• The Journal of Korean society of community based occupational therapy
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• v.9 no.2
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• pp.13-22
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• 2019

Objective : The purpose of this technical research is to determine decline of episodic memory by normal aging focucing on object, spatial location, and temporal order memory. Methods : We allocated seventy-seven of healthy adults from twenty to eighty years old, and performed computer-based cognitive tasks which were consisted of the object, spatial location, and temporal order memory. We used OpenSesame(OpenSesame Inc, OR), put ten pictures people normally see in their daily life, and evaluated those aspects through asking the objects types, object spatial locations, and picture temporal orders from 10 sheets of the picture. Results : Object and spatial location memory were not affected by normal aging whereas, temporal order memory significantly decreased with normal aging. Specifically, temporal order memory for in their age of forty was significantly decreased compared with their age of twenty and object memory at their age of eighty was relatively high compared to spatial location and temporal order memory. We found out that temporal order memory worse fastest and object memory lasted longest. Conclusion : In this study, we confirmed characteristics of declines of episodic memory consisting of object, spatial location, and temporal order memory. Notably, we could specifically identify declines of spatial location and temporal order memory with normal aging previous studies investigated on a limited basis using conventional neuropsychological assessments. These findings would be helpful to screen impairment in episodic memory by normal aging and provide an evidence that cognitive intervention for healthy older adults needs to include spatial and temporal aspect of memory.

• Journal of Life Science
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• v.1 no.1
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• pp.2-14
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• 1991

활성산소 및 그의 반응산물들에 의해 노화가 진행되고, 특히 혈관의 노화인 동맥경화가 활성산소 및 지질과산화에 의해 유발된다면, 생체 내에서 끊임없이 생성되고 있고 경우에 따라 필수 불가결한 활성산소를 어떻게 잘 처리하는 가가 중요하다. 즉, 활성산소 발생정도에 대한 항산화능의 유도가 미치지 못한다면, 체내의 활성산소 및 그 생산물에 의해 노화, 동맥경화가 진행될 것이다. 활성산소의 생성계와 제거계의 balance가 잘 유지된다면 정상적인 노화로 자연사에 이르게 될 것이고, 이 balance가 깨어져 과도한 활성산소의 축적에 대해 제거계가 따르지 못할 경우에는 활성산소와 그 생산물에 의해 동맥경화와 비정상적인 노화가 진행될 것이다.

• Proceedings of the KSLP Conference
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• 1996.11a
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• pp.75-75
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• 1996

노화와 흡연에 따른 음성의 변화에 대하여 객관적인 음향 지표들을 측정함으로써, 노화와 흡연에 따른 정상적인 음성의 변화와 질병에 기인한 변화를 감별하는 지표를 제시하고자 본 연구를 시행하였다. 정상의 발성기관과 청력을 가진 20세 이상의 성인으로, 60세 이상군과 35세 이하군으로 남녀 각각 30명을 대상으로 CSL50-MDVP(Computerized Speech Lab50-Multidimensional voice program)을 이용하여 기본 주파수(Fundamental frequency), jitter, shimmer, NHR(Noise to harmonic ratio)을 측정하였다. (중략)

• Journal of Life Science
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• v.10 no.3
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• pp.254-261
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• 2000

In order to observe the bioactivity of ovariectomized rats, ovariectomized group (Ovx), nonovariectomized group (Sham), ovariectomized Vitamin C-treat group (Ovx+Vit C), ovariectomized Vitamin E-treat group (Ovx+Vit E) and ovariectomized Vitamin C+Vitamin E-treat group(Ovx+Vit C+E) were made. Lipidperoxides of liver and kidney, serum total cholesterol and HDL-cholesterol were investigate as follows. Lipidperoxides of liver and kidney in Ovx group were 1.78 times and 1.61 times increased compared to Sham group respectively. But, they were significantly decreased in Ovx+Vit C group, Ovx+Vit E group, Ovx+Vit C+E group compared to Ovx group. Serum total cholesterol in Ovx group was increased 2.57 times compared to Sham group. Injections of each substance such as ascorbate, tocopherol, mixture (C+E) make data of Cholesterol become low. When especially Vit C is injected, the data of cholesterol lowed by about 94%. Serum HDL-cholesterol in Ovx group decreased 36.7% compared to Sham group. And as the result of the measurement of SOD, Catalase, and GPx which are antioxidant enzyme, SOD and Catalase activities in Ovx group much higher than in Sham group. Based on the results, it is supposed that more produced free radicals increased antioxidant enzyme. And it is also thought that vitamin can inhibit aging by reducing antioxidant enzyme.

