• Title/Summary/Keyword: 포텐셜

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Centella asiatica and Asiaticoside Regulate H2O2-induced Cellular Inflammation via Mitochondrial Respiration and the TLR4 Pathway (병풀(Centella asiatica) 및 아시아티코사이드는 미토콘드리아 호흡 및 TLR4 경로를 통해 H2O2 유도 세포염증 조절)

  • Ji, Juree;Nam, Young sun;Kang, Sang Mo
    • Journal of Life Science
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    • v.31 no.4
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    • pp.389-399
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    • 2021
  • This study determined the effects of Centella asiatica leaf on H2O2 induced cell cycle arrest, mitochondrial activity, and proinflammatory cytokine production in human dermal fibroblast (HDF) cells. We used an 80% methanol extract of C. asiatica, its ethyl acetate fraction, and asiaticoside, the major constituent of C. asiatica. The C. asiatica extract, its ethyl acetate fraction, and asiaticoside attenuated G1 cell cycle-arrest and the apoptotic effect caused by H2O2-induced oxidative stress. The cells treated with C. asiatica extract, its ethyl acetate fraction, and asiaticoside secreted lower levels of TNF-α and IL-6. The antioxidant effect of asiaticoside was higher than that of C. asiatica extract and its ethyl acetate fraction. Treatment with C. asiatica extract, its ethyl acetate fraction, and asiaticoside also increased the mitochondrial membrane potential and restored normal mitochondrial morphology. Following H2O2 stress induction, cells treated with C. asiatica extract, its ethyl acetate fraction, and asiaticoside showed increased mitochondrial oxygen consumption rates and decreases in the TLR4-MyD88-TRAF6-p65 pathway activity. These findings suggest that C. asiatica extract, its ethyl acetate fraction, and asiaticoside have antioxidant and anti-inflammatory effects, as well as the ability to control the mitochondrial activities of HDF cells.

Analysis on the Changes in Abandoned Paddy Wetlands as a Carbon Absorption Sources and Topographic Hydrological Environment (탄소흡수원으로서의 묵논습지 변화와 지형수문 환경 분석)

  • Miok, Park;Sungwon, Hong;Bonhak, Koo
    • Land and Housing Review
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    • v.14 no.1
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    • pp.83-97
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    • 2023
  • The study aims to provide an academic basis for the preservation and restoration of abandoned paddy wetland and the enhancement of its carbon accumulation function. First, the temporal change of the wetlands was analysed, and a typological classification system for wetlands was attempted with the goal of carbon reduction. The types of wetland were classified based on three variables: hydrological environment, vegetation, and carbon accumulation, with a special attention on the function of carbon accumulation. The types of abandoned paddy wetlands were classified into 12 categories based on hydrologic variables- either high or low levels of water inflow potential-, vegetation variables with either dominance of aquatic plants or terrestrial plants, and three carbon accumulation variables including organic matter production, soil organic carbon accumulation, and decomposition. It was found that the development period of abandoned paddy analyzed with aerial photographs provided by the National Geographic Information Institute happened between 2010 and 2015. In the case of the wetland in Daejeon 1 (DJMN01) farming stopped by 1990 and it appeared to be a similar structure to natural wetlands after 2010 . Over the past 40 years the abandoned paddy wetland changed to a high proportion of forests and agricultural lands. As time went by, such forests and agricultural lands tended to decrease rapidly and the lands were covered by artificial grass and other types of forests.

Study on Stabilization of Retinaldehyde using Drug-in-Cyclodextrinin-Liposome (DCL) for Skin Wrinkle Improvement (레틴알 안정화를 위한 사이클로덱스트린-리포좀에 관한 연구)

  • Ha, Ji Hoon;Choi, Hyeong;Hong, In Ki;Han, Sang-Kuen;Bin, Bum Ho
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.48 no.1
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    • pp.77-85
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    • 2022
  • Retinaldehyde (RA), vitamin A derivative, is an intermediate between retinol and retinoic acid and has an excellent wrinkle improving effect. In this study, Drug-in-cyclodextrin-in-liposome (DCL) was used to enhance the stability and skin penetration of RA. The complex of RA and hydroxypropyl-beta-cyclodextrin (HP-β-CD) was prepared by the freeze-drying method, and the presence or absence of inclusion of retinal was confirmed by UV-Vis spectrometer, FT-IR and SEM images. RA was captured in HP-β-CD about 95.6% on 1 : 15 (w/w). The retinal-HP-β-CD complex was encapsulated in liposomes using a homomixer and microfluidizer, with an average particle size of 215 ± 4.2 nm and a zeta potential of -31.2 ± 0.5 mv. In the evaluation of the degradation stability of RA, degradation rate of RA-HP-β-CD-liposomes in water was 1.8% higher than RA-liposome (5.8%), RA-HP-β-CD complex (9.7%) and RA alone (37.6%). RA cream (0.05% RA) including RA-HP-β-CD-liposomes was prepared for clinical test with wrinkle-improving efficacy and skin dermis denseness evaluated for 2 or 4 weeks. RA cream showed a significant wrinkle improving effect without skin irritation. In conclusion, it was confirmed that the double stabilization technology using the DCL system contribu tes to the effect of improving skin wrinkles by increasing the stabilization of retinal.

