• Bulletin of Food Technology
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• v.12 no.3
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• pp.8-13
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• 1999

키틴/키토산은 지질흡수의 억제, 혈중 콜레스테롤의 저하, 항고혈압활성, 면역활성, 항종양/항암활성 등 다양한 생체기능성을 나타내어 건강지향적인 기능성 식품으로서의 이용가치가 매우 큰것으로 평가되고 있다. 키토산은 성인남자의 혈중 콜레스테롤을 감소시키고 HDL cholesterol은 증가시켜 동맥경화지수를 낮추며 비만환자에게 투여시 체중, 중성지질, LDL cholesterol을 유의하게 낮춤으로서 고지혈증과 비만증의 개선에 유용한 것으로 평가된다. 키토산은 또한 성인의 고염식에 의한 혈압상승을 억제하며 3량체 내외의 키틴/키토산 올리고당은 혈압상승의 중요인자인 angiotensin converting enzyme과 직접 반응하여 활성을 현저히 저하시키고 SHR에서의 혈압을 유의하게 억제하는 특성을 보여 고혈압의 억제 및 치료에도 응용가치가 클 것으로 생각된다. 키틴/키토산 및 그 올리고당은 sarcoma 180, Meth-A solid tumor의 성장을 저해하고 L1210와 같은 negative charge를 갖는 malignant cell을 흡착시키는 등 항종양/항암활성을 보이는데 이는 tumoricidal immunocite의 활성화에 의한 것으로 추정되고 있다. 키틴/키토산의 생체활성은 분자크기, 탈아세틸화도, 유도체의 종류 및 적용방법 등에 따라 차이를 보이기 때문에 키틴/키토산을 기능성 식품으로서 폭넓게 이용하게 위해서는 용도에 맞는 적절한 규격 설정이 요구되고 있다.

• Economic and Environmental Geology
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• v.25 no.3
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• pp.359-365
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• 1992

The parameters of the Korean earthquake have been determined by the manual method, which results in consuming more time and more errors. In this study we used HYPO71PC to determine earthquake parameters and to identify unknown active faults and lineaments in South Korea. The epicenters determined by the new computer technique are almost identical with the manual method of Korea Meteorological Agency. It is also found that most of epicenters are coincident with unknown faults that are defined as the un-determined faults on the tectonic map of Korea, and/or structural lineaments in South Korea.

• 한국방재학회:학술대회논문집
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• 2011.02a
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• pp.161-161
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• 2011

지진, 산사태, 액상화 등의 지질재해 예측을 위한 지역적 지반특성을 규명하기 위해서 지질도 또는 지형도를 이용하여 간접적인 방법이 사용되기도 한다. DEM에서 추출한 경사도는 지반분류 시 하나의 기준으로 사용되어질 수 있고, 이때 DEM의 해상력에 따라 그 결과가 다르게 산출될 수도 있다. 이번 연구에서는 DEM의 해상력에 따라 우리나라 일부지역의 지반분류 결과에 어떤 영향을 미치는지 살펴보았다. 각기 다른 해상도의 DEM을 적용하여 우리나라 동남부 지형을 경사도 기준으로 지반분류한 후 그 면적차이를 해상도별로 비교한 결과, 지반분류 C 지역의 면적 변화가 가장 뚜렷하였다. $V_s30$ 범위로 분류한 결과에서는 180 m/sec 이하의 지역에서 해상도별로 가장 큰 변화가 있었다. 고해상도에서는 지반분류 B와 E의 지역에서 면적이 저해상도 보다 크게 산출되는 경향이 있었고, 저해상도에서는 지반분류 C와 D 지역의 면적이 고해상도 보다 크게 산출되는 경향이 있었다. 이는 DEM의 해상도가 낮아질수록 각기 다른 지반정보를 함유한 작은 셀이 큰 셀로 만들어지는 과정에서 평균화되는 지반정보가 과대평가 또는 저평가되었기 때문이다. 연구지역 내 시추지역의 지반과 지반분류 결과를 비교하면 해상도별로 78%~52%까지 일치하였고, 고해상도에서 일치율이 더 높았다. 지형의 변화가 심하고 인구나 산업시설이 밀집된 재해 고위험군 지역은 고해상도의 지도를 이용하고, 지형의 변화가 없거나 단단한 지반의 지역은 재해가 상대적으로 작아서 저해상도의 사용으로 자료처리 시간의 효율성을 증대시키는 방안도 생각할 수 있다.

