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Clinical Value of Cardiovascular Calcifications on Non-Enhanced, Non-ECG-Gated Chest CT

비 조영증강 비 심전도동기 흉부 CT에서 발견되는 심혈관계 석회화의 임상적 가치

  • Tae Seop Choi (Department of Radiology, Korea University Guro Hospital, College of Medicine, Korea University) ;
  • Hwan Seok Yong (Department of Radiology, Korea University Guro Hospital, College of Medicine, Korea University) ;
  • Cherry Kim (Department of Radiology, Korea University Ansan Hospital, College of Medicine, Korea University) ;
  • Young Joo Suh (Department of Radiology, Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine)
  • 최태섭 (고려대학교 의과대학 고려대학교 구로병원 영상의학과) ;
  • 용환석 (고려대학교 의과대학 고려대학교 구로병원 영상의학과) ;
  • 김채리 (고려대학교 의과대학 고려대학교 안산병원 영상의학과) ;
  • 서영주 (연세대학교 의과대학 세브란스병원 영상의학과)
  • Received : 2019.11.08
  • Accepted : 2020.03.24
  • Published : 2020.03.01

Abstract

Cardiovascular calcifications can occur in various cardiovascular diseases and can serve as a biomarker for cardiovascular event prediction. Advances in CT have enabled evaluation of calcifications in cardiovascular structures not only on ECG-gated CT but also on non-ECG-gated CT. Therefore, many studies have been conducted on the clinical relevance of cardiovascular calcifications in patients. In this study, we divided cardiovascular calcifications into three classes, i.e., coronary artery, thoracic aorta, and cardiac valve calcifications, which are closely associated with cardiovascular events. Further, we briefly described pericardial calcifications, which can be found incidentally. Since the start of lung cancer screening in Korea in the second half of 2019, the number of non-enhanced, non-ECG-gated, low-dose chest CT has been increasing, and the number of incidentally found cardiovascular calcifications has also been increasing. Therefore, understanding the relevance of cardiovascular calcifications on non-enhanced, non-ECG-gated, low-dose chest CT and their proper reporting are important for radiologists.

심혈관계 석회화는 다양한 심혈관계 질환에서 나타나며 심혈관 사건 발생의 표지자의 역할을 한다. CT의 기술이 발전함에 따라 심전도동기 CT뿐만이 아닌 비 심전도동기 CT에서도 심혈관계 석회화를 평가하는 것이 가능해졌다. 이번 종설에서는 비 조영증강 비 심전도동기 흉부 CT에서 발견되는 심혈관계 석회화를 심혈관 사건 발생과 연관되었다고 알려진 3가지 석회화(관상동맥, 흉부 대동맥, 판막 석회화)에 대해 자세히 살펴보고 추가적으로 우연적으로 발견될 수 있는 심막 석회화에 대해서도 간단히 기술하였다. 우리나라에서 2019년 하반기부터 폐암 검진이 시작되면서 고령 흡연자의 비 조영증강 비 심전도동기 저선량 CT의 영상의 수가 늘어나고 있고 이에 우연히 발견되는 심혈관계 석회화도 늘어나고 있다. 그러므로 비 조영증강 비 심전도동기 흉부 CT에서 발견되는 심혈관계 석회화의 의미를 이해하고 적절히 보고하는 것이 영상의학과 의사에게 중요할 것이다.

