• Herbal Formula Science
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• v.27 no.4
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• pp.269-284
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• 2019

This study was to investigate whether cultivated ginseng (CG), cultivated wild simulated ginseng (CWG) and cultivated red ginseng (CRG) extracts influences on the obesity. The saponin contents of 3 kinds of ginsengs were analysed by HPLC-ESI-TOF-MS. Total saponin contents were determined in CG on the most contents and since red ginseng has the highest PD (protopanaxadiol type) / PT (protopanaxatriol type) ratio, there may be differences between ginseng, wild ginseng, and red ginseng with respect to their pharmacological effects. Male C57BL/6J mice were fed a normal diet(N), HFD (60% Kcal fat, C), HFD with CG, CWG and CRG extracts (800 mg/kg) for 5 weeks. We observed change of total body weight, degree of hepatic lipid accumulation and immunohistochemical change of GLP-1 and insulin-secreting cells. Also this study attempts to use the physiological analysis method to analyze the changes of blood lipids, insulin and leptin concentration. The change of body weight and size of accumulated lipid droplets in liver lobules decreased in all of the experimental groups than the control(C) group. In the pancreas, the immunohistochemical density of insulin-secreting cells were significantly stronger in the CWG and CRG than C group. The levels of serum insulin and leptin significantly decreased 55.6%, 54.3% respectively in CWG and CRG. The changes of triglyceride, total cholesterol in serum decreased in CRG than the C group. Obesity related CG, CWG and CRG extracts might have contribute to improvement of obesity by regulating the levels of blood lipids and biochemical indicator of fat accumulation.

• Journal of the Korean Geotechnical Society
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• v.28 no.8
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• pp.43-53
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• 2012

In the conventional design of a piled raft, the axial resistance offered by the raft itself is typically neglected and only that of the group pile is accounted in estimating the total axial resistance of the piled raft. As a consequence, piled rafts are usually designed conservatively by neglecting the raft resistance. In this study, a series of centrifuge model tests have been performed to compare the axial behavior of a group pile with that of a piled raft (both having 16 component piles with an array of $4{\times}4$) in sands with different relative densities and in clays with different preconsolidated pressures. The test results revealed that, with respect to the allowable settlement of 25 millimeters for bridge foundations, the piled raft resistances were greater than those of the group pile by 13% for dense sand, by 22% for loose sand, by 30% for stiff clay, and by 22% for soft clay. Furthermore, the ratio of piled raft resistance to group pile resistance increased as the settlement increased.

• Korean Journal of Health Education and Promotion
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• v.11 no.1
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• pp.3-15
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• 1994

This study was conducted to investigate changes of knowledge and attitude toward AIDS of soldier through health education. The sample was selected with and experimental group(160 persons who were received health education group) and control group(160 persons who were not received), 20-21 years of age from 320 persons(soldier) who were between in a certain base located in Kyung Gi province. The data was collected from 24th Feb. to 21st April 1993. By questionnaires before and post test for education process about 4 weeks(pre and post test). The results of this study were as follows ; Of 320 soldiers 66.6% had received health education on sex before attending in base, 58.8%(94 persons) of experimental group and 58.1%(93 persons) had experience with sexual intercourse. In characteristics related to sexual intercourse experience, age of first sexual intercourse for experimental group was 19 in highest percentage as 30.0%, 18 in control group, 64.9% of experimental group and 61.4% of control group answered no use condom during sexual intercourse. About the reasons why use condom 51.5% of experimental group answered to prevention of VD and 44.4% of control group answered to prevention of partner's pregnancy in the highest percentage. There was no significant difference between mean score of knowledge level of experimental group and mean score of control group in pre-test. There was significant difference between mean score(15.23) of experimental group and mean score(12.98) of control group(p<0.01) in post-test. The attitude level in pre, post education was mean score 11. There was significant difference between mean score(9.04) of experimental group in pre-test and mean score(9.39) in post education(p<0.05), There was also significant difference between mean score(9.16) of control group in pre-test and mean score(9.60) in post-test(p<0.05), Mean score of perceived susceptability level of experimental group decreased from mean score 2.84 in pre-test to 2.66 in post-test, there was no significant difference between mean score of pre-test and that of post-test in 2 group. There was no significant difference between mean scores of perceived severity of experimental group in pre-test and that in post-test and there was no significant difference between mean score of perceived severity of control group in pre-test and post-test. There was no significant differences between mean scores of perceived benefits to act health behavior of experimental group or control group and pre-test and post-test.

