• Food Engineering Progress
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• v.15 no.2
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• pp.97-115
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• 2011

A review about the application of response surface methodology in the optimization of food technology is presented. The theoretical principles of response surface methodology and steps for its application are described. The response surface methodologies : three-level full factorial, central composite, Box-Behnken, and Doehlert designs are compared in terms of characteristics and efficiency. Furthermore, recent references of their uses in food technology are presented. A comparison between the response surface designs (three-level full factorial, central composite, Box-Behnken and Doehlert design) has demonstrated that the Box-Behnken and Doehlert designs are slightly more efficient than the central composite design but much more efficient than the three-level full factorial designs.

• Proceedings of the Korean Statistical Society Conference
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• 2005.11a
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• pp.5-11
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• 2005

본 연구에서는 최근에 널리 사용되고 있는 R 프로그램을 이용하여 실험계획법 중 요인배치법과 반응표면분석을 구현하였다. 특히 반응표면분석에서 직교계획, 회전계획, 기울기 회전계획을 만족하는 실험계획을 제공함으로써 상업용 프로그램의 미진한 부분을 개선하여 실험선택의 폭을 넓게 하였다.

• Journal of Life Science
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• v.27 no.1
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• pp.38-43
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• 2017

Glycosyl aesculin, a potent anti-inflammatory agent, was synthesized by transglycosylation reaction, catalyzed by Thermotoga neapolitana ${\beta}-glucosidase$, with aesculin as an acceptor. The key reaction parameters were optimized using response-surface methodology (RSM) and $2{\mu}g$ of the enzyme. As shown by a statistical analysis, a second-order polynomial model fitted well to the data (p<0.05). The response surface curve for the interaction between aesculin and other parameters revealed that the aesculin concentration and reaction time were the primary factors that affected the yield of glycosyl aesculin. Among the tested factors, the optimum values for glycosyl aesculin production were as follows: aesculin concentration of 9.5 g/l, temperature of $84^{\circ}C$, reaction time of 81 min, and pH of 8.2. Under these conditions, 61.7% of glycosyl aesculin was obtained, with a predicted yield of 5.86 g/l. The maximum amount of glycosyl aesculin was 6.02 g/l. Good agreement between the predicted and experimental results confirmed the validity of the RSM. The optimization of reaction conditions by RSM resulted in a 1.6-fold increase in the production of glycosyl aesculin as compared to the yield before optimization. These results indicate that RSM can be effectively used for process optimization in the synthesis of a variety of biologically active glycosides using bacterial glycosidases.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2010.04a
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• pp.624-627
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• 2010

최근 자동차 업계서는 차량의 온실가스 배출량을 줄이고 연비를 개선시킬 수 있는 방법 중의 하나로 경량화 소재를 사용하여 차체의 중량을 줄이는 연구가 활발히 진행 중에 있다. 특히 알루미늄 합금의 경우 기존 강재에 비해 비중이 낮아 가볍고 부식에 대한 저항성이 높아 많이 사용되어지고 있는 추세이다. 본 연구에서는 먼저, 저입열 용접공정을 적용하여 용접 변수와 토치의 각도에 따른 인장강도 특성을 비교하여 적정 용접 범위를 산정하였으며, 인장강도와 비드형상의 관계를 다중 회귀 분석을 이용하여 비드 예측 회귀 모델을 제시하였다. 또한 호감도 함수를 적용한 반응표면분석법을 이용하여 자동차 생산 현장에서 겹치기 용접 이음부의 강건한 용접 품질을 가질 수 있는 최적용접 공정 조건을 도출할 수 있는 효과적인 방법을 제안하고자 한다.

• 한국신재생에너지학회:학술대회논문집
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• 2010.06a
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• pp.228.1-228.1
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• 2010

선택적 CO 산화반응(PrOx)을 위한 Ru이 고분산 담지된 $Ru/{\alpha}-Al_2O_3$ 촉매를 증착-침전법(deposition-precipitation)으로 제조하였다. 용액의 pH와 aging 시간에 따른 Ru 입자의 크기 변화와 분산도의 영향을 살펴보았으며 함침법(impregnation)으로 비교 촉매를 제조하였다. 촉매의 특성분석은 BET, TPR, CO-Chemisorption분석을 수행하여 촉매의 비표면적, 환원특성, 분산도를 알 수 있었다. 특성분석결과, 증착-침전법으로 제조한 $Ru/{\alpha}-Al_2O_3$ 촉매가 함침법으로 제조한 촉매에 비해 분산도가 높았으며, pH별 촉매 제조에서는 pH6.5로 제조한 촉매가 22.06%로 가장 높은 분산도를 보였다. 또한, 담체의 비표면적 영향에 따른 Ru 입자의 분산도를 살펴보기 위해 ${\gamma}-Al_2O_3$와 ${\alpha}-Al_2O_3$ 담체를 적용한 결과, 비표면적이 작은 ${\alpha}-Al_2O_3$ 담체 표면에서 Ru 분산도가 ${\gamma}-Al_2O_3$ 담체에 비해 높았다. 이는 기공이 발달하여 비표면적이 넓은 ${\gamma}-Al_2O_3$ 담체는 소량의 Ru을 고분산 담지 시 담체 표면보다는 기공 내에 담지 되는 양이 많아 실제 반응 시 반응에 참여하는 표면 활성 금속양이 적음을 알 수 있다. 특히, 선택적 산화반응과 같이 표면에서 빠른 반응이 일어나는 경우, 기공 내부의 활성금속이 반응에 참여하기 어려워 반응 활성이 낮음을 PrOx 반응실험을 통해 확인할 수 있었다. PrOx test 조건은 GHSV 250000~60000, 온도는 80~200도, 람다값은 2~4로 성능 비교하여 실험 하였다. PrOx의 성능평가 결과 담체를 ${\alpha}-Al_2O_3$를 사용하여 deposition-precipitation방법으로 제조한 pH6.5 촉매에서 $100{\sim}160^{\circ}C$에서 90%의 가장 높은 CO conversion을 가지고 18%의 선택도를 가졌다.

