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The clinical effects of a hydroxyapatite containing toothpaste for dentine hypersensitivity (민감성 치아에 대한 수산화인회석 함유 치약의 임상적 효과)

  • Kim, Su-Hwan;Park, Jun-Beom;Lee, Chul-Woo;Koo, Ki-Tae;Kim, Tae-Il;Seol, Yang-Jo;Lee, Yong-Moo;Ku, Young;Chung, Chong-Pyung;Rhyu, In-Chul
    • Journal of Periodontal and Implant Science
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    • v.39 no.1
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    • pp.87-94
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    • 2009
  • Purpose: The aim of this study was to compare the effectiveness of hydroxyapatite containing toothpaste with positive control toothpastes in reducing dentine hypersensitivity. Materials and methods: This clinical trial was a double-blind, randomized, parallel group comparison of two, namely hydroxyapatite containing toothpaste and strontium chloride containing toothpaste. A total of 55 subjects were included in this study. The subjects were given randomly assigned one of the two toothpastes after received tooth brushing instruction at baseline. Some clinical indices(PI, GI, PD), verbal rating score(VRS) for sensitivity to stimulus, the effect in relieving sensitivity and visual analogue scale(VAS) for sensitivity at baseline, week 2, week 4 and week 8 were assessed. All data were evaluated by intention-to-treat analysis. Results: Overall, PI and GI scores were significantly reduced compare baseline in all groups(p<0.05). In addition, there was significant difference in PI at 4 weeks and in GI at 4, 8 weeks between groups. The proportions of subjects relieved sensitivity were 70.4% in experimental group and 57.1% in control group at 8 weeks respectively. The VRS for sensitivity to three kinds of stimuli and VAS for sensitivity decreased according to time, there was no overall difference between two groups(p>0.05). Conclusion: This study demonstrated that the new hydroxyapatite containing toothpaste was similarly effective in reducing dentine hypersensitivity with pre-existing benchmark toothpaste.

Osteogenic effects of polyethyleneimine-condensed BMP-2 genes in vitro and in vivo (Polyethyleneimine-응축 BMP-2 발현 유전자를 이용한 골형성 효과)

  • Cheong, Hee-Sun;Kim, Kyoung-Hwa;Park, Yoon-Jeong;Kim, Tae-Il;Lee, Yong-Moo;Ku, Young;Rhyu, In-Chul;Lee, Dong-Soo;Lee, Seung-Jin;Chung, Chong-Pyoung;Han, Soo-Boo;Seol, Yang-Jo
    • Journal of Periodontal and Implant Science
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    • v.37 no.4
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    • pp.859-869
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    • 2007
  • Naked DNA and standard vectors have been previously used for gene delivery. Among these, PEI can efficiently condense DNA and has high intrinsic endosomal activities. The aim of this study is to investigate whether the cationic polycation PEI could increase the transfection efficiency of BMP expressing DNA using a vector-loaded collagen sponge model. BMP-2/pcDNA3.1 plasmid was constructed by subcloning human BMP-2 cDNA into the pcDNA3.1 plasmid vector. PEI/DNA complexes were prepared by mixing PEI and BMP-2/pcDNA3.1 and the constructed complexes were loaded into the collagen sponges. In vitro studies, BMSCs were transfected with the PEI/BMP-2/pcDNA3.1 complexes from collgen sponge. The level of secreted BMP-2 and alkaline phosphatase activities of transfected BMSCs were significantly higher in PEI/BMP-2/pcDNA3.1 group than in BMP-2/pcDNA3.1 group (p<0.05). Transfected BMSCs were cultured and mineralization was observed only in cells treated with PEI/BMP-2/pcDNA3.1 complexes. In vivo studies, PEI/BMP-2/pcDNA3.1/collagen, BMP-2/pcDNA3.1/collagen and blank collagen were grafted in skeletal muscle of nude mice. Ectopic bone formation was shown in PEI/BMP-2/pcDNA3.1/collagen grafted mouse 4 weeks postimplantation, while not in BMP-2/pcDNA3.1 grafted tissue. This study suggests that PEI-condensed DNA encoding for BMP-2 is capable of inducing bone formation in ectopic site and might increase the transfection rate of BMP-2/pcDNA3.1. As a non-viral vector, PEI offers the potential in gene therapy for bone engineering.

