• Applied Microscopy
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• v.29 no.4
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• pp.493-498
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• 1999

With increasing demand for fast and reliable, yet economical data storage devices, the role of optical disk technology is becoming more important. In recent years, advanced laser technology combined with new materials has given the competitive edge over the traditional magnetic memory devices both in memory capacity and reliability of data retrieval. Continuing effort is being put into developing smaller and more complex structures for optical disks to increase their memory density. Characterization of such multilayered structure requires not only high spatial resolution for observation but also laborious specimen preparation. In this paper, the method of preparing optical disk specimens for TEM characterization is described in detail. The microstructural features in optical disks observed by TEM are also discussed.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.425-434
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• 2011

In the present study was to examine the influence of cold stress conditions on memory function in relation with 5-hydroxytryptamine(serotonin, 5-HT), trptophanhydroxylase(TPH) expression and cell proliferation in the hippocampus. For this study, male Sprague-Dawley rats weighing $250{\pm}10g$ (7 weeks in age) were used. The rats were randomly divided into three groups(n = 10 in each group): the $22^{\circ}C$-control group, the $4^{\circ}C$-3 days group, the $4^{\circ}C$-5 weeks group. The environmental temperature at $22^{\circ}C$ set as the normal conditions, $4^{\circ}C$ was as the cold stress conditions. The present results showed that cold stress conditions shorten latency, representing cold stress disturbed memory function. 5-HT and TPH expressions in the dorsal raphe were increased cold stress. Neurogenesis in the dentate gyrus was increased under cold conditions. The present study revealed that cold stress exerted deteriorative memory function. However, through increasing of 5-HT, TPH and BrdU expression under cold stress conditions did not show memory enhancing effect.

• Management & Information Systems Review
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• v.37 no.4
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• pp.237-256
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• 2018

This study focused on the concept of organizational learning as a prior variable of innovation activities, and reviewed the relationship between organizational learning, innovation and management performance. According to prior studies, the ability to perform these activities may be enhanced through organizational learning, as the success of the innovation requires activities to acquire and share knowledge within the organization. In other words, organizational learning is playing a role as a precursor to innovation. Therefore, in this study, the effects of organizational learning on management performance are to be verified through the mediation effect of product and innovation activities. Organizational learning provides various definitions and components for each scholar, but this study consisted of a series of knowledge acquisition, information distribution, information analysis and process memory using the framework of the learning ability analysis by Levitt and March(1988) and Huber(1991), Innovation was also divided into product innovation and process innovation, and measured with sub-variables such as presentation of new products and improvement activities to increase productivity. Management performance was measured as financial and non-financial performance. To verify the effects of the mediation, we used a three-step regression analysis procedure of Baron and Kenny(1986)'s and a sobel-test. Empirical studies show that organizational learning has a positive effect on management performance and that knowledge acquisition and information distribution, which are the early stages of learning activities in the lower variables, affect performance through product innovation. Based on the results of the above empirical study, the implications, limitations of the study and future research directions were presented.

• Korean Journal of Food Science and Technology
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• v.49 no.5
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• pp.550-558
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• 2017

The effect of Artemisia argyi H. under liquid-state fermentation by Monascus purpureus (AAFM) on cognitive impairments has been studied in a mice model of diabetes-associated cognitive decline induced by streptozotocin (STZ). C57BL/6 mice (9 weeks of age, male) were separated into four groups: a normal control, STZ-induced diabetic mouse group (STZ group), Artemisia argyi H. (AA) 10 group (diabetic mouse+AA 10 mg/kg/day), AAFM 10 group (diabetic mouse+AAFM 10 mg/kg/day). Administration of AA and AAFM significantly improved glucose tolerance, as shown by the intraperitoneal glucose tolerance test (IPGTT), and ameliorated cognitive deficit, as shown by the behavioral tests including passive avoidance, Morris water maze, and Y-maze tests. After behavioral tests, the cholinergic system was examined by assessment of the acetylcholine (ACh) level and acetylcholinesterase (AChE) inhibitory activity, and the antioxidant system was also assessed by measuring malondialdehyde (MDA) and superoxide dismutase (SOD) levels in the brain and liver.

• Journal of Life Science
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• v.26 no.4
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• pp.475-483
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• 2016

