• Journal of Preventive Medicine and Public Health
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• v.32 no.4
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• pp.452-458
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• 1999

Objectives: The authors conducted the study to evaluate bias when potentially diseased subjects were included in cohort members while analyzing risk factors of chronic liver diseases. Methods: Total of 14,529 subjects were followed up for the incidence of liver diseases from January 1993 to June 1997. We have used databases of insurance company with medical records, cancer registry, and death certificate data to identify 102 incident cases. The cohort members were classified into potentially diseased group(n=2,217) when they were HBsAg positive, serum GPT levels higher than 40 units, or had or has liver diseases in baseline surveys. Cox's model were used for potentially diseased group, other members, and total subjects, respectively. Results: The risk factors profiles were similar for total and potentially diseased subjects: HBsAg positivity, history of acute liver disease, and recent quittance of smoking or drinking increased the risk. while intake of pork and coffee decreased it. For the potentially diseased, obesity showed marginally significant protective effect. Analysis of subjects excluding the potentially diseased showed distinct profiles: obesity increased the risk, while quitting smoking or drinking had no association. For these intake of raw liver or processed fish or soybean paste stew increased risk; HBsAg positivity, higher levels of liver enzymes and history of acute liver diseases increased the risk. Conclusions: The results suggested the potential bias in risk ratio estimates when potentially diseased subjects were included in cohort study on chronic liver diseases, especially for lifestyles possibly modified after disease onset. The analytic strategy excluding potentially diseased subjects was considered appropriate for identifying risk factors for chronic liver diseases.

• Korean Journal of Ecology and Environment
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• v.44 no.3
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• pp.280-291
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• 2011

Bottom-up approaches to control of Microcystis aeruginosa blooms were comparatively investigated through an in situ mesocosm experiment using aquatic plants (Iris pseudoacorus). In the mesocosm experiments, floating I. pseudoacorus, seemed to be effective in controlling massive M. aeruginosa blooms in an agricultural reservoir, exhibiting a close coupling with temporal variations in Chl-a and DO concentration. Shading by floating I. pseudoacorus resulted in a reduced phytoplankton abundance inhibiting light energy availability. Moreover, I. pseudoacorus may suppress phytoplankton growth through the excretion of chemical substances, likes a allelopathy, that inhibit phytoplankton photosynthetic activity. The $^{15}N$ atom % of I. pseudoacorus showed higher values than POM, suggesting that I. pseudoacorus assimilates DIN predominantly compared to phytoplankton, which was mostly M. aeruginosa. This result strongly suggests that the M. aeruginosa bloom should be regulated by aquatic plants, like I. pseudoacorus, this approach can affect zooplankton composition. This is the first study that has used stable isotope tracers to evaluate the biomanipulation efficiency through floating I. pseudoacorus.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.9
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• pp.794-806
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• 2017

It is essential to protect the national space assets and space environment safely as a space development country from the continuously increasing space debris. And Active Debris Removal(ADR) is the most active way to solve this problem. In this paper, we studied the Artificial Neural Network(ANN) for a stable recognition model of vision-based space debris tracking system. We obtained the simulated image of the space environment by the KARICAT which is the ground-based space debris clearing satellite testbed developed by the Korea Aerospace Research Institute, and created the vector which encodes structure and color-based features of each object after image segmentation by depth discontinuity. The Feature Vector consists of 3D surface area, principle vector of point cloud, 2D shape and color information. We designed artificial neural network model based on the separated Feature Vector. In order to improve the performance of the artificial neural network, the model is divided according to the categories of the input feature vectors, and the ensemble technique is applied to each model. As a result, we confirmed the performance improvement of recognition model by ensemble technique.

• Clinical and Experimental Pediatrics
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• v.52 no.1
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• pp.50-55
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• 2009

Purpose : This study aimed to determine the influence of low-dose oxygen ($FiO_2$ <25%) therapy through nasal cannulae on the progress and prognosis of retinopathy of prematurity (ROP) as well as methods of preventing ROP. Methods : Our subjects comprised premature infants (gestation period <37 weeks; birth weight <1,750 g) born in Daegu Fatima Hospital between February 1, 2001 and January 31, 2006. We retrospectively reviewed and analyzed the medical records of 273 patients who were available for eye examination and follow up over 6 months. Results : The factors maximally influencing the occurrence of ROP were low gestation age and low birth weight. We observed that the incidence of ROP increased with the increasing duration of low-dose oxygen therapy. ROP onset was delayed during ongoing oxygen therapy; however, rapid progression of ROP occurred after the discontinuation of oxygen therapy among premature infants up to the prethreshold stage. Conclusion : To prevent of occurrence of severe ROP and its rapid progression, the period of low-dose oxygen therapy needs to be shortened. Moreover, frequent eye examinations should be performed after the discontinuation of oxygen therapy.