A literature review on implant abutment and soft tissue response (임플란트 지대주와 임플란트 주위 연조직의 반응에 관한 고찰)

  • Lee, Young-Hoon;Ko, Kyung-Ho;Huh, Yoon-Hyuk;Park, Chan-Jin;Cho, Lee-Ra
    • Journal of Dental Rehabilitation and Applied Science
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    • v.32 no.4
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    • pp.263-273
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    • 2016
  • In the implant prosthetic procedure, the soft tissue reaction was varied with the material and surface treatment of the abutment. It may be the cause of the peri-implantitis, and hence it can affect the long-term prognosis of the implant prosthesis. Titania and zirconia abutment presented superior biocompatibility and stable soft tissue reaction, while gold alloy abutment showed unfavorable reaction sometimes. A soft tissue reaction can be differed by the surface characteristics even in the same material type. Because rougher surface induces a bacterial attachment, the part contacting a soft tissue should have smooth surface. Additional surface treatment can enhance the cellular response without increasing bacterial attachment. Repeated removal and insertion of the abutment and the shape of the abutment may affect the soft tissue reaction, also. Ultrasonic cleaning and argon plasma cleaning are effective way to clean the retained micro-dust on the customized abutment.

Development of FURA Code and Application for Load Follow Operation (FURA 코드 개발과 부하 추종 운전에 대한 적용)

  • Park, Young-Seob;Lee, Byong-Whi
    • Nuclear Engineering and Technology
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    • v.20 no.2
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    • pp.88-104
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    • 1988
  • The FUel Rod Analysis(FURA) code is developed using two-dimensional finite element methods for axisymmetric and plane stress analysis of fuel rod. It predicts the thermal and mechanical behavior of fuel rod during normal and load follow operations. To evaluate the exact temperature distribution and the inner gas pressure, the radial deformation of pellet and clad, the fission gas release are considered over the full-length of fuel rod. The thermal element equation is derived using Galerkin's techniques. The displacement element equation is derived using the principle of virtual works. The mechanical analysis can accommodate various components of strain: elastic, plastic, creep and thermal strain as well as strain due to swelling, relocation and densification. The 4-node quadratic isoparametric elements are adopted, and the geometric model is confined to a half-pellet-height region with the assumption that pellet-pellet interaction is symmetrical. The pellet cracking and crack healing, pellet-cladding interaction are modelled. The Newton-Raphson iteration with an implicit algorithm is applied to perform the analysis of non-linear material behavior accurately and stably. The pellet and cladding model has been compared with both analytical solutions and experimental results. The observed and predicted results are in good agreement. The general behavior of fuel rod is calculated by axisymmetric system and the cladding behavior against radial crack is used by plane stress system. The sensitivity of strain aging of PWR fuel cladding tube due to load following is evaluated in terms of linear power, load cycle frequency and amplitude.

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Socio-Demographic Characteristics and Subjective Class Identification of 'Joongsancheung' (중산층의 사회인구학적 특성과 주관적 계층의식)

  • Jo, Dong-Gi
    • Korea journal of population studies
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    • v.29 no.3
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    • pp.89-109
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    • 2006
  • The 'Joongsancheung(JSC)', a unique term for the middle class in Korea, is defined as a stratum sharing common lifestyles and a certain level of life chances. It involves non-economic factors such as life chance, educational attainment, occupational groups as well as economic factor. Such objective measures as the occupational status of the main breadwinner, family income, and the educational level of respondent, and subjective measures of class identification are used for the operational definition of the JSC. Data from a national survey of 1,515 respondents is analyzed to investigate the change of the JSC in size and the major determinants of class identification. The results show that while there is no strong evidence of any significant change of the JSC by the objective measures during the recent decade, there seems to be a slight decrease in the subjective class identification. In addition, binary logistical regression analysis reveals that self-identification of JSC is heavily influenced by house ownership, along with subjective evaluation of one's own income and property ownership. This study demonstrates that the apparent class polarization in Korean society reflects not so much objective conditions but subjective perception of respondent of his or her circumstance. It is suggested that problems of housing and relative derivation people have as regards income and property should be resolved to alleviate such class polarization in Korean society.

