• Journal of Life Science
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• v.29 no.9
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• pp.1002-1009
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• 2019

Early life stress (ELS) increases the risk of depression. ELS may be involved in the susceptibility to subsequent stress exposure during adulthood. We investigated whether epigenetic mechanisms of p11 promoter affect the vulnerability to chronic unpredictable stress (CUS) induced by the maternal separation (MS). Mice pups were separated from their dams (3 hr/day from P1-P21). When the pups reached adulthood, we applied CUS (daily for 3 weeks). The levels of hippocampal p11 expression were analyzed by quantitative real-time PCR. The levels of acetylated and methylated histone H3 at p11 promoter were measured by chromatin immunoprecipitation. Depression-like behavior was measured by the forced swimming test (FST). The MS and CUS group exhibited significant decreases in p11 mRNA level and the MS plus CUS group had a greater reduction in this level than the CUS group. The MS plus CUS group also resulted in greater reduction in H3 acetylation than the CUS group. This reduction was associated with an upregulation of histone deacetylase 5. Additionally, the MS plus CUS group showed a greater decrease in H3K4met3 level and a greater increase in H3K27 met3 level than the CUS group. Consistent with the reduction of p11 expression, the MS plus CUS group displayed longer immobility times in the FST compared to the control group. Mice exposed to MS followed by CUS had much greater epigenetic alterations in the hippocampus compared to adult mice that only experienced CUS. ELS can exacerbate the effect of stress exposure during adulthood through histone modification of p11 gene.

• Tuberculosis and Respiratory Diseases
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• v.66 no.5
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• pp.358-364
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• 2009

Background: The appropriate empirical antimicrobial choice in the treatment of community-acquired pneumonia (CAP) should be advocated by community-based information on the etiologic pathogens, their susceptibility to antimicrobials, clinical characteristics and outcomes. Jeju is a geographically isolated and identical region in Korea. However, there is no regional reference on adult CAP available. This study investigated the etiologic agents and clinical outcomes of adult patients diagnosed with CAP in Jeju, Korea, to help guide the empirical antimicrobial choice. Methods: A prospective observational study for one year in a referral hospital in Jeju, Korea. Patients diagnosed with CAP were enrolled with their clinical characteristics. Microbiological evaluations to identify the etiologic agents in the adult patients with CAP were performed with blood culture, expectorated sputum smear and culture, antibody tests for mycoplasma, chlamydophila, and antigen tests for legionella and pneumococcus. The clinical outcomes of the initial empirical treatment were analyzed. Results: Two hundred and three patients with mean age of 64 and 79 females were enrolled. Ten microbials from 90 cases (44.3%) were isolated and multiple isolates were confirmed in 30. Among the microbial isolates, S. pneumoniae (36.3%) was the most common, followed by M. pneumoniae (23.0%), C. pneumoniae (17.0%), S. aureus (9.6%) and P. aeruginosa (5.9%). The initial treatment failure (23.8%) was related to the isolation of polymicrobial pathogens, elevated inflammatory markers, and the presence of pleural effusion. Among the 30 isolates of S. pneumoniae, 16 (53.3%) were not susceptible to penicillin, and 19 isolates (63.3%) to erythromycin and clarithromycin. However, 29 isolates (96.7%) were susceptible to levofloxacin and ceftriaxone. Conclusion: S. pneumoniae, M. pneumoniae, S. aureus, and P. aeruginosa are frequent etiologic agents of adult CAP in Jeju, Korea. The clinical characteristics and antibiotic resistance should be considered when determining the initial empirical antimicrobial choice. Respiratory quinolone or ceftriaxone is recommended as an empirical antimicrobiotic in the treatment of adult CAP in Jeju, Korea.

• Korean Journal of Psychosomatic Medicine
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• v.31 no.1
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• pp.25-32
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• 2023

Objectives : This study investigated the level of sexuality knowledge and gender sensitivity and factors influencing on them among Korean high school and college students. Methods : 129 questionnaires from high school and college students with consent forms, collected from July to December of 2022, were analyzed. After identification of participants' gender, age, major, their report of the practicality of sex education, and their experience of violence or sexual assaults, participants' level of sexuality knowledge and gender sensitivity were compared. Results : Females showed higher gender sensitivity, regardless of age and group (p=0.004). The early adulthood group (≥19 years old) showed higher sexuality knowledge and gender sensitivity, compared to those adolescents (<19 years old). Among college students, those who majored in health science were identified with higher sexuality knowledge and gender sensitivity, compared to non-health science major students(p<0.001; p=0.005). Conclusions : This study revealed the significant differences in sexuality knowledge and gender sensitivity according to sex, age, and majors in adolescents and early adults. Therefore, it seems to be necessary to consider the differences in sexuality knowledge and gender sensitivity among age, sex, and majors when establishing public policy or legislation for sex crimes, including digital sex crimes.

