• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.11
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• pp.5179-5186
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• 2012

Miglitol, a well-known therapeutic intervention agents for diabetes, exhibits competitive inhibitory activity against ${\alpha}$-glucosidase and it is usually produced through three sequential steps including chemical and bioconversion processes. Gluconobactor oxydans (G. oxydans) belonging to acetic acid bacteria biologically, converts 1-deoxy-1-(2-hydroxyethylamino)-D-glucitol (P1) into a key intermidiate, 6-(2-hydroxyetyl) amino-6-deoxy-${\alpha}$-L-sorbofuranose (P2) by incomplete oxidation. In this study, we identified and optimized fermentation conditions of CK-2165, that was selected in soil samples by comparing the bioconversion yield. CK-2165 strain was found to be closely related to G. oxydans based on the result of phylogenetic analysis using 16S rDNA sequence. Utilization of API 20 kits revealed that this strain could use glucose, mannose, inositol, sorbitol, rhamnose, sucrose, melibiose, amygdalin and arabinose as carbon sources. The culture conditions were optimized for industrial production and several important factors affecting bioconversion rate were also tested using mycelial cake. Cell harvested at the late-stationary phase showed the highest bioconversion yield and $MgSO_4$ was critically required for the catalytic activity.

• Korean Journal of Ichthyology
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• v.11 no.1
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• pp.46-51
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• 1999

Age, hatching date and growth in length of juvenile Limanda yokohamae were determined by analysis of microstructure in otoliths. Monthly samples were collected by a beach seine in the shallow water off Gaduk-do from January to December, 1998. The juveniles were collected between February and April. Mean total length was $22.6{\pm}1.77\;mm$ ($\pm$SD) in February, $23.6{\pm}3.86\;mm$ in March, and $38.2{\pm}8.38\;mm$ in April. The core of otoliths ranged from 18 to $21\;{\mu}m$ in diameter and the growth increments were deposited concentrically from the hatching mark. The secondary growth layer began to appear at the 48 to 56-th increment. It indicates that L. yokohamae larvae may be completed the metamorphosis at this time of ca. 52 d after hatching, and moved into the shallow water for demersal stage. The hatching date calculated from the number of daily increments was between late November and early January, showing a peak in December. The total length (L, mm) was related to otolith radius (R, ${\mu}m$); L=0.055 R+5.81 ($r^2=0.88$). The growth in total length was represented by the Gompertz growth curve; $L_t=3.39e^{4.51(1-e^{-0.0067t})}$ ($r^2=0.81$). Daily growth rate was 0.35 mm/d at the age of 70 d and increased up to 0.55 mm/d at the age of 120 d.

• Investigative Magnetic Resonance Imaging
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• v.11 no.2
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• pp.87-94
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• 2007

Purpose: The purpose of this study was to evaluate the usefulness of fast inversion recovery (FIR) and magnetization-prepared three dimensional gradient echo sequence (3D GRE) T1-weighted sequences for neonatal brain imaging compared with spin echo (SE) sequence in a 3T MR unit. Materials and Methods: T1-weighted axial SE, FIR and 3D GRE sequences were evaluated from 3T brain MR imaging in 20 neonates. The signal-to-noise ratio (SNR) of different tissues was measured and contrast-to-noise ratios (CNR) were determined and compared in each of the sequences. Visual analysis was carried out by grading gray-white matter differentiation, myelination, and artifacts. The Wilcoxon signed ranked test was used for evaluation of the statistical significance of CNR differences between the sequences. Results: Among the three sequences, the 3D GRE had the best SNRs. CNRs obtained with FIR and 3D GRE were statistically superior to those obtained with SE; these CNRs were better on the 3D GRE compared to the FIR. Gray to white matter differentiation and myelination were better delineated on the FIR and 3D GRE than the SE. However, motion artifacts were more commonly observed on the 3D GRE and flow-related artifacts of vessels were frequently seen on the FIR. Conclusion: FIR and 3D GRE are valuable alternative T1-weighted sequences to conventional SE imaging of the neonatal brain at 3T providing superior image quality.

• Journal of Mushroom
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• v.2 no.4
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• pp.200-206
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• 2004

The optimal temperature for mycelial growth the F. fomentarius was $30^{\circ}C$ and the range of the temperature for mycelial growth wsa about 10~30. The optimal pH for the growth was 4.0. The percentage of weight loss percentage wsa 17.4%. The percentage of WEC extractives wsa increased to 2.24%. The observation of micromorphological showed that the detected cell wall were erosive and thinning as typical degradation pattern of white-rot fungi.

