• The Korean Journal of Applied Statistics
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• v.26 no.3
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• pp.389-399
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• 2013

This article introduces Gaussian process regression and shows its application with time-course microarray gene expression data. Gene screening for yeast cell cycle microarray expression data is accomplished with a ratio of log marginal likelihood that uses Gaussian process regression with a squared exponential covariance kernel function. Gaussian process regression fitting with each gene is done and shown with the nine top ranking genes. With the screened data the Gaussian model-based clustering is done and its silhouette values are calculated for cluster validity.

• Journal of the korean academy of Pediatric Dentistry
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• v.34 no.3
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• pp.370-382
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• 2007

The aims of this study were to compare the status of dental caries between mental retarded persons(MR) and normal persons and investigated the association among dental caries and oral factors(plaque index, S. mutans, Lactobacillus, buffering capacity, salivary total IgA and anti-S. mutans IgA titers). DMFS index and plaque index were significantly greater in the MR person group than in the normal person group. The concentration of S. mutans-specific IgA was significantly greater in the normal person group than in the MR person group, but that of salivary total IgA was not show the significant difference. Salivary buffering capacity was significantly greater in the normal person group than in the MR person group, but the counts of salivary S. mutans and Lactobacillus were not significantly different. By age group(I: 9-11Y, II: 12-14Y, III: 15-18Y), DMFS index and plaque index were significantly greater in the MR person group than in the normal person group at III. The S. mutans counts and Lactobacillus counts were significantly greater in the normal person group than in the MR person group at I, but those were contrary at II, III. There was a high correlation among caries index and buffering capacity, level of S. mutans and Lactobacillus, plaque index at III.

• Journal of Korean Society of Forest Science
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• v.77 no.2
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• pp.216-222
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• 1988

This study was conducted to investigate the effect of meteorological factors on the diameter growth and Key-year in Pinus koraiensis and Pinus densiflora trees grown in Chuncheon and Hongcheon. The results obtained were summarized as follows : 1. The diameter growth of Pinus koraiensis was better than that of Pinus densiflora grown in the same meteorological condition and site environment. 2. The influence of meteorological factors on the diameter growth of Pinus koraiensis was the highest in the descending order fog, hours of sunshine, precipitation, relative humidity, warm index, and evaporation. 3. The influence of meteorological factors on the diameter growth of Pinus densiflora was the highest in the descending order fog, hours of sunshine, relative humidity, precipitation, and warm index. But evaporation was not significant. 4. The Key-years for Pinus koraiensis and Pinus densiflora trees appeared in 1964 and 1913 when the diameter growth was influenced by the specific climate change.

• Journal of the Korean Data and Information Science Society
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• v.25 no.6
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• pp.1195-1205
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• 2014

Compared with single design, powers of rank transformed statistic for testing main and interaction effects for $2{\times}2$ factorial in $4{\times}4$ latin square design are rapidly increased as effect size and replication size are increased. In general powers of rank transformed statistic are superior without regard to the diversified effect composition and the type of error distributions as nontesting factors are few and effect size are small. Powers of rank transformed statistic show much higher level than those of parametric statistic in exponential and double exponential distributions. Further powers of rank transformed statistic are very similar with those of parametric statistic in normal and uniform distributions.

• Journal of Convergence for Information Technology
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• v.10 no.11
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• pp.148-155
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• 2020

The purpose of the study was to test the reliability and validity of the Korean version of Pittsburgh Sleep Quality Index (PSQI-K) and to examine the cutoff point of the PSQI-K for screening insomnia among young adults. The subjective quality and patterns of sleep in 64 participants were measured using PSQI-K and Fitbit Charge 3^TM. The properties of the instrument were analyzed using Cronbach's alpha coefficient for the internal consistency reliability, factor analysis for the construct validity, and Spearman's rho correlation coefficient for the correlation between the PSQI-K total scores and Fitbit tracker scores. The Cronbach's alpha coefficient of the PSQI-K was 0.69. The Spearman's rho correlation coefficient between the PSQI-K and Fitbit tracker was higher than 0.67. A cutoff point of ≥6.0 had a sensitivity of 0.93 and a specificity of 0.84. In conclusion, the PSQI-K is a reliable and valid instrument to evaluate sleep disturbance in Korean young adults.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.370-370
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• 2017

