• Journal of Internet of Things and Convergence
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• v.6 no.1
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• pp.83-95
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• 2020

Being a dense and complex task of precisely detecting the weeds in practical crop field environment, previous approaches lack in terms of speed of processing image frames with accuracy. Although much of the attention has been given to classify the plants diseases but detecting crop weed issue remained in limelight. Previous approaches report to use fast algorithms but inference time is not even closer to real time, making them impractical solutions to be used in uncontrolled conditions. Therefore, we propose a detection model for the complex rice weed detection task. Experimental results show that inference time in our approach is reduced with a significant margin in weed detection task, making it practically deployable application in real conditions. The samples are collected at two different growth stages of rice and annotated manually

• The Korean Journal of Pharmacology
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• v.25 no.1
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• pp.109-113
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• 1989

Human neutrophil elastase (HNE, EC 3, 4 21, 11), a major causative factor in the induction of pulmonary emphysema, were purified by two steps of liquid chromatography. Purified elastases were cross-reacted with antibody to human neutrophil elastases. Methicillin and cefamandole, which are known as inhibitors of cell wall synthesis of microorganisms, could inhibit the activity of human neutrophil elastase up to 50% with 10mM of both agents and $IC_{50}$ of methicillin was 9.8 mM. Gentamicin, one of the aminoglycosides, also inhibits human neutrophil elastases up to 60% of original activity with 10 mM of this agent and $IC_{50}$ was 9.0 mM. We could demonstrate similar effects in oxytetracycline. 10 mM of oxytetracycline inhibited 95% of human neutrophil elastase and $IC_{50}$ was 0.3 mM. Overall, oxytetracycline, cefamandole and methicillin are strong inhibitors of human neutrophil elastase, and they could be a drug of cholice for the diseases which were known as pathogenesis related to elastase. We also suggest that the mechanism of action of these antibitics are different from the mechanism of antimicrobial effects like inhibition of both cell wall synthesis and protein synthesis.

• Journal of Life Science
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• v.28 no.6
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• pp.753-763
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• 2018

Cysteine cathepsins are lysosomal enzymes that belong to the papain family and can induce the degradation of damaged proteins through the endo-lysosomal pathway. It is highly upregulated in many cancers by regulating gene amplification and transcriptional, translational, and post-transcriptional modifications. Cathepsin S is part of the cysteine cathepsin family. Many studies have demonstrated that cathepsin S not only plays a specific role in MHC class II antigen presentation but also plays a crucial role in cancers. Cathepsin S is more stable at a neutral pH compared to other cysteine cathepsins, which supports the importance of cathepsin S in disease microenvironments. Therefore, the dysregulation of cathepsin S has participated in a variety of pathological processes, including cancer, arthritis, and cardiovascular disease. Furthermore, a decrease or depletion in the expression of cathepsin S has been implicated in the processes of tumor growth, invasion, metastasis, and angiogenesis. Taken together, cathepsin S has been suggested as an attractive therapeutic target for cancer therapy. In this review, the known involvement of cathepsin S in diseases, particularly with respect to recent work indicating its role in cancer therapy, is examined. An overview of current literature on the inhibitors of cathepsin S as a therapeutic target for cancer is also provided.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.2
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• pp.707-712
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• 2013

In patients with acute myocardial infarction (AMI), the delay from symptom onset to hospital arrival has a critical effect on morbidity and mortality. This study examined to find out the determinants of the prehospital delay in patients with AMI. The study sample consisted of 597 patients hospitalized with AMI between Jan and Dec 2009. Demographic, medical history, and clinical data were abstracted from the hospital medical records of patients with confirmed AMI, the prehospital delay was categorized as less than or greater than 6 hours. Older age, low socioeconomic status(medical aid), and low use of Emergency medical system were associated with delays in seeking emergency care for Acute myocardial infarction. Education programs to improve patient knowledge of acute coronary syndrome symptoms and promote patient responsiveness with regard to seeking medical care should be used to reduce the prehospital delay time, especially in the low socioeconomic group.