• The Zoological Society Korea : Newsletter
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• v.18 no.1
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• pp.10-15
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• 2001

사람의 체세포가 분열수명에 한계가 있다는 것은 1960년대 초기에 보고되었으며 이것은 artifact가 아니며 세포자신이 가지는 프로그램에 의한 것임이 보고된 것은 최근의 일이다. 그러나 이 프로그램 안에 체세포가 실지로 증식을 정지하는 시기, 모든 세포노화의 타이밍이 어떻게 설정되는가\ulcorner 에 대해서는 아직 알 수 없다. 한편 노화세포가 왜 증식할 수 없는가\ulcorner 에 대해서는 세포주기를 조절하는 유전자에 관한 최근의 연구에 의해 상당부분 밝혀졌다. 또한 분열회수를 인식하는 분열시계의 진행은 세포증식을 억제하는 유전자의 발현을 촉진하여 증식을 정지시킨다. 분열시계를 정지시킨 세포는 기본적으로 무한히 분열하는 것이 가능하다. 분열시계를 정지시키는 주역은 telomerase이다. 정상 세포에서는 생식소(生殖巢)에 존재한다. 대부분의 정상체세포, 세포조직에는 없으나 대부분의 암에서 존재한다. 본 논단에서는 전반부에 노화를 후반부에 암에 관해서 분자세포생물학 차원에서 최근 연구성과를 중심으로 살펴보고자 한다.

• Journal of radiological science and technology
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• v.30 no.4
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• pp.407-417
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• 2007

The purpose of this study is to determine whether change of the lumbar intervertebral disc diameters and size is a risk factor for development of lumbar disc lesion and this changes are associated with aging. The L4-5 and L5-S1 intervertebral disc diameters and size were measured in 50 normal subjects and 50 low back pain patients in the age range $20{\sim}60$ by MRI. The data were analysed with independent t-test to differentiation between normal subjects and low back patients. We also analysed with one-way ANOVA, Pearson correlation and simple linear regression to differentiate between different age ranges. This study has shown that older subjects of both normal and low back pain patients have significantly larger transverse diameters and sizes of the L4-5 and L5-S1 intervertebral disc, compared with those of younger subjects. In addition, low back pain patients's disc sizes were larger than normal subjects but there was statistically no significant difference. The measurement of the intervertebral disc size can be considered as a clinically useful method for diagnosis of the low back pain and aging of the intervertebral disc. However, further study should be conducted to establish normal value of intervertebral disc size on large number of subjects.

• The tire
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• s.225
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• pp.21-22
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• 2005

지난 봄 주요 자동차 제조사인 Ford사와 Daimler Chrysler사가 '정상적으로 6년 사용된 타이어는 교체되어야 한다'는 권고사항을 운전자 메뉴얼 등에 삽입할 것이라고 발표한 이래, 타이어 노화와 수명관련 논란은 계속되고 있다.

• The Korean Journal of Pharmacology
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• v.27 no.1
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• pp.33-43
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• 1991