• Proceedings of the Korea Water Resources Association Conference
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• 2015.05a
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• pp.111-111
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• 2015

한 지점의 수문 반응을 결정짓는 주요 인자 중의 하나는 유역의 형상과 유역 내 하계망 구조이다. 유역의 형상과 하계망 구조는 지질시간 규모에 걸쳐 서서히 형성된 것으로, 주로 지반운동, 암석 및 지질구조, 그리고 이에 대응하는 지표 침식 정도에 의해 결정된다. 따라서, 암석 및 지질구조가 균질하다면, 유역의 특성은 지반운동과 지표 침식에 의해 좌우될 것이다. 본 연구는 지반운동의 시간적인 분포가 서로 다른 조건일 때 유역 특성이 각각 어떠한지를 수치지형발달모형(numerical landscape evolution model)을 이용한 모의실험을 통해 이론적으로 탐색해보았다. 구체적으로 모의 기간 동안의 총 지반융기량은 동일하더라도, 융기율이 전 기간동안 동일한 조건, 융기율이 특정 시점에 집중되는 조건, 그리고 융기율이 높았던 때와 낮았던 때가 반복되는 조건 등 세가지 시나리오를 실험하였다. 각 조건에 대해, 유역 형상과 하계망 구조는 어떻게 형성되는지를 살펴본 것이다. 모의결과 유역의 형태와 하계망 구조는 총융기량보다는 융기율의 시간 분포에 결정적인 영향을 받는다는 것을 확인하였다. 또한, 융기율의 시간분포는 유역의 전반적인 경사(하천 종단의 요형도)와 충적하상 및 기반암하상 하도의 분포 등에 큰 영향을 주었다.

• Journal of the Korea Convergence Society
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• v.8 no.8
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• pp.345-353
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• 2017

This study attempts to explore changes in the BDNF and blood lipid level through a 12-week aerobic exercise program aimed at the elderly women of a misdemeanor dementia, and was carried out for 3 times a week, 50 minutes each with the exercise angle 9-14. The following conclusions were obtained through this purpose and procedure. First, the results of BDNF showed a significant increase in the exercise group after conducting a 12-week aerobic exercise program. Second, after a 12-week aerobic exercise program in the athletic group, the results of the blood stop has showed the reduction of both total cholesterol and low density lipoprotein cholesterol, and the amount of high density lipoprotein cholesterol has increased. Therefore, the aerobic exercise program conducted in this study has a positive effect on lipid improvement along with dementia prevention, and through it helps to improve the quality of life of the elderly including significant improvement in physical and mental health.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.115-120
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• 2019

This study was undertaken to determine the correlation between β-amyloid, serum lipid levels, and cognitive function in the elderly with mild Alzheimer's dementia. The study was conducted in December 2018, enrolling 45 elderly people with mild Alzheimer's disease. Blood analysis measured the β-amyloid and serum lipid levels, and cognitive function was measured using MMSE-K. The correlation between β-amyloid, serum lipid levels and cognitive function was determined using Pearson's correlation analysis. A significantly negative correlation was observed between the β-amyloid level and cognitive function (p<0.05). Furthermore, serum lipid levels and cognitive function also revealed a significantly negative correlation between TC and LDL levels (p<0.05). These results indicate that increasing levels of β-amyloid, TC, and LDL augments a negative correlation that decreases the cognitive function, signifying that management of pathologic factors related to dementia is important for the prevention and improvement of cognitive function in dementia patients.

• KSBB Journal
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• v.13 no.1
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• pp.58-64
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• 1998

An extracellular lipid-producing strain, Rhodotorula glutinis K-501, was isolated from soil. The extracellular lipid produced by the cell was found to have good and stable emulsifying activity. Factors affecting the extracellular lipid production were studied to optimize culture conditions for maximum production. Sucrose and ammonium sulfate were selected as best carbon and nitrogen sources, respectively because they gave the highest concentration of product. The optimum C/N ratio was 50. Optimum concentrations of $KH_2PO_4,\; Na_2HPO_4, \;and\; CaCl_2 $were 3.5, 1.0, 0.75, and 0.1g/L, respectively. The optimum temperature and initial pH were determined as $22^{\circ}C$ and 7.0, respectively. When the batch culture was conducted with a sucrose concentration of 60g/L under the optimized conditions, extracellular lipid was produced to a concentration of 8.1g/L with a high production yield of 51.9% based on dry cell weight.

