• Polymer(Korea)
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• v.30 no.6
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• pp.512-518
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• 2006

A biodegradable polymer poly((R) -3-hydroxybutyric acid) (PHB) was conjugated with a hydrophilic polymer poly(ethylene glycol) (PEG) by the ttansesterification reaction to form the amphiphilic block copolymer. PHB with low molecular weight ($3000{\sim}30000$) was appropriated for the drug delivery materials. High molecular weight PHB was hydrolyzed by an acid-catalyst to produce the low molecular weight one. Amphiphilic block copolymer was formed the self-assembled polymeric micelle system in the aqueous solution that the hydrophillic PEG was wraped the hydrophobic PHB. Generally, polymeric micelle forms the small particle between $10{\sim}200nm$. These polymeric micelle systems have been widely used for the drug delivery systems because they were biodegradable, biocompatible, non-toxic and patient compliant. The hydroxyl group of PEG was substituted with carboxyl group which has the reactivity to the ester group of PHB. Amphiphilic block copolymer was conjugated between PHB, and modified PEG at $176^{\circ}C$ which was higher than the melting point of PHB. Transesterification reaction was verified with DSC, FTIR, $^1H-NMR$. In the aqueous solution, critical micelle concentration (CMC) of the mPEG-co-PHB copolymer measured by the fluororescence scanning spectrometer was $5{\times}10^{-5}g/L$. The shape and size of the nanoparticle was taken by dynamic light scattering and atomic force microscopy. The size of the nanoparticle was about 130 nm and the shape was spherical. Our polymeric micelle system can be used as the passive targeting drug delivery system.

• Journal of Korea Water Resources Association
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• v.48 no.5
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• pp.379-391
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• 2015

Multi-functional weirs has been installed in four rivers are hydraulic structures across the river. The structures were divided into movable and fixed weirs. Hence, riverbed-level variation and sediment transport can be varied due to water gate operation. In this study, the long-term riverbed-level variation of Geum river basin due to water gate operation of multi-functional weirs was studied. Result of this study shows that the variation of thalweg elevation was greater than the variation of annual average riverbed elevation due to multi-functional weirs construction and water gate operation. Maximum riverbed degradation of thalweg elevation that occurred was 2.79m and riverbed aggradation was 1.90m. Maximum riverbed degradation of the annual average riverbed elevation that occurred was 2.16m and riverbed aggradation was 1.24m. Analysis result of flood stage by the variation of riverbed-level shows that flood stages were increased in majorities area. The maximum increase in the value of flood stage was 2.23m. For this reason, flood stages can be greater than the freeboard of the levees. Therefore, we should consider the water gate operation of multi-functional weirs when planning and managing sediment in the river. We are expecting to use the result of this study in river planning for river management and selecting the river regime.

• Journal of Korea Water Resources Association
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• v.48 no.10
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• pp.807-816
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• 2015

In general, the water stage-discharge relationship curve is established based on the assumptions of linearity and homoscedasticity. However, the relationship between the water stage and discharge is affected from geomorphological factors, which violates the basic assumptions of the water stage-discharge relationship curve. In order to reduce the error due to the violations, the curve is divided into several sections based on the manager's judgement considering change of cross-sectional shape. In this research, the objective-splitting criteria of the curve is proposed based on the measured data without the subjective decision. First, it is assumed that the coefficient of variation follows the normal distribution. Then, if the newly calculated coefficient of variation is outside of the 95% confidential interval, the curve is divided. Namely, the groups is divided by the characteristics of the coefficient of variation and the reasonable criteria is provided for establishing a multi-segmented rating curve. To validate the proposed method, it was applied to the data generated by three artificial power functions. In addition, to confirm the applicability of the proposed method, it is applied to the water stage and discharge data of the Muju water stage gauging station and Sangegyo water stage gauging station. As a result, it is found that the automatically divided rating curve improves the accuracy and extrapolation accuracy of the rating curve. Finally, through the residual analysis using Shapiro-Wilk normality test, it is confirmed that the residual of water stage-discharge relationship curve tends to follow the normal distribution.

• Journal of Korea Water Resources Association
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• v.48 no.4
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• pp.269-279
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• 2015

Nowadays, the world has suffered by natural disaster of climate change due to global warming. Korea has also faced with similar situation. To prevent these natural disaster, Four Major River Management has conducted. One of conducted content in Four Major River Management is the levee maintenance which classified into fill-up the inland, levee of reinforcement and so on. These maintenances may make the characteristics of groundwater flow change and affect to the levee safety (piping phenomenon). Therefore, analysis on groundwater fluctuation according to level of riverside and inland should be required. This study focus on levee of Hoe stream, which is connected to Nakdong river, and piping safety factor in the levee analyzed by using pore water pressure. Besides, groundwater fluctuation, which is depended on level of riverside and inland, is simulated by using the SEEP/W (2D ground water model). This simulation considered steady flow and unsteady flow. As a result, piping safety factor increased due to rising the inland level. Piping safety factor of riverside was effected by only river water level. Therefore, external levee factor considering inland level raising and suitable control of river water level is need to increase piping safety factor.

