• Tuberculosis and Respiratory Diseases
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• v.41 no.5
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• pp.568-573
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• 1994

Corticosteroids are widely used in the treatment of various diseases because of its potent antiinflammatory effect. According to recent knowledge, bronchial asthma is also chronic inflammatory disease. Therefore antiinflammtory agent such as cromoyln sodium and corticosteroid is highly recommended for treament of chronic bronchial asthma. Especially hydrocortisone succinate (Solu-Cortef) is commonly used for treament to acute asthmatic attack via intravenous injection due to have rapid therapeutic onset and short duration. Since Sunaga et al. reported acute asthma attack after hydrocortisone injection in 1973, several cases of bronchospam with or without angioedema and urticaria after intravenous injection of hydrocortisone have been reported. We experienced a case of severe bronchospasm and acute respiratory failure after intraveous injection of hydrocortisone succinate in 64 year-old female asthmatic patient who visited to emergency room for acute asthmatic attack. About 5 minites after Solu-Cortef injection, a severe bronchospasm with arterial hypoxemia was developed. In order to confirm the suspected relationship between the offending drug(Solu-Cortef) and acute bronchospasm, we examed intravenous and inhalation provocation test by hydrocortisone succinate and methylprednisolone(control). After administration of hydrocortisone succinate via intravenous and inhalation route, severe asthmatic attack occurred. But administration of intravenous methylprednisolone and orall triamcinolone and saline were not provoke bronchospasm. Skin test using hydrocortisone sodium succinate was also positive. Administration of hydrocortisone is very serious to asthmatic patient with hydrocortisone hypersensitivity. Therefore, the clinician must be have history taking about previous adverse reaction of steroid before its clinical use. And methylprednisone may be useful and safe drug to the treatment of acute asthmatic patient with hydrocortisone hypersensitivity.

• Tuberculosis and Respiratory Diseases
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• v.60 no.4
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• pp.464-468
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• 2006

The incidence of Mycobacterium kansasii pulmonary diseases are on the increase in Korea with the higher probability of occurrence in middle-aged and older men with underlying lung diseases Among nontuberculosus mycobacterial (NTM) infections, the clinical features of M. kansasii pulmonary infection are most similar to those of tuberculosis (TB). The chest radiographic findings of M. kansasii infection are almost indistinguishable from those of M. tuberculosis (predominance of an upper lobe infiltration and cavitary lesions), even though some suggest that cavities are more commonly thin-walled and have less surrounding infiltration than those of typical TB lesions. Although there are reports on the rare manifestations of M. kansasii infections, such as endobronchial ulcer, arthritis, empyema, cutaneous and mediastinal lymphadenitis, cellulites and osteomyelitis, the association with bronchial anthracofibrosis has not yet been reported. This report describes the first case of M. kansasii infection presenting as a lung mass in the right lower lobe with accompanying bronchial anthracofibrosis.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.31 no.2B
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• pp.187-192
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• 2011

Nitrate nitrogen is common contaminant in groundwater aquifers, its concentration is regulated many countries below 10 mg/L as N (As per WHO standards) in drinking water. An attempt was made to get optimal results for the treatment of nitrate nitrogen in groundwater by conducting various experiments by changing the experimental conditions for ZVI bipolar packed bed electrolytic cell. From the experimental results it is evident that the nitrate nitrogen removal is more effective when the reactor conditions are maintained in acidic range but when the acidic environment changes to alkaline due to the hydroxide formed during the process of ammonia nitrogen there by increasing the pH reducing the hydrogen ions required for reduction which leads to low effectiveness of the system. In the ZVI bipolar packed bed electrolytic cell, the packing ratio of 0.5~1:1 was found to be most effective for the treatment of nitrate nitrogen because ZVI particles are isolated and individual particle act like small electrode with low packing ratio. It is seen that formation of precipitate and acceleration of clogging incrementally for packing ratio more than 2:1, decreasing the nitrate nitrogen removal rate. When the voltage is increased it is seen that kinetics and current also increases but at the same time more electric power is consumed. In this experiment, the optimum voltage was determined to be 50V. At that time, nitrate nitrogen was removed by 94.9%.

• The Journal of the Korea Contents Association
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• v.14 no.10
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• pp.514-526
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• 2014

The predominant concern of the study consist of: (1) whether Chinese young people think Korean Wave would lasts; (2) the direct effect of viewing degree of Korean contents on the sustainability of Korean Wave; (3) the mediation effect of liking for Korean Wave and receptiveness to foreign cultural inflow on that sustainability; (4) the moderating effect of sense of rivalry between Korean and China. The research is based on a survey conducted with 371 chinese people between high teen and early 30's, located in Guilin of Guangxi and Zhengzhou of Henan in China. The notable findings are as follow: While the group with strong rivalry does not have a direct effect of viewing degree on the sustainability for Korean Wave, the group with weak rivalrous sense and higher viewing degree of Korean contents predict shorter sustainability of Korean Wave, therefore, the moderating effect of sense of rivalry between Korea and China is significant .Next, liking for Korean Wave shows a full mediating effect among Chinese with weak rivalry and a partial mediating effect among them with strong rivalry. The mediating effect of receptiveness to foreign cultural inflow is non-significant.

