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An analysis of benzoic acid, methyl paraben and butyl paraben in soy sauce using isotope dilution liquid chromatography mass spectrometry (동위원소희석 질량분석법을 이용한 간장 중의 안식향산, 메틸파라벤, 부틸파라벤의 분석)

  • Ahn, Seonghee
    • Analytical Science and Technology
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    • v.31 no.6
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    • pp.225-231
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    • 2018
  • Benzoic acid, methyl paraben, and butyl paraben are preservatives that have been used in pharmaceutical, cosmetic, and food products. However, as their toxicities for human have been reported, many nations and organizations including Korea have established a regulation limit for thier usage of these preservatives in food products. The present study developed the isotope dilution liquid chromatography mass spectrometry method for accurate determination of three target preseratives in soysauce. In this study, the isotope dilution liquid chromatography mass spectrometry method was developed for accurate determination of three target preservatives in soy sauce. LC separation was optimized considering the pKa of benzoic acid which is lower than those of methyl and butyl parabens. A C18 column was used with 5 mM ammonium acetate and methanol as mobile phases. Mass spectrometry was operated in negative mode and selected reaction monitoring mode (SRM). Soy sauce sample was cleaned-up with C18 SPE cartridge for removing matrix inferences and color material. Optimized conditions and the method were validated with soy sauce reference materials for the analysis of food preservatives from Health Science Authority in Singapore. The measured values of benzoic acid, methyl and butyl paraben agreed well with reference values within their uncertainties.

Development and Validation of Analytical Method for Decursin in Aerial Parts of Angelica gigas Nakai Extract (참당귀 지상부 추출물의 지표성분 decursin의 분석법 개발 및 검증)

  • Kim, Hee-Yeon;Lee, Ki-Yeon;Kim, Tae-Hee;Park, A-Reum;Noh, Hee-Sun;Kim, Si-Chang;Ahn, Mun-Seob
    • Journal of Food Hygiene and Safety
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    • v.34 no.1
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    • pp.52-57
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    • 2019
  • Method development and validation of decursin for the standardization of Angelica gigas Nakai as a functional ingredient and health food were accomplished. The quantitative determination method of decursin as a marker compound of aerial parts of Angelica gigas Nakai extract (AAGE) was optimized by HPLC analysis using a C18 column ($3{\times}150mm$, $3{\mu}m$) with 0.1% TFA in water and acetonitrile as the mobile phase at a flow rate of 0.5 mL/min and detection wavelength of 330 nm. The HPLC/PDA method was applied successfully to quantification of the marker compound in AAGE after validation of the method with linearity, accuracy, and precision. The method showed high linearity in the calibration curve at a coefficient of correlation ($R^2$) of 0.9994 and the limit of detection and limit of quantitation were $0.011{\mu}g/mL$ and $0.033{\mu}g/mL$, respectively. Relative standard deviation (RSD) values of data from intra- and inter-day precision were less than 1.10% and 1.13%, respectively. Recovery of decursin at 0.5, 1, 5 and $10{\mu}g/mL$ were 92.38 ~ 104.11%. These results suggest that the developed HPLC method is very useful for the determination of marker compound in AAGE to develop a health functional material.

Non-parametric Trend Analysis Using Long-term Monitoring Data of Water Quality in Paldang Lake (장기 모니터링 자료를 이용한 팔당호 수질변화의 비모수적 추세분석)

  • Cho, Hang-Soo;Son, Ju-Yeon;Kim, Guee-Da;Shin, Myoung-Chul;Cho, Yong-Chul;Shin, Ki-Sik;Noh, Hye-Ran
    • Journal of Environmental Impact Assessment
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    • v.28 no.2
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    • pp.83-100
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    • 2019
  • This study, we conducted a non-parametric trend test (Seasonal Kendall tests, LOWESS) and Cross Correlation. We aimed to identify water quality trends using the weekly data for 9 variables (Water Temperature, EC, DO, BOD, COD, T-N, T-P, TOC and Chl-a) collected from 4 sites in the Paldang Lake from 2004.01 to 2016.12. According to the Seasonal Kendall test, Water temperature increased but EC, T-N and T-P decreased trend. LOWESS showed that BOD was gradually decreased from 2013 to 2016. but COD gradually increased between 2012 and 2016. As a result, it was confirmed that the period between 2012 and 2013 was a turning point in the increase of COD along with the decrease of BOD at all sites in Paldang Lake. Results of Cross Correlation showed that there was no time difference between all of Water variables and Sites. In this study, it is necessary to analyze the cause of the transition period and to monitoring the water quality more precisely for better water quality management in Paldang Lake.