• The Journal of the Korea Contents Association
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• v.20 no.8
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• pp.75-87
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• 2020

The purpose of this study is to examine teachers' stages of concern and levels of use about SW education based on Concerns-Based Adoption Model and to provide implications for teacher education. For this purpose, 152 survey responses were collected from elementary school teachers in South Korea. The result indicated that elementary school teachers' concerns about SW education showed the nonuser pattern in that teachers score highest in stage 0(awareness) to stage 2(personal) and in stage 6(refocusing). Additionally, teachers who are currently implementing SW education showed a tendency to be in the level of mechanical use or routine, and more than half of the teachers who are not implementing SW education showed no motivation to change current practices. There were statistically significant differences in the stages of concern depending on gender, teaching experience, SW training experience, SW teaching experience, and there were differences in the levels of use depending on the teachers' grade level in charge, SW training experience, and SW teaching experience. Based on the results of the research, various SW related programs as well as successful SW education experience for teachers need to be provided for teacher education in order to promote SW education.

• Journal of dental hygiene science
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• v.4 no.1
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• pp.39-44
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• 2004

The primary purpose of this report is to investigate the index of dental caries experiences and the state of oral hygiene for the children with mental retardation, cerebral palsy, and autism. In order to get those things we investigated 99 students that ages from 8 to 13 in three special schools (which are the school for the children with mental retardation, physical difficulties, emotional disturbance). Then collected the statistics and examined if there were some regardful differences among each type. (1) The investigation shows that there is no regardful differences among them in statistice. However, the averages of their dental caries experience have a little gap. The average of the children with mental retardation group is the highest and the autistic children group is the lowest, as we can see the facts of 4.70 for group of children with mental retardation, 4.58 for group of children with cerebral palsy, 3.67 for group of autistic children, children with mental retardation group is severe, autistic children group is few. (2) The conclusion from research of oral hygiene among each type, statistically regardful differences were revealed (p<0.05). It shows children with cerebral palsy is on worst state, children with mental retardation is on next state, autistic children is on best state by compare for averages among each type, 32.30 for group of children with mental retardation 35.00 for group of children with cerebral palsy, 27.79 for autistic children.

• Korean Journal of Family Social Work
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• no.43
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• pp.87-110
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• 2014

This study is to understand the psychosocial experience in 'Cheonan Warship Incident Survivors'. The study question was how psychosocial experience in The Union of Family Bereaved by Cheonan Warship had been progressed. To answer this question 4 representers ofthe group and 2 reporters had been interviewed using a qualitative research method based on Phenomenology method. From this study the group's experience in had been revealed that they first crisis intervention are to identify and reinforce the strengths and coping skills of a one's family. Second, they gathered their opinion together and assigned the roles to the members, and then, requested what they want responding reasonably. The families' love, the representers' quick judgements and decisions, and the embarrassment of the military and media for the dead, who had been abandoned for long and decayed under the cold ocean, made the national support and respectful treatment possible for the dead and the family. The results of study will be applicable for individuals and groups, who need social work service as an empowerment intervention approach and crisis intervention are to identify and reinforce the strengths and coping skills of a one's family. The social worker's ability to anticipate, understand, and give therapeutic direction to the crisis reaction and the concerns of family members helps to bring around a successful crisis resolution. It is clear to us that wars, suicides, homicides in school settings, disaster and other events are providing unique challenges to social workers who are interested in learning more about the effects such events have on victims of traumatic events.

