• The Monthly Diabetes
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• s.148
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• pp.18-19
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• 2002

우리나라의 사회$\cdot$경제 전반에 걸친 급속한 변화와 발전으로 식생활이 서구화되면서 당뇨병이 급격히 증가하고 있어서 향후 매우 심각한 사회, 경제적 문제를 안고 있다. 우리 나라에서의 흔한 대부분의 당뇨병은 제 2형 당뇨병이다.

• The Monthly Diabetes
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• s.78
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• pp.46-49
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• 1996

• Journal of the Korea Convergence Society
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• v.9 no.12
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• pp.485-493
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• 2018

This study analyzed the motivational interviewing of type 2 diabetes patients in order to understand the difficulties and motivations associated with starting insulin treatment in psychosomatic insulin-resistant patients. The method used the consistent comparative analysis. The results of study were as follows: building relationships, focusing (Self-explore of problems with diabetes self-management, Recognizing the limitations of diabetes management, Concerns about complications, Imagine the future), inducing (Imagine the expected benefits and disadvantages of insulin administration, Discovering the benefits of insulin, Changes in thinking about starting insulin therapy), planning (Show specific curiosity about change, Planning change), maintaining change behavior (Keeping change confident), and evaluating. This study will contribute to understanding patients with type 2 diabetes with psychological insulin resistance. It may also provide implications for professionals helping these subjects.

• Journal of Convergence for Information Technology
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• v.8 no.4
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• pp.9-14
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• 2018

The purpose of this study was to analyse the relationship between the characteristics of the patients who received oral antihyperglycemic drugs and their medical adherence in Korea. The study method was a cross-sectional study using the patient sample data of the Health Insurance Review and Assessment Service for 2016, and it was analyzed with 109 major components of diabetes drug. The medical adherence was slightly higher in male than female. The patriots & veterans(free) type had the highest medication adherence because they have low self burden to access medical institutions compared to other insurance types. It is expect that this study result will be used as a basic data to understand the burden of outpatients with health insurance and establish a policy to reduce of the self outpatients' burden with chronic diseases such as type 2 diabetes.

• Clinical and Experimental Pediatrics
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• v.48 no.6
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• pp.624-633
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• 2005

Purpose : This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase(TPO) and anti-thyroglobulin(TG) antibodies] in Korean patients with type 1 diabetes(T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders. Methods : A total of 59 Korean patients with type 1 diabetes[26 males, median age 13.7 years(range 5.7-29.9 years), diabetes duration 7.6 years(-1.7-22.5 years)] were enrolled in this study, and 200 healthy Koreans without a family history of diabetes were selected as a normal control for the comparison of HLA genotypes. Seventeen patients with anti-TPO or anti-TG were followed [median duration 3.96 years(1 day-10.7 years)] with measurement of anti-TPO, anti-TG, $T_3$, $T_4$ or free $T_4$, TSH levels and physical examinations. HLA-DR and DQ genotyping were done by PCR-SSO, PCR-SSCP, PCR-RFLP and PCR-SSP methods. Results : HLA analysis showed higher frequencies of HLA-DRB1*0301, *090102 and DQB1*0201, *030302 alleles, DRB1*0301/*090102, *090102/*090102 and DQB1 *0201/*030302, *030302/*030302, *0201/ *0302 genotypes in T1DM patients compared to controls(Pc<0.05). Fifteen(25.4 percent) had anti-TPO antibody, 12(20.3 percent) had anti-TG, 17(28.8 percent) had either autoantibody and 10(16.9 percent) had both autoantibodies. No clinical or subclinical hypothyroidism developed during follow-up after the first detection of anti-thyroid autoantibody. There was no significant correlation between thyroid autoimmunity and gender, onset age of T1DM, and diabetes duration, respectively(P>0.05). Conclusion : We thought this unique HLA-DR, DQ allele distribution might be an important factor for the low incidence of T1DM in Korea. And a high prevalence of thyroid autoantibodies in these populations suggests examinations of thyroid antibodies should be performed regularly. Optimal age for the initial screening and the frequency of re-screening for associated thyroid autoimmune diseases in T1DM remains to be determined through prospective follow-up.

• Journal of Periodontal and Implant Science
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• v.37 no.sup2
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• pp.353-369
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• 2007

