• Title/Summary/Keyword: 지연변이

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Preventive Adaption Threshold Mechanism in Buffer Allocation for Shared Memory Buffer (공유 메모리 버퍼에서의 예방적 적응 한계치 버퍼 할당 기법)

  • Shin, Tae-Ho;Lee, Sung-Chang;Lee, Hyeong-Ho
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.38 no.10
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    • pp.24-33
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    • 2001
  • Delay, delay variation and packet loss rate are principal QoS(Quality of Service) elements of packet communication. This paper proposes a new buffer allocation mechanism to improve the packet loss performance in such a situation that multiple logical buffers share a single physical memory buffer. In the proposed buffer allocation mechanism, the movement of dynamic threshold follows a curved track instead of a straight line which is used in the DT(dynamic threshold) mechanism. In order evaluate the effectiveness of the proposed mechanism, it is compared with the existing previously proposed mechanisms in several aspects including NC(no control), ST(Static Threshold) and DT mechanisms.

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Modeling and Simulation of the Cardiovascular System Using Baroreflex Control Model of the Heart Activity (심활성도 압반사 제어 모델을 이용한 심혈관시스템 모델링 및 시뮬레이션)

  • Choi Byeong Cheol;Jeong Do Un;Shon Jung Man;Yae Su Yung;Kim Ho Jong;Lee Hyun Cheol;Kim Yun Jin;Jung Dong keun;Yi Sang Hun;Jeon Gye Rok
    • Journal of Biomedical Engineering Research
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    • v.25 no.6
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    • pp.565-573
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    • 2004
  • In this paper, we proposed a heart activity control model for simulation of the aortic sinus baroreceptor, which was the most representative baroreceptor sensing the variance of pressure in the cardiovascular system. And then, the heart activity control model composed electric circuit model of the cardiovascular system with baroreflex control and time delay sub-model to observe the effect of time delay in heart period and stroke volume under the regulation of baroreflex in the aortic sinus. The mechanism of time delay in the heart activity baroreflex control model is as follows. A control function is conduct sensing pressure information in the aortic sinus baroreceptor to transmit the efferent nerve through central nervous system. As simulation results of the proposed model, we observed three patterns of the cardiovascular system variability by the time delay. First of all, if the time delay over 2.5 second, aortic pressure and stroke volume and heart rate was observed non-periodically and irregularly. However, if the time delay from 0.1 second to 0.25 second, the regular oscillation was observed. And then, if time delay under 0.1 second, then heart rate and aortic pressure-heart rate trajectory were maintained in stable state.

A Case of Kabuki Syndrome Confirmed by Genetic Analysis: A Novel Frameshift Mutation in the KMT2D Gene (분자유전학적으로 진단된 가부키 증후군 1례)

  • Park, Su Jin;Ahn, Moon Bae;Jang, Woori;Cho, Won Kyung;Chae, Hyo Jin;Kim, Myung Shin;Suh, Byung Kyu
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.17 no.3
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    • pp.103-108
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    • 2017
  • Kabuki syndrome is a rare congenital disorder that causes multiple birth defects and mental retardation. Mutation of the lysine methyltransferase 2D (KMT2D) gene is the primary cause of Kabuki syndrome. We report a 4-year-old Korean girl diagnosed with Kabuki syndrome based on distinctive facial features (eversion of the lower lateral eyelid, arched eyebrows, depressed nasal tip, prominent ears), skeletal anomalies, short stature, and molecular analysis, which revealed a novel frameshift mutation in the KMT2D gene. A 4-year-old patient had a past history of congenital cardiac malformations (coarctation of the aorta, ventricular septal defect, atrial septal defect, patent ductus arteriosus), subclinical hypothyroidism and dysmorphic features at birth including webbed neck, short fingers, high arched palate, micrognathia and horseshoe kidney. She showed unique facial features such as a long palpebral fissure, long eyelashes, arched eyebrows with sparseness of the lateral third, broad nasal root, anteverted ears, and small mouth. Her facial features suggested Kabuki syndrome, and genetic analysis discovered a novel heterozygous frameshift mutation (c.4379dup, p.Leu1461Thrfs*30) in exon 15 of the KMT2D gene. The diagnosis of our 4-year-old patient was made through thorough physical examination and history taking, and genetic testing. It is challenging to diagnose patients with Kabuki syndrome at birth, since the characteristic facial features are expressed gradually during growth. Clinical suspicion aroused by regular follow-ups may lead to earlier diagnosis and interventions.