• Journal of the Korean Applied Science and Technology
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• v.35 no.1
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• pp.157-162
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• 2018

The partial molar volumes of an antidepressant in Halobacteriun Halobium and in suspensions of several lipids have been determined at $25^{\circ}C$ it using a excess volume dilatometer. The potency of general antidepressant, Fluoxetine has long been known to correlate with lipid solubility. Denaturations of the vesicle, which is a sole membrane protein in the purple membrane of Halobacteriun Halobium, were studied by absorption changes at 280 nm and fluorescence changes at 330 nm with excess volume dilatometer. The 1H NMR analysis of viscous polymer solutions by diffusion interchange is the important step by measurement. The partial molar volume and particle size of Fluoxetine in Halobacteriun Halobium were measured to be positive. An antidepressant can prevent diseases that produce a variety of cognitive and mental symptoms based on low morale and depression, resulting in poor daily performance.

• Proceedings of the Materials Research Society of Korea Conference
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• 2011.05a
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• pp.17.2-17.2
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• 2011

모든 생물은 늙어가면서 그 생물체를 이루고 있는 생체조직들이 낡게 되고 약해지기 마련이며, 이외에도 자동차 사고 등 재해에 의해 생체 장기의 손상을 가져올 수도 있다. 또한 인간의 평균수명 연장과 함께 소득 수준이 높아지고 또한 'quality of life'를 추구하는 고령화 시대로 접어듦에 따라, 인공골, 인공치아 또는 인공 고/슬관절 등의 골조직 대체재료의 수요가 빠르게 증가하고 있다. 이와 같은 골조직 대체, 즉 골이식은 크게 자기골 이식(autografting), 동종이식(allografing), 인공재료(man-made materials)의 이식으로 구분된다. 현재 대체물질의 약 58%를 차지하고 있는 자기골 이식의 경우, 거부면역 반응이 없어 임상성공율이 80%에 달한다는 장점을 가지고 있으나, 비용이 비싸고 감염과 통증의 위험이 있다. 또한 시신으로부터 골을 이식하는 동종이식의 경우 대체물질의 약 34%를 차지하고 있는데, 성공률이 떨어지고 질병 감염의 위험이 있는 단점이 있다. 이외에 약 8%를 차지하고 있는 인공재료 이식의 경우, 파단, 독성반응, 마모, 골조직의 remodeling 등이 일어나는 단점이 있으나, 앞에서 언급한 바와 같이 그 필요성이 급격히 증가함에 따라 보다 나은 치료법과 골이식 대체물질의 개발에 많은 노력이 경주되고 있다. 2003년 6월 미국 Financial Times에 의하면, 인체내 식립형 생체재료의 세계시장 규모는 약 650억 달러에 이르며, 매년 200% 이상씩 신장하고 있다고 한다. 따라서 세계 각국의 의학, 약학, 임상학, 생명과학, 공학 등의 관련 연구 분야에서는 이 수요를 충족시키기 위한 활발한 연구활동을 펼치고 있다. 한편 인체내 식립용 임플란트의 국내 시장규모는 치과 임플란트의 경우 2006년 현재 2000억원 규모로, 정형외과, 악안면 성형외과, 이비인후과를 포함하면 소위 'bone-anchored metal implant' 영역의 시장 규모는 4~5조원에 이를 것으로 추산 되고 있다. 또한 소비 신장률 10~15%를 감안하면 향후 시장 규모는 폭발적으로 증가될 것으로 예상된다. 이에 발맞추어, 최근 들어 선진국은 물론, 국내에서도 인체내 식립을 목적으로 하는 생체재료에 관한 연구개발이 활발히 진행되고 있으며, 일부는 실용화 단계에 진입하고 있다. 본 강연에서는 금속 임플란트의 시장현황과 앞으로의 추세에 대하여 조망하고, Ti 임플란트를 중심으로 이의 생체활성을 부여하는 표면개질 필요성 및 최근의 연구개발 동행에 대해 소개하고자 한다.