• Journal of Nutrition and Health
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• v.29 no.6
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• pp.642-650
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• 1996

Apo E polymorphism (e2, e3, e4) was among the first reported genetic polymorphism that explained part of the normal variation in plasma cholesterol concentrations. Both alleles E2 and E4 are significantly more frequent in patients with mixed forms of hyperlipidemia and contribute on the observed differences in CHD risk among different populations. Effects of apo E polymorphism on the distribution of plasma lipid profiles were studied in 105 normolipidemic healthy women. The relative frequencies of common alleles for gene locus of apo E in this study were that E3 allele was 0.848, E4 allels was 0.087, and E2 allele was 0.067. SBP and DBP were slightly more elevated in E2 allele than those in E3 and E4. The pulsation was also significantly (p<0.016) increased by E2 allele with excess body fat % in E2 allele. There were no differences in total-, total HDL-, VLDL+LDL-, VLDL- and LDL cholesterol among the apo E alleles. However, apo E2 allele subject had lower level of total HDL and HDL2 cholesterol (P<0.047) and significantly higher lev디 of HDL3 cholesterol (P<0.05) than those in apo E3 and E4 allele subject. The conclusion is that first, it seems that apo E4-mediated alteration through LDL B/E receptors or E receptors in cholesterol metabolism results in lower plasma TG or remanate particles and in higher levels of VLDL+LDL or LDL. Second, apo E2 allele shows reciprocal effects of E4 on the plasma lipid metabolism, respecitvely. Third, apo E2 allele was more atherogenic than apo E4 because the higher levels of HDL3/HDL2 ratio and atherogenic index[(TC-HDL)/HDL]were criticized.

• Clinical and Experimental Pediatrics
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• v.46 no.3
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• pp.217-223
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• 2003

Purpose : Every year, there is a remarkable increase in the prevalence of children with excess body fat. The aim of this study is to find a useful screening method in assessing adolescent, obesity and to specify the predictable risk factors that are related to adult cardiovascular disease according to BMI and obesity index. Methods : From July to November in 2001, a total of 2,814(male : female=2,011 : 803) mid to high school students who were in the obesity range according to obesity index(>20%) were evaluated according to height, weight, body mass index(BMI), obesity index, and serum lipid levels. Results : Among the obese students over 20% by obesity index, 86.6% were over the range of 95 percentile by BMI. Among students defined as obese by BMI, 21.0% of males and 21.4% of females students had hypercholesterolemia; by obesity index, the ratio was 20.7% male and 19.0% female. The frequency of hypertriglyceremia in male students was 15.0% in group I(overweight group, 85P97p); in female students 11.8%, 20.7% and 28.2% respectively. Conclusion : In this study, using BMI alone to test the serum lipid level in adolescent obesity had a limit of 10.0-17.0% omission. Therefore using obesity index as a screening method to find the adult cardiovascular disease would rather reduce the omission rate. The risk factor of cardiovascular disease according to BMI was the increasing level of triglyceride in both male and female students. We think that using the obesity index has more rationale rather than BMI in assessing lipid profiles.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.7
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• pp.140-148
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• 2017

The purpose of this study was to examine the effects of acute aerobic exercise at different intensities on the blood pressure, blood lipids and fibrinolytic markers in pre-hypertension college-aged males. Six subjects performed an acute running exercise at three different intensities(low intensity(LI): 50-60% heart rate reserve(HRR), moderate intensity(MI): 60-70%HRR, and high intensity(HI): 70-80%HRR). The blood pressure(systolic(SBP) and diastolic blood pressure(DBP), blood lipids(total cholesterol(TC) and high-density lipoprotein cholesterol(HDL-C)) and fibrinolytic markers(tissue plasminogen activator(tPA) and plasminogen activator inhibitor-1(PAI-1)) were determined before(PRE), immediately after(POST) and 60minutes after the exercise(60 POST). Results: the SBP in the LI group was significantly increased at POST(p=0.013). The ES levels for the SBP in the MI and HI groups were reduced (-1.33 and -1.23, respectively), though the differences were not significant. The HDL in the MI(p=0.003) and HI(p=0.002) groups were significantly increased at 60 POST. Also, the tPA in the MI(p=0.021) and HI(p=0.042) groups were significantly increased at POST.