• The Korean Society of Law and Medicine
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• v.24 no.3
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• pp.3-26
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• 2023

This paper reviewed the Pharmaceutical Affairs Act issues in case of self-administration of medicines by medical personnel without going through the general process (prescription, dispensing, distribution, administration). If a medical personnel self-medicates, the medicine supplier or medical personnel may be subject to criminal punishment under the Pharmaceutical Affairs Act. The core reprehensibility of the punishment lies in undermining the order in distribution of medicines stipulated in the Pharmaceutical Affairs Act. First, the sale of medicines by a medicine supplier to medical personnel may be the violation of Article 47 of the Pharmaceutical Affairs Act. However, if it was distributed for the case where medical personnels can dispense it directly under the Pharmaceutical Affairs Act, it can be justified under the general provision of the Criminal Act (justifiable act, the exclusion of illegality). If medicine suppliers distribute medicines knowing that the medical personnel acquires medicines for selfadministration, they can be punished as the violation of Article 47 of Pharmaceutical Act. Second, when a medical personnel acquires a medicine for the purpose of self-administration, the medicine supplier distributes the medicine under the false pretense that the medical personnel acquires the medicine for the case in which the medical personnel can directly dispense the medicine according to the Pharmaceutical Affairs Act. At this time, even if the medicine supplier has received all the payment for the medicines, the distribution of the medicines by deceit can constitute the fraud under the Criminal Act. Third, self-administration by medical personnel is a the violation of Article 23 of the Pharmaceutical Affairs Act. It is not a justifiable act under the general provision of the Criminal Act. This is because it is the abuse of the special status granted to medical personnel in the Pharmaceutical Affairs Act, which undermines the order in distribution of medicines.

• The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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• v.8 no.2
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• pp.138-150
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• 2003

In the mid-west coast of Korea where Mankyung and Dongjin rivers discharge fresh water, Saemangeum tidal dyke of 33 km long is under construction to reclaim the very shallow estuary region of 41,000ha. Main source of freshwater in this coastal area is Keum River locating closely north of the dyke. At present, the dyke connected with Gogunsan-Gundo separates this area into three regions; northwestern, southwestern and eastern (Saemangeum) region of the dyke, and the water in Saemangeum region is exchanged through one gap in the northern dyke and two gaps in the southern dyke. We have observed distributions and structures of temperature and salinity to examine the summer circulation related with low-salinity water in this coastal area in 1998 and 1999. In the surface layer off the northern dyke a tongue-like distribution of low-salinity extends 60 km long from Keum River estuary mouth to the northwest, forming plume front bounded by offshore water. In the inner region of Saemangeum dykes salinity distributions show that two river waters are merged together and the low salinity water is deflected toward northern gap of the dyke. In the surface layer off the southern dyke we observed small tongue-like distribution of another low-salinity water extending to the north from Gomso Bay. Based on the analysis of distributions of low-salinity water and frontal structures, we can suggest an anticlockwise circulation of coastal water around the dyke, composed by the estuarine water outgoing from the inner region of the dyke through the northern dyke's gap and the inflow through two gaps of southern dyke from offshore. After completing the dyke construction, this coastal circulation around the dyke will be, however, changed because fresh water discharge of Mankyung and Dongjin rivers will be routed artificially and directly into the area offshore of the southern dyke.

• Food Science of Animal Resources
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• v.31 no.6
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• pp.944-951
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• 2011

An improved cholesterol analysis method was developed for powdered infant formula by gas chromatographic separation after liquid-liquid extraction and partition. In the official Korea Food Standard method for cholesterol analysis, the water phase and solvent phase were not well separated in the case of emulsified foods such as powdered infant formulas and baby foods. For the rapid and simple sample preparation method, an optimized direct saponification condition was established for heating temperature, heating time, and KOH concentration. From the results, the optimum conditions were as follows: heating temperature $90^{\circ}C$, heating time 60 min, and 16 M KOH 10 mL for a 2 g infant formula sample; improved separation condition for gas chromatography was as follows: the initial oven condition was $250^{\circ}C$ for 25 min, the oven temperature was increased to $290^{\circ}C$ by $10^{\circ}C$/min ratio, and finally the oven temperature remained at $290^{\circ}C$for 9 min. The developed method could be implemented for the study of cholesterol, providing the advantages of reduced inspection time and cost in emulsified foods such as infant formula.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.25 no.3
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• pp.95-99
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• 2019