Adsorption Characteristics of Hydrogen in Regular Single-Walled Carbon Nanotube Arrays at Low Temperature (저온에서 규칙적인 단일벽 탄소나노튜브 배열의 수소 흡착 특성)

  • Yang Gon Seo
    • Clean Technology
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    • v.29 no.3
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    • pp.217-226
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    • 2023
  • The amount of hydrogen adsorbed in arrays of single walled carbon nanotubes (SWNTs) was studied as a function of nanotube diameter and distance between the nearest-neighbor nanotubes on square arrangements using a grand canonical Monte Carlo simulation. The influence of the geometry of a triangle array with the same diameters and distances was also studied. Hydrogen-carbon and hydrogen-hydrogen interactions were modeled with Lennard-Jones potentials for short range interactions and electrostatic interactions were added for hydrogen-hydrogen pairs to consider quantum contributions at low temperatures. At 194.5 K, Type I isotherms for large-diameter SWNTs and Type IV isotherms without hysteresis between adsorption and desorption processes for wider tube separations were observed. At 200 bars, the gravimetric hydrogen storage capacity of the SWNTs was reached or exceeded the US Department of Energy (DOE) target, but the volumetric capacity was about 70% of the DOE target. At 77 K, a two-step adsorption was observed, corresponding to a monolayer formation step followed by a condensation step. Hydrogen was adsorbed first to the inner surface of the nanotubes, then to the outer surface, intratubular space and the interstitial channels between the nanotube bundles. The simulation indicated that SWNTs of various diameters and distances in a wide range of configurations exceeded the DOE gravimetric and volumetric targets at under 1 bar.

ViscoElastic Continuum Damage (VECD) Finite Element (FE) Analysis on Asphalt Pavements (아스팔트 콘크리트 포장의 선형 점탄성 유한요소해석)

  • Seo, Youngguk;Bak, Chul-Min;Kim, Y. Richard;Im, Jeong-Hyuk
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.28 no.6D
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    • pp.809-817
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    • 2008
  • This paper deals with the development of ViscoElastic Continuum Damage Finite Element Program (VECD-FEP++) and its verification with the results from both field and laboratory accelerated pavement tests. Damage characteristics of asphalt concrete mixture have been defined by Schapery's work potential theory, and uniaxial constant crosshead rate tests were carried out to be used for damage model implementation. VECD-FEP++ predictions were compared with strain responses (longitudinal and transverse strains) under moving wheel loads running at different constant speeds. To this end, an asphalt pavement section (A5) of Korea Expressway Corporation Test Road (KECTR) instrumented with strain gauges were loaded with a dump truck. Also, a series of accelerated pavement fatigue tests have been conducted at pavement sections surfaced with four asphalt concrete mixtures (Dense-graded, SBS, Terpolymer, CR-TB). Planar strain responses were in good agreement with field measurements at base layers, whereas strains at both surface and intermediate layers were found different from simulation results due to the complexity of tire-road contact pressures. Finally, fatigue characteristics of four asphalt mixtures were reasonably described with VECD-FEP++.

Effect of Seed-Fertilizer Distance with Soil Moisture and Fertilizer Application Levels on the Emergence and Initial Growth of Barley (토양수분(土壤水分) 및 시비량(施肥量)에 따른 종자(種子)와 비료(肥料)의 수직거리(垂直距離)가 보리 출아(出芽) 및 초기생육(初期生育)에 미치는 영향(影響))

