• Korean Journal of Clinical Pharmacy
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• v.17 no.1
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• pp.13-18
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• 2007

The purpose of the present study was to investigate the effect of cimetidine on theophylline pharmacokinetics in Korean healthy normal subjects. Eight subjects were enrolled and open label, two period cross-over study was conducted without significant drug related adverse reactions. Cimetidine seemed that significantly inhibited the metabolism of theophylline, oral clearance decreased significantly when cimetidine was coadministered. Coadministered cimetidine increased $AUC_t$ and $C_{max}$ of theophylline. All subjects were genotyped using PCR-RFLP methods to evaluate the differences in metabolic capacity in accordance with CYP1A2 genotypes, but no mutant genotype was found. This suggests that metabolic capacities were not significantly affected by CYP1A2 genotypes among subjects. In conclusion, disposition of theophylline was significantly affected by coadministered cimetidine. Further evaluation with well-designed drug interaction study in accordance with various genotype of CYP1A2 is needed.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.9
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• pp.794-806
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• 2017

It is essential to protect the national space assets and space environment safely as a space development country from the continuously increasing space debris. And Active Debris Removal(ADR) is the most active way to solve this problem. In this paper, we studied the Artificial Neural Network(ANN) for a stable recognition model of vision-based space debris tracking system. We obtained the simulated image of the space environment by the KARICAT which is the ground-based space debris clearing satellite testbed developed by the Korea Aerospace Research Institute, and created the vector which encodes structure and color-based features of each object after image segmentation by depth discontinuity. The Feature Vector consists of 3D surface area, principle vector of point cloud, 2D shape and color information. We designed artificial neural network model based on the separated Feature Vector. In order to improve the performance of the artificial neural network, the model is divided according to the categories of the input feature vectors, and the ensemble technique is applied to each model. As a result, we confirmed the performance improvement of recognition model by ensemble technique.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.1D
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• pp.149-155
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• 2011

The aim of this study is to grasp how the dwellers of apartment cognize the real condition of the management such as general control of janitor office or management of maintenance, environment, account and imposing price of management. The analysed results of recognition are as following. First, as the dwellers judged that the janitors are incapable to control dispute among the households, it needs to develop the ability to cope with the demand of control dispute by various curriculum. There should be more strict management of parking lot for the handicapped. Second, it needs to establish the plan to improve maintenance of the rest facility. Third, as dwellers thought the management expenses not to be made public clearly, it needs to use various way, not only by neighborhood meeting but also information system such as establishing web page or E-mail notice for better announcement of the settled matters such as management expenses. Forth, the audit result of management expenses and the measures conducted after audit should be reported widely, contract of construction work services needs to be publicized by neighborhood meeting or other information system.

• Childhood Kidney Diseases
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• v.3 no.1
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• pp.42-47
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• 1999

Angiotensin-converting enzyme inhibitors lower urinary protein excretion in hypertensive and normotensive patients with renal disease. Most children with nephrotic syndrome have minimal change histology and the great majority of these patients respond to the treatment with oral prednisone. Here we have studied the effects of combination of Inhibace and oral prednisone in pediatric patients with nephrotic syndrome. 45 patients with nephrotic syndrome were selected. Of these, 29 patients were treated with prednisone(2mg/kg/day) and 16 children were treated with prednisone and Inhibace(2.5mg/day). Urinary protein, blood pressure, creatinine clearance, serum creatinine, serum albumin and serum cholesterol were measured in both control and Inhibace group. Also the duration to remission after treatment was compared in both groups. The amounts of proteinuria before and after treatment were not significantly different in both group. The duration to remission of proteinuria was significantly shorter in Inhibace group compared to that in control group. The changes of blood pressure and creatinine clearance were not significant in Inhibace group. In conclusion, the combination therapy of oral prednisone and ACE inhibitor have shortened the duration to remission of proteinuria in nephrotic syndrome of children.

• The Journal of the Korea Contents Association
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• v.10 no.3
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• pp.454-462
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• 2010

The current curriculum in the 7th informatics, which simply highlights the use of applied programs rather than enhancing creativity through learning several principles in information science and thus making it hard to have optimism on the future as a powerhouse in IT. By diagnosing these problems, Education Ministry revised the existing curriculum to have a more scientific access to the informatics. However, the curricular revision fails to meet the needs of learners sufficiently because it tends to put the considerations of theoretical specialists before the learners them selves. This paper compares and analyzes the overall understanding of learners on informatics, current-curriculum and 7th revised curriculum and that of college-level, thus offering the student-centered one. Also, the research tries to bridge the opinion gap between developer and learner by looking into the understanding level of university majors about the current curriculum. In doing so, thesis may provide the basis on exploring new approaches and contribute to establishing 7th revised curriculum in school.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.173-179
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• 2020

The purpose of this study was to examine whether chicken-rearing activity is effective on the character, emotion and self-esteem of middle school students, as a pilot study for the development of an animal-assisted education program based on chicken-rearing activity. School was selected as the place where students have experience with raising animals before and no poultry farms were located near the school. The experimental group consisted of 11 students as the chicken-rearing group. The conducted activities were greeting chickens, cleaning henhouse, feeding them, and picking eggs up for five months. Character, emotion and self-esteem scales were used as test tools, and pre-testing and post-testing were conducted to verify the effectiveness of the study. Data collected were analyzed by using SPSS Win 25.0 statistical program. As a result, the character, emotional stability and self-esteem of middle school students who participated in chicken-rearing activity were improved. This study is meaningful in that the chicken-rearing activity proved to be effective for the character, emotion and self-esteem of middle school students and prepared an experimental case study for developing an animal-assisted education program based on chicken-rearing activity. It is expected to be useful as basic data of animal-assisted education for adolescents in school.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.4
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• pp.218-225
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• 2020

