• 한국노년학
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• v.30 no.3
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• pp.843-853
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• 2010

The purpose of this study is to find out the characteristics of elderly pedestrian accidents and to suggest policy implications to enhance the level of elderly pedestrian safety. Although much efforts has made to enhance traffic safety environment, pedestrian traffic accidents among elderly population are not significantly decreased. This is mainly because current traffic safety measures do not much consider the characteristics of elderly pedestrians in the aspects of physical and psychological conditions. Main findings from vehicle-pedestrian traffic accident data and survey are as follows. First elderly pedestrians have high probability of traffic accident near crosswalks or cross streets rather than on crosswalk or cross streets. Second they need more green light time for crossing the streets. Third, they feel motor cycles running on the side walk and parked vehicles on the side walk are the most dangerous factors. Forth, general drivers do not have reasonable understanding for the walking behaviors of elderly pedestrians. Fifth, elderly pedestrians frequently need to rest while walking. Sixth, elderly people do not see clearly or understand traffic signs. Finally, many elderly pedestrians experience accidents or inconvenience while walking on the sidewalk.

• Mood & Emotion
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• v.10 no.1
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• pp.13-21
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• 2012

Suicide is a complex behavior associated with various neurobiological and psychosocial factors. It is considered that genetic polymorphism combined with environmental stress such as child-adolescent trauma make differences in neurobiological systems, which cause psychiatric disorders or pessimistic personality, impulse-aggressive behaviors, lack of judgment, and finally result in suicidal behavior. Much progress in the neurobiology of suicide has been made over the several decades. There seems to be a hereditary disposition to suicide independent of psychiatric disorder. The changes in neurotransmitters, neurohormones, neurotrophic factors, cytokines, lipid metabolisms related with their genetic polymorphism can contribute to disturbance of signal transductions and neuronal circuits vulnerable to suicide. It is likely that the main factors are dysfunctions of serotonin (5-HT) and hypothalamus-pituitary-adrenal (HPA) axis. Our understanding about the neurobiology of suicide is still limited. However, clinical practice could be assisted by neurobiological findings capable of making the detection of risk populations with higher sensitivity and the development of new treatment interventions. The settlement of biological markers in suicidal behaviors and their relationships is required.

• Journal of the Korean Society of Marine Environment & Safety
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• v.29 no.7
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• pp.893-901
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• 2023

The International Association Marine Aids to Navigation and Lighthouse Authorities (IALA) proposed guidelines for VTS manual operation in 2016 for safe and efficient operation of ship. The Korea Coast Guard (KCG) established and operated 19 VTS centers in ports and coastal waters across the country by 2022 based on the IALA VTS manual and VTS operator's education and training guidelines. In addition, IALA proposed the Inter-VTS Exchange Format (IVEF) Service recommendation (V-145), a standard for data exchange between VTS, in 2011 for efficient e-Navigation system services and safe and efficient VTS service support by VTS authorities. The IVEF service in a common framework for ship information exchange, and it presents seven basic IVEF service (BISs) models. VTS service providers can provide safer and more efficient VTS services by sharing VTS information on joint area using IVEF standards. Based on the BIS data, interaction, and interfacing models, this paper introduced the development of the cloud-based VTS integration services performed by the KCG and the results of the VTS integration platform test-bed for IVEF service implementation. In addition, the results of establishing a cloud VTS integrated platform test-bed for the implementation of IVEF service and implementing the main functions of IVEF service were presented.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.22 no.5
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• pp.182-199
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• 2023