• Journal of the Korean Society of Groundwater Environment
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• v.5 no.3
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• pp.155-161
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• 1998

Retardation effect of heavy metals in soils caused by adsorption onto the surfaces of solids particles is well known phenomenon. In this study, we investigated the retardation effect on the mobility of a Zn in a sandy soil by conducting batch and column tests. The column test consisted of monitoring the concentrations of effluent versus time known as a breakthrough curve (BTC). We used NaCl and ZnCl$_2$ solutions with the concentration of 10 g/L as a tracer, and injected them respectively into the inlet boundary of the soil sample as a square pulse type, and monitored the effluent concentrations at the exit boundary under a steady state condition using an EC-meter and ICP-AES. The batch test was conducted based on the standard procedure of equilibrating fine fractions collected from the soil with various initial ZnCl$_2$ concentrations, and analysis of Zn ions in the equilibrated solutions using ICP-AES. The results of column test showed that i) the peak concentration of ZnCl$_2$analyzed by ICP was far less than that of either NaCl or bulk electrical conductivity and ⅱ) travel times of peak concentrations for two tracers were more less identical. The relatively low concentration of Zn can be explained by ion exchange between Zn and other cations, and possible precipitation of Zn in the form of Zn(OH)$_2$due to high pH range (7.0∼7.9) of the effluent. The identical result of travel times of peak concentrations indicates that the retardation effect is not present in the soil. The only way to describe the prominent decrease of Zn ion was to introduce decay or sink coefficient in the CDE model to account for irreversible decrease of Zn ions in the aqueous phase.

• Journal of Biomedical Engineering Research
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• v.20 no.1
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• pp.29-36
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• 1999

The objective of this study is to analyse the flow field in the branching duct by visualizing the flow phenomena using the PIV system. A bifurcation model is fabricated with transparent acrylic resin to visualize the whole flow field with the PIV system. Water was used as the working fluid and the conifer powder as the tracer particles. The single-frame and two-frame methods of the PIV system and 2-frame of the grey level correlation method are applied to obtain the velocity vectors from the images captured in the flow filed. The velocity distributions in a lid-driven cavity flow are compared with the so-called standard experimental data, which was obtained from by 4-frame method in order to validate experimental results of the PIV measurements. The flow patterns of a Newtonian fluid in a branching duct were successfully visualized by using the PIV system and the sub-pixel and the area interpolation method were used to obtain the final velocity vectors. The velocity vectors obtained from the PIV system are in good agreement with the numerical results of the 3-dimensional branch flow. The results of numerical analyses and the PIV experiments for the three-dimensional flows in the branch ing duct show the recirculation zone distal to the branching point and the sizes of the recirculation length and height of the tow different methods are in good agreement.

• Korean Journal of Remote Sensing
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• v.15 no.2
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• pp.175-181
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• 1999

A recurring eddy which located at the terminal end of the Korean East Warm Current was captured on ocean color and sea surface temperature imagery from satellite in spring and autumn. During late April, 1997 thermal infrared imagery from the NOAA AVHRR sensor and ocean color data from the Japanese ADEOS-I OCTS sensor, revealed this feature. The cold core had elevated chlorophyll concentrations, based on OCTS estimates, of greater than 3 mg/m$^3$ while the warmer surrounding waters had chlorophyll concentrations of 1 mg/m$^3$ or less. The elevated cholophyll accociated with this eddy has not been previously described. The eddy is also evident in SST images from autumn, but the SST in the core is warmer than in spring, and the warm jet flowing to the west of the eddy is also warmer is autumn compared to spring. A reccurring eddy and the high chlorophyll_a concentration area which surround around the eddy show on NOAA and SeaWiFS images in March 2, 1998. The eddy forms at the northern extent of the Korean East Warm Current as those waters collide with the cold, south-flowing Liman Current over a topographic shelf about 1500 m deep. This region of the eddy formation appears to have a strong connection with the dynamics of the western part of the polar front eddy field that dominates surface mesoscale structure in the central East (Japan) Sea. Interaction of the eddy with ARGOW tracked drifters, and evidence for its persistence are discussed.

