• Journal of Pharmaceutical Investigation
• /
• v.25 no.2
• /
• pp.101-108
• /
• 1995

The surface of albumin microspheres could be modified with methotrexate (MTX) by using 1,3-dicyclohexylcarbodiimide (DCC). Surface-modified albumin microspheres entrapping no MTX (SAMS), free MTX (SAMSF) and MTX-bovine serum albumin (BSA) conjugates (SAMSC) were prepared. respectively, and their release characteristics were investigated in the presence of trypsin using a dissolution tester. The mean diameters of all the microspheres were $5{\sim}8\;{\mu}m$, and their shapes was small and uniform. MTX bound tn their surfaces was released slower than the entrapped free MTX, and laster than the entrapped MTX-BSA conjugates. Also, surface-modified MTX was scarcely released in the absence of a proteolytic enzyme. Therefore, the surface-modified MTX may be released rapidly from SAMSC at the target site, and thereafter MTX may be released slowly from the encapsulated MTX-BSA conjugates in SAMSC for a long period.

• Special Issue of the Society of Naval Architects of Korea
• /
• 2017.10a
• /
• pp.105-108
• /
• 2017

Condensation is one of the common issues which we can easily see in everyday life. For example, the surface of glasses with cold water is easily moisturized. This wet surface gives us uncomfortable feeling and is sometimes dangerous because it is slippery. As the safety on working space is one of the most important issue on offshore project, condensation is also important matter to take care of with precaution. Since the bottom of vessel or offshore facility is submersed in the water, the risk of having condensate on the steel surface is getting higher because sea water temperature is normally lower than ambient temperature. And if there is any electric equipment or person working in that space, condensation is normally not allowed. The pontoon of semi-submersible drilling rig is such a space which is submersed, with electric and mechanical equipments and person working periodically. To prevent condensation in pontoon, study was conducted by checking several cases.

• Journal of the Computational Structural Engineering Institute of Korea
• /
• v.22 no.3
• /
• pp.223-229
• /
• 2009

Most of structural analyses are concerned with the deformation and stress in a body subjected to external loads. In many fields, however, the interpretation of inverse problems is needed to determine surface tractions or internal stresses from measured displacements. In this study, the inverse processes by using the boundary element method are formulated for the evaluation of boundary tractions from displacements measured on a remote surface. Small errors in measured displacements often result in a substantial loss of accuracy of an inverse system. Numerical results show that the error in reconstructed tractions by using the inverse boundary element methods is sensitive to measurement location and noise.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.7 no.2
• /
• pp.105-116
• /
• 1996

The design and analysis of the transversely fed EMC(electromagnetically coupled) microstrip dipole have been accomplished by using the integral equation and MOM(method of moment)in frequency domain in order to find the current distribution of the dipole. In this study, we proposed the possibilities for design and analysis of EMC micro-strip dipole array antenna by means of calculating the current distribution of each dipole directly using the FDTD(finite difference time domain) method. In this case, we applied the formulation which is the finite difference expression of the Maxwell's integral equation. From the current distribution of each dipole, we calculated the far field electric component and showed that the calculation process and running time was reduced with respect to the method which calculates the radiation field with surface electric and magnetic current density.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.39 no.6
• /
• pp.589-596
• /
• 2015

The occurrence of an inclined edge crack in transversely piezoelectric material is analyzed. Concentrated antiplane mechanical and inplane electrical loads are applied at the boundary and crack surface, respectively. The crack surfaces are assumed to be impermeable to the electric field. Using the Mellin transform with the introduction of a generalized displacement vector, the problem is formulated, and the Wiener-Hopf equation is derived. By solving the equation, the solution is obtained in a closed form. The intensity factors of the stress, the electric displacement, and the energy release rate are obtained for any crack length and inclination angle. These solutions can be used as fundamental solutions and can be superimposed to represent any arbitrary electromechanical loading.

• Journal of Powder Materials
• /
• v.14 no.4
• /
• pp.256-260
• /
• 2007

The surface of magnetite ($Fe_{3}O_{4}$) nanoparticles prepared by coprecipitation method was modified by carboxylic acid group of poly(3-thiophenacetic acid (3TA)) and meso-2,3-dimercaptosuccinic acid (DMSA). Then the lysozyme protein was immobilized on the carboxylic acid group of the modification of the magnetite nanoparticles. The magnetite nanoparticles are spherical and the particle size is approximately 10 nm. We measured quantitative dispersion state by dispersion stability analyzer for each $Fe_{3}O_{4}$ nanoparticles with and without surface modification. The concentration of lysozyme on the modified magnetite nanoparticles was also investigated by a UV-Vis spectrometer and compared to that of magnetite nanoparticles without surface modification. The functionalized magnetite particles had higher enzymatic capacity and dispersion stability than non-functionalized magnetite nanoparticles.

