• Clinical and Experimental Pediatrics
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• v.52 no.3
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• pp.370-375
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• 2009

Purpose : The risk of metabolic syndrome (MS) and cardiovascular disease in Turner syndrome (TS) patients is high. We analyzed metabolic factors in adults with TS and evaluated the metabolic risk of insulin resistance. Methods : Forty-three adults with TS were enrolled. The frequency of MS and the values of the metabolic factors were analyzed. Patients were divided into insulin resistant and non-resistant groups according to values of homeostasis model assessment of insulin resistance (HOMA-IR). The correlations of HOMA-IR with metabolic parameters were analyzed. Results : The frequency of MS was 7% and those of each metabolic parameter were as follows: insulin resistance, 16.3%; central obesity, 15.4%; hypertriglyceridemia, 2.3%; low HDL cholesterol, 9.3%; hypertension, 36.8%. The insulin-resistant group had significantly higher values of body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), HOMA-IR, and systolic blood pressure (SBP) than the non-resistant group (P<0.05). HOMA-IR showed a significantly positive correlation with BMI, WC, FPG, and SBP and showed a negative correlation with HDL cholesterol. Conclusion : This study suggests that adults with TS have a high risk of metabolic syndrome, and insulin resistance is correlated with metabolic factors. Therefore, TS patients should have their metabolic parameters monitored regularly to minimize metabolic complications and prevent cardiovascular diseases.

• Childhood Kidney Diseases
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• v.1 no.2
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• pp.123-129
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• 1997

Purpose : The Childhood Steroid Resistant Nephrotic Syndrome (SRNS) has a poor prognosis and there has been no effective therapy against SRNS of children. In 1990, Mendoza have reported that methylprednisolone pulse therapy was effective against SRNS of children. But in 1992, Waldo have reported that methylprednisolone pulse therapy was not as effective as in the report of Mendoza. So, retrospectively, we have studied 20 korean children with SRNS to evaluate the effect of methylprednisolone pulse therapy, Methods : Mothylprednisolone pulse therapy were given to 20 korean children with SRNS who admitted to Seoul National University Hospital from 1990 to 1995 and follow up was done Results : 1) During methylprednisolone pulse therapy, remission of nephrotic syndrome was induced in 45% of patients. 2) during follow up after the end of methylprednisolone pulse therapy, remission of nephrotic syndrome was maintained in 45% of patients. 3) 25% of patients has progressed to chronic renal failure. Conclusion : We think that the methylprednisolone pulse therapy is a effective therapy against SRNS of children with the 45%, remission rate of of SRNS in Korean Children

• The Journal of the Korea Contents Association
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• v.9 no.6
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• pp.237-246
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• 2009

This study was carried out to investigate of the associations of Alcoholic & Nonalcoholic fatty liver disease(AFLD & NAFLD) with metabolic syndrome(MS) defined by IDF criteria. We conducted a cross-sectional study of 799 adult males with alcohol consumption underwent laboratory investigation(control 297, alcoholic 206, nonalcoholic 296). The ultrasound scan of the liver was performed to determine the presence and the severity of FLD. We analyzed the association between the severity of AFLD & NAFLD and MS by logistic regression analysis. The distribution of metabolic syndrome was 7.4%, 48.8%, 34.9% in control, AFLD & NAFLD. The association of blood pressure, glucose, triglycerides, obesity were risk factor in AFLD & NAFLD. According to the severity of FLD, AFLD was significantly increased with MS, Obesity, low HDL-cholesterol. MS, High triglycerides was increased significantly in NAFLD(p<0.05). The prevalence of AFLD & NAFLD was increased with increasing the number of features of metabolic syndrome. This study shows that AFLD & NAFLD was closely associated with MS and its components. The patients of AFLD & NAFLD should managed and monitored to prevent metabolic abnormalities.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.2
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• pp.134-144
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• 2019