Keywords

References

  1. Wang Y, Osborne MT, Tung B, Li M, Li Y. Imaging cardiovascular calcification. J Am Heart Assoc 2018;7:e008564 
  2. Zhu D, Mackenzie NC, Farquharson C, Macrae VE. Mechanisms and clinical consequences of vascular calcification. Front Endocrinol (Lausanne) 2012;3:95 
  3. Kavousi M, Elias-Smale S, Rutten JH, Leening MJ, Vliegenthart R, Verwoert GC, et al. Evaluation of newer risk markers for coronary heart disease risk classification: a cohort study. Ann Intern Med 2012;156:438-444 
  4. Iribarren C, Sidney S, Sternfeld B, Browner WS. Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. JAMA 2000;283:2810-2815 
  5. Owens DS, Budoff MJ, Katz R, Takasu J, Shavelle DM, Carr JJ, et al. Aortic valve calcium independently predicts coronary and cardiovascular events in a primary prevention population. JACC Cardiovasc Imaging 2012;5:619-625 
  6. Hoffmann U, Massaro JM, D'Agostino RB Sr, Kathiresan S, Fox CS, O'Donnell CJ. Cardiovascular event prediction and risk reclassification by coronary, aortic, and valvular calcification in the Framingham Heart Study. J Am Heart Assoc 2016;5:e003144 
  7. Eijsvoogel NG, Hendriks BMF, Park HB, Altintas S, Mihl C, Horehledova B, et al. The role of standard non-ECG gated chest CT in cardiac assessment: design and rationale of the Cardiac Pathologies in standard chest CT (CaPaCT) study. Eur Radiol Exp 2018;2:9 
  8. Secchi F, Di Leo G, Zanardo M, Ali M, Cannao PM, Sardanelli F. Detection of incidental cardiac findings in noncardiac chest computed tomography. Medicine (Baltimore) 2017;96:e7531 
  9. Kuetting D, Muller A, Feisst A, Luetkens J, Dabir D, Schild HH, et al. Incidental cardiac findings in non-electrocardiogram-gated thoracic computed tomography of intensive care unit patients: assessment of prevalence and underreporting. J Thorac Imaging 2018;33:168-175 
  10. National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011;365:395-409 
  11. Kucharczyk MJ, Menezes RJ, McGregor A, Paul NS, Roberts HC. Assessing the impact of incidental findings in a lung cancer screening study by using low-dose computed tomography. Can Assoc Radiol J 2011;62:141-145 
  12. Greenland P, Bonow RO, Brundage BH, Budoff MJ, Eisenberg MJ, Grundy SM, et al. ACCF/AHA 2007 clinical expert consensus document on coronary artery calcium scoring by computed tomography in global cardiovascular risk assessment and in evaluation of patients with chest pain: a report of the American College of Cardiology Foundation Clinical Expert Consensus Task Force (ACCF/AHA Writing Committee to Update the 2000 Expert Consensus Document on Electron Beam Computed Tomography) developed in collaboration with the Society of Atherosclerosis Imaging and Prevention and the Society of Cardiovascular Computed Tomography. J Am Coll Cardiol 2007;49:378-402 
  13. Rasmussen T, Kober L, Abdulla J, Pedersen JH, Wille MM, Dirksen A, et al. Coronary artery calcification detected in lung cancer screening predicts cardiovascular death. Scand Cardiovasc J 2015;49:159-167 
  14. Jacobs PC, Gondrie MJ, Van der Graaf Y, De Koning HJ, Isgum I, Van Ginneken B, et al. Coronary artery calcium can predict all-cause mortality and cardiovascular events on low-dose CT screening for lung cancer. AJR Am J Roentgenol 2012;198:505-511 
  15. Shemesh J, Henschke CI, Shaham D, Yip R, Farooqi AO, Cham MD, et al. Ordinal scoring of coronary artery calcifications on low-dose CT scans of the chest is predictive of death from cardiovascular disease. Radiology 2010;257:541-548 