• Journal of Korean Society for Geospatial Information Science
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• v.18 no.4
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• pp.21-30
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• 2010

In this paper, the parallel distributed rainfall runoff model(K-DRUM) using MPI(Message Passing Interface) technique was developed to solve the problem of calculation time as it is one of the demerits of the distributed model for performing physical and complicated numerical calculations for large scale watersheds. The K-DRUM model which is based on GIS can simulate temporal and spatial distribution of surface flow and sub-surface flow during flood period, and input parameters of ASCII format as pre-process can be extracted using ArcView. The comparison studies were performed with various domain divisions in Namgang Dam watershed in case of typoon 'Ewiniar' at 2006. The numerical simulation using the cluster system was performed to check a parallelization effectiveness increasing the domain divisions from 1 to 25. As a result, the computer memory size reduced and the calculation time was decreased with increase of divided domains. And also, the tool was suggested in order to decreasing the discharge error on each domain connections. The result shows that the calculation and communication times in each domain have to repeats three times at each time steps in order to minimization of discharge error.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2006.02a
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• pp.109-114
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• 2006

최근 Human 지놈 프로젝트를 포함한 다양한 종의 지놈 프로젝트가 수행되고 수많은 지놈정보가 생산되고 있으며 이를 해석하고 서로 연관성를 찾기 위한 다양한 연구가 진행되고 있다. 즉 최신 생명공학과 관련된 연구방향이 DNA의 구조적 해석에서 기능 해석과 유전자들의 상호연관성을 규명하는 방향으로 변화하고 있으며 이를 위한 강력한 도구로서 DNA microarray (DNA chip)는 방대한 양의 지놈 정보를 이용하여 단시간에 대량으로 고속처리하여 효율적으로 유전자 기능을 분석할 수 있는 주목받고 있는 방법이다. DNA microarray 실험과 분석에 있어 데이터분석, 재현성, 종간의 비교, 확인실험 및 비용 등의 문제가 있지만 유전자발현양상 데이터로부터 정확한 환자의 예후를 예측할 수 있는 비교적 적은 유전자 그룹의 진단마커를 찾거나, 하나의 유전자가 아니라 mouse 전체 지놈의 유전자발현 패턴을 인간의 암을 위시한 각종 질병 연구를 위한 발현 신호나 변화 등을 발견하여 신약개발 등에 활용하고자 하는 시도가 활발히 진행되고 있다. 서로 다른 종간에 비슷한 phenotype의 유전자발현도 진화적으로 보존되었다는 전제 하에서 지놈 sequence의 비교연구가 가능하고 DNA microarray 발현 데이터에 근거하여 독립적으로 각 종간의 유전자발현패턴을 비교함으로써 난치병 등을 새롭게 분류할 수 있다. 즉, 암세포 등에서 유전자발현 양상은 유전학적, 환경적 alteration들이 잘 반영되어 있다고 간주하고, 이러한 양상을 바탕으로 인간의 암을 위시한 다양한 질병 연구를 위한 최적의 mouse 모델을 찾을 수 있고, 이는 결국 새로운 치료 방법 개발이나 맞춤의학 실현에 중요한 역할을 할 것으로 기대된다. 특히 pathway 타겟으로 하는 치료를 위해서는 Human-mouse 비교를 통한 발현 신호를 찾는 것이 진단에서는 매우 유용한 방법이다. 이를 위한 고성능의 분석방법이나 시스템의 개발이 중요하게 된다.. 관류의 정도와 조영증강정도를 중심으로 관류 MR 영상소견과 조직학적 소견을 관련지어 분석하였다. 결과: 조영증강 T1강조MR영상에서 환상조영증강을 보이는 다형성 교보세포종 2예에서는 변연부 외륜이 고관류를, 중심부의 괴사부위는 저관류로 나타났다. 저등급 교종은 경계가 불분명한 저관류부위로 보였다. 뇌농양 2예는 변연부 외륜이 경도의 고관류를, 중심부는 저관류로 나타났다. 뇌수막종은 미만성의 균일한 중등도 혹은 고도의 고관류로 보였으며, 임파종과 배아종은 경계가 명확한 저관류부위로 나타났다. 신경세포종은 종괴\ulcorner 일부에 중등도 혹은 고도의 고관류부위가 관찰되었고, 전이암은 다수병변중 일부에서 중등도의 고관류를 보였다. 방사선괴사는 저관류부위내에 국소적 고관류부위를 보였다. 결론: 관류 MR영상은 뇌종양의 관류상태를 비교적 잘 반영하며, 조직학적 특성을 예측하는데에 도움을 주 수 있을 것으로 기대된다. 뇌종야에서의 관류MR영상의 분명한 역할을 규명하기 위해서는 앞으로 더 많은 임상적 연구가 필요할 것으로 생각된다.조증 환자의 자극성 전타액내 lactobacilli양은 peroxidase system을 함유한 세치제를 사용한 군에서 대조군에 비해 상대적으로 낮게 나타났으나(p = 0.067) 통계학적 유의성은 없었다.같은 예에서 찾아 볼 수 있다. 첫째, 발음상으로 동사의 변화형에서 "porte[$p{\jmath}rte$](들다: 현재형), porte[$p{\jmath}rte$](과거분사형), porta[$p{\jmath}rte$](단순과거형)"등이 대립되며, 이휘 "Porto[$p{\jmath}rte$](포르토)"와도 대립된다. 둘째, 어휘적 대립 "le haut[$l{\partial}o$](위)/l'eau[lo](물)"와 형태론적 대립 "le[$l{\partial}$](정관사, 남성단수)/l