  • Park, Moo-Eon;Kim, Seok-Dong;Ha, Yong-Woong;Yoo, Sun-Ho
    • Korean Journal of Soil Science and Fertilizer
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    • v.17 no.3
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    • pp.274-282
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    • 1984
  • In order to study the effect of seed-fertilizer vertical distance with soil moisture and fertilizer levels on the emergence and initial growth, barley cv. Olbori was seeded in the pots filled with sandy loam or loamy sand soils which were adjusted to 80-100% (higher soil moisture) or 50-60% (lower soil moisture) of soil moisture retention percent at 1/10 atmosphere tension. Prior to seeding of barley seed-fertilizer distance was appropriately controlled by adding soils after dressing fertilizer at three levels-normal application ($N:P_2O_5:K_2O=6-9-7kg/10a$), 50% increase of normal dose and double application. In addition, germination experiment was conducted in the various concentrations of fertilizer solutions under room temperature. The results are summarized as follows; 1. Seed-fertilizer vertical distance must be more than three centimeters to avoid from the decrease and retardation of emergence and poor initial growth of bareley by fertilizer application. 2. Emergence of barley more decreased and retarded in sandy soils than loamy soils and was decelerated with increase of application rate in fertilizer and decrease of soil moisture content. 3. Germination rate remarkably decrease from 0.4 percent of nitrogen solution and 0.5 percent of potassium solution and reached zero at 2.3 and 2.4 percent of nitrogen and potassium solutions, respectively. 4. Germination of seeds affected by concentrated fertilizer solutions was remarkably recovered with dilution degree of fertilizer solution.

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A Characterization of Oil Sand Reservoir and Selections of Optimal SAGD Locations Based on Stochastic Geostatistical Predictions (지구통계 기법을 이용한 오일샌드 저류층 해석 및 스팀주입중력법을 이용한 비투멘 회수 적지 선정 사전 연구)

  • Jeong, Jina;Park, Eungyu
    • Economic and Environmental Geology
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    • v.46 no.4
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    • pp.313-327
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    • 2013
  • In the study, three-dimensional geostatistical simulations on McMurray Formation which is the largest oil sand reservoir in Athabasca area, Canada were performed, and the optimal site for steam assisted gravity drainage (SAGD) was selected based on the predictions. In the selection, the factors related to the vertical extendibility of steam chamber were considered as the criteria for an optimal site. For the predictions, 110 borehole data acquired from the study area were analyzed in the Markovian transition probability (TP) framework and three-dimensional distributions of the composing media were predicted stochastically through an existing TP based geostatistical model. The potential of a specific medium at a position within the prediction domain was estimated from the ensemble probability based on the multiple realizations. From the ensemble map, the cumulative thickness of the permeable media (i.e. Breccia and Sand) was analyzed and the locations with the highest potential for SAGD applications were delineated. As a supportive criterion for an optimal SAGD site, mean vertical extension of a unit permeable media was also delineated through transition rate based computations. The mean vertical extension of a permeable media show rough agreement with the cumulative thickness in their general distribution. However, the distributions show distinctive disagreement at a few locations where the cumulative thickness was higher due to highly alternating juxtaposition of the permeable and the less permeable media. This observation implies that the cumulative thickness alone may not be a sufficient criterion for an optimal SAGD site and the mean vertical extension of the permeable media needs to be jointly considered for the sound selections.

Study of Nutrient Uptake and Physiological Characteristics of Rice by $^{15}N$ and Purified Si Fertilization Level in a Transplanted Pot Experiment (중질소와 순수규산 시비수준이 벼의 양분흡수 및 생리적 특성에 미치는 영향)

  • Cho Young-Son;Jeon Won-Tae;Park Chang-Young;Park Ki-Do;Kang Ui-Gum
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.51 no.5
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    • pp.408-419
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    • 2006
  • A pot experiment was conducted for two years to evaluate the effects of purified Si fertilization combined with $^{15}N$ on the nutrient uptake, plant growth characteristics, and photosynthetic characteristics of rice in water melon cultivated soil. In 2002, plant height was positively affected at 25 DAT (Day After Transplanting) by Si fertilization in 100%N treatment. However, in 2003, plant height at 25 DAT was negatively affected by Si fertilization in low N level but it was reversed in high N level with initial increase of plant height. Tiller number per pot was positively affected by N and Si fertilization level, especially for high N fertilized treatment. Leaf color was positively affected by Si fertilizatlon in no N fertilized pots, however, Si was not effected in 50%N and 100%N fertilized treatments. N harvest index (NHI) increased with increased Si fertilization in no N plots, however it decreased with increasing of N fertilization level. Nitrogen use efficiency (NUE) decreased with increasing of fertilized N but Si fertilization increased NUE in 50%N plots, however, it was not different by the Si fertilization level in 100%N plots. In 50%N+200%Si plots, NUE was greatest with 130 and shoot N content was $16.2g-N/m^{2}$. N content ($g/m^{2}$) in rice plant increased with increasing Si fertilization in no N plots at panicle initiation stage, 50 and 100%N plots at heading stage and all N treatment at harvesting time. This was mostly more efficient in late growth stage than early growth stage. The concentration (%) of P and K increased with increasing N fertilization level at heading and harvesting but it was not significantly different by the Si fertilization treatment except a little decreasing with increasing Si fertilization level at heading. Potassium content was also not significantly related with N fertilization level except increasing with Si fertilization level at panicle initiation stage. Plant Ca content (%) decreased with increasing of Si fertilization at heading stage and Si fertilization increased Ca content at panicle initiation stage and heading stage and it increased with increasing of Si fertilization level. Photosynthetic activity was not directly related with Si fertilization amount, however, Fluorescent factors, Fv'/Fm' and PsII, were positively affected by Si fertilization level. In conclusion, N fertilization in Si 200% fertilized condition should be reduced by about 50% level of recommended N fertilization for rice cropping in green-house water-melon cultivated paddy field. However, improvement of Ps by Si fertilization could not be attributed to Ps activity in the same leaf area but because of increased total leaf area per pot improved fluorescent characteristics.