최근 기후변화와 이상기후의 영향으로 인하여 홍수재해의 시 공간적 패턴은 보다 복잡해지고, 예측이 어려워지고 있다. 이러한 기상이변에 따른 홍수피해를 예방하기 위한 비구조적 대책으로 홍수위험등급 및 범람범위 등의 정보를 포함하고 있는 홍수위험지도의 작성이 필요하다. 실제로 고정밀도 홍수위험지도를 작성하기 위해서는 지형, 지질, 기상 등의 디지털 정보 및 사회 경제와 관련된 다양한 DB를 필요로 하며, 강우-유출-범람해석 모델링을 통해 범람면적 및 침수깊이 등의 정보를 획득하게 된다. 하지만 일부지역, 특히 개발도상국에서는 이러한 계측 홍수 데이터가 부족하거나 획득할 수가 없어 홍수위험지도 제작이 불가능하거나 그 정확도가 매우 낮은 실정이다. 따라서 본 연구에서는 ASTER 또는 SRTM과 같은 범용 DEM 등 지형자료만을 기반으로 한 선형이진분류법(Liner binary classifiers)과 ROC분석(Receiver Operation Characteristics)을 이용하여 미계측 유역 (DB부재 또는 부족으로 강우-유출-범람해석 모델링이 불가능한 북한지역)의 홍수위험지역을 탐지하고, 적용성을 평가하고자 한다. 5개의 단일 지형학적 지수와 6개의 복합 지형학적 지수를 이용하여 Area Under the Curve (AUC)를 계산하고, Sensitivity (민감도)와 Specificity (특이도)가 가장 높은 지수를 선별하여 홍수위험지도를 작성하고, 실제 홍수범람 영상(2007년 북한 함경남도지역 용흥강 홍수)과 비교 분석하였다. 본 연구에서 제시하는 선형이진분류법과 ROC분석 방법은 홍수범람해석을 위한 다양한 기초정보를 필요로 하지 않고, 지형정보만을 사용하기 때문에 관측 데이터가 없거나 부족한 지역에 대해서 우선적으로 홍수위험지역을 탐지하고, 선별하는데 유용할 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
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• v.43 no.5
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• pp.720-727
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• 1996

Objectives: $^{201}TI$ - chloride, $^{99m}Tc$ - MIBI, $^{99m}Tc$(V) - DMSA SPECT has been used in distinguishing lung cancer from benign lesion. To compare the diagnostic efficacy of SPECT with these tumor - seeking agents, we perfonned three consecutive SPECT using $^{201}TI$, $^{99m}Tc$ - MIBI, $^{99m}Tc$(V) - DMSA in same subjects with a solitary pulmonary lesion. Methods: SPECT was carried out at 10min and 3hr for $^{201}TI$ after injection of 20mCi, and 2hr for $^{99m}Tc$ - MIBI and $^{99m}Tc$(V) - DMSA after injection of 20mCi, respectively, in 37 patients with a solitary pulmonary lesion(27 lung cancer and 10 benign diseases). In patients showing visual uptake on lesion site, we obtained the lesion - to - background(target lesion/contralateral normal lung) uptake ratio from transverse slice for each radionuclide and also calculated the retention index for $^{201}TI$. Results: The diagnostic sensitivity of $^{201}TI$, $^{99m}Tc$ - MIBI and $^{99m}Tc$(V) - DMSA SPECT to lung cancer was 100%, 96% and 73%, and the specificity was 40%, 70% and 70%, respectively. The low specificities for these agents were mainly due to high positive uptake in patients with active pulmonary tuberculosis. There were no significant differences in uptake ratios and retention index between malignant and benign lesions, and among the histologic types of lung cancer. Conclusion : $^{201}TI$ and $^{99m}Tc$ - MIBI showed higher sensitivity than $^{99m}Tc$(V) - DMSA for detecting lung cancer, but was of limited usefulness in distinguishing lung cancer from benign lesion due to low specificity, especially in area with a high prevalence of active pulmonary tuberculosis.