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Effects of Various Vernalization Duration and Growth Habit on Ear Primordium Development and Heading Date in Barley (보리의 파성정도가 유수분화 및 출수기에 미치는 영향)

  • Chun, Jung-Un;Huh, Sang-Man;Lee, Eun-Sup
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.32 no.3
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    • pp.341-346
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    • 1987
  • Seven barley varieties were tested under three different vernalization durations for observing the effects of vernalization duration and different growth habit on shoot apex development and heading date. The final leaf number per main stem in 3 and 6 weeks vernalized seedlings did not vary among varieties, but ranged 7 to 14 leaves in non-vernalized seedlings. The winter types had more leaves than the spring types. Days for each leaf emergence in non-vernalization were retarded 1. 3 to 1. 5 days in comparison with 3 or 6 weeks vernalized seedlings. In general, the leaf emergence speed of spring types was faster than that of winter types. The VI stage whose double ridge formed, did not vary in 6 weeks vernalization, but spring (Gangbori & Dongbori 2) and facultative or winter types showed two conspicuous difference patterns. The differences of days to X stage were great among different vernalization duration and varieties; the stage of spring types was reached faster than that of winter types. The early varieties within the same growth habit were reached to X stage faster, and the time of flag leaf emergence showed the similar tendency to the differentiation of X stage. The time of the first rapid stem internode elongation became late as for incompletely vernalized seedlings. The time within the same vernalization duration became later in winter types than in spring types, and even within the same growth habit, the time of early varieties became faster than that of late varieties. The growth habit in especially non-vernalized seedlings had highly significant correlation coefficients with the times of leaf development speed, leaf number per main stem, the first rapid stem internode and young spike elongations, X stage, and flag leaf emergence. However, the relationship between growth habit and time of heading in the field was not close.

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A Study on QoS Measurement & Evaluation for MPEG Transmission in Network (통신망에서 MPEG 영상 전송을 위한 QoS 측정 및 평가에 관한 연구)

  • Suh Jae-Chul
    • Journal of Digital Contents Society
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    • v.3 no.1
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    • pp.101-111
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    • 2002
  • Lately development of network around Internet expands range of data traffic to multimedia information, and so for the guarantee of multimedia services end-to-end QoS(Quality of Service) must service because comparing with existing Internet service can not support For satisfying those QoS requirements, network have to guarantee not only network on parameter, such as delay, jitter, throughput but also system resources like CPU utilization, memory usage. Therefore it is urgent to develop QoS based middleware to distribute multimedia data and maximize network utilization in the limited resource environment. And it must be necessary of network to provide end-to-end QoS(Quality of Service) for multimedia applications. Multimedia applications want that QoS which satisfy their own service properties be guaranteed Then, We must analyze those necessary QoS requirements md define QoS parameter which specify as two viewpoint, user's and network's perspective. Therefore network provider supplying network for usual user and university, enterprise must want to find about their own network performance and problem. It is essential for network manager to want to use a tool like this. On the basis of technique about QoS test-bed in the AIM network, We studied on the method of QoS measurement and management about end-to-end connection in the Internet. We measured network status about end-to-end connection and analyze the result of performance.

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Performance Analysis of DBA Algorithm for ATM-PON System (ATM-PON 에서의 효율적인 DBA 알고리즘 제안 및 성능 분석)

  • 이유태;한동환;전덕영;김승환
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.27 no.8C
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    • pp.803-811
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    • 2002
  • Asynchronous Transfer Mode-Passive Optical Network(ATM-PON) Technology is one of the best solutions for implementation of broadband access network. In this paper, we propose a new Dynamic Bandwidth Allocation (DBA) algorithm for ATM-PON systems. The DBA is a key technique for data traffic management. DBA has been studied widely to allow ATM-PON to transport data traffic cost-effectively and efficiently, and currently a hot standardization issue in Full Service Access Network(FSAN) and ITU-T. The proposed DBA algorithm efficiently manages the user traffics according to their service categories. Performance of the proposed algorithm, in aspect of Cell Transfer Delay(CTD) and Cell Delay Variation(CDV), is evaluated using computer simulation.

User Centric Cache Allocation Schemes in Infrastructure Wireless Mesh Networks (인프라스트럭처 무선 메쉬 네트워크에서 사용자 중심 캐싱 할당 기법)

  • Jeon, Seung Hyun
    • Journal of Industrial Convergence
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    • v.17 no.4
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    • pp.131-137
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    • 2019
  • In infrastructure wireless mesh networks (WMNs), in order to improve mobile users' satisfaction for the given cache hit ratio, we investigate an User centric Cache Allocation (UCA) scheme while reducing cache cost in a mesh router (MR) and expected transmission time (ETT) for content search in cache. To minimize ETT values of mobile users, a genetic algorithm based UCA (GA-UCA) scheme is provided. The goal is to maximize mobile users' satisfaction via our well defined utility, which considers content popularity and the number of mobile users. Finally, through solving optimization problem we show the optimal cache can be allocated for UCA and GA-UCA. Besides, a WMN provider can find the optimal number of mobile users for user centric cache allocation in infrastructure WMNs.