Detecting Surface Changes Triggered by Recent Volcanic Activities at Kīlauea, Hawai'i, by using the SAR Interferometric Technique: Preliminary Report (SAR 간섭기법을 활용한 하와이 킬라우에아 화산의 2018 분화 활동 관측)

  • Jo, MinJeong;Osmanoglu, Batuhan;Jung, Hyung-Sup
    • Korean Journal of Remote Sensing
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    • v.34 no.6_4
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    • pp.1545-1553
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    • 2018
  • Recent eruptive activity at Kīlauea Volcano started on at the end of April in 2018 showed rapid ground deflation between May and June in 2018. On summit area Halema'uma'u lava lake continued to drop at high speed and Kīlauea's summit continued to deflate. GPS receivers and electronic tiltmeters detected the surface deformation greater than 2 meters. We explored the time-series surface deformation at Kīlauea Volcano, focusing on the early stage of eruptive activity, using multi-temporal COSMO-SkyMed SAR imagery. The observed maximum deformation in line-of-sight (LOS) direction was about -1.5 meter, and it indicates approximately -1.9 meter in subsiding direction by applying incidence angle. The results showed that summit began to deflate just after the event started and most of deformation occurred between early May and the end of June. Moreover, we confirmed that summit's deflation rarely happened since July 2018, which means volcanic activity entered a stable stage. The best-fit magma source model based on time-series surface deformation demonstrated that magma chambers were lying at depths between 2-3 km, and it showed a deepening trend in time. Along with the change of source depth, the center of each magma model moved toward the southwest according to the time. These results have a potential risk of including bias coming from single track observation. Therefore, to complement the initial results, we need to generate precise magma source model based on three-dimensional measurements in further research.

A Study on the Migration of Heavy Metals from Polycarbonate Food Contact Materials Using an Inductively Coupled Plasma Mass Spectrometry (ICP-MS) (식품용 폴리카보네이트 기구류 중 ICP-MS를 이용한 중금속 이행량 조사)

  • Park, Se-Jong;Park, So-Ra;Kim, MeeKyung;Choi, Jae Chun
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.24 no.3
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    • pp.107-112
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    • 2018
  • The purpose of this study was to investigate the migration levels of lead (Pb), cadmium (Cd) and arsenic (As) from polycarbonate food contact materials into food simulant at different temperatures ($70^{\circ}C$ and $100^{\circ}C$). The method was validated by linearity of calibration curves, limit of detection (LOD), limit of quantification (LOQ), recovery, precision and uncertainty. All of 200 samples, including bottles, cups, containers, ladles, spoons and tongs were purchased from domestic markets and analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Mean concentrations of positive samples were higher at $100^{\circ}C$ than $70^{\circ}C$ as showing a dependency of migration temperature. The migration concentrations ranged from not-detected (ND) to $4.67{\mu}g/L$, ND to $0.49{\mu}g/L$L and ND to $2.91{\mu}g/L$ for Pb, Cd and As, respectively, which were far below the migration limits of Korea standards and specifications for food utensils, containers and packages.

Digital Gravity Anomaly Map of KIGAM (한국지질자원연구원 디지털 중력 이상도)

  • Lim, Mutaek;Shin, Younghong;Park, Yeong-Sue;Rim, Hyoungrea;Ko, In Se;Park, Changseok
    • Geophysics and Geophysical Exploration
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    • v.22 no.1
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    • pp.37-43
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    • 2019
  • We present gravity anomaly maps based on KIGAM's gravity data measured from 2000 to 2018. Until 2016, we acquired gravity data on about 6,400 points for the purpose of regional mapping covering the whole country with data density of at least one point per $4km{\times}4km$ for reducing the time of the data acquisition. In addition, we have performed local gravity surveys for the purpose of mining development in and around the NMC Moland Mine at Jecheon in 2013 and in the Taebaeksan mineralized zone from 2015 to 2018 with data interval of several hundred meters to 2 km. Meanwhile, we carried out precise gravity explorations with data interval of about 250 m on and around epicenter areas of Gyeongju and Pohang earthquakes of relatively large magnitude which occurred in 2016 and in 2017, respectively. Thus we acquired in total about 9,600 points data as the result. We also used additional data acquired by Pusan National University for some local areas. Finally, gravity data more than 16,000 points except for the repetition and temporal control points were available to calculate free-air, Bouguer, and isostatic gravity anomalies. Therefore, the presented anomaly maps are most advanced in spatial distribution and the number of used data so far in Korea.