• Journal of the Korean GEO-environmental Society
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• v.11 no.1
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• pp.19-26
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• 2010

The batch experiments and response surface methodology (RSM) have been applied to the investigation of the cadmium (Cd) adsorption by coal fly ash (CFA). CFA having maximum Cd removal mass of 8.51 mg/g were calculated from Langmuir model. Cd removal reaction with different initial pH ranged from 4 to 9. When the initial pH was higher, Cd was removed more by adsorption and precipitation. These results suggest that the lower pH cause an increase of $H^+$ ion concentration which competed with Cd ions for exchange sites in CFA. Also, The Cd adsorption was mathematically described as a function of parameters initial Cd concentration ($X_1$), initial pH ($X_2$), and initial CFA mass ($X_3$) being modeled by use of the Box-Behnken methods. Empirical models were developed to describe relationship between the experimental variables and response. Statistical analysis indicates that tree factors ($X_1$, $X_2$, and $X_3$) on the linear term (main effects), and tree factors ($X_1X_2$, $X_1X_3$, and $X_2X_3$) on the non-linear term (Interaction effect; cross-product) had significant effects, respectively. In this case, the value of the adjusted determination coefficient (adjusted $R^2=0.9280$) was closed to 1, showing a high significance of the model. Statistical results showed the order of Cd removal at experimental factors to be initial initial pH > initial Cd concentration > initial CFA mass.

• Journal of the Korean Wood Science and Technology
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• v.38 no.3
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• pp.191-198
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• 2010

This research was performed to investigate the effect of hydrogen peroxide on the stain removal in japanese hackberry. Response surface method (RSM) was used to optimize the bleaching conditions such as reaction temperature, reaction time and the concentration of hydrogen peroxide. Fifteen different bleaching conditions were selected according to $2^3$ factorial central composite design (CCD). The bleaching effect were evaluated by lightness differences of wood surface before and after the bleaching. The RSM model was determined and its $R^2$ values were 0.93, showing it well represented the bleaching effect. The most affecting factor on the stain removal was the concentration of hydrogen peroxide, followed by reaction time and reaction temperature. Second degree of concentration was proved to have an effect on the bleaching. Bleaching rates above 3% concentrations of hydrogen peroxide were tended to be slightly decreased, and low bleaching effect was found at $20^{\circ}C$. The determined RSM model may offer very practical ways to obtain the desired levels of bleaching because it offers multiple solutions.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.23 no.2
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• pp.163-170
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• 2011

An optimal layout condition of the offshore wind turbines is studied by using the response surface analysis which is a kind of the design of experiments. Based on the assumption that total 36 turbines would be installed in the offshore wind farm, the number and distance of the rows and columns are used as the design variables and the efficiency decrease of power generation due to the wake decay by the interactions of turbines and the installation cost of the internal electric grid are considered as the objective functions of the response surface analysis for the layout design of turbines. Useful design information can be derived by analyzing the relationship between the design variables and target functions. It is found that the row number and the distance between rows should be minimized, and the optimal distance between columns should be estimated and adopted to the layout design within the specified design range in order to ensure the economics for the offshore wind farm.

• Journal of Korean Society of Environmental Engineers
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• v.39 no.12
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• pp.689-697
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• 2017

As a fundamental study to apply the new flocculation method using ballast in water treatment process, the optimal conditions for general and ballast coagulant dosage, and pH, which are known to have a significant influence, were derived by response surface methodology. Poly aluminum chloride (PAC) and magnetite ballast were used as a general coagulant and ballast, respectively. Coagulation experiments were performed by jar-tester using the kaolin based synthetic water. The effects of three independent variables (pH, PAC, and ballast) on response variables (turbidity removal rate and average settling velocity of flocs) and the optimum condition of independent variables to induce the optimum flocculation were obtained by 17 experimental conditions designed by Box-Behnken procedure. After performing experiments, the quadratic regression model was derived for each of response variables, and the response surface analysis was conducted to explore the correlation between independent variables and response variables. The $R^2$ values for the turbidity removal rate and the average settling velocity were 0.9909 and 0.8295, respectively. The optimal conditions of independent variables were 7.4 of pH, 38 mg/L of PAC and 1,000 mg/L of ballast. Under these conditions, the turbidity removal rate was more than 97% and the average settling velocity exceeded 35 m/h.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1992.10a
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• pp.145-150
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• 1992

화인세라믹의 우수한 공학적 특성으로 인한 최근의 이용가치 증대와 더불어 세라믹의 고정도 가공에 대한 관심이 높아지고 있다. 다이아몬드휠을 이용한 연삭이나 다이아몬드 공구를 이용한 선삭에 의해 세라믹의 고정도 표면생성을 실현시키고자 하는 연구가 활발히 진행되고는 있으나 아직 미흡한 상태에 있다. 따라서 전통적으로 고정도 표면생성에 널리 용되어 온 래핑에 의한 표면다듬질이 현재 행하여지고 있는 일반적인 방법이다. 본 연구에서는 화인세라믹의 고정도 표면생성을 위한 원통래핑 공정의 최적화 방법으로 실험계획법의 한 응용분야인 반응표면분석법을 이용하였으며 그 결과, 적은 재료와 시간으로 능률적이고 체계적인 실험 및 통계적인 분석을 통해서 원통세라믹의 고정도 표면생성을 위한 최적래핑조건을 찾아내었다.