• Journal of the Korean Data and Information Science Society
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• v.20 no.1
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• pp.149-158
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• 2009

Tsutsugamushi fever occupies more than 80% of total fall epidemic diseases and has an incubation period of 1 or 2 weeks as well. We have assumed that the incubation period distribution is gamma and therefore, reach an agreement that the infected distribution is normal with ${\hat{\mu}}=309.92$, ${\hat{\sigma}}=14.154$ by back calculation method. The infection cases are found severely large around the month of October. The infection case distribution demonstrates the incidence number increasing rapidly and progresses fast during the month of November. In this study, we have calculated the future prevalence number of maximum 1,200 people by inferred infection probability and incubation period distribution with some sort of limitation that the trend of increasing incidence number is not taking into an account. We considered the SIRS model which is also known as epidemic model, familiar to interaction between epidemiological classes. Our estimated parameters converged well with the initial parameter values.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.14 no.10
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• pp.1017-1023
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• 2003

Recently, the use an electric apparatus has brought into concerns about health risks from exposure to electromagnetic fields. During the last 2 decades, a number of epidemiological studies have explored the association between childhood leukaemia and residential exposure to power-frequency electromagnetic fields. Several studies have suggested that there is a small excess leukaemia risk with magnetic field exposure above 2 mG. A number of governmental and international organizations have developed exposure gudelines. The most rigid regulation with exposure levels for the elementary school and hospital has been enacted by Switzerland. Although there is no convincing supportive laboratory evidence, and the absence of a plausible biological mechanism of disease causation limits, governments are increasingly called on to adopt precautionary approaches to regulating electromagnetic field exposures. The government would need to establish the policy for electromagnetic fields and continually to be concerned about possible health risks from exposure to electromagnetic fields.

• Journal of the Korea Society of Computer and Information
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• v.24 no.12
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• pp.119-126
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• 2019

Korea is rapidly becoming an aging society due to lower birth rate and longer life expectancy. As elderly diseases are of a serious concern, the number of patients with dementia has been increasing significantly. For now, it has become a nationwide problem, as dementia is difficult to manage and requires a lot of social costs. To solve this, an IoT device has been devised that efficiently screens Mild Cognitive Impairment(MCI), the early stage of dementia. To design and implement the device, the latest IoT technology is introduced, the optimized Korean Version of Hasegawa Dementia Scale Revised(K-HDS) is utilized, and convenient service scenario with user-friendly design is applied. As a result, the symptoms of MCI have been screened quickly with convenient operation, which lead to the healthier society by the prevention of dementia.

• Journal of the Korean Society of Radiology
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• v.14 no.5
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• pp.705-713
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• 2020

Arteriosclerosis is a disease in which blood circulation is impaired due to loss of elasticity as blood vessels become narrower, and is a potential cause of recently increasing cardiovascular and cerebrovascular diseases. Carotid ultrasound is used as a predictor of cardiovascular and cerebrovascular diseases by evaluating the degree of atherosclerosis. Therefore, this paper attempted to investigate the correlation between the increase in the thickness of the inner media and various clinical variables in carotid ultrasound. Patients with carotid ultrasound findings were classified into three stages: mild intima thickening, sclerosis, and significant stenosis. CAVI (Carotid Ankle Vascular Index: vascular age) data measured in the degree and physical characteristics of the carotid artery(gender, age, body mass index, blood pressure), blood test(total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, creatine phosphokinase, fasting blood sugar), and arteriosclerosis test were collected. It was confirmed that the carotid intima thickness was correlated with variables such as hypertension, hyperlipidemia, and BMI, and also correlated with the risk factors of cardiovascular disease as CAVI increased.