• Journal of Korean Medicine Rehabilitation
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• v.19 no.2
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• pp.51-72
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• 2009

Objectives : This study was designed to evaluate the effects of Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul pharmacopuncture on pain reduction and nerve regeneration after crush injury in rat sciatic nerve. Methods : Animal model was produced through crush injury of right sciatic nerve and they were divided into four groups; Group I: no treatment control group; Group II: experimental group treated with Ohyaksungi-san(Wuyaoshungi-san); Group III: experimental group treated with Jungsongouhyul pharmacopuncture; Group IV: experimental group treated with Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul pharmacopuncture. For the assessment of pain, this study was observed the paw withdrawal latency(PWL) and immunoreactivity on the substance-P. For the assessment of nerve regeneration, the sciatic functional index(SFI) and immunoreactivity on the BDNF were measured. Results : 1. In the assessment of pain, the PWL of experimental groups was significantly higher than control group and group IV was significantly higher than other groups at the all days. 2. In immunohistochemical response of substance-P, as time passes, the immunoreactivity of all groups were decreased gradully. Especially, group IV had the lowest immunoreactivity. 3. In the assessment of SFI, the SFI of experimental groups were significantly higher than control group. 4. In immunohistochemical response of BDNF, the BDNF immunoreactivity of all groups was significantly higher than control group and especially, group IV had the highest immunoreactivity at the 14 days after injury. 5. H & E stain was used on the liver and kidney to investigate toxic effect of Jungsongouhyul pharmacopuncture and Ohyaksungi-san(Wuyaoshungi-san) on on 21 days after injury. However there were no any toxic effects both control group and experimental groups. Conclusions : On the basis of these results, we propose that Ohyaksungi-san(Wuyaoshungi-san) and Jungsongouhyul pharmacopuncture were related to pain reduction and motor nerve recovery, also decreased substance-P expression and increased BDNF expression after crush injury of sciatic nerve, especially these two treatments could be more effective when they were combined simultaneously.

• Tuberculosis and Respiratory Diseases
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• v.65 no.4
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• pp.313-317
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• 2008

Lipoma is a common neoplasm in soft tissues. However, an intrapulmonary lipoma is a rare benign tumor. Patients with a bronchial lipoma might have a malignant potential related to their smoking history due to the case reports of lung cancer accompanied with lipoma. Endobronchial lipoma can cause irreversible parenchymal lung damage if not diagnosed and treated early. Therefore, it should initially be treated by fiberoptic bronchoscopy or surgery depending on the status of distal parenchymal lung damage. Bronchiolitis obliterans with organizing pneumonia (BOOP) is a pathological syndrome that is defined by the presence of buds of granulation tissue consisting of fibroblasts and collagen within the lumen of the distal air spaces. BOOP is caused by drug intoxication, connective tissue disease, infection, obstructive pneumonia, tumors, or an unknown etiology. We encountered a 58 year-old male patient with endobronchial lipoma, causing the collapse of the right middle and lower lobes, and BOOP due to obstructive pneumonia.

• The Journal of the Korea Contents Association
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• v.20 no.3
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• pp.298-308
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• 2020

This study was designed to verify reliability and feasibility by analyzing elderly drivers' ability test tools for older drivers aged 65 or older, which were improved in 2018 and are currently being conducted by the Korea Highway Traffic Authority. Only those aged 65 or older who voluntarily applied to the elderly driving ability evaluation system implemented by the Seoul branch of the Korea Highway Traffic Authority. The research was conducted for about 50 days until Aug. 31, 2018, starting with the registration and inspection of the first study subjects. The analysis performed a correlation analysis with existing tools and cognitive testing tools (MMSE_K) to determine their feasibility and reliability as an improved tool in 2018. As a result, the first, the speed distance, time-space memory, and dispersionism of each sub-component of the old version showed statistically significant static correlation with the sub-factor of the current version. Persistence, on the other hand, was not statistically significant to the current version. The limitations of this study were as follows. Most of the people in the study were highly educated and residents in the metropolitan area. Therefore, it is likely that the results of MSE_K, which checks cognitive and judgment skills, have been upgraded. Also, cognitive tools that are measured by computers are likely to have real measurement errors for generations who are not familiar with computers. Therefore, it is expected that improvement and development of tools for improving the limit points at the site and assessing actual operation capability will be required.