• Journal of Food Hygiene and Safety
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• v.37 no.4
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• pp.216-224
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• 2022

This study was aimed at validating the analysis methods for deacetylasperulosidic acid (DAA), total sugar, galacturonic acid, glucose, and galactose, which are the indicator components of fermented Morinda citrifolia polysaccharide extract (Vitalbos). We modified the previously reported methods for validating the analytical methods. The specificity, linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ) were measured using phenol-sulfuric acid method and high-performance liquid chromatography (HPLC). The retention time and spectrum of the standard solution of Vitalbos coincided, confirming the specificity. The calibration curve correlation coefficient (R²), of five indicator components, ranged from 0.9995-0.9998, indicating excellent linearity of 0.99 or more. The intra-day and inter-day precision range of the assay was 0.14-3.01%, indicating a precision of less than 5%. The recovery rate was in the range of 95.13-105.59%, presenting excellent accuracy. The LOD ranged from 0.39 to 0.84 ㎍/mL and the LOQ ranged from 1.18 to 2.55 ㎍/mL. Therefore, the analytical method was validated for DAA, total sugar, galacturonic acid, glucose, and galactose, in Vitalbos. The indicator component content in Vitalbos was determined using a validated method. The contents of DAA, total sugar, galacturonic acid, glucose, and galactose were 2.31±0.06, 475.92±5.95, 72.83±1.05, 71.63±2.44, and 67.30±2.31 mg/g of dry weight, respectively. These results suggest that the developed analytical method is efficient and could contribute to the quality control of Vitalbos, as a healthy functional food material.

• Journal of the korean academy of Pediatric Dentistry
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• v.45 no.3
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• pp.354-362
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• 2018

Periogen is a new caries activity test using real-time polymerase chain reaction. The aim of this study was to assess the validity of Periogen by evaluating the correlation with dmft, dmfts indices and comparing with Cariview and caries risk assessment tool (CAT). 83 children under 6 participated in this study. Dmft, dmfts indices and CAT were collected through an examination of oral health status. Plaque samples for Periogen and Cariview were collected and manipulated according to the manufactures' instructions. The correlation coefficient of Periogen, Cariview and CAT with the dmfts index were 0.38, 0.56 and 0.66 in each (p < 0.01). The sensitivity of Periogen, Cariview and CAT were 43%, 76% and 95% and specificity were 80%, 72% and 74% respectively. Area under curve under the receiver operating characteristic curves in each method indicated 0.69, 0.81 and 0.85. CAT and Cariview were more effective in evaluation the risk of dental caries than Periogen so far. To be used Periogen clinically, more improvements for higher validity were needed.

• Journal for History of Mathematics
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• v.25 no.4
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• pp.53-67
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• 2012

Today, it is necessary to calculate orbits with high accuracy in space flight. The key words of Poincar$\acute{e}$ in celestial mechanics are periodic solutions, invariant integrals, asymptotic solutions, characteristic exponents and the non existence of new single-valued integrals. Poincar$\acute{e}$ define an invariant integral of the system as the form which maintains a constant value at all time $t$, where the integration is taken over the arc of a curve and $Y_i$ are some functions of $x$, and extend 2 dimension and 3 dimension. Eigenvalues are classified as the form of trajectories, as corresponding to nodes, foci, saddle points and center. In periodic solutions, the stability of periodic solutions is dependent on the properties of their characteristic exponents. Poincar$\acute{e}$ called bifurcation that is the possibility of existence of chaotic orbit in planetary motion. Existence of near exceptional trajectories as Hadamard's accounts, says that there are probabilistic orbits. In this context we study the eigenvalue problem in early 20th century in three body problem by analyzing the works of Darwin, Bruns, Gyld$\acute{e}$n, Sundman, Hill, Lyapunov, Birkhoff, Painlev$\acute{e}$ and Hadamard.