• Herbal Formula Science
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• v.25 no.2
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• pp.193-207
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• 2017

Objectives : This study was designed to investigate anti-obesity effects of DF in a ob/ob mouse model. Methods : Fifteen-week-old ob/ob mice were divided into four groups: a normal lean group given a standard diet, an ob/ob control group given a standard diet, and DF(1) and DF(2) groups given a standard diet with DF(1) (300 mg/kg), and DF(2) (600 mg/kg), respectively. After 10 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : Body weight gain and fat mass were significantly decreased in DF(1) and DF(2) groups compared with control. The extent of decreases was eminent in DF(2) group. Feeding efficiency ratio were significantly decreased in DF(2) group compared with control. Consistent with their effects on body weight gain and fat mass, circulating concentrations of LDL, total cholesterol, free fatty acid, and insulin were decreased in DF(2) group compared with control. The size of adipocytes were significantly decreased by DF(2) compared with control. Consistent with their effects on body weight gain, hepatic lipid accumulation and liver weights were reduced in DF compared with control. Conclusions : In conclusion, these results suggest that DF not only decrease feeding efficiency ratio, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF also inhibits hepatic lipid accumulation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.346-356
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• 2018

Overweight and abdominal obesity caused by sedentary lifestyle may induce deconditioned and atrophied extensor musculature of the lumbar spine and be a potential risk factor for low back pain (LBP). Therefore, this study was conducted to evaluate the validity of high intensity circuit training (HICT) on weight loss and subsequent alleviation of spine curvature (SC) and visual analog scale (VAS) among middle aged men with abdominal obesity. The training program (1 exercise session for 30 minutes, three times a week for 12 weeks) consisted of 12 different functional exercises based on core strengthening multiple joint circuit training. Portions of the obesity index related to body composition were positively changed, which improved the angles of thoracic kyposis and lumbar lordosis, which appeared to effectively reduce lower back pain. Taken together, HICT specifically designed for LBP effectively decreased obesity related body composition and was superior to other treatments for decreasing aggravation of the spine curvature and LBP caused by abdominal obesity; however, weight loss should be the primary treatment target for LBP patients.

• The Journal of Korean Medicine
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• v.41 no.2
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• pp.58-79
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• 2020

Objectives: The purpose of this study is to predict the weight loss by applying machine learning using real-world clinical data from overweight and obese adults on weight loss program in 4 Korean Medicine obesity clinics. Methods: From January, 2017 to May, 2019, we collected data from overweight and obese adults (BMI≥23 kg/m2) who registered for a 3-month Gamitaeeumjowi-tang prescription program. Predictive analysis was conducted at the time of three prescriptions, and the expected reduced rate and reduced weight at the next order of prescription were predicted as binary classification (classification benchmark: highest quartile, median, lowest quartile). For the median, further analysis was conducted after using the variable selection method. The data set for each analysis was 25,988 in the first, 6,304 in the second, and 833 in the third. 5-fold cross validation was used to prevent overfitting. Results: Prediction accuracy was increased from 1^st to 2^nd and 3^rd analysis. After selecting the variables based on the median, artificial neural network showed the highest accuracy in 1^st (54.69%), 2^nd (73.52%), and 3^rd (81.88%) prediction analysis based on reduced rate. The prediction performance was additionally confirmed through AUC, Random Forest showed the highest in 1^st (0.640), 2^nd (0.816), and 3^rd (0.939) prediction analysis based on reduced weight. Conclusions: The prediction of weight loss by applying machine learning showed that the accuracy was improved by using the initial weight loss information. There is a possibility that it can be used to screen patients who need intensive intervention when expected weight loss is low.

• Journal of Nutrition and Health
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• v.44 no.4
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• pp.292-302
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• 2011

Adipocytokines (adiponectin, leptin and resistin) are known to play a major role in development of cardiovascular disease (CVD) and intervention program is effective in reducing CVD risk factors. However, intervention program to improve the CVD risk factors including adipocytokines has been less studied. This study investigated the effects of 12-weeks worksite intervention program on cardiovascular risk factors, adipocytokines and nutrients intakes in industrial workers. 157 industrial male workers (32 metabolic syndrome (MS) subjects, 125 healthy subjects using age-matched stratified random sampling) received 5 face-to-face counseling based on their health profiles. Anthropometry, biochemical parameters and nutrients intakes were measured. The diagnosis of MS was adapted from modified NCEP-ATP III criteria (2001) and Asia-Pacific definition criteria (2000) for waist circumference (WC). After the intervention program, WC, BMI, SBP, insulin, leptin and intakes of total energy and fiber were significantly decreased (p < 0.05), while adiponectin was significantly increased (p < 0.05) in MS subjects. The WC, BMI, SBP, total cholesterol, LDL and HDL-cholesterol, HbA1c, leptin and intakes of total energy, protein and fat were significantly decreased (p < 0.05) and adiponectin was significantly increased (p < 0.05) in normal subjects. Multiple linear regression revealed that adiponectin was positively correlated with HDL-cholesterol (p < 0.01). Leptin was positively correlated with WC (p < 0.01), and resistin was positively correlated with HbA1c (p < 0.05) and intakes of total energy (p < 0.05), and negatively correlated with HDL-cholesterol (p < 0.05). The results of the 12 weeks intervention showed a positive impact on adipocytokines and nutrients intakes of industrial workers to reduce cardiovascular risk factors. Further research is needed to verify a tailored long-term worksite intervention program including adipocytokines as a protective factor for the CVD.