Gingival tissue samples were obtained during periodontal surgery or tooth extraction. According to the patient's systemic condition & clinical criteria of gingiva, each gingival sample was divided into three groups. Group 1 (n=8) is clinically healthy gingiva without bleeding and no evidence of bone resorption or periodontal pockets, obtained from systemically healthy 8 patients. Group 2 (n=8) is inflamed gingiva from patients with chronic periodontitis. Group 3 (n=8) is inflamed gingiva from patients with chronic periodontitis associated with type 2 diabetes. Tissue samples were prepared and analyzed by Western blotting. The quantification of $IL-1{\beta}$, MMP-13 and TIMP-1 were performed using a densitometer and statistically analyzed by one-way ANOVA followed by Tukey test. 1. The expressions of MMP-13 and TIMP-1 showed increasing tendency in group 2 & 3 compared to group 1. 2. The expressions of $IL-1{\beta}$ & MMP-13 were showed increasing tendency in group 3 compared to group 2. 3. As $IL-1{\beta}$ levels were increasing, MMP-13 showed increasing tendency in group 3, and although $IL-1{\beta}$ , MMP-13 levels were increasing, TIMP-1 levels were similar expressed comparing to group 2. In conclusion, this study demonstrated that the expression levels of MMP-13 and TIMP-1 had increasing tendency in inflamed tissue. It can be assumed that $IL-1{\beta}$ and MMP-13 may be partly involved in the progression of periodontal inflammation associated to type 2 DM.

• The Monthly Diabetes
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• s.222
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• pp.15-17
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• 2008

우리나라 당뇨병환자의 95%를 차지하고 있는 제 2형 당뇨병(인슐린 비의존형 당뇨병)은 크게 두 가지 기전에 의해 발생하게 된다. 하나는 포도당을 사용하고 만들어내는 근육이나 간에서 인슐린이 제대로 작용하지 않는 인슐린 저항성이고, 다른 하나는 인슐린 저항성을 극복하기 위해 췌장에서 인슐린을 많이 만들어야 하는데 필요한 양만큼을 못 만들어내는 인슐린의 상대적 부족 상태이다. 따라서 이 두 과정을 해결하면 혈당을 떨어뜨리고 몸의 포도당 농도를 정상으로 만들 수 있게 된다. 두 번째 과정인 인슐린의 상대적 부족을 해결하여 혈당을 조절하는 것으로 췌장에서 인슐린 분비를 촉진시키는 약제가 설폰요소제, 메글리티나이드이다. 그리고 첫 번째 과정인 인슐린 저항성을 극복하여 혈당을 조절하는 약제가 본 연제에서 다루게 될 메트포르민, 치아졸리디네디온제 계통의 약물로 인슐린이 작용하는 근육, 간에서 인슐린이 보다 효율적으로 작용하게 하여 인슐린 효과 증강제로 분류한다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.8
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• pp.348-358
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• 2020

The purpose of this study was to examine the effects of auricular acupressure in patients with type 2 diabetes mellitus. Data collection was conducted from March 16 to May 11, 2018. A total of 44 participants with type 2 diabetes were recruited from welfare facilities. Participants in the experimental group (n=22) and placebo control group (n=22) received auricular acupressure on diabetes-related points (shenmen, pancreas, appetite control point, thirst point, and master endocrine point) and diabetes-unrelated points. The intervention was implemented on 5 consecutive days per week for a total of 6 weeks. To examine the effects of treatment, postprandial glucose, glycated hemoglobin, and blood lipid levels were evaluated. Postprandial glucose levels in the experimental group exhibited significant reduction over time compared to those in the placebo control group (p=.030). Glycated hemoglobin levels in the experimental group decreased significantly (t=-2.44, p=.024). However, there were no significant differences in blood lipid levels between the two groups. This study demonstrates that auricular acupressure on diabetes-related points for 6 weeks was highly effective in decreasing blood glucose levels in patients with type 2 diabetes.

• The Monthly Diabetes
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• s.184
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• pp.28-32
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• 2005

당뇨교육, 식사 및 운동요법, 지속적인 혈당측정과 3개월 마다 A1c를 측정하고 소변검사로 미세알부민뇨를 확인하고 안저 검사와 규칙적인 발 관리를 계속하고 매년 심혈관계 합병증에 대한 검사 등 일반적인 당뇨관리를 계속한다. 이식 후 새로 생긴 당뇨병은 제2형 당뇨병 관리와 같이 관리한다.

• Korean Journal of Human Ecology
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• v.23 no.1
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• pp.137-148
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• 2014

The aim of this study was to determine whether the addition of soy isoflavones to dairy ice cream modifies diabetic biomarkers in the type 2 diabetic model mice. Forty male C57BL/6J-ob/ob mice were randomly divided into 4 groups and fed control diet (basal, 7% fat), MS diet (milk ice cream with sugar, 20% fat), MS-SI diet (MS ice cream with 0.01% soy isoflavones, 20% fat), or MF-SI diet (milk ice cream with 0.01% soy isoflavones, 5% fructooligosaccharide, 20% fat) for 12 weeks. Blood response area by glucose tolerance test, plasma levels of glucose, insulin, C-peptide, leptin, and blood $HbA_{1c}$ were not significantly different among all the groups. Concentrations of interleukin-6 and tumor necrosis factor-${\alpha}$ secreted from splenocytes induced by Concanavalin A were not significantly different among all the groups. In conclusion, soy isoflavones supplemented to ice cream did not alter diabetic biomarkers in diabetic type 2 model mice.