• Applied Microscopy
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• v.34 no.1
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• pp.1-11
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• 2004

The wound healing is very complex biological processing including inflammatory, reepithelialization and matrix construction. According to the biological systematic category, the ability of the healing is very different. Generally healing ability of the lower animal group has been known more excellent compared to its higher group. Therefore, lower animals have been used as the experimental model to explore the mechanism of the wound healing or repair. To verify histochemical characteristics of the wound healing, we have used skin of the frog (Bombina orientalis) as known common amphibian. At day 1, 10, and 16, the mucous substance was very actively synthesized and strong positive by PAS and Alcian blue (pH 2.5). Day 10 after wounding, margin of the wound was gradually strong positive by PTAH staining for detection of collagen synthesis. At 3 to 6 hour and day 23 to 27, we have found the cell division was active through the MG-P staining, in which the concentration and division of DNA in nucleus was green to deep blue color.

• Applied Microscopy
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• v.35 no.2
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• pp.65-72
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• 2005

The ultrastructure of submandibular gland was examined in the lesser white-toothed shrew, Crocidura suaveolens. The submandibular gland of C. suaveolens was a mixed gland composed of serous and mucous acinar cells. Secretory granules from the acini were discharged through the salivary ducts into the oral cavity. Serous and mucous acinar cells had well developed rough endoplasmic reticulum and mitochondria and large amount of granules. In case of serous acinar granules, an immature granule was formless and had only dense specks, and a matured granule was a complete round type delimiting by a single membrane and had a homogeneous dense center with dense specks on the border. In case of mucous acinar granules, while an immature granule was a round type and had an only homogeneous matrix and an indistinct limiting membrane, a mature granule was an even round type having a variety of pattern with several dense bands into the homogeneous matrix and had a distinct membrane. Therefore, a mature mucous acinar granule of C. suaveolens was not only distinct from those of the other mammalian species to have a variety of pattern but also from those of C. lasiura to have an even round type. A great serous-like secretory granules and Myelin-like body were observed in the cytoplasm and lumen of granular duct cells. Myelin-like body, a characteristic structure only reported in salivary gland of three shrews, was discharged from secretory cell into lumen by the manner of exocytosis which has little differences from discharging manner of secretory granules.

• Applied Microscopy
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• v.35 no.2
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• pp.57-64
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• 2005

The ultrastructure and histochemical characteristics of the submandibular gland was examined in the big white-toothed shrew, Crocidura lasiura. A submandibular gland of Crocidura lasiura was a mixed gland composed of serous and mucous acinar cells. Secretory granules from the acini were discharged through the intercalated duct, the granular duct and the striated duct into the oral cavity. Serous and mucous acinar cells and granular duct cells had large amount of rough endoplasmic reticulum, free ribosome and prominent Golgi apparatus at the basal cytoplasm of the cell, and many granules at the apical cytoplasm. Oval type serous granules had a homogeneously pale round shape of bead at the center. Mucous granules were distinct from those of the other mammalian species having variety patterns with several dense bands into homogeneous pale matrix. A serous-like secretory granules and myelin-like body were observed in the cytoplasm and the lumen of granular duct cells. The myelin-like body is a characteristic structure only reported in the salivary glands of two shrews, Suncus murinus and C. dsinezumi. Striated duct cell had numerous well-developed mitochondria but secretory granule was not shown at all.

• Food Science and Preservation
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• v.24 no.2
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• pp.312-319
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• 2017

In the present study, disinfection efficacy of slightly acidic electrolyzed water [SlAEW, 30 ppm of effective chlorine at $20{\pm}1^{\circ}C$, oxidation-reduction potential (ORP) $562{\pm}23mV$, pH 6.4] on 4 kinds of vegetables (lettuce leaf, endive leaf, perilla leaf and kale leaf) was evaluated to obtain a microbial reduction characteristics which are necessary to design a process control for non-thermal sterilization of fresh vegetables. Active chlorine, residual chlorine, microbial counts and residual microbial counts, which are the key factors in the non-thermal sterilization process were measured by dipping them in SlAEW three times for 30 minutes in order to analyze the relationship between factors. Total microbial count was decreased mostly during the first 10 minutes of washing, and the limit value that can be reduced by immersion treatment was 3 log CFU/g for the total microbial count surviving in 4 kinds of vegetables. The total number of microorganism that can be reduced by washing in SIAEW for 10 min was found to be about 2 log CFU/g on average. In addition, the active chlorine decreased in the initial 10 minutes in 2.2 ppm, 2.0 ppm, 1.7 ppm and 2.5 ppm in lettuce, perilla leaf, endive leaf and kale leaf, respectively, and about 50-80% of the chlorine was reduced in the initial 10 min appear.