  16. Hecht HS, Cronin P, Blaha MJ, Budoff MJ, Kazerooni EA, Narula J, et al. 2016 SCCT/STR guidelines for coronary artery calcium scoring of noncontrast noncardiac chest CT scans: a report of the Society of Cardiovascular Computed Tomography and Society of Thoracic Radiology. J Cardiovasc Comput Tomogr 2017;11:74-84 
  17. Budoff MJ, Nasir K, Kinney GL, Hokanson JE, Barr RG, Steiner R, et al. Coronary artery and thoracic calcium on noncontrast thoracic CT scans: comparison of ungated and gated examinations in patients from the COPD Gene cohort. J Cardiovasc Comput Tomogr 2011;5:113-118 
  18. Wu MT, Yang P, Huang YL, Chen JS, Chuo CC, Yeh C, et al. Coronary arterial calcification on low-dose ungated MDCT for lung cancer screening: concordance study with dedicated cardiac CT. AJR Am J Roentgenol 2008;190:923-928 
  19. Xie X, Zhao Y, De Bock GH, De Jong PA, Mali WP, Oudkerk M, et al. Validation and prognosis of coronary artery calcium scoring in nontriggered thoracic computed tomography: systematic review and meta-analysis. Circ Cardiovasc Imaging 2013;6:514-521 
  20. Callister TQ, Cooil B, Raya SP, Lippolis NJ, Russo DJ, Raggi P. Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method. Radiology 1998;208:807-814 
  21. Blaha MJ, Mortensen MB, Kianoush S, Tota-Maharaj R, Cainzos-Achirica M. Coronary artery calcium scoring: is it time for a change in methodology? JACC Cardiovasc Imaging 2017;10:923-937 
  22. Deprez FC, Vlassenbroek A, Ghaye B, Raaijmakers R, Coche E. Controversies about effects of low-kilovoltage MDCT acquisition on Agatston calcium scoring. J Cardiovasc Comput Tomogr 2013;7:58-61 
  23. Chiles C, Duan F, Gladish GW, Ravenel JG, Baginski SG, Snyder BS, et al. Association of coronary artery calcification and mortality in the national lung screening trial: a comparison of three scoring methods. Radiology 2015;276:82-90 
  24. Thomas CK, Muhlenbruch G, Wildberger JE, Hohl C, Das M, Gunther RW, et al. Coronary artery calcium scoring with multislice computed tomography: in vitro assessment of a low tube voltage protocol. Invest Radiol 2006;41:668-673 
  25. Wan YL, Tsay PK, Wu PW, Juan YH, Tsai HY, Lin CY, et al. Impact of filter convolution and displayed field of view on estimation of coronary Agatston scores in low-dose lung computed tomography. Int J Cardiol 2017;236:451-457 
  26. Kim SM, Chung MJ, Lee KS, Choe YH, Yi CA, Choe BK. Coronary calcium screening using low-dose lung cancer screening: effectiveness of MDCT with retrospective reconstruction. AJR Am J Roentgenol 2008;190:917-922 
  27. Suh YJ, Lee JW, Shin SY, Goo JM, Kim Y, Yong HS. Coronary artery calcium severity grading on non-ECG-gated low-dose chest computed tomography: a multiple-observer study in a nationwide lung cancer screening registry. Eur Radiol 2020 [In press] doi: https://doi.org/10.1007/s00330-020-06707-x 
  28. Yoon SH, Hong J, Hwang EJ, Kim H, Lim HJ, Suh YJ, et al. Significant abnormalities other than lung cancer in Korean lung cancer CT screening. J Korean Soc Radiol 2019;80:837-848 
  29. Greenland P, Blaha MJ, Budoff MJ, Erbel R, Watson KE. Coronary calcium score and cardiovascular risk. J Am Coll Cardiol 2018;72:434-447 
  30. Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 AHA/ACC/AACVPR/AAPA/ ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 2019;139:e1082-e1143 
  31. Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T, et al. Medial vascular calcification revisited: review and perspectives. Eur Heart J 2014;35:1515-1525 