In the modified atmosphere packaging of powdered infant formula, the oxygen inside the package may cause its quality deterioration and needs to be minimized for quality preservation. A way of oxygen scavenger inclusion in the single-serve package without contacting the product was devised for removing oxygen residing initially and permeating through the seal layer during the storage. A polyethylene/pulp multi-layer porous filter bag of 5 × 7 cm containing 13 g of powdered infant formula was packaged in an 8 × 9 cm size aluminium laminated film package with a Fe-based oxygen scavenger of 1.8 g. After nitrogen flushed packaging, the active packages were stored at 30℃ for 254 days with periodical quality measurement. The active package could remove the initial residual oxygen of 1.4% completely and maintain absence of oxygen for the whole storage, which contributed to reduced oxidation observed in lower product peroxide value compared to that of the product in the control package. There was no influence of packaging treatment on content of 5-hydroxymethylfurfural, reaction product of initial nonenzymatic browning. The devised oxygen-scavenging single-serve package showed a potential to improve the preservation of infant formula powder and extend the shelf life.

• 우유
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• s.60 spring
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• pp.5-12
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• 1995

발효유 시장의 판도가 재편될 조짐을 보이고 있다. 오는 96년 유제품 시장의 완전 개방으로 신제품 개발과 기술 경쟁이 불가피한 실정에 놓이게 되자 유가공업체는 앞 다퉈 고부가 가치 상품을 직접 공략하는 추세다. 이에 따라 각 업체는 단순가공처리로 부가가치가 낮은 일반 시유나 조제분유 등의 생산 비중을 점차 낮추고 최근 매출이 급신장하는 요구르트 제품 및 치즈 등 고부가 가치성 제품 개발에 주력하고 있다. 가장 눈에 띄는 것은 90년대 초 정통요구르트로 각광받았던 떠먹는 요구르트(호상요구르트)의 퇴조 대신 떠먹는 불편함을 없앤 드링크요구르트[D/Y]가 급격한 신장세를 보이면서 발효유 시장을 휩쓸고 있다. 차세대 요구르트로 불리는 드링크요구르트가 요구르트 시장을 주도하고 있는 가운데 요구르트에 칼슘 · 미네랄 · 비타민 등을 강화한 고기능성 제품도 속속 개발되고 있다.

• Journal of Plant Biotechnology
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• v.34 no.3
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• pp.229-235
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• 2007

Artificial seeds were produced by encapsulation of somatic embryos of Kalopanax septemlobus and investigated the effects of alginic acid concentration, size of somatic embryos, additives in capsules and nursery seedbeds for germination. The most suitable concentration of alginic acid was 3% for germination of encapsulated seeds. Germination was suppressed at higher concentration more than 3% alginic acid. For germination of artificial seeds, 1/2 MS medium with 0.02% activated charcoal was effective. There was no significant differences on the germination among the different size of somatic embryos. Additives in hydrated capsule was very important for germination and post-germinative growth of artificial seeds. Germination was severly inhibited in hydrated capsule containing only distilled water. Both sucrose and MS medium addition in hydrate capsule was effective for germination of artificial seeds. When artificial seeds were transferred to soilbed, germination rate was high in perlite containing 3% sucrose but very low in perlite with only water. These results indicate that nursery additives in both hydrate capsules and soilbeds was important for germination of artificial seeds in Kalopanax septemlobus.

• The Korean Journal of Zoology
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• v.10 no.2
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• pp.1-8
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• 1967

토끼의 골격근 homogenate에서 23,000$\times$G, 60 분간의 원심분리와 얻은 근 microsome의 ATPase 활성, 근수축에 대한 이완작용, 및 Ca 의 흡수작용을 여러 가지 조건에서 측정하였다. ATPase 활성은 Ca++ Mg++ 양 이온의 존재에 의하여 활성화되며 , 5 mM Mg++ 의 존재하에서는 Ca++ 의 최적농도는 0.1mM이다. Oxalate의 존재하에서는 1 mM 의 Ca++ 이 최적농도이므로 oxalate의 작용은 불용성 Ca-oxalate의 작용은 불용성 Ca-oxalate를 microsome vesicle so 및 medium 내에 침전시켜 유리 Ca++ 농도를 저하시키는 것이라고 생각된다. Microsome의 이완작용은 조제후 120 시간까지 시간에 따라 감소되어 가나, 그이 ATPase 활성은 거의 변화가 없는 것으로 보아 Ca++ + Mg++ -의존성 ATPase 는 이완작용에는 직접 관련이 없는 것으로 해석된다. Oxalatedmlwhswo는 microsome의 Ca++ 흡수량을 현저히 증대시키며 동시에 흡수포화에 도달하는 시간을 지연시킨다. Oxalate의 이러한 효과도 Ca-oxalate의 형성에 기인하는 것으로 해석된다. Microsome 내에 축적되는 Ca 의 량은 ATP 농도가 커질수록 많아진다. 그러나 축적된 Ca 의 량과 ATP 농도사이에 화학정량론적 관계는 없는 것같다.