• Journal of Korean Society of Forest Science
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• v.112 no.3
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• pp.374-381
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• 2023

The travel time of flash floods along mountain streams is mainly governed by reach-average velocity, rather than by the point velocity of the locations of interest. Reach-average velocity is influenced by various factors such as stream geometry, streambed materials, and the hydraulic roughness of streams. In this study, the reach-average velocity in mountain streams was measured for storm periods using rhodamine dye tracing. The point cloud data obtained from a LiDAR survey was used to extract the average hydraulic roughness height, such as R_a, R_max, and R_z. The size distribution of the streambed materials (D₅₀, D₈₄) was also considered in the estimation of the roughness height. The field experiments revealed that the reach-average velocities had a significant relationship with flow discharges (v = 0.5499Q^0.6165 ), with an R² value of 0.77. The root mean square error in the roughness height of the R_a-based estimation (0.45) was lower than those of the other estimations (0.47-1.04). Among the parameters for roughness height estimation, the R_a -based roughness height was the most reliable and suitable for developing the reach-average velocity equation for estimating the travel time of flood waves in mountain streams.

• Nuclear Engineering and Technology
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• v.26 no.3
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• pp.401-410
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• 1994

Validation study of two radionuclide migration models for single fracture developed in geologic medium the hydrodynamic dispersion diffusion model(HDDM) and the channeling dispersion diffusion model(CDDM), was studied by migration experiment of tracers through an artificial granite fracture on the labolatory scale. The tracers used were Uranine and Sodium lignosulfonate know as nonsorbing material. The flow rate ranged 0.4 to 1.5 cc/min. Related parameters for the models were estimated by optimization technique. Theoretical breakthrough curves with experimental data were compared. In the experiment, it was deduced that the surface sorption for both tracers did not play an important role while the diffusion of Uranine into the rock matrix turned out to be an important mass transfer mechanism. The parameter characterizing the rock matrix diffusion of each model agreed well The simulated result showed that the amount of flow rate could not tell the CDDM from the HDDM quantitatively. On the other hand, the variation of fracture length gave influence on the two models in a different degree. The dispersivity of breakthrough curve of the CDDM was more amplified than that of the CDDM when the fracture length was increased. A good agreement between the models and experimental data gave a confirmation that both models were very useful in predicting the migration system through a single fracture.

• Investigative Magnetic Resonance Imaging
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• v.16 no.1
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• pp.47-54
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• 2012

Purpose : This study was performed to evaluate the characteristics of rat mesenchymal stem cells (RMSCs) transduced with human ferritin gene and investigate $in$ $vitro$ MRI detectability of ferritin-transduced RMSCs. Materials and Methods: The RMSCs expressing both myc-tagged human ferritin heavy chain subunit (myc-FTH) and green fluorescence protein (GFP) were transduced with lentiviurs. Transduced cells were sorted by GFP expression using a fluorescence-activated cell sorter. Myc-FTH and GFP expression in transduced cells were detected by immunofluorescence staining. The cell proliferative ability and viability were assessed by MTT assay. The RMSC surface markers (CD29+/CD45-) were analyzed by flow cytometry. The intracellular iron amount was measured spectrophotometically and the presence of ferritin-iron accumulation was detected by Prussian blue staining. $In$ $vitro$ magnetic resonance imaging (MRI) study of cell phantoms was done on 9.4 T MR scanner to evaluate the feasibility of imaging the ferritin-transduced RMSCs. Results: The myc-FTH and GFP genes were stably transduced into RMSCs. No significant differences were observed in terms of biologic properties in transduced RMSCs compared with non-transduced RMSCs. Ferritin-transduced RMSCs exhibited increased iron accumulation ability and showed significantly lower $T_2$ relaxation time than non-transduced RMSCs. Conclusion: Ferritin gene as MR reporter gene could be used for non-invasive tracking and visualization of therapeutic mesenchymal stem cells by MRI.