  32. McCollough CH, Ulzheimer S, Halliburton SS, Shanneik K, White RD, Kalender WA. Coronary artery calcium: a multi-institutional, multimanufacturer international standard for quantification at cardiac CT. Radiology 2007;243:527-538 
  33. Yoon HC, Greaser LE 3rd, Mather R, Sinha S, McNitt-Gray MF, Goldin JG. Coronary artery calcium: alternate methods for accurate and reproducible quantitation. Acad Radiol 1997;4:666-673 
  34. Eisen A, Tenenbaum A, Koren-Morag N, Tanne D, Shemesh J, Imazio M, et al. Calcification of the thoracic aorta as detected by spiral computed tomography among stable angina pectoris patients: association with cardiovascular events and death. Circulation 2008;118:1328-1334 
  35. Hermann DM, Lehmann N, Gronewold J, Bauer M, Mahabadi AA, Weimar C, et al. Thoracic aortic calcification is associated with incident stroke in the general population in addition to established risk factors. Eur Heart J Cardiovasc Imaging 2014;16:684-690 
  36. Budoff MJ, Nasir K, Katz R, Takasu J, Carr JJ, Wong ND, et al. Thoracic aortic calcification and coronary heart disease events: the multi-ethnic study of atherosclerosis (MESA). Atherosclerosis 2011;215:196-202 
  37. Cho IJ, Chang HJ, Cho I, Heo R, Lee SE, Shim CY, et al. Association of thoracic aorta calcium score with exercise blood pressure response and clinical outcomes in elderly individuals: differential impact of aorta calcification compared with coronary artery calcification. J Am Heart Assoc 2016;5:e003131 
  38. Cho IJ, Chang HJ, Heo R, Kim IC, Sung JM, Chang BC, et al. Association of thoracic aorta calcium score with left ventricular hypertrophy and clinical outcomes in patients with severe aortic stenosis after aortic valve replacement. Ann Thorac Surg 2017;103:74-81 
  39. Churchill TW, Rasania SP, Rafeek H, Mulvey CK, Terembula K, Ferrari V, et al. Ascending and descending thoracic aorta calcification in type 2 diabetes mellitus. J Cardiovasc Comput Tomogr 2015;9:373-381 
  40. Takasu J, Budoff MJ, O'Brien KD, Shavelle DM, Probstfield JL, Carr JJ, et al. Relationship between coronary artery and descending thoracic aortic calcification as detected by computed tomography: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2009;204:440-446 
  41. Jacobs PC, Prokop M, Van der Graaf Y, Gondrie MJ, Janssen KJ, De Koning HJ, et al. Comparing coronary artery calcium and thoracic aorta calcium for prediction of all-cause mortality and cardiovascular events on low-dose non-gated computed tomography in a high-risk population of heavy smokers. Atherosclerosis 2010;209:455-462 
  42. Lessmann N, De Jong PA, Celeng C, Takx RAP, Viergever MA, Van Ginneken B, et al. Sex differences in coronary artery and thoracic aorta calcification and their association with cardiovascular mortality in heavy smokers. JACC Cardiovasc Imaging 2019;12:1808-1817 
  43. Meissner I, Khandheria BK, Sheps SG, Schwartz GL, Wiebers DO, Whisnant JP, et al. Atherosclerosis of the aorta: risk factor, risk marker, or innocent bystander? A prospective population-based transesophageal echocardiography study. J Am Coll Cardiol 2004;44:1018-1024 
  44. Desai MY, Cremer PC, Schoenhagen P. Thoracic aortic calcification: diagnostic, prognostic, and management considerations. JACC Cardiovasc Imaging 2018;11:1012-1026 
  45. Hecht H, Blaha MJ, Berman DS, Nasir K, Budoff M, Leipsic J, et al. Clinical indications for coronary artery calcium scoring in asymptomatic patients: expert consensus statement from the Society of Cardiovascular Computed Tomography. J Cardiovasc Comput Tomogr 2017;11:157-168 