The current study was conducted to evaluate beneficial effects of a new formula (CWC-9) using four traditional Oriental medicinal herbs, Cynanchum wilfordii, Rehmannia glutinosa, Polygala tenuifolia, and Acorus gramineus, on hippocampal cells and memory function. To examine the neuroprotective effects of a new four-herb extract, cell viability, cytotoxicity, and reactive oxygen species (ROS) assays were performed in HT22 cells and behavioral tests (Morris water maze and passive avoidance retention), Western blot, and immunohistochemistry were performed in a mouse model of focal cerebral ischemia. In HT22 hippocampal cells, pretreatment with CWC-9 resulted in significantly reduced glutamate-induced cell death with suppression of ROS accumulation caused by glutamate. In a mouse model of focal cerebral ischemia, we observed significant improvement of spatial and short-term memory function by treatment with CWC-9. Phosphorylated p38 mitogen-activated protein kinases (MAPK) in hippocampus of ischemic mice were decreased by treatment with CWC-9, but phosphorylated phosphatidylinositol-3 kinase (PI3K) and cAMP response element binding protein (CREB) were significantly enhanced. By immunohistochemical analysis, we confirmed higher expression of phosphorylation of CREB in the hippocampal neurons of CWC-9 treated mice. These results suggest that new multi-herb formula CWC-9 mainly exerted beneficial effects on cognitive function through regulation of neuro-protective signaling pathways associated with CREB.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.16 no.5
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• pp.403-412
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• 1991

This paper proposes a type of self organizing neural network which recognizes arbitrary symbols as well as numerical or alphabetic characters. The proposed algorithm autonomically organizes and classifies similar patterns on the basis of the distribution types of characteristics in the input images. Thus it can be appliced for the recognition of arbitrary images when it is difficult to establish a learning rule. It performs a stale recognition process with in the limit of the memory capacity. The cheme was applied and tested to 50 different image patterns with increased noise level up to 44%(SNR 2dB). The implementation results demonstrate that the proposed algorithm successfully recognizes the image patterns changed due to the various noise levels and thus proves excellent antinoise characteristics.

• Proceedings of the Korean Society for Information Management Conference
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• 2004.08a
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• pp.247-252
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• 2004

도서관은 ‘인간의 기록지식을 사회적 기억으로서 체계있게 조직하여 제공하는 사회기관’으로, 도서관과 사회는 서로 영향을 주고받는 유기적인 관계이다. 세라(Jesse H. Shera, 1903-1982)는 문헌정보학계의 교육자이며 철학자이며 이론가로, 도서관이란 무엇인가를 사회적 측면에서 깊이 연구한 학자이다. 이러한 세라의 도서관과 사회의 유기적 관계를 설명한 사상을 중심으로 북한도서관을 살펴보고자 한다. 도서관과 사회가 어떠한 관계를 가지고 서로 어떠한 영향을 미치는지를 보고, 이에 대해 북한사회와 북한도서관이 갖는 관계는 어떠하며 북한만이 갖는 특수성은 무엇인지를 살펴봄으로써 북한도서관에 관한 이해를 넓히고자 한다.

• Journal of the Institute of Convergence Signal Processing
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• v.3 no.4
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• pp.62-66
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• 2002

An attempt of using SOCMAC neural network for the prediction of a nonlinear sequence, which is generated by Mackey-Glass equation, is reported. The ,report shows the SOCMAC can handle a system with multi-dimensional continuous inputs, which has been considered very difficult, if not impossible, task to be implemented by a CMAC neural network because of a huge amount of memory required. Also, an improved training method based on the variable receptive fields is proposed. The Performance ranged somewhere around those of TDNN and BP neural networks.

• Management & Information Systems Review
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• v.31 no.2
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• pp.61-87
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• 2012

In order to improve the value of individuals and the organization's performance, strenuous efforts have been made on improving their human capital and expanding their social capital by members of the organization. Accordingly, the purpose of this study is to verify how members' intimacy network of an organization affects the organization's performance. In this research, they are verified by setting the characteristic of individuals intimacy network as an independent variable, and the job performance and the degrees of cooperation in the network as dependent variables. The results of this study show as follows. First, the size, strength, approach of intimacy network showed significant results. In particular, the first impression when first saw him becomes an important variable. And, that is affected by the approach of intimacy network. Second, the approach of intimacy network has a high impact on the cooperative behavior and job performance in a group which is formed by relationships through face-to-face contract.

• Korean Journal of Food Science and Technology
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• v.44 no.4
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• pp.428-433
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• 2012

Probiotics and their products, such as yogurt and cheese have been widely consumed in many countries with proven health benefits including anti-microbial activity and anti-diarrheal activity. LHFM (Lactobacillus helveticus - fermented milk) is a processed skim milk powder, fermented by a probiotics, L. helveticus IDCC3801. In the present study, we aimed to investigate the neuroprotective effects and the cognitive improvements of LHFM. LHFM itself did not show any cytotoxicity to the human neuroblastoma cell line, SH-SY5Y; however, it dose-dependently protected against glutamate-induced neuronal cell death. LHFM also attenuated scopolamine-induced memory deficit in Y-maze and Morris-water maze. In the analysis of hippocampus after a behavior test, LHFM significantly increased the acetylcholine level and also inhibited acetylcholine esterase activity. Therefore, the raised acetylcholine release partially contributes to the improvement of learning and memory by a treatment with LHFM. These results suggest that LHFM is an effective material for prevention or improvement of cognitive impairments caused by neuronal cell damage and central cholinergic dysfunction.