Rhythmic Tapping Task Performance in Children With Autism Spectrum Disorder: A Meta-Analysis (자폐스펙트럼장애 아동 대상 리드믹 운동과제 평가 연구 메타분석)

  • Yoo, Ga Eul;Yoon, Ye Eun
    • Journal of Music and Human Behavior
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    • v.16 no.1
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    • pp.47-72
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    • 2019
  • This study reviewed and analyzed English-written studies using a rhythmic tapping task for motor control of children with autism spectrum disorder (ASD). Inclusion criteria for the participants were children with ASD and typically developing (TD) children. The keywords used for the outcome variables included rhythmic tapping, timed movement, and synchronization. Ten studies were included in the final analysis. The included studies were analyzed in terms of target variables, auditory stimuli, and measurements. A meta-analysis was also conducted to examine how children with ASD performed rhythmic tapping tasks compared to children with TD. In the identified studies, five variables were used: timed movement control, timing reproduction, bimanual coordination, synchronization, and interpersonal synchronization. It was found that rhythmic tapping performance was analyzed in terms of accuracy and precision of the movement and reported as significantly correlated to social skills measures. The meta-analysis results showed that there were no significant differences between the ASD and TD groups in continuing rhythmic movements when the presented auditory stimuli ended, whereas there were significant group differences in their ability to maintain their motor performance consistently and to synchronize with auditory cue or with others. These results support the rhythmic tapping task as an effective measure for not only motor control but also social skills development in children with ASD.

The Effects of the Government Funding on Venture Firms' Management Performance: Focusing on the Mediation Effect of Firms' Internal Competencies and the Moderation Effect of Firm's Growth Stage (정부지원자금이 벤처기업의 경영성과에 미치는 영향에 관한 연구: 내부역량의 매개효과와 기업 성장단계의 상호작용효과를 중심으로)

  • Lee, Younghun;Song, Eugene
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.14 no.2
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    • pp.31-46
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    • 2019
  • As the importance of venture firms has increased as a new growth engine, the South Korea government makes various efforts to establish healthy ecosystems for ventures and start-ups. Especially in order to foster the competitiveness of venture firms, various support policies such as financial and R&D expenses are being expanded and promoted. In this study, the author analyzed the impact of government funding on venture firms' internal competencies and management performance by using the resource-based theory. Moreover, this study tested the moderation effect of firm's growth stages. Unlike previous studies, this study focused on qualitative rather than quantitative aspects of internal competencies and the financial and non-financial performance are used to measure the management performance of the ventures to examine the effects of government funding for venture firms in more details. For the purpose of verifying the hypothesis of this research, "The Research On The Precision Status Of Venture Firms" in 2017 from the Ministry of Small and Medium Business was utilized, which has been compiled since 1999. According to the results of this study, the government funding experience did not significantly affect the company's internal competencies and financial performance, but had a significant impact on the non-financial performance, which in turn seemed to have a significant effect on the financial performance. In addition, it was found that the technology, price, design, and quality competencies affected non-financial performance, while the organizational management and marketing competencies did not. However, the price, design, organizational management, and marketing competencies affected financial performance, while the technology competency was not. Finally, there were no differences in the effectiveness of government funding, depending on the growth stages.