To study the age dependent change of Na, K-ATPase in the erythrocyte of hypertensive rat, 1-kidey 1-clip hypertensive rat was made by the removal of right kidney and partial ligation of left renal artery. After 4 weeks, aged erythrocyte fraction was separated by density gradient centrifugation, and Na, K-ATPase activity and $^3H-ouabain$ binding with ghost cell membrane and ouabain sensitive Rb-uptake with whole cell were measured. 1) In the hypertensive rats, blood pressure was significantly increased to 165.5/119.0 mmHg (systolic/diastolic). Mean corpuscular volume and membrane protein(mg) per $10^9RBC$ were decreased and hemoglobin content was increased in the aged erythrocyte. 2) Na, K-ATPase activity in the solution containing 110 mM NaCl and 10 mM KCI, was decreased in hypertensive rat, and decreased in aged erythrocyte of both group. 3) Ouabain sensitive Rb-uptake by low RbCl concentration(4 mM) was slightly decreased in aged erythrocyte compared to that in young erythrocyte of each group, but slightly increased in young erythrocyte in hypertensive rat compared to that in normotensive rat. 4) Ouabain sensitive Rb-uptake by high RbCl concentration(16 mM) was decreased about 30% to 50 % in aged erythrocyte in both group. And in hypertensive rat, especially in young erythrocyte it was significantly decreased compared to that in normotensive rats. 5) $^3H-ouabain$ binding at 0.13 or $1{\times}10^-6M$ ouabain concentration was slightly decreased in aged erythrocyte of normotensive rat, and significantly decreased in aged erythrocyte of hypertensive rats. 6) $^3H-ouabain$ binding at 6 or $64{\times}10^-6M$ ouabain concentration is slightly decreased in aged erythrocyte of both group, but significantly decreased in young and aged erythrocyte of hypertensive rats compared to that of normotensive rats. The present results suggest that (1) in the young erythrocyte of hypertensive rat, the alterations of Na-pump activity that slightly increased in weak stimulation and inhibited in strong stimulation, may be related to increased molecular activity and the decrease in the number of low affinity site without change in high affinity site, (2) in the aged erythrocyte of normotensive rat, inhibited Na-pump may be related to the change in molecular activity of pump. (3) And in the aged erythrocyte of hypertensive rat, it may be related to the decrease in the number of high and low affinity site as well as the change in molecular activity

• Journal of the KSME
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• v.33 no.5
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• pp.414-420
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• 1993

원자력 발전소의 운전환경에 따른 노화손상은 발전소 운전 내력에 연류된다. 통상SCC는 40년 또는 40년 이하의 수명을 가정하여 이에 따른 설계 여유도나 안전 계수를 기초로 하여 설계된다. 그러나 설계여유도나 안전계수는 운전중 변경될 수도 있다. 원자력 발전소 기기의 변경될 수도 있다. 원자력 발전소 기기의 수명평가를 위해서는 초기설계치 및 잔여수명이나 실제 설계치의 변화 등을 평가하여야 한다. 주요 물성치 및 손상 매개변수의 실제 변경 상황은 수명기간 설정에 근간이 된다. SSC의 수명평가를 위해 재료의 노화손상은 철저히 파악되어야 한다. 또한 기계적 하중, 열적하중 등의 노화 촉진요인과 정상운전 및 시험도 노화손상에 영향을 미치므로 이들에 대해 상세 평가를 수행하여야 한다. 수명평가는 운전환경 및 노화촉진요인들과 밀접한 관련이 있으므로, SSC의 수명을 평가하기 위해서는 이러한 복잡한 변수들 사이의 연관관계를 구체적 으로 고려하여야 한다. 그러므로 SSC의 수명을 평가하기 위해서는 이러한 복잡한 변수들 사이의 연관관계를 구체적으로 고려하여야 한다. 그러므로 SSC의 설계, 제작, 설치, 시험, 운전상태 및 보수주기 등에 대한 정보파악이 선행되어야 한다.

• Korean Journal of Cognitive Science
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• v.24 no.1
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• pp.1-24
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• 2013

The elderly population continues to increase in Korea and there has been a growing interest in understanding normal aging. In response to this public interest, the present paper reviewed human aging research focusing on recently published neuroimaging studies. For the first half of the paper, I reviewed the effects of aging on the brain and cognition. In normal aging, structural changes in the brain include atrophy and volume reduction in the prefrontal and temporal cortices. Functional changes are exhibited in the form of overactivation of the brain. Moreover, age-related cognitive decline is particularly observed in inhibition and memory, which are also associated with the age-related structural changes in the brain. For the second half of the paper, I introduced physical exercise studies showing that exercise played a protective role in the age-related neurocognitive decline. More specifically, engaging in physical exercise (particularly, aerobic exercise) for a relatively long period of time (e. g., > 6 mon.) protected older adults from volume loss in the prefrontal cortex and the hippocampus, and induced better inhibition and memory. These exercise-induced benefits appear to be associated with changes in neuronal levels, indicating that the aging brain is still plastic and this plasticity can be enhanced by physical exercise.