Metabolic syndrome and allergic rhinitis are two important chronic diseases that affect people all over the world. Metabolic syndrome very often induces other diseases and the prevalence of allergic rhinitis is currently increasing. Aging is known to affect the pathogenesis of various diseases such as metabolic syndrome and allergy. This study examined the effects of metabolic syndrome and the prevalence of allergic rhinitis depending on different age groups and several general characteristics. This study was conducted by using the data from the Korea National Health and Nutrition Examination Survey from the 4th, 5th, 6th, and 7th-1 (2007~2016). The data used for this study was obtained from 51,854 people. In all age groups, our studies have shown that people without metabolic syndrome have a higher prevalence of allergic rhinitis than those people with metabolic syndrome, and the younger age group had the higher prevalence of allergic rhinitis (P<0.05). Overall, the results of this study found a significant effect on the prevalence of allergic rhinitis in each category of age, general characteristics (physical activity, smoking and drinking) and the presence or absence of metabolic syndrome (P<0.05). The evidence found in this study will help to understand the correlation between metabolic syndrome and allergy, and specifically allergic rhinitis.

• Journal of Industrial Convergence
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• v.19 no.5
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• pp.69-77
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• 2021

This study identified vitamin E associated with metabolic syndrome and metabolic syndrome components among Korean adults aged over 19 years. Secondary data from the 2016-2018 Korean National Health and Nutrition Examination Survey were used for this study. Data from 6,425 were analyzed by logistic regression analysis using a complex sample procedure. As a result of logistic regression analysis, the odds ratio was increased in the group with high vitamin E levels compared to the group with normal vitamin E levels. There are metabolic syndrome (Adjusted Odds Ratio [AOR]: 1.889, 95% Confidence Interval [CI]: 1.550-2.303, p<.001), abdominal obesity (AOR: 1.444, CI: 1.205-1.730, p<.001), hyperglyceridemia(AOR: 3.182, CI: 2.641-3.835, p<.001), systolic blood pressure (AOR: 1.711, CI: 1.446-2.026, p<.001), diastolic blood pressure (AOR: 1.806, CI: 1.521-2.144, p<.001), low high density lipoprotein cholesterol (AOR: 1.558, CI: 1.060-2.290, p=.024). Therefore vitamin E was associated with metaboic syndrome and metabolic syndrome components. So when providing nursing intervention for people with metabolic syndrome, education on vitamin E should be actively included.

• 한국노년학
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• v.28 no.4
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• pp.1179-1200
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• 2008

Knowledge about somatization (somatic manifestation of psychological distress symptoms) among immigrant populations is limited. While several studies have recognized somatization as a culturally distinctive expression of depression amongst older Korean immigrant population, somatization has not been incorporated into the comprehensive empirical model for depression of this population. In order to improve our general understanding of the phenomenon, the objective of this study is to empirically investigate principal contributing factors of somatization as well as inter-relationships among them. Data were collected from a cross-sectional community survey of 234 older Korean immigrants ($$age{\geq_-}55$$) in the New York metropolitan area. The statistical methodology employed a robust hierarchical regression procedure that iteratively downweights outliers. The results indicated that living arrangement, greater numbers of physical illnesses, and depression were significant explanatory factors of somatization. Furthermore, physical illness had a significant joint effect with perception of health on somatization, which confirms that positive perception of health exerts a moderating effect on the relationship between physical illness and somatization. The knowledge obtained from this study will contribute toward extending our knowledge on somatization and implementing more culturally sensitive mental health services for this population.

