• Tuberculosis and Respiratory Diseases
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• v.39 no.4
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• pp.310-317
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• 1992

Background: Angiotensin converting enzyme is a glycoprotein peptidyldipeptide hydrolase which cleaves the c-terminal dipeptides of several oligopeptides. It is a menbrane-bound protein mainly synthesized by the endothelial cells. Since the lung has the largest capillary bed of any organ in the body, it is here that ACE acts on circulating substrates like angiotensin I and bradykinin. It is well known that ACE correlates with disease activity in sarcoidosis and also there are reports that changes in serum ACE activity are found in many acute and chronic lung diseases. So we planned this study to see if serum ACE activity can act as a prognostic factor in lung cancer. Methods: Forty-one newly diagnosed lung cancer patients were included in the study group. There were 19 patients with squamous cell lung cancer, 13 with adenocarcinoma, and 9 with small cell carcinoma. Patients were excluded from the study if they had high blood pressure, heart disease, liver disease, renal disease, or other lung disease. Serum ACE activity was analyzed according to cell type, staging, mode of treatment, and clinical response to treatment. Results: 1) There was no difference in serum ACE activity between lung cancer patients and the control group. Also no difference in serum ACE activity was found according to cancer cell type or staging. 2) In patients who underwent curative resection of lung cancer, serum ACE activity was decreased significantly after the operation. 3) In patients who were diagnosed as non-small cell lung cancer and were treated with 4 cycles of anti-cancer chemotherapy without clinical improvement, changes in serum ACE activity were not seen after the treatment. 4) In patients diagnosed as small cell lung cancer treated with 4 cycles of anti-cancer chemotherapy with clinical improvement, changes in serum ACE activity were also not observed. Conclusion: Serum ACE activity was decreased after lung resection but had no relation to cell type, staging, or clinical response to treatment in lung cancer patients. Therefore, serum ACE activity is not suitable in predicting clinical outcome of lung cancer patients.

• Tuberculosis and Respiratory Diseases
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• v.46 no.4
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• pp.455-465
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• 1999

Background: Even though lung cancer has become a major cancer in Korea, national survey for lung cancer has not been available except several reports from individual hospitals. Methods: Korean Academy of Tuberculosis and Respiratory Diseases retrospectively investigated the characteristics of lung cancer diagnosed from January 1997 to December 1997 at general hospitals over 400 beds. Results: Among 3,794 patients, 76.8% are smokers and 89.8% of male patients are smokers. Squamous cell carcinoma is the leading type of lung cancer(44.7%) followed by adenocarcinoma(27.9%). Smoking rate in adenocarcinoma was significantly lower than in squamous cell carcinoma and small cell cancer. Cough is the most common symptom, however, 7.2% are asymptomatic. Bronchoscopic biopsy has a main role in the diagnosis of squamous cell carcinoma and small cell cancer but percutaneous needle biopsy has more important role in adenocarcinoma. Two-thirds of NSCLC patients were found in unresectable advanced stages. Conclusion: In contrast to other countries, squamous cell carcinoma is still the most frequent type of lung cancer. High proportions of smoker and advanced, unresectable lung cancer urge us to develop the program for cessation of smoking and early detection.

• Tuberculosis and Respiratory Diseases
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• v.46 no.4
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• pp.533-541
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• 1999

Background: Lung cancer in younger patients seems to be a more aggressive disease and their prognosis may be worse than that of older patients. Abnormal p53 expression in primary lung cancer may be an independent prognostic factor for poor prognosis. This study was conducted to determine the difference of abnormal p53 mutation in patients with primary non-small cell lung cancer (NSCLC) under 45 years of age and 55 years old or greater. Method: The present study was performed to compare the clinical and pathological features of primary NSCLC between patients younger than 45 years old and older than 55 years old and to evaluate the difference of abnormal p53 mutation between two groups. Immunohistochemical detection of abnormal p53 mutation was assessed in all primary NSCLC specimens by pathologist. Results: Positive nuclear staining of p53 mutation was found in 76.0% of younger patients and in 76.9% of older patients with variable intensity of staining. And there was no significant correlation between abnormal p53 mutation according to the disease stage or histologic subtype. Conclusion: In this investigation, these were no difference in p53 mutation between two groups.

