• The Journal of Pediatrics of Korean Medicine
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• v.20 no.2
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• pp.129-137
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• 2006

목적 : 본 연구를 통하여 아토피 피부염 환아의 한약치료 후 임상 효능, 안전성을 평가하고, 나아가 효능과 안전성을 종합적으로 평가함으로써 아토피 피부염에 대한 한약치료의 유용성을 평가하고자 한다. 방법 : 경희대학교 한의과대학 부속한방병원 한방소아과에 내원한 아토피 피부염 환아 39명의 한약치료 전후의 의무기록을 검토하였다. 아토피피부염 치료에 대한 한약의 효능을 평가하기 위하여 치료 후 아토피 피부염의 개선정도에 대한 부모의 평가를 VAS를 사용하여 분석하였다. 아토피 피부염에 패한 한약치료 후 안정성의 평가를 위하여 치료 전후 혈중 AST, ALT, BUN, creatinine 변화를 검토하여 한약치료의 간신독성 여부에 대해 조사하였고, 보호자에 대한 설문조사를 통하여 한약치료 후 발생한 부작용 및 불편한 증상의 종류 및 정도를 평가하였다. 나아가 한약의 효능 및 안정성을 종합적으로 평가하여 아토피 피부염에 대한 한약 치료의 유용성을 분석하였다. 결과 및 결론 : 환아 39명 중 27명 (69%)의 부모가 한약치료가 아토피 피부염의 개선에 효과가 있다고 보고하였다. 안정성의 평가에 있어서, 39명의 환자에게서 한약 치료 후 간장과 신장에 미치는 독성이 발견되지 않았다. 2명의 환아가 일시적이고 경미한 복부 불쾌감을 호소하였으나, 한약투여와의 관련성은 관찰되지 않았다. 1명의 환아에서 경미한 복통이 발견되었으나, 의학적 치료 없이 증상은 소실되었으며, 치료 과정의 중단 없이 계획되었던 모든 치료 과정을 종료하였다. 치료 후 상기 환아는 아토피 피부염의 증상 개선 뿐 아니라 변비증상의 완화, 만성적 어지러움의 개선 등 제반 신체 조건의 호전을 보고 하였다. 임상적 효능과 안전성을 종합적으로 고려할 때, 환아 39명 중 27명 (69%)의 사례에서 한약치료가 아토피 피부염의 유용한 치료수단으로 평가되었다. 이를 근거로 한약치료가 아토피 피부염에 대하여 안전성을 가진 유용한 치료방법이라 사료되며, 향후 임상적 효능과 안전성을 객관적으로 평가할 수 있는 대규모의 임상연구가 필요하리라 사료된다.

• The Korean Journal of Nuclear Medicine
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• v.34 no.2
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• pp.107-118
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• 2000

Purpose: To evaluate the effectiveness of radioiodine treatment for metastatic thyroid carcinoma, we reviewed results of radioactive iodine treatment in patients with functional lung or bone metastases. Materials and Methods: Of 760 patients who were treated for differentiated thyroid cancer between 1984 and 1998, we detected pulmonary metastases and bone metastases in 76 patients (10.0%) and 20 patients (2.6%), respectively. Among them, we could evaluate the effectiveness of I-131 therapy in 53 patients with lung metastases and 15 patients with bone metastases. Results: Of 53 patients who received I-131 therapy with a mean cumulative dose of 26.2 GBq (1.1-84.4 GBq) for pulmonary metastases, metastatic lung lesions completely resolved in 19 patients (35.8%) and improved in 22 patients (41.5%). In 13 of 19 patients with complete remission of pulmonary metastases, the total accumulated dose of I-131 was less than 18.5 GBq. We found 43 sites of metastatic bone lesions in 15 patients with bone metastases. Of 29 lesions which received I-131 therapy, metastatic lesions improved in 14 sites (48.3%), but did not change or progress in 15 sites (51.7%) despite the I-131 therapy. Three lesions were completely cured with a combination treatment of surgery(${\pm}$ external radiotherapy) and I-131 therapy, and the other 11 lesions improved. Conclusion: Radioactive iodine treatment gives favorable results for pulmonary metastases. However, for bone metastases, there might be a need to use combination therapy including I-131 and surgery or external irradiation.