Since 2021, government departments have been promoting Automated Driving Technology Development and Innovation Project as national research and development(R&D) project. The automated vehicles and service technologies developed as part of these projects are planned to be subsequently provided to the public at the selected Living Lab City. Therefore, it is important to determine a spatial area and operation section that enables safe and stable automated driving, depending on the purpose and characteristics of the target service. In this study, the static Operational Design Domain(ODD) elements for Level 4 automated driving services were reclassified by reviewing previously published papers and related literature surveys and investigating field data. Spatial analysis techniques were used to consider the reclassified ODD elements for level 4 in the real area of level 3 automated driving services because it is important to reflect the spatial factors affecting safety related to real automated driving technologies and services. Consequently, a total of six driving mode changes(disengagement) were derived through spatial information analysis techniques, and the factors affecting the safety of automated driving were crosswalk, traffic light, intersection, bicycle road, pocket lane, caution sign, and median strip. This spatial factor analysis method is expected to be useful for determining special areas for the automated driving service.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.6
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• pp.793-799
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• 2023

This study classifies the types of urban railway stations that reflect the location characteristics of urban railway stations, the structure and form of station taxes, and the number of users, and the level of inconvenience in the transfer movement line for users by station type, the number and connectivity of transfer information, and the level of transfer convenience facilities. The number of installations, conflicts between users, and transfer information signs were analyzed. As a result of data analysis, it was found that the factors that cause the most inconvenience to urban rail users when transferring are the length and curvature of the transfer line, pedestrian density and number of passengers in the transfer passage, presence or absence of transportation convenience facilities, and the size and height of transfer information letters. These transfer inconveniences were objectified, quantified, and presented as evaluation indicators that can measure the transfer convenience of urban railway stations. Additionally, an evaluation scale was developed to measure the service level for each evaluation indicator. The evaluation scale for each indicator presented six levels by applying linear interpolation based on the maximum and minimum values of data derived through field surveys. However, it is judged that a comprehensive evaluation of transfer convenience that combines the importance and weight of each convenience evaluation indicator should be established through future research.

• Journal of Life Science
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• v.34 no.6
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• pp.418-425
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• 2024

Solid tumors are heterogeneous populations of multiple cell types. While the majority of the cells that comprise cancer are unable to divide, cancer stem cells have self-renewal and differentiation properties. Normal stem cell pathways that control self-renewal are overactivated in cancer stem cells, making cancer stem cells important for cancer cell expansion and progression. Dick first proposed the definition of cancer stem cells in acute myeloid leukemia, according to which cancer stem cells can be classified based on the expression of cell surface markers. Cancer stem cells maintain their potential in the tumor microenvironment. Multiple cell types in the tumor microenvironment maintain quiescent cancer stem cells and serve as regulators of cancer growth. Since current cancer treatments target proliferative cells, quiescent state cancer stem cells that are resistant to treatment increase the risk of recurrence or metastasis. Various signals of the tumor microenvironment induce changes to become a tumor-supportive environment by remodeling the vasculature and extracellular matrix. To effectively treat cancer, cancer stem cells and the tumor microenvironment must be targeted. Therefore, it is important to understand how the tumor microenvironment induces reprogramming of the immune response to promote cancer growth, immune resistance, and metastasis. In this review, we discuss the cellular and molecular mechanisms that can enhance immunosuppression in the tumor microenvironment.

• Journal of Life Science
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• v.34 no.5
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• pp.320-332
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• 2024

The aims of this study were to compare the differences in hemodynamics between cigarette smoking and using heated tobacco products (HTPs) and to determine the acute effects of using HTPs on cardiac autonomic regulation. Another goal was to examine the acute cardiac autonomic responses when using different tobacco sticks in HTPs. Sixteen healthy male smokers completed an open-label, randomized, crossover trial consisting of non-smoking (NS), cigarette smoking, and the use of two different HTPs (IQOS with HEETS; lil SOLID with Fiit). Sub-trials, which included NS, lil SOLID with Fiit, and lil SOLID with HEET, were performed on eight smokers among the total subjects. Hemodynamic variables, such as systolic blood pressure (SBP) and diastolic blood pressure (DBP), and heart rate variability were measured before, during, and 30 minutes after using each tobacco product. Using HTPs resulted in a significant increase in both SBP and DBP, comparable to smoking cigarettes. Cardiac sympathetic activity significantly increased, and cardiac vagal tone (CVT) significantly decreased after acute exposure to HTP aerosol, similar to the effects of cigarette smoke exposure. Furthermore, differences in the withdrawal of CVT were observed when using different tobacco sticks in the same HTPs. The findings of this study indicate that acute exposure to HTP aerosol increases the hemodynamic burden and disrupts cardiac autonomic balance, similar to exposure to cigarette smoke. Moreover, depending on the type of tobacco stick inserted into the HTP device, acute withdrawal of CVT may have been enhanced.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.261-268
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• 2023