  46. Kanza RE, Allard C, Berube M. Cardiac findings on non-gated chest computed tomography: a clinical and pictorial review. Eur J Radiol 2016;85:435-451 
  47. Cowell SJ, Newby DE, Burton J, White A, Northridge DB, Boon NA, et al. Aortic valve calcification on computed tomography predicts the severity of aortic stenosis. Clin Radiol 2003;58:712-716 
  48. Mahnken AH, Muhlenbruch G, Das M, Wildberger JE, Kuhl HP, Gunther RW, et al. MDCT detection of mitral valve calcification: prevalence and clinical relevance compared with echocardiography. AJR Am J Roentgenol 2007;188:1264-1269 
  49. Nair CK, Thomson W, Ryschon K, Cook C, Hee TT, Sketch MH. Long-term follow-up of patients with echocardiographically detected mitral anular calcium and comparison with age- and sex-matched control subjects. Am J Cardiol 1989;63:465-470 
  50. Pawade T, Sheth T, Guzzetti E, Dweck MR, Clavel MA. Why and how to measure aortic valve calcification in patients with aortic stenosis. JACC Cardiovasc Imaging 2019;12:1835-1848 
  51. Jairam PM, Gondrie MJ, Grobbee DE, Mali WP, Jacobs PC, Van der Graaf Y, et al. Incidental imaging findings from routine chest CT used to identify subjects at high risk of future cardiovascular events. Radiology 2014;272:700-708 
  52. Lee HY, Kim SM, Lee KS, Park SW, Chung MJ, Cho H, et al. Quantification of aortic valve calcifications detected during lung cancer-screening CT helps stratify subjects necessitating echocardiography for aortic stenosis diagnosis. Medicine (Baltimore) 2016;95:e3710 
  53. Van Hamersvelt RW, Willemink MJ, Takx RA, Eikendal AL, Budde RP, Leiner T, et al. Cardiac valve calcifications on low-dose unenhanced ungated chest computed tomography: inter-observer and inter-examination reliability, agreement and variability. Eur Radiol 2014;24:1557-1564 
  54. Willemink MJ, Takx RA, Isgum I, De Koning HJ, Oudkerk M, Mali WP, et al. Prognostic value of heart valve calcifications for cardiovascular events in a lung cancer screening population. Int J Cardiovasc Imaging 2015;31:1243-1249 
  55. Gondrie MJ, Mali WP, Jacobs PC, Oen AL, Van der Graaf Y; PROVIDI Study Group. Cardiovascular disease: prediction with ancillary aortic findings on chest CT scans in routine practice. Radiology 2010;257:549-559 
  56. Tison GH, Guo M, Blaha MJ, McClelland RL, Allison MA, Szklo M, et al. Multisite extracoronary calcification indicates increased risk of coronary heart disease and all-cause mortality: the Multi-Ethnic Study of Atherosclerosis. J Cardiovasc Comput Tomogr 2015;9:406-414 
  57. Kianoush S, Al Rifai M, Cainzos-Achirica M, Al-Mallah MH, Tison GH, Yeboah J, et al. Thoracic extra-coronary calcification for the prediction of stroke: the Multi-Ethnic Study of Atherosclerosis. Atherosclerosis 2017;267:61-67 
  58. Nguyen T, Phillips C, Movahed A. Incidental findings of pericardial calcification. World J Clin Cases 2014;2:455-458 
  59. Weiss SA, Anderson AS, Raman J, Jolly N. Postoperative pericardial calcification causing diastolic coronary compression. Ann Thorac Surg 2010;90:1001-1004 
  60. Shaw M, Pandey NN, Sharma A, Sharma S. Pericardial calcification: an uncommon presentation of rheumatic heart disease. BMJ Case Rep 2018;2018:bcr-2018-226435 
  61. Sverzellati N, Cademartiri F, Bravi F, Martini C, Gira FA, Maffei E, et al. Relationship and prognostic value of modified coronary artery calcium score, FEV1, and emphysema in lung cancer screening population: the MILD trial. Radiology 2012;262:460-467