Development of Advanced Manufacturing Process of Light Interference Pearl Pigment (광 간섭 펄 안료의 신규 제조 공정 개발)

  • Son, Hong Ha;Yu, Jae Won;Kim, Kyung Seob
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.41 no.2
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    • pp.121-126
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    • 2015
  • In general, the pearlescent pigment is a pigment which was used for optical characteristics like pearl, rainbow and metallic luster. Titanium dioxide coated mica plate developed by DuPont in 1965 is currently being used as a main part of pearlescent pigment for cosmetics. Although the smooth and clear surface substrate laminated with 2 ~ 3 ingredients is thicker than a previous monolayer coated substrate, it has been applied for cosmetics as the optical interference powder to realize stronger shine and brighter interference color than monolayer one. In this study, we developed a new optical interference powder with thinner and higher chroma than a current pearlescent pigment for the strong luster and bright interference color. It was prepared from the manufacturing process, in which the coated titanium dioxide precursor was changed and crystallized by coating and heat treatment process with a half of dividing the coated amount of titanium dioxide. We confirmed the dense coating of titanium dioxide grain with Scanning Electron Microscope and measured superior crystallization degree compared with a monolayer coated pearlescent pigment by X-ray Diffraction. It is concluded that our new pearlescent pigment had higher reflectivity of light and stronger interference color than previous products.

A Comparative Study on Evaluation Methods of Permanent Impairment in Korea (우리나라의 신체장애평가법에 관한 비교연구 - 신체장해등급법, McBride법, 미국의학협회 (AMA)기준법을 중심으로 -)

  • Rhee, Chang-Ok;Choi, Jung-Keun;Son, Mi-A;Moon, Ok-Ryun
    • Journal of Preventive Medicine and Public Health
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    • v.27 no.3 s.47
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    • pp.627-651
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    • 1994
  • In this study, literature review was done to examine and compare the current status and problems of different evaluation approaches toward permanent impairment in Korea. Alternatives and improvements in the current approaches in Korea were suggested. Series of cases were also examined to compare different approaches applied to the real cases, using 105 cases from a hospital data and another 207 cases from a insurance company data. The main findings of the literature review are as follows; 1. The current evaluation methods of permanent impairment in Korea are grouped into two categories, grading and rating. Gradings of impairments are expressly specified in 17 various statutes. 2. In Grading methods, the rigid system of 74 different grades has been adopted uniformally for the convenience of administration, which may not be, appropriate or valid from medical and scientifical aspect. 3. The adventage of McBride method is assessment of occupational disability rate. However the classified compensable occupations are only 280 and limited to manufacturing industries in 1960s'of U.S.A., which is not appropriate to current Korean circumstances. Especially, the job list does not include managerial officers or mental workers. 4. AMA Guides is the scientific and reasonable method for the assessment of physical impairment rate. However compensation and reparation of impairment case is difficult because this method cannot assess the disability rate according to occupation, age, etc. The results of cases comparative study are as follows: 5. The physical Impairment could be compared in 167 out of total 312 cases, and for the cases of complex impairment, McBride method underestimate physical impairment rate compared with AM A method. 6. When disability late was assessed, occupation was considered the compensation of only 85 cases, and age was used in only 21 cases. This was because occupation and age compensation in McBride method are unreasonable. 7. The most Ideal alternative is to assess physical impairment according to AMA method and then to develop a compensation method appropriate for the circumstances of Korea society.