• Journal of Broadcast Engineering
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• v.25 no.3
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• pp.405-417
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• 2020

Due to the popularization of the Extended Reality, research is actively underway to implement human motion in real-time 3D animation. In particular, Microsoft developed Kinect cameras for 3D motion information can be obtained without the burden of facilities and with simple operation, real-time animation can be generated by combining with 3D formats such as FBX. Compared to the marker-based motion capture system, however, Kinect has low accuracy due to its lack of estimated performance of joint information. In this paper, two algorithms are proposed to correct joint estimation errors in order to realize natural human motion in motion capture animation system in Kinect camera-based FBX format. First, obtain the position information of a person with a Kinect and create a depth map to correct the wrong joint position value using the human body segment length constraint information, and estimate the new rotation value. Second, the pre-set joint motion range constraint is applied to the existing and estimated rotation value and implemented in FBX to eliminate abnormal behavior. From the experiment, we found improvements in human behavior and compared errors between algorithms to demonstrate the superiority of the system.

• Proceedings of the Korean Society of Community Living Science Conference
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• 2009.09a
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• pp.97-97
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• 2009

본 연구에서는 초 중등 교원들의 농업 농촌에 대한 가치 인식 및 학교 현장에서의 학생 지도력을 높이기 위해 교원들에게 농촌어메니티에 대한 이론과 체험 학습을 제공하는 '농촌어메니티 체험 연수 프로그램'의 개발 적용하고, 프로그램의 효과를 분석하였다. '농촌어메니티 개념 및 정책 이해', '농촌어메니티 현장 이해 및 체험', '농촌어메니티 수업 적용'의 3개 영역으로 구성된 총 20시간의 교원연수 프로그램을 개발하였으며, '09. 7. 23. ~ 8. 13.까지 2박 3일씩 5차에 걸쳐 200명의 교사를 대상으로 연수 프로그램을 운영하고, 연수 전후 설문조사를 실시하여 그 결과를 분석하였다. 연수에 참여한 교원들의 인구통계학적 특성을 분석한 결과, 여성의 비율이 56.9%로 남성(43.1%)에 비해 높았으며, 일반교사의 비율(53.3%)이 부장교사(26.9%)나 교장 교감 (19.8%)의 비율에 비해 높았다. 연령 분포에서는 50대가 35.2%로 가장 많고, 40대가 32.7%를 차지하고 있었으며, 경력이 20년 이상인 교원들이 67.2%인 것으로 나타났다. 근무기관 분포에서는 초등학교 교원들이 54.8%로 가장 많았으며, 중학교, 고등학교 교원이 각각 20.3%, 18.8%인 것으로 나타났다. 근무지역 분포에서는 중소도시에서 근무하는 교원들이 70.6%로 대다수를 차지하고 있었으며, 농촌거주 경험이 있는 교원들이 64.8%인 것으로 분석되었다. 연수 참여 사전-사후 설문조사를 통한 인식 변화를 분석(Paired samples t-test)한 결과 참여 이후 '농업 농촌에 대한 관심 정도', '농업의 중요도에 대한 인식', '농촌의 생활 정주, 관광 휴양 여건에 대한 인식', '농촌어메니티에 대한 이해도'가 모두 개선된 것으로 나타났다. '농촌어메니티에 대한 중요도 인식'(5점 척도)에서는 환경자원, 자연자원, 역사자원, 경관자원, 시설자원, 경제활동자원, 공동체활동자원으로 분류된 37개의 세부자원들에 대한 중요도 인식이 연수 참여 이후 높아진 것으로 나타났다. 단, 환경자원 가운데 '수질'의 평균 점수는 사전 4.8671, 사후 4.8960로 유의미한 차이가 발견되지 않았다. 연수 전반에 대해 만족하는 교원의 비율이 98.5%로 나타났으며, 연수 이후 농업 농촌에 대한 이해도가 증가했다는 응답이 98.0%, 학생 지도력이 증가했다는 응답이 95.0%, 연수에서 학습한 내용을 학생지도시 활용하겠다는 응답이 97.5%로 집계되어, 개발된 연수 프로그램이 설계시 수립한 목적 달성에 기여하고 있는 것으로 분석되었다.