• Ecology and Resilient Infrastructure
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• v.3 no.3
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• pp.182-188
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• 2016

This study evaluated structural alternatives for managing water quality problems by reinterpreting and then applying the robustness-cost index (RCI) for urban flood problems. Cases of endogenous hormone pollution in treated sewage and proliferation of protozoa in intake-water were chosen as representative examples because they have different types of regulation standards for the treatment. Current facilities and structural alternatives with robustness indices (RIs) greater than unity were determined to be robust. The RI was combined with the cost index (CI) to obtain the RCI values. For the endogenous hormone pollution in treated sewage, a human-oriented estrogen $17{\beta}$-estradiol was selected as a target pollutant. The RI and RCI values for a structural alternative, extension of the current sewage treatment facility for advanced treatment, were greater than the values for the current practice of conventional activated sludge process. For the intake-water pollution by protozoa, UV and ozone disinfection facilities were evaluated for inactivation of Cryptosporidium parvum. The RCI values for ozone disinfection were greater than those for UV disinfection. Based on the results and the logics involved in the calculation of RCI for water quality issues we studied, we proposed procedures for establishing and implementing structural alternatives for the restoration from and prevention of outbreaks of water quality problems.

• Journal of the Korean Society of Marine Environment & Safety
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• v.19 no.6
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• pp.629-636
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• 2013

There is no safety evaluation index with marine accidents and information of ship's safety management result for good grasp of safety management level of shipping company and effective monitoring. In this paper, we proposed a SMEI(Safety Management Evaluation Index) for evaluation of shipping companies. The SMEI is consist of MAR(marine accidents ratio), SSMR(ship safety management ratio) and SAP(safety advantage point) through brainstorming of the expert group and AHP(analysis hierarchy process)in previous study. And weights of SMEI are calculated using experts's opinions through the Delphi method. We also verified the validity of proposed SMEI to 119 Korean shipping companies with 916 ocean-going ships of Korean flag, which grouped three part (small, mid and big) by number of ship and gross tonnage. And we found out 19 shipping companies, 8 companies in group1 & group2 respectively and 3 companies in group 3, with score below 1.0 by SMEI. In these companies, there are no marine accidents in recent 3 years and appeared low frequency remarkably in the detention and mojor non-conformity by data analysis.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.1
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• pp.170-175
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• 2004

This study was conducted to determine the minimum concentration of citrus juice for basal medium and also to search for an additional carbon source for the best production of the gel. A concentrate of citrus fruit juice of 65$^{\circ}$Brix, it was diluted to be used as a basal medium. Static cultivation of Gluconacetobacter hansenii TL-2C for 14 days at 3$0^{\circ}C$ produced the best gel with 7.5$\pm$0.4 mm thickness in the 6-fold diluted citrus Juice concentrate without any additional nutrient. However, the same thickness could be obtained with 60 to 100-fold diluted juice concentrate when refined white sugar was added at appropriate concentrations. Glucose was the most effective sugar for the both of gel and acid production, and optimal concentration of the sugar was 10$^{\circ}$Brix. Ethyl alcohol at 1.0% had synergistic effects in combination with refined sugar and increased the gel thickness up to 15.1 mm which was 1.85 times thicker than that of refined sugar alone. However, acetic acid was not effective. Gel productivity with supplement of ethanol was 172.6$\pm$8.4 g wet/L, and it was approximately equal to 4.7 g of dry gel/L.

• Journal of the korean academy of Pediatric Dentistry
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• v.31 no.3
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• pp.355-361
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• 2004

Impaction is generally defined as the lack of eruption of a tooth after the normal age for the eruption. An impacted tooth may appear blocked by another tooth, bone, or soft tissue, but cause of tooth impaction is often unknown. The clinician should consider the various treatment options available : (a) No treatment and observation, (b) surgical exposure and orthodontic traction (c) auto transplantation (d) extraction. These cases were about the patients with delayed eruption of maxillary central incisor. We surgically exposed impacted tooth and guided it into normal position by the orthodontic traction. Especially, in case 1, #21 was ectopic impacted state with root dilaceration. It is required to examine further root development and alignment of dentition serially.