• The Journal of the Korea Contents Association
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• v.22 no.8
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• pp.527-541
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• 2022

The purpose of this study is to explore the economic hardship experiences of low-income single-parent families by COVID-19 to find ways to improve after COVID-19. To this end, 10 single parents with children under the secondary school age were recruited through snowball sampling method and in-depth interviews with economic activities, income, expenditure, and economic life. As a result of the study, participants suffered from unemployment and the disappearance of extra income activities in the early stages of COVID-19, additional expenses incurred by children's food and increased utility bills. In addition, it was recognized that COVID-19 has come to be more difficult and unequal to single-parent families of low-income women. It was found that the temporary living difficulties were resolved with disaster support funds, and it was helpful in the short term by spending according to priorities such as overdue monthly rent, food expenses, children's academy expenses, and purchasing home appliances. However, it was recognized that disaster support funds were inappropriate for customized disaster support and long-term and selective support was necessary. In the conclusion, to improve economic problems after COVID-19, it proposed measures to improve social welfare policies and practices

• Journal of Internet Computing and Services
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• v.25 no.4
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• pp.109-119
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• 2024

This study aims to contribute to the initial research on on-device AI in an environment where generative AI-based services on mobile and other on-device platforms are increasing. To derive success strategies for generative AI-based chatbot services in a mobile environment, over 200,000 actual user experience review data collected from the Google Play Store were analyzed using the LDA topic modeling technique. Interpreting the derived topics based on the Information System Success Model (ISSM), the topics such as tutoring, limitation of response, and hallucination and outdated informaiton were linked to information quality; multimodal service, quality of response, and issues of device interoperability were linked to system quality; inter-device compatibility, utility of the service, quality of premium services, and challenges in account were linked to service quality; and finally, creative collaboration was linked to net benefits. Humanization of generative AI emerged as a new experience factor not explained by the existing model. By explaining specific positive and negative experience dimensions from the user's perspective based on theory, this study suggests directions for future related research and provides strategic insights for companies to improve and supplement their services for successful business operations.

• Journal of Music and Human Behavior
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• v.13 no.2
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• pp.49-66
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• 2016

This study investigated the song-induced autobiographical memory of patients with early Alzheimer's Dementia (AD) by comparing the effects of patient-selected songs (M-AD) versus music therapist-selected songs (M-MT). A total of 19 patients with early AD participated in this study. In the M-AD and M-MT conditions, each participant listened to a song and was instructed to recall memory. The time to recall memory, the specificity of the memory, mood changes, and the type of recalled memory were measured. Perceived familiarity and preference of the used songs and association of the song with the recalled memory were also analyzed. The results of the study showed that the M-AD condition elicited more specific memory and positive mood change than the M-MT condition. In addition, AD patients reported a higher level of familiarity with and preference of songs in the M-AD condition, compared to the M-MT condition. These results indicate that patient-selected songs, which have a personal meaning to an individual, could be effectively used for intervening with memory of this population, which would support music therapists to make better decision with regard to song selection. Further studies would be needed to deepen the understanding of autobiographical memory in older population with cognitive impairment and to propose more effective music therapy strategies for intervening with memory.

• Journal of the Korean Society of Child Welfare
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• no.59
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• pp.183-208
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• 2017

The purpose of this study was to identify groups depending on the change trajectory of child maltreatment in childhood and early adolescence. For this study, the data from waves two through six (2011-2015) of the Korean Children and Youth Panel Survey (KCYPS) were used. Participants included first-grade (n=2,300) and fourth-grade (n=2,325) elementary school students. A latent class growth model (LCGM) using Mplus 7.21 was adopted to classify the types of developmental trajectories of child maltreatment. The main results were as follows: First, in physical abuse, childhood from the second to the sixth grades was classified into four groups: decreased, low maintenance, increased, and no maltreatment type. In addition, early adolescence from the fifth grade of elementary school to the third grade of middle school was also classified into the same types. Second, in emotional abuse, childhood was classified into three groups: decreased, increased, and no maltreatment type. Early adolescence was classified into four groups: decreased, low maintenance, increased, and no maltreatment type. Third, in neglect, childhood was classified into four groups: maintenance, low decreasing, low increasing, and no maltreatment type. Early adolescence was classified into three groups: maintenance, low increasing, and no maltreatment type. According to the change of child maltreatment by developmental period, physical abuse continued from childhood to early adolescence, whereas emotional abuse and neglect increased in early adolescence compared to childhood. This study is meaningful in classifying latent classes depending on maltreatment types. Theoretical and practical implications were suggested based on the study results.