This study analyzed the priorities of the cross-compliance items of public-benefit direct payment using an Analytic Hierarchy Process and Fuzzy Decision Making Analysis. The valuation criteria are policy efficiency, farm acceptability, and feasibility, and the valuation targets are the basic and additional cross-compliance items. The survey was performed by targeting 50 experts from each class, and conducted for about a month starting from the beginning of July 2019. The results show that the weight of the valuation criteria is higher in the order of farm acceptability, feasibility, and policy efficiency. Compliance with PLS standards, compliance with disposal standards of waste vinyl and pesticides, soil testing, compliance with toxic substance standards, education, etc. are comparatively evaluated to be higher cross-compliance items in basic cross-compliance. Disposing of an abandoned well, jointly collecting and disposing of agricultural by-products, common area care and cleaning, maintenance of empty houses and poor facilities, growing green manure crops during the fallow period, etc. are comparatively evaluated to be higher cross-compliance items for the additional cross-compliance. The results of this study are expected to contribute to the government's policy related to the cross-compliance of public-benefit direct payment.

• Journal of the Korea institute for structural maintenance and inspection
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• v.24 no.2
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• pp.9-14
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• 2020

Four developed patents have applied for a new type of Composite Cyclone Scrubber followed by the previous research (Cho and Kim, 2017), including dust reducing fan with filters. Regarding target installation and maintenance cost, 64% reduction for investment costs (6.2 billion won vs. 17 billion won) compared to existing road pollution reduction system, while social benefit costs increase by 43% compared to existing road pollution reduction measures (72.6 billion won vs. 50.8 billion won). The composition of the device is an air blower type spiral guide vane, and an injection pressure collecting dust efficiency. A nozzle varies Injection angle and contact range, spray liquid species (waterworks, salty water). The proposed patent tests are circulation water Time-by-Time Spray and collected 41.4% more increased micro dust since the sprayed water meets contaminated gas due to the 45° degree colliding, which is 141% increased conventional dust collector. (Ratio of collection over 85%). As regards the source of collection liquid, circulated rainwater and well water, we expect a huge amount of energy and economically saved eco-friendly system in our patent. Finally, the guided vane and metal filter reduced over 90% micro-dust, while sprayed water cleans the vane and filters, resultantly minimizing the maintenance budget. The preliminary evaluations of the developed design make it possible to reduce not only cheaper maintenance budget due to the characteristic water spraying but the cost of water comes from mainly rain and underground.

• Journal of the Korea Organic Resources Recycling Association
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• v.20 no.4
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• pp.97-105
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• 2012

This study examined for possibility of the food wastewater incineration treatment method as one of overland treatment method by incineration through liquefied spray of food wastewater when incinerating domestic wastes under operation and for the relationship, etc of air discharge material discharged in incineration, and the results of study are as follow: The food wastewater as one of overland treatment method was analysed 94-96% of moisture contents. Temperature of incinerator outduct during mixed incineration of food wastewater with MSW was average $897^{\circ}C$ and incineration of only MSW was $925^{\circ}C$. Temperature of the mixed incineration of food wastewater was dropped about $28^{\circ}C$ by incineration of only MSW. Concentration of nitrogen oxides(NOx) among air discharge gases was studied by 50ppm, 46ppm when inputting $200{\ell}/hr$, $300{\ell}/hr$ into the incinerator as the quantity of food wastewater. In the mixed incineration of food wastewater, generation speed of scales in the inside of a tubular exhaust gas boiler became rapid and the scale generation quantity became large but the exhaust gas boiler normally operated since scales were removed in cleaning of the tube with a compressive air cleaning facility and there was no opening clogging phenomena in a filter cloth of the filtering dust collector. The overland treatment method, not ocean dumping of food wastewater can be proposed as a technology since mixed incineration of food wastewater with MSW in the existing domestic waste incineration plant is possible, and operation costs of the incineration facility were reduced since use of chemicals such as ammonia and urinary hydrogen ion excretion, etc used in incineration facilities for removing nitrogen oxides(NOx).

• Journal of Veterinary Clinics
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• v.23 no.2
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• pp.87-90
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• 2006

The aim of the present study was to investigate the disposition pharmacokinetics of roxithromycin in broilers. Roxithromycin was administered at a single dose of 20 mg/kg body weight by intravenous (i.v.) routes. Plasma concentrations of roxithromycin were determined by liquid chromatography/mass spectrometry. After a single i.v. dose plasma concentrations were best fitted to a two-compartment open model. The values of the pharmacokinetic parameters after i.v. administration were: elimination half-life = $5.83{\pm}1.79h$, mean residence time = $6.33{\pm}0.32h$, total body clearance = $0.55{\pm}0.15L/h/kg$, and volume of distribution at steady state = $3.47{\pm}0.84L/kg$. The pharmacokinetic interpretation of roxithromycin after i.v. administration revealed that the drug was well distributed throughout the body in broilers and slowly eliminated. More studies for the application of roxithromycin against poultry disease are needed to establish a suitable pharmaceutical formulation, propose optimum dosage regimens, investigate clinical efficacy and study the tolerability of repeated doses.