• Journal of the Korean Data and Information Science Society
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• v.28 no.6
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• pp.1371-1382
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• 2017

The purpose of this study was to identify the mediating effect of resilience in the relationship between stigma and quality of life (QOL) in lung cancer patients. Participants were 119 lung cancer patients who visited the outpatient department of a hospital. The subjects completed a questionnaire of stigma, resilience and QOL. Data were analyzed using t-test, ANOVA, Scheffe test, Pearson correlation, three-step regressions to test mediating effect and Sobel test. Stigma was negatively correlated with resilience and QOL. Resilience was positively correlated with QOL. Stigma explained 15.0% of the variance of resilience. Stigma and resilience explained 41.0% of the variance of QOL. Resilience had a partial mediating effect in the relationship between stigma and QOL. The results suggest that a nursing intervention to decrease stigma and enhance resilience is recommended to improve QOL in lung cancer patients.

• Tuberculosis and Respiratory Diseases
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• v.47 no.5
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• pp.660-668
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• 1999

Background: Lung cancer continues to increase and one half of all cases of lung cancer occur in patients age 65 years and older. However, it seems that lung cancer is less treatable in elderly patients because of co-morbid illness or poor tolerance of surgery and chemotherapy. The intention of this study is to seek an adequate treatment approach for lung cancer in the elderly through an understanding of its characteristics. Method: The clinical data of 207 patients who were diagnosed with histologically proven lung cancer at the department of internal medicine in Seoul Municipal Boramae Hospital between September 1994 and August 1998 were retrospectively analyzed according to their age groups; group I$\geq$65 years(n=122) and group II<65 years(n=85). Results: The peak incidence of age was 7th decade(36.2%) and male age 65 years and older were 42% of all patients. Although dyspnea was more common in group I(26%) than in group II(11%)(p=.0l), there were no significant difference in other symptoms, stage, and histologic type between two groups. Group I significantly had more patients with poor performance(ECOG 3&4) than group II(35.2% vs.12.9%, p=.000). The percentage of patients with non-small cell carcinoma received supportive care only was significantly higher in group I than in group I(74% vs. 35%, p=.000). However, survival of patients who had curative intent treatment was similar between two groups(median survival 11.3 mos vs. 23 mos, p>.05). The histologic subtype, stage and performance status were significant prognostic factors affecting survival, but age itself was not. Conclusion : Lung cancer is prevalent in the elderly and aggressive diagnosis and treatment should be considered in elderly patients with good performance status.

• The Journal of the Convergence on Culture Technology
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• v.8 no.3
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• pp.33-41
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• 2022

This study is a qualitative study to identify the educational needs for home-based lung cancer patients receiving chemotherapy. The study participants were 20 patients with home-based lung cancer patients receiving chemotherapy at a university hospital at D city. Data collected through interviews from July 2016 to September 2017 were analyzed using Krippendorff's method. As a result, 3 categories, 9 themes, 19 sub-themes, and 54 meaningful statements were derived. The three categories of educational needs were 'psychological needs', 'knowledge needs', and 'social needs'. Home-based lung cancer patients receiving chemotherapy wanted to support prognosis and stress and receive accurate knowledge of side effects and information on social support systems through education. The results of this study are expected to be used as basic data for the development of educational intervention programs for home-based lung cancer patients receiving chemotherapy in the future.

• Proceedings of the Korea Information Processing Society Conference
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• 2020.11a
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• pp.784-787
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• 2020

폐암 환자의 생존율을 예측할 때 미국암연합회(AJCC)의 TNM병기 분류체계에 의해 진단되는 최종병기를 많이 사용한다. 최종병기는 폐암환자의 임상데이터 중 하나로 종양의 위치, 크기, 전이정도를 고려하여 환자의 폐암 상태를 판별하는 정보이다. 최종병기는 개략적인 환자의 상황을 설명하는 데 효과적이지만, 보다 구체적인 생존분석을 위해서는 임상데이터 뿐만 아니라 PET/CT와 같은 영상 데이터를 함께 분석해야 한다. 이 논문에서는 데이터 과학적 접근을 통해 폐암환자의 임상데이터, CT영상과 PET영상 등 다양한 종류의 데이터를 함께 활용하는 생존분석기법을 검토한다. 실험을 통해 다중 모드 데이터를 활용하는 생존분석을 위해 비선형모델 개발과 Feature임베딩 기법 고도화가 필요함을 확인하였다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.248-259
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• 2017