[¹⁸F]Fluorocholine is a radiopharmaceutical used non-invasively in positron emission tomography to diagnose parathyroid adenoma, prostate cancer, and hepatocellular carcinoma by evaluating the choline metabolism. In this study, a radiolabeling method for [¹⁸F]fluorocholine was optimized using a solid phase extraction (SPE) cartridge. [¹⁸F]Fluorocholine was labeled in two steps using an automated synthesizer. In the first step, dibromomethane was reacted with [¹⁸F]KF/K2.2.2/K₂CO₃ to obtain the intermediate [¹⁸F]fluorobromomethane. In the second step, [¹⁸F]fluorobromomethane was passed through a Sep-Pak^Ⓡ Silica SPE cartridge to remove the impurities and then reacted with N,N-dimethylaminoethanol (DMAE) in a Sep-Pak^Ⓡ C18 SPE cartridge to label [¹⁸F]fluorocholine. The reaction conditions of [¹⁸F]fluorocholine were optimized. The synthesis yield was confirmed according to the number of silica cartridges and DMAE concentration. No statistically significant difference in the synthesis yield of [¹⁸F]fluorocholine was observed when using four or three silica cartridges (P>0.05). The labeling yield was 11.5±0.5% (N=4) when DMAE was used as its original solution. On the other hand, when diluted to 10% with dimethyl sulfoxide, the radiochemical yield increased significantly to 30.1±5.2% (N=20). In conclusion, [¹⁸F]Fluorocholine for clinical use can be synthesized stably in high yield by applying an optimized synthesis method.

• Journal of the Korean Society of Radiology
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• v.83 no.3
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• pp.473-485
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• 2022

The incidence of neurodegenerative diseases in the older population has increased in recent years. A considerable number of studies have been performed to characterize these diseases. Imaging analysis is an important biomarker for the diagnosis of neurodegenerative disease. Objective and reliable assessment and precise detection are important for the early diagnosis of neurodegenerative diseases. Artificial intelligence (AI) using brain MRI applied to the study of neurodegenerative diseases could promote early diagnosis and optimal decisions for treatment plans. MRI-based AI software have been developed and studied worldwide. Representatively, there are MRI-based volumetry and segmentation software. In this review, we present the development process of brain volumetry analysis software in neurodegenerative diseases, currently used and developed AI software for neurodegenerative disease in the Republic of Korea, probable uses of AI in the future, and AI software limitations.

• Journal of the Korean Society of Radiology
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• v.81 no.2
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• pp.324-336
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• 2020

Cardiovascular calcifications can occur in various cardiovascular diseases and can serve as a biomarker for cardiovascular event prediction. Advances in CT have enabled evaluation of calcifications in cardiovascular structures not only on ECG-gated CT but also on non-ECG-gated CT. Therefore, many studies have been conducted on the clinical relevance of cardiovascular calcifications in patients. In this study, we divided cardiovascular calcifications into three classes, i.e., coronary artery, thoracic aorta, and cardiac valve calcifications, which are closely associated with cardiovascular events. Further, we briefly described pericardial calcifications, which can be found incidentally. Since the start of lung cancer screening in Korea in the second half of 2019, the number of non-enhanced, non-ECG-gated, low-dose chest CT has been increasing, and the number of incidentally found cardiovascular calcifications has also been increasing. Therefore, understanding the relevance of cardiovascular calcifications on non-enhanced, non-ECG-gated, low-dose chest CT and their proper reporting are important for radiologists.