• Journal of Convergence for Information Technology
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• v.11 no.3
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• pp.54-67
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• 2021

This study is a secondary data study that analyzes the factors affecting the quality of life of the elderly with metabolic syndrome and the elderly with metabolic syndrome with osteoporosis using data from the 7th year of the National Health and Nutrition Survey (2018). The subjects of this study were 639 patients with metabolic syndrome and 161 patients with metabolic syndrome with osteoporosis. For data analysis, the composite sample Rao-Scott χ2 test, general linear model t-test, and regression model were used. As a result of the study, the factors that lowered the quality of life of metabolic syndrome were age, cohabitation, strength training, subjective health status, activity restriction, body mass index and depression, and the explanatory power was 50.4% (F=515.96, p<.001). In metabolic syndrome with osteoporosis, age, subjective health status, activity restriction, and stress were the factors that lowered the quality of life, and the explanatory power was 48.6% (F=10.42, p<.001). Based on these results, it is necessary to develop and provide an intensive multidisciplinary program for the elderly with metabolic syndrome accompanied by osteoporosis to solve the problem of activity restrictions and manage stress reduction through positive acceptance of health status, instrumental and social support, and caring support.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.23 no.1
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• pp.17-24
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• 2023

Purpose: In the past, detection of metabolic abnormalities in plasma amino acid (PAA) and urine organic acid (UOA) has been widely used to diagnose clinical mitochondrial diseases, such as mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). In this study, the diagnostic values of PAA and UOA were reviewed, and their effectiveness in the diagnosis of MELAS was examined retrospectively. Methods: Blood and urine samples at the time of diagnosis were collected from all clinically diagnosed MELAS patients (n=31), and PAA and UOA tests were performed. All samples were collected in a fasting state to minimize artifacts in the results. The difference in the ratio of abnormal metabolites of PAA and UOA at initial diagnosis was statistically compared between the MELAS with genetic confirmation (n=19, m.3243A>G mutation) and MELAS without genetic confirmation (n=12) groups. The MELAS without genetic confirmation group was used as control. Results: Comparison of PAA and UOA between the two groups revealed that no abnormal metabolites showed characteristic differences between gene-confirmed MELAS patients with and those without genetic confirmation. Conclusions: Abnormal values of metabolites in PAA or UOA might be useful as a screening test but are not sufficient to diagnose MELAS patients.

• Journal of Korea Entertainment Industry Association
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• v.13 no.6
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• pp.175-186
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• 2019

Purposes: This study aimed to investigate the differences in the prevalence of obesity according to sex and age and self-rated health in adults with metabolic syndrome according to sex, age, and the presence or absence of metabolic syndrome. Methods: The study subjects were 5,674 adults, who completed all three components of the KNHANES VI-2. The subjects were categorized, using life transition periods, into young adults, middle-aged adults, and older adults. Research methods were selected based on the research objectives of the KNHANES VI-2. IBM SPSS 23.0 was used for complex samples cross-tabulation and a complex samples general linear model analysis. Results: Obesity was prevalent in 77.2% of young male adults, 66.2% of middle-aged male, and 52.3% of older male adults with metabolic syndrome, whereas it was prevalent in 72.4% of young female adults, 73.9% of middle-aged female adults, and 64.6% of older female adults with metabolic syndrome. Men had higher self-rated health than women. As age increased, self-rated health status decreased. Those with metabolic syndrome had lower self-rated health status than those without metabolic syndrome. Conclusion: The prevalence of obesity was found to be high in those with metabolic syndrome. This study found that based on sex, men had the highest self-rated health status, and based on age, young adults had the highest self-rated health status, whereas those with metabolic syndrome had low self-rated health status.

• The Journal of the Korean bone and joint tumor society
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• v.11 no.2
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• pp.208-212
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• 2005

Maffucci syndrome was first reported by Maffucci, an Italian, in 1881. This rare, nonhereditary syndrome is characterized by multiple enchondromas combined with hemangiomas and less commonly lymphangiomas. Maffucci syndrome is sometimes confused with Ollier disease, which was described in 1899 and consists of multiple enchondromas without hemangiomas. Although the prevalence of malignant change in skeletal lesions in Maffucci syndrome and Ollier disease is quite similar, it is important to differentiate between these two conditions because of the greater risk of developing nonmusculoskeletal malignancies in the former. We experienced a case of this rare syndrome and because of it's rarity, we report with review of literature.