This descriptive correlational study was conducted to identify the factors influencing the uncertainty of patients undergoing chemotherapy for lung neoplasms. One hundred and eleven patients were recruited from the chemotherapy clinic of a university hospital. Data were collected from July 25 to December 31, 2014, and analyzed by descriptive statistics, the t-test, ANOVA, the Scheffe test, Pearson's product moment correlation coefficients and multiple regression analysis with SPSS for Windows Version 18.0. The mean score of the uncertainty of the patients undergoing chemotherapy for lung neoplasms was 2.61(${\pm}0.46$), which was higher than that of the patients with other diseases. The uncertainty was positively correlated with the seriousness of the illness (r=.74, p<.01) and consistency of the symptoms (r=.27, p<.01). Multiple regression analysis showed that the (main) factor influencing the uncertainty was the seriousness of the illness, which explained 54% of the uncertainty of the patients undergoing chemotherapy for lung neoplasms. As a result, nursing interventions are needed to reduce the uncertainty of lung neoplasm patients who are receiving chemotherapy. The seriousness of the illness should be considered when developing nursing interventions to reduce the uncertainty of lung neoplasm patients.

• Tuberculosis and Respiratory Diseases
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• v.41 no.3
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• pp.262-269
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• 1994

Background : A clinical study was carried out on 153 new cases with small cell lung cancer registered at Presbyterian Medical Center, Chonju during the 7 years from 1986 to 1992. They were analyzed by sex and age distribution, symptoms and signs, classification of stage and site and its treatments. Especially, an effort was made to compare the overall survival time between limited stage and extensive stage. Methods : Among 806 lung cancer patients diagnosed by biopsy or cytologic evaluation for the 7 years, 153 patients was shown small cell lung cancer. These 153 cases was analyzed retrospectivery through patient's records, letters or telephones. Results : The results of evaluation of small cell lung cancer are as follows. Over 85 percent of the small cell lung cancer patients were over 50 years of age and prominent clinical features were cough(86.3%), sputum(75.8%) and dyspnea(54.9%). One hundred and five patients(68.7%) was staged to have limited stage. Mean survival time of the chemotherapy and chemoradiotherapy in limited stage has significant difference and its survivals are 5.3 months and 15.0 months. Patients whose disease was staged as limited, regardless of whether or not chemotherapy was administered, had a median survival time of 10.9 months, compared with 4.8 months for those with extensive stage. Conclusion : Lung cancer is one of the malignant diseases tend to increase gradually in Korea and proven to be the most common cancer next to the gastric cancer among various cancers in males found at the Presbyterian Medical Center in the past seven years. This report is a retrospective view of the clinical therapeutic results of the small cell lung cancer patients. Especially at the limited stage, the combined therapy revealed higher survival rate than the chemotherapy alone. For a more accurate evaluation. a prospective view, without any bias, of patients selected at random is needed.

• Journal of Chest Surgery
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• v.32 no.1
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• pp.32-37
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• 1999

Background: Early detection and surgical resection offer the most advantage out of all cures for lung cancer. Elderly patients may fail to benefit maximally from these interventions because of their general condition and residual lung function. To study the impact of age on stages, histology, symptoms, and treatments of the patients with non-small cell lung cancer, we undertook a retrospective review. Material and Method : Two hundred eleven patients with non-small cell lung cancer were operated on at Samsung Seoul hospital between October 1994 and June 1997. Patients were arbitrarily arbitrarily by age less than 70 years(176 patients) and 70 years or more(35 patients), and their medical records were reviewed. Result: There were no differences in pathologic staging and diagnosis. But there were differences in surgical methods, complications, and mortality rates between the two groups. There were much more complications in the 70 years or more group(p=0.02). We chose less invasive surgical methods in the 70 years or more group. Conclusion: More complications were experienced in the 70 years or more group. Although thoracic operation imparts the greatest survival advantage, this benefit is diminished in elderly patients because of their high complications and mortality rate. We recommend serious consideration of surgical indications and operative methods.