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Accessibility Changes in the Metropolitan Seoul Subway System: Time-distance Algorithms based on the T-card Big Data and an Accessibility Measurement Model for Un-fixed Transportation Networks (수도권 광역철도망 확충에 따른 서울 대도시권 접근도 변화: 교통카드 빅데이터를 이용한 시간거리 산출 알고리즘 및 비고정성 교통망 접근도 산출 모형의 개발과 적용)

  • Lee, Keumsook;Park, Jong Soo;Jeong, Mi Seon
    • Journal of the Economic Geographical Society of Korea
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    • v.17 no.1
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    • pp.98-113
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    • 2014
  • The purpose of this study is to investigate the changes in the accessibility of the Metropolitan Seoul Transit systems since 2000, in which many new subway lines have been constructed as well as other urban transit lines have been connected to the systems. We suggest an accessibility measure model for Un-fixed Transportation Networks. In order to measure the nodal accessibility based on the mobility, we apply path-distance, physical-distance, and time-distance as the distance impedance measurement. Specifically, we develop time-distance algorithms to measure the time-distance between each pairs of transit stations based on the T-card transaction databases. We apply the model to the Metropolitan Seoul Transit systems in two time points(2005 and 2011). We examine the results in terms of three distance accessibility measures. Time-distance accessibility explains better the urban land use patterns in the Metropolitan Seoul area than the other two. We visualize the spatial patterns of time-distance accessibility by applying GIS, and analyze the spatial structures of accessibility in the Metrropolitan Seoul area between two time points.

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Effect of Reflow Number and Surface Finish on the High Speed Shear Properties of Sn-Ag-Cu Lead-free Solder Bump (리플로우 횟수와 표면처리에 따른 Sn-Ag-Cu계 무연 솔더 범프의 고속전단 특성평가)

  • Jang, Im-Nam;Park, Jai-Hyun;Ahn, Yong-Sik
    • Journal of the Microelectronics and Packaging Society
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    • v.16 no.3
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    • pp.11-17
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    • 2009
  • The drop impact reliability comes to be important for evaluation of the life time of mobile electronic products such as cellular phone. The drop impact reliability of solder joint is generally affected by the kinds of pad and reflow number, therefore, the reliability evaluation is needed. Drop impact test proposed by JEDEC has been used as a standard method, however, which requires high cost and long time. The drop impact reliability can be indirectly evaluated by using high speed shear test of solder joints. Solder joints formed on 3 kinds of surface finishes OSP (Organic Solderability Preservation), ENIG (Electroless Nickel Immersion Gold) and ENEPIG (Electroless Nickel Electroless Palladium Immersion Gold) was investigated. The shear strength was analysed with the morphology change of intermetallic compound (IMC) layer according to reflow number. The layer thickness of IMC was increased with the increase of reflow number, which resulted in the decrease of the high speed shear strength and impact energy. The order of the high speed shear strength and impact energy was ENEPIG > ENIG > OSP after the 1st reflow, and ENEPIG > OSP > ENIG after 8th reflow.

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The Formaion of N-nitrosamine in Soy Sauce, Soybean Paste and Beer under Simulated Gastric Digestion (간장, 된장 및 맥주의 인공소화시 N-nitrosamine의 생성)

  • Kim, Kyung-Ran;Lee, Soo-Jung;Shin, Jung-Hye;Seo, Jong-Kwon;Shon, Mi-Yae;Sung, Nak-Ju
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.3
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    • pp.378-383
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    • 2002
  • The aim of the study was to analyze N-nitrosamine (NA) and its precursors in serveral fermented foods which were treated with nitrite, thiocyanate and ascorbic acid under simulated gastric digestion. Every analyzed sample contained nitrate, with levels ranging from 0.3 to 1.3 mg/kg, but nitrite was present at very low levels of less than 0.3 mg/kg. And other precursors of amines such as dimethylamine and trimethylamine were detected less than 0.5 mg/kg in every samples. N-nitrosodimethylamine (NDMA) was detected in the levels of <0.5 ∼ 2.7 ug/kg in soy sauce,1.5∼3.1 ug/kg in soybean paste and <0.5∼1.8 ug/kg in beer, while NDMA levels increased by 1.1∼4.5 times in the fermented foods which were digested under simulated gastric conditions.