• The Journal of Internal Korean Medicine
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• v.37 no.1
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• pp.47-64
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• 2016

Objectives: In the present study, a genetic analysis was conducted to investigate the association of the expression of SNPs of EDN1 gene polymorphism with the clinical phenotype in bronchial asthma patients with either excess or deficiency syndrome.Methods: Ninety-four healthy control subjects and 52 asthma patients were included in this study. The asthma patients were divided into two groups: those with deficiency syndrome and those with excess syndrome. We searched the exonic and promoter areas of the EDN1 gene in the NCBI website SNPs with <0.01 minor allele frequency (MAF) and <0.01 heterozygosity. Pro programs were performed to obtain the odds ratio, 95% confidence interval, and p-value. Multiple logistic regression models were conducted to analyze the genetic data.Results: In our genotype and allele analyses, there were significant differences in the codominant 2 model of the rs3087459 SNP genotype and also in the CGG haplotype between the control group and the asthma group. Genotype and allele analyses were conducted between the deficiency and excess syndrome group. There were significant differences in the dominant and log-additive model and also in the frequency of C-alleles of rs3087459 SNP genotype. There were significant differences in codominant 1, dominant and log-additive model and T-allele of rs5370 SNP genotype. The AGG haplotype also revealed significant differences.Conclusions: EDN1 SNPs (rs3087459, rs5370) showed a significant association with symptomatic excess syndrome in Korean asthmatic patients.

• Journal of Life Science
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• v.28 no.1
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• pp.1-8
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• 2018

To confirm the function of lactate dehydrogenase (LDH) (EC 1.1.1.27, LDH), its metabolism was studied by activity, kinetics, and isozyme analysis in tissues of Ldh testis-specific C expressing mice (Mus musculus) maintained in a state of starvation for 48 hr and 96 hr. In skeletal muscle, liver, and eye tissues, LDH and LDH $A_4$ activity increased and anaerobic metabolism predominated. While LDH activity in the heart and kidney tissues decreased, LDH $B_4$ activity increased and aerobic metabolism predominated, producing pyruvic acid. In the testis tissue, LDH $C_4$ activity decreased. In the brain tissue, LDH activity increased, but the isozyme change was small and the amount of pyruvic acid decreased. $K{_m}^{PYR}$ increased in tissues other than kidney tissue, and the affinity for pyruvic acid decreased. Consequently, in Ldh-A and B-expressing tissues, the activities of isozymes with higher concentrations increased. However, in Ldh-A, B, and C-expressing tissue, $C_4$ decreased and the function of the tissue also decreased. In particular, LDH in brain tissue played a role as a pyruvate reductase. Therefore, this process might be the mechanism for producing energy in the state of starvation.

• Pediatric Infection and Vaccine
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• v.27 no.2
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• pp.90-101
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• 2020

Purpose: The multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) test developed recently can help detect enteric pathogens of acute gastroenteritis (AGE). This study aimed to investigate the epidemiology of pathogens in children with AGE using the multiplex RT-PCR. Methods: From May 2015 to June 2018, multiplex RT-PCR tests were performed to identify pathogens in the feces of pediatric patients diagnosed with AGE at a secondary hospital in Seoul, Korea. Results: Of the 1,366 stool samples examined for viral pathogens, 483 (35.3%) tested positive for ≥1 pathogen. Group A rotavirus (RV) was detected in 106 cases (7.8%). The positivity rate increased annually from 3.0% (8/263) to 16.7% (48/288) and surged in 2018 (P<0.001). Norovirus (NoV) GII was the most common viral pathogen (263/1,366, 19.3%), and the positivity rate did not increase during the 3 years. Of the 304 stool samples tested for bacterial pathogens, Campylobacter spp. was the most common bacterial pathogen (32/304, 10.5%), followed by Clostridium difficile (22/304, 7.2%) and Salmonella spp. (17/304, 5.6%). The positivity rate of these bacterial pathogens did not change significantly during the study period. Conclusions: NoV GII is the main pathogen in childhood AGE since the introduction of RV vaccine, yet the number of rotavirus-infected patients increased during our study, especially in 2018. Therefore, further research is needed including the possibility of emergence of novel RV strains. Campylobacter spp. is the predominant cause of bacterial AGE in children. For proper treatment, the clinical characteristics of the bacteria should be taken into consideration, and continuous monitoring is necessary.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.6
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• pp.649-656
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• 2011

A model for the numerical simulation of lithium-ion batteries (LIBs) is developed for use in battery cell design, with a view to improving the performances of such batteries. The model uses Newman-type electrochemical and transfer $theories^{(1,2)}$ to describe the behavior of the lithium-ion cell, together with the Levenberg-Marquardt optimization scheme to estimate the performance or design parameters in nonlinear problems. The mathematical model can provide an insight into the mechanism of LIB behavior during the charging/discharging process, and can therefore help to predict cell performance. Furthermore, by means of least-squares fitting to experimental discharge curves measured at room temperature, we were able to obtain the values of transport and kinetic parameters that are usually difficult to measure. By comparing the calculated data with the life-test discharge curves (SB LiMotive cell), we found that the capacity fade is strongly dependent on the decrease in the reaction area of active materials in the anode and cathode, as well as on the electrolyte diffusivity.