The End-to-end Performance Evaluation Method on Next Generation Network (NGN 환경에 적합한 단대단 성능평가 방법)

  • Nam, Chang-Sup;Kim, Hyung-Soo;Kim, Nam;Jeon, Hong-Beom
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.31 no.10B
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    • pp.857-865
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    • 2006
  • In order to test and evaluate the various functions and services of NGN would be promised, a specified methodology is needed and a development for the identification of testing object, configuration and test traffic are required. Simulation and analytical modeling methodshave used for IP performance testing, but further study issue still remains. This paper proposes new evaluation methodology to achieve an objective approach rather than a subjective and isolated, based on the real-field environment, for NGN network. For this purpose, background traffic pattern to interfere test traffic was specified and it was tested in actual NGN testbed with systems having NGN technology, such as per bandwidth and packet size. The results shows the suggested methodology is appropriate, comparing with parameters which are Delay, Jitter and Loss the current approach for the end-to-end performance evaluation on NGN.

Delayed Post-Hypoxic Leukoencephalopathy Induced by an Overdose with Fentanyl Patches: A Case Report (펜타닐 첩포 남용으로 인한 지연성 저산소성 백색질뇌증: 증례 보고)

  • Jin Sol Choi;Eun Ae Yoo;Jin Ok Choi;Soo Jung Kim
    • Journal of the Korean Society of Radiology
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    • v.81 no.4
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    • pp.972-978
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    • 2020
  • Fentanyl intoxication has occasionally been reported since fentanyl patches became available for medical use. Delayed post-hypoxic leukoencephalopathy is a complication of hypoxia. However, its neuropsychiatric symptoms can be delayed, and it can progress to leukoencephalopathy even after full recovery from coma due to acute intoxication. Herein, we report a case of fentanyl intoxication in a 65-year-old man who was presented to the hospital because of unconsciousness for 13 hours after using ten fentanyl patches simultaneously. Initial brain CT findings were non-specific. Twenty days later, delayed neuropathologic symptoms manifested, and MRI showed bilaterally symmetrical, heterogeneous, confluent high signal intensities on T2-weighted/fluid attenuated inversion recovery MRI in the cerebral white matter with diffusion restriction. This was followed by rapid exacerbation of neuropathological symptoms with diffuse severe cerebral atrophy over 1 year.

A Case Report of Novel Mutation in GNPTAB in Two Siblings with Mucolipidosis Type III Alpha/beta (GNPTAB 유전자에서 새로운 돌연변이가 확인된 뮤코지방증 III형 남매)

  • Kim, Min-Sun;Park, Esther;Song, Ari;Im, Minji;Park, Hyung-Doo;Cho, Sung Yoon;Jin, Dong-Kyu
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.18 no.3
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    • pp.99-106
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    • 2018
  • Mucolipidosis type III (pseudo-Hurler polydystrophy) is a mucolipids degrading disorder caused by a mutation in the GNPTAB gene and is inherited by autosomal recessive. It is diagnosed by examining highly concentrated mucolipids in blood and the diagnosis can be confirmed by genetic testing. Mucolipidosis type III is a rare and progressive metabolic disorder. Its initial signs and symptoms usually occur around 3 years of age. Clinical manifestations of the disease include slow growth, joint stiffness, arthralgia, skeletal abnormalities, heart valve abnormalities, recurrent respiratory infection, distinctive facial features, and mild intellectual disability. Here, we are presenting two siblings of mucolipidosis type III, a 4-year-old female and a 2 years and 7 months old male with features of delayed growth and coarse face. The diagnosis was confirmed by [c.2715+1G>A(p.Glu906Leufs*4), c.2544del(p.Glu849Lysfs*22)] mutation in targeted gene panel sequencing. In this case, c.2544del is a heterozygote newly identified mutation in mucolipidosis type III and was not found in the control group including the genome aggregation database. And it is interpreted as a pathogenic variant considering the association with phenotype. Here, we report a Korean mucolipidosis type III patients with novel mutations in GNPTAB gene who have been treated since early childhood. Owing to recent development of molecular genetic techniques, it was possible to make early diagnosis and treatment with pamidronate was initiated appropriately in case 1. In addition to these supportive therapies, efforts must be made to develop fundamental treatment for patients with early diagnosis of mucolipidosis.

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