• Radiation Oncology Journal
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• v.18 no.2
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• pp.127-132
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• 2000

Purpose : To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with metastatic Iymph node in head and neck area can predict radiotherapy outcome. Materials and Methods : In 26 biopsy Proven metastatic Iymph node Patients in head and neck area with accessible by direct inspection and palpation, and of sufficient thickness (>1 cm) to permit accurate needle placement, we measured TIFP at cervical Iymph node before and during radiotherapy. Tumor size was measured clinically and radiologically. Results : The mean preradiotherapy TIFP was 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size (p=0.06). Preradiotherapy TIFP significantly decreased when tumor size decreased (p=0.009). Preradiotherapy TIFP was not different between complete response group and group with partial or less response (p=0.75). Radiotherapy outcome was not different between group with above and group with below than average TIFP (p=0.229). TIFP decreased 36mmHg in complete response group and 29.7 mmHg in group with partial or less response. Conclusion :The mean TIFP was elevated with 24.7 mmHg. Preradiotherapy TIFP had marginally significant relationship with tumor size (p=0.06). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone but there was no statistically significant relationship in two groups.

• Proceedings of the KSLP Conference
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• 1997.11a
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• pp.256-256
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• 1997

조기후두암에서의 치료방법은 방사선치료, 수술적치료등 여러 가지가 있는데 최근들어 사용되고 있는 방법중의 하나가 레이저를 이용하여 병변을 제거하는 방법이다. 서울대학교병원 이비인후과에서 레이저를 이용한 후두미세술을 이용하여 치료한 조기 후두암 환자와 방사선 치료를 이용한 조기후두암환자의 치료 후 성대의 기능을 주관적인 애성의 정도와 Kay voice analysis system을 이용하여 구한 객관적인 척도로 분석하였다. (중략)

• Journal of agricultural medicine and community health
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• v.26 no.2
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• pp.111-132
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• 2001

This study was conducted to examine the therapeutic compliance and its related factors in rural women with osteoporosis. A questionnaire survey was performed from April to May in 2000 for 140 osteoporotic patients who were diagnosed from April to June in 1999 through community health program. The study employed the health belief model for predicting and explaining sick role behavior. The analysis techniques employed included contingency table analysis and path analysis using LISREL. The major results of this study were as follows: Of the subjects, 12.1% were continuously complaint, 53.6% were intermittently compliant, and 34.3% were non- compliant to calcium supplement therapy. As the result of path analysis, the therapeutic compliance was significantly higher(${\mid}T{\mid}$ >2.0) as patients had higher perceived severity of disease, lower perceived barriers of treatment, and when patients thought their disease status as severe. As the patients had higher educational level, more experience of mass media contact or health education about osteoporosis, and when family had more concern for patient treatment, they had higher perceived susceptibility of complication(bone fracture)${\mid}T{\mid}$ >2.0). The patients had higher perceived severity(${\mid}T{\mid}$ >2.0) as they had more educational level, more advice for treatment from their doctors, and when family had more concern for their treatment. As the patients had more advice for treatment from their doctors and when family had more concern for their treatment, they had higher perceived benefit of treatment and lower perceived barriers to treatment(${\mid}T{\mid}$ >2.0). In order to improve the therapeutic compliance in rural osteoporotic women, it would be necessary that the patient should recognize their disease severity properly. And the perceived barriers should be removed through supportive environments for osteoporosis treatment such as doctor 's more advice and family 's more concern for treatment. In addition, effective and continuous management system for osteoporotic patients should be established.

• Therapeutic Science for Rehabilitation
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• v.8 no.2
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• pp.55-66
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• 2019

Objective : The purpose of this study is to confirm whether the effectiveness of the program is sustainable 9 months after project completion for the children and adolescents participating in a childcare and rehabilitation support project. Methods : This study was carried out in three phases: pre-(2016.5~6), post-(2016.10~12) and follow-up evaluation phases (2017.9) of 120 children and adolescents who participated in a treatment and rehabilitation of children project in 2016. The analysis was conducted using a repeated mesures ANOVA to identify changes in problem behaviors. Results : The problem behavior of preschoolers in middle and high schools decreased after the post-evaluation compared to the pre-evaluation, and the effect of treatment was maintained afterward. Elementary school students displayed fewer problem behaviors after the post-evaluation than in the pre-evaluation, and follow-up more. Conclusions : This study confirms that the effects of therapy are maintained for a long period of time. Furthermore, it has been confirmed that therapeutic intervention is effective for children and adolescents in foster care.