• Environmental Analysis Health and Toxicology
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• v.24 no.1
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• pp.43-52
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• 2009

Fullerene의 유전독성을 평가하기 위하여 Chinese hamster유래의 난소유아세포(CHO-K1 cell)를 이용하여 직접법(-S9)과 대사활성화법(+S9 mix)의 염색체이상시험을 실시하였다. 시험물질은 1% CMC 나트륨염의 현탁액(1% CMC 용액)에 희석하여 조제하였다. 대사활성화를 시키지 않은 직접법의 염색체이상시험에서 24시간 투여군은 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10 mM)로 투여하여 실시하였다. 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 48시간의 투여군에서는 8단계의 농도(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10 mM)로 투여하여 실시하였는데 투여 농도 증가에 따른 염색체이상의 빈도가 증가하는 양상이 나타나지 않았다. 배수체의 염색체이상은 직접법에서 관찰되지 않았다. 대사활성화법을 이용하여 6시간 시험물질을 투여한 시험에 있어서는 8단계의 용량단계(0.078, 0.156, 0.313, 0.625, 1.25, 2.5, 5, 10mM)를 설정하였는데 투여 농도가 증가함에 따른 염색체이상빈도의 증가양상이 관찰되지 않았다. 이상의 결과를 종합할 때 본 시험물질은 본 시험 조건하에서 CHO-K1세포에서 대사활성화를 시켰을 때 염색체이상을 유발하지 않는 것으로 판단된다.

• Journal of The Korean Society of Grassland and Forage Science
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• v.36 no.1
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• pp.34-40
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• 2016

The objective of this study was to determine the effect of moisture content on the physical and chemical characteristics of Italian ryegrass cube. Cube quality according to moisture contents (15, 20, 25, and 30%) was determined. Cubes made with 15 to 20% moisture showed a little cracks. But, the amount of powder generate from these cubes were lower by 10 to 16% compared to other cubes made with 25 to 30% moisture contents. The highest hardness at 159 kg/f was obtained when the cube was made with 15% moisture content and the lowest was 70 kg/f when the cube was made with 30% moisture content. The electrical loading and surface temperature were increased when moisture content was decreased. The chemical compositions of cube were differ from those of raw materials. Crude protein (CP) and ether extract (EE) contents were increased after cubing works. However, crude fiber (CF), acid detergent fiber (ADF), and neutral detergent fiber (NDF) contents were decreased after cubing. The crude ash content was not significantly (p > 0.05) different between raw material and cube. Higher moisture content resulted in higher crude protein content. However, crude fiber and crude ash content were not significantly (p > 0.05) different between each other. The contents of ADF and NDF were the lowest in cubes made with 30% moisture content. Our results suggest that the proper moisture content of Italian ryegrass cubing is recommended to be 15 to 20% and that cubing works should help increase forage quality.

• The Korean Journal of Pesticide Science
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• v.14 no.3
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• pp.219-225
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• 2010

The solubility in water of granular pesticides is not equal because the difference of methods of producing a granular pesticide. This study was conducted to investigate fish acute toxicity of butachlor 5% GR, fipronil 0.4% GR by impregnation and carbosulfan 3% GR, diazinon 0.4% GR by coating, using carp (C. carpio), medaka (O. tatipes) and loach (M. anguillicaudatus). The test solution of each pesticide was prepared by direct addition of granular pesticide and add after grinding granular pesticide to powder in test water, We also investigated $LC_{50}$ and residual concentration until 96 hours. Test results were appeared that the treatment of powder was 1.2~4 time higher than granular and toxicity increased clearly according to elapsed time, And the residual amounts by time were detected much at early time in the powder treatment of butachlor GR and diazinon GR. Conclusively, fish acute toxicity and residual concentration in test solution appeared higher in the powder treatment than treat granular form directly in water. Also, 96 hours toxicity values were stable comparatively and the error is less than 48 hours.