• KDI Journal of Economic Policy
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• v.18 no.2
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• pp.185-209
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• 1996

북한(北韓)의 경제개발전략(經濟開發戰略)의 제특징(諸特徵)은 저렴한 농산물가격(農産物價格)에 의한 농업부분(農業部分)에서의 잉여(剩餘), 저임금(低賃金)에 의한 도시노동자(都市勞動者)들로부터의 잉여(剩餘)를 가지고 경제발전(經濟發展)을 이룩하는 것이라 요약할 수 있다. 농민(農民), 도시노동자(都市勞動者) 양측(兩測)을 희생시키면서 유지되어 온 이러한 성장구조(成長構造)는 원래 같으면 저농산물가격(低農産物價格)${\rightarrow}$저임금(低賃金)${\rightarrow}$축적자금확대(蓄積資金擴大)${\rightarrow}$재투자(再投資)${\rightarrow}$생산량증가(生産量增加)${\rightarrow}$소비수준 (消費水準) 증가(增加)로 점진적으로 발전해야만 하는 것이다. 하지만 이러한 성장전략(成長戰略)은 처음부터 철저히 부정되어 왔다. 먼저 농촌부분(農村部分)부터 보면 농촌협동조합(農村協同組合)에서의 소유제도(所有制度), 분배제도(分配制度)의 문제(問題)로 인해 농민(農民)의 근로의욕(勤勞意欲)이 크게 상실되었고 그 결과(結果) 농업생산(農業生産)은 저하되었다. 한편 도시부분(都市部分)에서는 인민(人民)들의 저소비(低消費)의 결과(結果)로 축적된 자금(資金)이 군사부분(軍事部分)에 집중적으로 투자됨으로 인해 그 투자효과(投資效果)가 제 구실을 못하게 되었다. 뿐만 아니라 자급자족지향형(自給自足指向型)의 중공업화(重工業化)는 중공업(重工業)과 관련산업(關聯産業) 상호간(相互間)의 수요(需要)만을 충족시켜 왔다. 그 외에 기업(企業)이 국가(國家)의 지령(指令)에 의해서만 움직이는 국영기업관리체제(國營企業管理體制)의 비효율성(非效率性)도 지금의 북한경제(北韓經濟)를 침체(沈滯)의 늪에서 헤어나지 못하게 하는 주요(主要)한 요인(要因)으로 작용했다. 농업생산(農業生産)의 정체(停滯), 중공업(重工業)을 위한 중공업정책(重工業政策)이라고 하는 왜곡된 투자구조(投資構造), 기업관리체제(企業管理體制)의 비효율성(非效率性)은 북한(北韓)의 계획경제순환구조(計劃經濟循環構造)를 기본(基本)부터 뒤흔들기 시작하면서, 급기야 1980년대 후반부터는 순환구조(循環構造) 그 자체(自體)를 마비시키는 사태(事態)로까지 발전했다. 순환구조(循環構造)의 마비(痲痺)라고 하는 심각한 경제난(經濟難)을 타개하기 위해 북한(北韓)은 나진(羅津) 선봉(先鋒) 자유경제무역지대(自由經濟貿易地帶)를 설치(設置)하고 새로운 자금축적원(資金蓄積源)으로서 외국인직접투자(外國人直接投資)를 유치하는 개방정책(開放政策)을 추진하여 왔다. 하지만 북한(北韓)의 경제(經濟) 순환구조(循環構造)의 마비(痲痺)를 풀 수 있는 근본적(根本的)인 해법(解法)은 어디까지나 그 발단(發端)인 농촌(農村)의 경제체제개혁(經濟體制改革), 농(農) 경공업(輕工業)을 위한 중공업(重工業), 국영기업(國營企業)의 개혁(改革) 등을 과감히 실시하는 것이다. 왜냐하면 해외직접투자(海外直接投資)라는 새로운 자금축적원(資金蓄積源)은 어디까지나 지금의 악순환구조(惡循環構造)를 임시적(臨時的)으로 정지시켜 주는 보완적(補完的)인 조치(措置)에 불과하기 때문이다.

• Journal of Preventive Medicine and Public Health
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• v.6 no.1
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• pp.43-49
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• 1973

In this study noise source in a ward at four general hospitals in Seoul area has been investigated and analysed. The degree of reaction against noise by 171 randomly has also been examined. The results of the study have shown that the source of noise is the speakers of wired broadcasting or from visiting guests in two hospitals located in residential area. The patients at the two other hospitals located at commercial site have been suffered more from traffic noise. However, because of their separated living at hospital from their ordinary houselife, sixty one percent of the inpatients have wished a music sound of around 60 dB (A). After having considered the results of the investigation and wishes of the inpatients, following suggestions have been made: 1. Reduce the number of guests or their length of stay. 2. Wired broadcasting system should be substitued by wireless one, or if it's unavoidable, it should be used in office rooms only. 3. Since the stops and starts of vehicles induce much noise, Seoul City Government be requested to prepare an appropriate administrative measure for the vehicles around hospital area and it should prevent the establishment of new hospitals along high way site. 4. By using earphone, inpatients can choose a wireless channel according to each individual's taste. This through the masking effect, would cover up the noise source. 5. Rooms along the streets should be utilized as offices, otherwise double windows should be set up for inpatient's wards.