• Journal of Nutrition and Health
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• v.38 no.9
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• pp.739-749
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• 2005

This study was performed to investigate the effects of very low calorie diet (VLCD) using newly meal replacements that contain the wild grass extracts based on Samul-tang ingredients on weight reduction and health in the obese adult women ($BMI{\geq}25\;kg/^2$) for four weeks. Seventy five women participated in this experiment. Subjects were randomly classified three groups: 1) General Diet group (GD group, n=25) consumed 3 regular meals within 600 kcal/day, 2) Meal replacements group (MR group, n=25) consumed 1 regular meal and 2 meal replacements within 600 kcal/day, 3) Herbal Meal replacements group (HMR group, n=25) consumed 1 regular meal and 2 meal replacements within 600 kcal/day. Anthropometric measurements, body composition, biochemical measurements and body symptoms were assessed before (the initial) and after (the 4th week) the study. Anthropometry measurements such as weight, waist and hip circumference, and BMI and body composition such as body fat percent, fat mass significantly decreased in all groups after diet intervention. Anthropometric measurements and body composition of the ]lim group significantly decreased more than those of GD and MR groups. Serum Total cholesterol was significantly decreased in all groups. However, there was no significant difference among three groups during the experimental period. HMR group had significantly less felt a pain than GD and MR groups in body symptoms such as anemia, powerlessness, vomiting, constipation and dryness of skin during the experimental period. Therefore, very low calorie diet (VLCD) using meal replacements that contain the wild grass extracts based on Samul-tang ingredients was very effective on weight reduction and health in the obese adult women.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.sup1
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• pp.102-108
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• 2008

More children today are overweight or obese than ever before. childhood obesity results from an imbalance between the amount of energy consumed and the amount of energy expended. Whether child want to lose weight or maintain a healthy weight, it's important to balance between the calories body takes in and uses. Obesity treatment programs for children and adolescents is to slow or halt weight gain so the child will grow into his or her body weight over a period of months to years. Fasting or extreme caloric restriction is not advisable for children. More physical activity is a key element in the prevention and treatment of obesity. Children can't change their exercise and eating habits by themselves. They need the help and support of their families and parents. Children and adolescents who are just beginning to be physically active should start out slowly and gradually build to higher levels in order to prevent the risk of injury or feel defeated from unrealistic goals. It is important that children and adolescents are encouraged to be physically active by doing things that interest them. FUN physical activities that kids choose to do on their own are often best. Kids need about 60 minutes of physical activity a day, but this does not have to happen all at once. Several short 10- or even 5-minute periods of activity throughout the day are just as good. FUN physical activities will help them establish an active lifestyle early on. Obese people need care not for a short period, but throughout their lives.

• Korean Journal of Human Ecology
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• v.11 no.3
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• pp.273-285
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• 2002

Three materials for sport underwear were manufactured by order for study, and among them, suitable material in order to perform an experiment on the effect of wearing was adopted. The results are as follows: The result of wearing an experimental clothes for sports manufactured as a foundation-type underwear for sports showed that if the same compositional materials were applied, laminating material had higher rate than that of others in the amount of sweat. Concerning relative humidity in clothes and the amount of sweat absorbed in clothes among the two kinds of materials which were produced by laminate, material 2(nylon+modal) was statistically exerts higher influence on the amount of sweat. The humidity in clothes keeps the optimal condition of 59.8%, and breast part showed the highest relative humidity. The material 2(nylon+modal) showed the highest comfortableness, the sense of warmth, humidity and voluminousness, and the sense of pressure. Follow-up survey revealed that in case of material 2, higher amount of sweat than that of the group objects in its early phase, and the amount of sweat varies from individuals. The temperature in clothes of folded parts of experimental clothes and maximum surface temperature was equivalent to that of average skin. With the lapse of time, the weight decreased of 11.03% in maximum, and 3.12% in minimum. The amount of change in the girth was greater in part of body frame than that of limbs, and especially, navel and waist part showed high decrease, and upper breast, breast and the largest part of abdomen showed relatively low decrease. The above experiment revealed that materials for suitable to the underwear for sports for loss of weight by an exercise should be made of doubled-nylon and modal, along with the laminate processing, which heightens the amount of sweat. Thus, wearing an experimental wear gave satisfaction in the view of the beauty of appearance as it did not discharge flowing secretion to the outside at the time of exercise.