Application of Drone for Analysis of 2D Pollutant Mixing in River (하천에 유입된 오염물질의 2차원 혼합 분석을 위한 드론의 활용)

  • Seo, Il Won;Baek, Donghae
    • Proceedings of the Korea Water Resources Association Conference
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    • 2017.05a
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    • pp.100-100
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    • 2017
  • 하천에 유입된 오염물질의 2차원 혼합거동은 하천 주흐름에 의한 이송현상과 유속 성분의 수심평균 값에 대한 공간적 편차로부터 야기되는 분산현상으로 설명 할 수 있다. 이는 3차원 이송확산 방정식으로부터 수심 적분된 2차원 이송-분산 방정식으로 수학적 유도가 가능하며, 수심방향으로 적분하는 과정에서 발생되는 농도의 분산항은 Taylor Dispersion 개념에 기초하여 종방향 및 횡방향의 2차원 분산계수로 표현된다. Fischer(1978)는 연직방향 유속분포로부터 2차원 분산계수를 추정하는 해석해를 수학적으로 유도하였으나, 실제 하천에서 정밀한 연직방향 유속분포를 계측하는 것은 많은 비용 및 노동력을 초래한다. 따라서 선행 연구자들은 2차원 혼합모형의 분산계수를 산정하고자 실험적 방법으로써 추적자실험을 수행하였다. 추적자실험은 추적자 물질을 수체에 주입한 후 농도의 변화를 관측함으로써 추적자물질이 하천에서 이송 및 분산되는 과정을 이해하는데 유용하다. 기존의 추적자실험은 고정된 위치에서 농도를 계측하여 시계열적인 농도의 변화를 관측한 후, 오염운 동결가정을 통해 종,횡방향 분산계수의 산정이 가능하지만, 오염물질 농도의 공간적 분포를 얻기에는 한계가 있다. 본 연구에서는 기존의 추적자실험법의 한계를 극복하고자 형광물질을 이용한 추적자실험을 수행함과 동시에 드론에 장착된 디지털카메라를 이용하여 항공영상을 취득 및 분석하여, 하천에 주입된 형광물질의 농도분포를 시공간적으로 추출하는 기법을 개발하고, 이를 바탕으로 오염물질의 2차원 혼합거동을 분석하였다. 본 실험은 한국건설기술연구원의 안동하천실험센터의 A3실험수로에서 수행되었으며, 실험수로는 평균 하폭 5 m, 평균 수심 0.44 m, 유량 $0.96m^3/s$의 실제 소규모 하천과 유사한 축척을 가지고 있다. 추적자물질은 Rhodamine WT 용액이 사용되었으며, 실험수로 내 설치된 15개의 형광광도계(YSI-600OMS)를 이용하여 농도를 측정하였다. 항공영상의 취득을 위해 이용된 드론은 DJI-Phantom 3 Professional 이며, 3840x2160의 해상도로 초당 30 frame의 동영상으로 취득되었다. 영상의 정합 및 좌표화를 위해 RTK-GPS를 이용하여 12개의 지상 기준점의 좌표를 취득한 후, 사영변환을 통해 영상좌표를 지상좌표로 변환하였다. 영상의 픽셀값을 농도장으로 변환하기 위해 각 RGB 밴드의 픽셀값을 통계적으로 분석하여 농도장으로 변환하였으며, 영상으로부터 얻은 농도장은 형광광도계에 의해 실측된 농도와 결정계수 0.9이상의 수준으로 정확도를 나타냈다.

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Accuracy Analysis for Slope Movement Characterization by comparing the Data from Real-time Measurement Device and 3D Model Value with Drone based Photogrammetry (도로비탈면 상시계측 실측치와 드론 사진측량에 의한 3D 모델값의 정확도 비교분석)

  • CHO, Han-Kwang;CHANG, Ki-Tae;HONG, Seong-Jin;HONG, Goo-Pyo;KIM, Sang-Hwan;KWON, Se-Ho
    • Journal of the Korean Association of Geographic Information Studies
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    • v.23 no.4
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    • pp.234-252
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    • 2020
  • This paper is to verify the effectiveness of 'Hybrid Disaster Management Strategy' that integrates 'RTM(Real-time Monitoring) based On-line' and 'UAV based Off-line' system. For landslide prone area where sensors were installed, the conventional way of risk management so far has entirely relied on RTM data collected from the field through the instrumentation devices. But it's not enough due to the limitation of'Pin-point sensor'which tend to provide with only the localized information where sensors have stayed fixed. It lacks, therefore, the whole picture to be grasped. In this paper, utilizing 'Digital Photogrammetry Software Pix4D', the possibility of inference for the deformation of ungauged area has been reviewed. For this purpose, actual measurement data from RTM were compared with the estimated value from 3D point cloud outcome by UAV, and the consequent results has shown very accurate in terms of RMSE.