• Korean Journal of Plant Resources
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• v.30 no.1
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• pp.101-109
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• 2017

For analysis of the relationship among blueberry cultivars, the growth period and morphological characteristics were investigated in 28 blueberry cultivars, and cluster analysis using the SAS program was conducted based on the morphological data. The harvest period was later and longer in rabbiteye blueberry cultivars (Austin, Brightwell, Powderblue, Southland, Tifblue) than in highbush blueberry cultivars. The L/D ratio of flower was more than 2.0 in the Austin, Brightwell, Powderblue, Southland, Tifblue, and Brigitta cultivars, and this could be disadvantageous for pollination. The 28 blueberry cultivars were classified into two groups by the cluster analysis based on growth period and morphological characteristics. Group I included rabbiteye blueberries and Group II included highbush blueberries. However, the northern, southern, and half-highbush blueberry cultivars were not differentiated.

• Korean Journal of Plant Resources
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• v.30 no.1
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• pp.96-100
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• 2017

Shoot and the fruit growth characteristics of 'Campbell Early' grape cultivar were investigated after vine thinning using the main branch leader. Before vine thinning, branch diameter was 11.8 mm, but it decreased to 9.3 mm after vine thinning. The number of shoots per vine increased to 55.9-64.5 after vine thinning. The number of fruit clusters per shoot was higher (1.5-1.75) in the vine thinning plot than in the control (0.8). Consequently, the number of clusters per vine was 98.1-106.5 in the vine thinning plot, while that in the control was 24.4-28.0. However, soluble sugar content (SSC) and tartaric acidity showed no significant differences between the control and the vine thinning plot. The proportion of >351 g fruit cluster weight after vine thinning (81.0%) was significantly higher than that of the control (32.5%). These results imply that fruit quality based on the variation in cluster weight and fruit yield was enhanced by vine thinning using the main branch leader.

• Journal of Korea Foresty Energy
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• v.23 no.2
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• pp.34-43
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• 2004

This study was examined to investigate the effect of wood carbonization products on growth and body composition of oliver flounder(Paralichthys olivaceus) as a part of fishery utilization of charcoal and pyroligneous acid. Weight gain in oliver flounder fed with wood carbonization products was higher than that of the control group. Feed efficiency between the groups fed with charcoal and Mogchotan(the mixture of charcoal and pyroligneous acid, 80:20, w/w) and the control group showed no significant difference(p>0.05) and was significantly higher in group fed with pyroligneous acid than the control group(p<0.05). All groups fed with wood carbonization products were also higher than the control group in hemoglobin and hematocrit. Especially, the amount of both components was significantly higher in group fed with Mogchotan(p<0.05). The result indicates that the addition of Mogchotan can improve the health of oliver flounder, and was excellent in the mortality and the recovery rate. In conclusion, Mogchotan treatment would be suitable way for improving the growth and health of oliver flounder.

• Journal of Korea Water Resources Association
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• v.46 no.6
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• pp.655-666
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• 2013

Lately, intensity and frequency of natural disasters such as flood are increasing because of abnormal climate. Casualties and property damages due to large-scale floods such as Typhoon Rusa in 2002 and Typhoon Maemi in 2003 rapidly increased, and these show the limits of the existing disaster prevention measures and flood forecasting systems regarding irregular climate changes. In order to efficiently respond to extraordinary flood, it is important to provide effective countermeasures through an inundation model that can accurately simulate flood inundation patterns. However, the existing flood inundation analysis model has problems such as excessive take of analysis time and accuracy of the analyzed results. Therefore, this study conducted a flood inundation analysis by using the Gerris flow solver that uses quadtree grid, targeting the Baeksan Levee in the Nakdong River Basin that collapsed because of a concentrated torrential rainfall in August, 2002. Through comparisons with the FLUMEN model that uses unstructured grid among the existing flood inundation models and the actual flooded areas, it determined the applicability and efficiency of the quadtree grid-based flood inundation model of the Gerris flow solver.