• The Journal of Korean Society for Radiation Therapy
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• v.15 no.1
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• pp.61-65
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• 2003

I. Purpose Patient immobilization is essential factor for successful radiation therapy and major problem is reproducibility to maintain patient position during total radiation therapy period. Purpose of this study is evaluation for usefulness of the custom made immobilization device for the anteroperitoneal resection patients with rectal cancer II. Materials and Methods The object of this study were patients who underwent anteroperitoneal resection and undergo radiation therapy at present with rectal cancer. We made immobilization device for patient individually and analyzed its set up reproducibility, patient position deviation and errors. III. Results There was $5mm{\sim}10mm$ deviation in patient position without individual immobilization device, but we improved the deviation within few mm limitation with individual immobilization device. IV. Conclusion Custom made immobilization device was very helpful for anteroperitoneal resection patient with rectal cancer. We improved the patient position deviation within few mm limitation, shorten the set up time and we could give the comfort to patients.

• Parasites, Hosts and Diseases
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• v.27 no.1
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• pp.15-22
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• 1989

To observe antibody changes after praziquantel treatment in paragonimiasis, a total of 46 serum samples from 13 serologically diagnosed patients was collected for 4~28 months. The specific antibody (IgG) levels were measured by enzyme- linked immunosorbent assay (ELISA). All but one patient who needed retreatment became symptom-free within a week. Antibody levels were dropped near to or below a cut-off absorbance (abs.) of 0.25 in varying intervals from 4 to 18 months. Of 9 patients who were retested within 3 months, 5 revealed temporary elevation of antibody level. After the elevation, the levels be낙an to decline slowly to negative ranges. If treated earlier after symptoms developed, the temporary elevation did not occur and intervals to negative conversion were shorter. By sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) /immunoblot, antigen-antibody reactions in individual patient faded gradually without significant changes in reacting antigen bands.

• The Korean Journal of Nuclear Medicine
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• v.28 no.3
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• pp.377-383
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• 1994

Objective : We retrospectively analysed $^{99m}Tc$-MDP bone and $^{67}Ga$ scans to evaluate therapeutic response of bone lymphoma among patients with complete remission. Subjects and Methods : We reviewed 35 cases with an increased uptake finding $^{99m}Tc$-MDP bone scans and 16 $^{67}Ga$ scans that were follow-up studies during and after therapy. The $^{99m}Tc$-MDP bone and $^{67}Ga$ scans were graded visually from 1 to 4 in which grade 3 means same uptake density as that of normal sacroiliac articulation in bone scan and normal liver in $^{67}Ga$ scan, respectively. Results: The improvement findings during and after therapy were found in 66.0% (19/ 29) and 72.7% (24/33) with $^{99m}Tc$-MDP bone scan, 84.6% (l1/13) and 86.7% (13/15) with $^{67}Ga$ scan, respectively. The mean grades of the uptake density in $^{99m}Tc$-MDP bone scan were 3.06 before, 2.34 during, 1.75 after therapy. Those in the $^{67}Ga$ scan were 3.22 before, 1.42 during 1.30 after therapy. Conclusion. $^{67}Ga$ scans appeared more sensitive than bone scans in evaluating therapeutic response of bone lymphoma.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.3
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• pp.264-269
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• 2015

Although sodium hypochlorite is the most frequently used canal irrigant during endodontic treatment, its complications are not as well recognized as its effectiveness. This report demonstrates that sodium hypochlorite extrusion during endodontic treatment can cause severe complications. A 5-year-old boy experienced immediate pain and swelling, ecchymosis in surrounding tissues, and profuse bleeding from the root canal during endodontic treatment, because of accidental extrusion of sodium hypochlorite. The patient was hospitalized, and analgesics and antibiotics were prescribed. Accidental extrusion of the irrigating solution occurs more frequently in teeth with immature apices, root resorption, and apical perforations; therefore, caution is needed. When such complications occur, proper management and medications are needed.