Effect of Soil Water Potential on Pysico-Chemical Properties of Soil and Cucumber(Cucumis sativus L.) Growth (토양(土壤) 수분(水分)포텐셜이 오이(Cucumis sativus L.)생육(生育)과 토양(土壤) 이화학적(理化學的 ) 특성(特性)에 미치는 영향(影響))

  • Bum, In-Sook;Kim, Yong-Woong;Kim, Kwang-Sik;Kim, Kil-Yong;Sohn, Bo-Kyoon;Kim, Hyun-Woo
    • Korean Journal of Soil Science and Fertilizer
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    • v.32 no.2
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    • pp.171-181
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    • 1999
  • A field experiments was carried out to investigate the physicochemical properties of soil and cucumber growth in vinyl house when irrigation point was made at 0.2, 1/3, 0.5 and 1.0 bar. The obtained results was summarized as follow: The taxonomic class of the soil used was loam and each content of the required water was 4.4, 7.3, 9.6 and 13.4 mm per each irrigation time at 0.2, 1/3, 0.5 and 1.0 bar treatments in spring culture, respectively. At 0.2 bar and 1.0 bar treatments, interval of irrigation was 2.3 and 14.8 day, the times of irrigation was 37 and 6, and total irrigation volume was 163.5 and 80.3 mm, respectively. After cucumber culture, pH, EC concentration and exchangeable K content of soil at 0.2 bar treatment was distributed near to the level of improvement target while EC, available $P_2O_5$ and exchangeable base content in other treatments were higher compared to improvement target. At 1.0 bar treatment, ratios of the solid and liquid phase were 44.9 and 27.1%, respectively, and bulk density was $1.26g\;cm^{-3}$ which was the highest among the treatments. At 0.2 bar treatment, the ratio of the solid and liquid phase was 41.7 and 22.8%, respectively, and bulk density was $1.09g\;cm^{-3}$ which was the lowest. The root length and radius at 0.2 bar treatment were best, while those at 1/3 bar were worst. At 0.2 bar treatment, the total yield was 7,269 kg and the weight of good products was 5,677 kg which was the highest among treatments. At 0.33 bar treatment, the yield was the lowest with the high ratio of deformity.

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Seismic Design of Columns in Inverted V-braced Steel Frames Considering Brace Buckling (가새좌굴을 고려한 역 V형 가새골조의 기둥부재 내진설계법)

  • Cho, Chun-Hee;Kim, Jung-Jae;Lee, Cheol-Ho
    • Journal of Korean Society of Steel Construction
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    • v.22 no.1
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    • pp.1-12
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    • 2010
  • According to the capacity design concept which forms the basis of the current steel seismic codes, the braces in concentrically braced frames (CBFs) should dissipate seismic energy through cyclic tension yielding and cyclic compression buckling while the beams and the columns should remain elastic. Brace buckling in inverted V-braced frames induces unbalanced vertical forces which, in turn, impose the additional beam moments and column axial forces. However, due to difficulty in predicting the location of buckling stories, the most conservative approach implied in the design code is to estimate the column axial forces by adding all the unbalanced vertical forces in the upper stories. One alternative approach, less conservative and recommended by the current code, is to estimate the column axial forces based on the amplified seismic load expected at the mechanism-level response. Both are either too conservative or lacking technical foundation. In this paper, three combination rules for a rational estimation of the column axial forces were proposed. The idea central to the three methods is to detect the stories of high buckling potential based on pushover analysis and dynamic behavior. The unbalanced vertical forces in the stories detected as high buckling potential are summed in a linear manner while those in other stories are combined by following the SRSS(square root of sum of squares) rule. The accuracy and design advantage of the three methods were validated by comparing extensive inelastic dynamic analysis results. The mode-shape based method(MSBM), which is both simple and accurate, is recommended as the method of choice for practicing engineers among the three.