• Korean Journal of Materials Research
• /
• v.16 no.11
• /
• pp.663-667
• /
• 2006

CTAB(cetyltrimethylammonium bromide)-capped CdSe nanoparticles were prepared by using a 4 : 1(v/v) distilled water-isopropyl alcohol mixture. The cadmium chloride and sodium selenosulfate were used as the cadmium and selenium source. By the analysis of XRD and XPS, the resultant particle was confirmed to be cubic CdSe phase. TEM image showed CdSe nanoparticles with empty core. The CTAB-capped sample showed an maximum absorption at 418nm, blue-shifting compared with bulk CdSe, which indicated stronger quantum confinement effect compared with uncapped sample. From FT-IR analysis, it was found that the presence of the new peaks in the $850{\sim}1250cm^{-1}$ range indicated the existence of chemical bonding between CTAB and surface of CdSe nanoparticles. Also TG analysis indicated that there were two weight-loss steps for the CTAB-capped CdSe nanoparticles. It was suggested that CTAB played a significant role in protecting CdSe nanoparticles.

• Journal of the Korean Chemical Society
• /
• v.50 no.3
• /
• pp.216-223
• /
• 2006

To increase the stability of liposomes in blood circulation, surface modification of liposomes by incorporating a lipid-polymer derivative in the lipid bilayer or conjugating a hydrophilic polymer to the liposomal surface has been developed. In this study, the comblike copolymer, poly(HEMA-co-HPOEM), having multiple polyethyleneoxide side chains was prepared by free radical polymerization of hydroxyethylmethacrylate (HEMA) and hydroxypolyoxyethylenemethacrylate (HPOEM) as vinyl monomers. Poly(HEMA-co-HPOEM) was conjugated to the liposomal surface and the characteristics of the modified liposomes in serum were investigated. Conjugation of poly(HEMA-co-HPOEM) to liposomes increased the particle size of the liposomes by 30 nm and decreased the absolute value of zeta potential of the liposomes by shielding the negative charge of liposomal surface. Loading efficiency of model drug, doxorubicin, in liposomes was about 90% and the efficiency was not affected by conjugation of poly(HEMA-co-HPOEM) to liposomes. The particle size of poly(HEMA-co-HPOEM)-conjugated liposomes in serum did not changed and the protein adsorption was lower than that of control liposomes or liposomes containing polyethyleneoxide-lipid derivative (PEG-liposomes). These results suggest that poly(HEMA-co-HPOEM) is efficient for the stabilization of liposomes in blood circulation.

• Journal of Bio-Environment Control
• /
• v.4 no.2
• /
• pp.125-130
• /
• 1995

Observations on the seedling growth of red pepper responding to different temperature(10, 20, 3$0^{\circ}C$) and light intensity(5, 15, 25 klux) were made in the growth Chamber during 7 weeks. The results obtained were as follows; 1. Best results of the combinations of temperature and light intensity were obtained from the combinated treatment of 3$0^{\circ}C$ and 25klux. At all of the temperature levels in this experiment, the more the light intensity is high, the more the growth is favor, but at low temperature below 2$0^{\circ}C$ and low light intensity below 15 klux, the growth of red pepper seedlings was decreased markedly. 2. Multiple regression polynomial equations of the characteristics of red pepper seedlings grown in the different combinations of temperature and light intensity fitted well in the plant height, number of leaves, leaf area, stem dry weight and shoot dry weight. 3. Multiple regression polynomial equation to the shoot dry weight was partial differentiated and diagrammatized the response surface using its theoretical value. Light intensity affected more to the shoot dry weight in the temperature below 2$0^{\circ}C$ but above 2$0^{\circ}C$ the role of the temperature showed greatly influence however, interaction effects of light intensity and temperature showed strongly.

• Polymer(Korea)
• /
• v.29 no.3
• /
• pp.277-281
• /
• 2005

Recently, various curriers prepared by the modification both cationic polymers and liposomes have been examined. In this work, we prepared the lipid with polyethylenimine (PEI) to investigate the possibility as effective DNA carrier. Cationic lipid (PEI-DSPE) was synthesized by the reaction of PEI and 1,2-diacyl-sn-glycero-3-phosphoetha-nolamine (DSPE). The liposomes were prepared by the concenoation changes of PEI-DSPE for a mixture of 1,2-disteanyl-sn-glycero-3-phosphocholine (DSPC), L-$\alpha$-phosphatidylcholine, hydrogenated (HSPC) and cholesterol (CHOL). Particle size decreased as PEI-DSPE concentration increased. In addition, the charge of liposome surface increased to positive value according to increasing the relative of PEI-DSPE concentration. The complexation of DNA was confirmed by gel retardation assay and fluorescence measurement. The surface charge of liposome/DNA complexes increased as the liposome concentration or surface charge of liposome increased. In conclusion, we confirmed that the prepared liposomes have the possibility as a DNA carrier.