlight. This LED cat's eye studs is currently installed and used on expressway and bike route nationally as well as overseas.