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Woo, Sung-Il
- Korean Journal of Biological Psychiatry
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- v.10 no.2
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- pp.97-106
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- 2003
Criticisms about amyloid cascade hypothesis of Alzheimer's disease(AD) are based on the findings, first, that the degree of dementia does not correlate with the number of plaques, and second, that the neurofibrillary tangle formation seems to predate plaque formation. In addition, neurofibrillary tangle counts correlate well with the degree of cognitive impairment. These findings suggest the independent importance of tau abnormality in AD research which is involved in the neurofibrillary tangle formation. Recently, tau pathology without amyloid deposits and mutations in tau protein gene were reported to be the major pathogenic mechanism in Pick's disease, progressive supranuclear palsy, corticobasal degeneration and FTDP-17(frontotemporal dementia and parkinsonism linked with chromosome 17). These data suggest that understanding the causes and consequences of tau dysfunction might give new clinical and therapeutic solutions to many known tauopathies.
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김기수
- Korean Institute of Interior Design Journal
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- v.13 no.2
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- pp.20-28
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- 2004
This paper aims at researching the characteristics in Bruno Taut of architecture and its influence In Japanese modern architecture. We also can study how to harmonize Japanese traditional architecture with western architecture through activities of Bruno Taut in Japan. Especially, Japanese architectural society had a dispute on their national architectural style in 1910. During the 1930's, however, the rationalist architects denied this 'Jaegwan' style architecture, and insisted a different new Japanese architectural style. Thus Japanese modem architecture adapted two axis of Western and Japan, it had been developed with their conflict and harmony by turns. This activities of Bruno Taut in Japan deeply and freshly influenced on the contemporary Japanese Architectural situation.
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