• Korean Journal of Poultry Science
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• v.47 no.1
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• pp.1-7
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• 2020

The effect of stocking density on the growth and meat quality of native Korean chickens was investigated. A total of 364 one-day-old native Korean chickens were randomly assigned to one of 5 treatments, each of which was replicated 4 times. Five distinct stocking densities-14, 15, 16, 18, and 22 birds/㎡-were compared. The diet was fed ad libitum for 10 weeks. Results indicated that the final body weight, body weight gain, and feed intake were lower (P<0.05) for the 22 birds/㎡ stock density as compared to the other stock densities. There was no significant difference in the feed conversion ratio, proximate analysis (DM, crude protein, crude fat, and crude ash), water-holding capacity, and cooking loss among the different stock densities. These results indicate that increasing the stock density to 22 birds/㎡ elicits some negative effects on the growth performance and meat quality of Korean-native chickens.

• Korean Journal of Community Nutrition
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• v.24 no.6
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• pp.485-496
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• 2019

Objectives: This study was conducted to investigate the effect of a 6-week low-calorie diet (LCD) program including high protein-low carbohydrate protein bar on weight loss, blood pressure, and blood lipid profile in 40 overweight women according to dietary compliance. Methods: Subjects were 62 healthy overweight women (BMI ≥ 23.0 or body fat percentage ≥ 28%), aged 20~59 yrs who were provided a high protein-low carbohydrate protein bar (each 35 g, 154 kcal, protein energy %: 28.6%, carbohydrate energy %: 38.7%) as part of dinner for 6 weeks. Forty subjects who completed the whole diet program were categorized into high compliance (HC) group (days of eating protein bar ≥ 5 weeks) or low compliance (LC) group (days < 5 weeks). Results: Energy intake significantly decreased from 1,867.5 kcal at baseline to 1,137.4 kcal at 6 weeks for the HC group and from 1,971.7 kcal to 1,362.2 kcal for the LC group, respectively. On the other hand, a significant increase in protein energy percentage was observed in each group (HC group: 3.5%, LC group: 2.2%). Both groups showed significant decreases in weight (HC group: 1.8 kg, LC group: 1.1 kg), BMI, fat mass, systolic blood pressure, total cholesterol, and LDL-cholesterol. Reduction of body fat percentage and diastolic blood pressure were only observed in the HC group. Conclusions: The inclusion of a high protein-low carbohydrate protein bar as part of a low-calorie diet for a short period can be effective to achieve weight loss and concomitantly improve blood cholesterol level without serious physiological side effects. More evident results can be achieved by eating a diet with low calorie diet including high protein-low carbohydrate protein bar for more than 5 weeks.

• Journal of Korean Medicine for Obesity Research
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• v.20 no.1
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• pp.20-30
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• 2020

Objectives: The purpose of this study is to verify the effects of H Gambitang (GB-001) on body composition and basal metabolic rate in pre- and post-menopausal obese woman retrospectively. Methods: The study was conducted on 57 middle-aged obese women. They were divided into two groups; pre-menopausal obesity group (Pr-MOG; n=34) and post-menopausal obesity group (Po-MOG; amenorrhea was continued to 14~48 month, n=23) with no significant difference of age, height, body weight and body mass index. All subjects took herbal medicine 3 times a day, for 6 weeks during treatment period. The weight, height, body fat mass, skeletal muscle mass, and basal metabolic rate of all subjects were measured on first visit. The following measurements were repeated after 2 weeks (2nd), 4 weeks (3rd) and 6 weeks (4th) with Inbody 370 (Biospace) equipment to identify changes of body fat mass, skeletal muscle mass, and basal metabolic rate. Results are represented as mean and standard deviation. Results: Po-MOG showed significantly lower decrease rate in weight reduction on 2~6 weeks while significantly higher decrease rate in skeletal muscle reduction on 4~6 weeks. There were no significant differences between two groups in body fat reduction rate and basal metabolic increasing rate. Conclusions: H Gambitang (GB-001) can be used not only in Pr-MOG but in Po-MOG in weight loss although the effect can be lower in Po-MOG. To prevent skeletal muscle mass loss in Po-MOG, following study on adjusting dose and components of H Gambitang (GB-001) thought to be necessary.