• Journal of Digital Convergence
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• v.13 no.9
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• pp.531-540
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• 2015

Traditionally we consider the food and the medicine have common roots, that is, energies from them share the same source, and it brought us an unique food culture of our own, and nurtured an unique academic area of oriental medicated dietary therapy. Thus we devise chocolate based on oriental theory and western food and convergence prevention nutritional approach. The study analyzed and examined the nutritional composition, physical properties and analysis DPPH radical scvenging, total polyphenolic compound contents, total flavonoids contents of chocolate added with 5% tangerine peel powder(TPC). Total polyphenolic compound content of TPC was 394.1 mg GAE/100g and DPPH radical scvenging activity was 68.66% and total flavonoid content was 148.88 mg QE/100g. Antioxidative activity of TPC was significantly higher than that of come into the market milk chocolate(p<0.05). In sensory evaluation, significantly difference(p<0.05)of TPC were surface color, flavor, overall acceptance.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.5 no.3
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• pp.144-151
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• 2012

Chronic gastritis is the disease that is occuring in one in every 10 persons in Korea. In western medicine, endoscopy is needed to diagnose chronic gastritis, but it causes patients a pain and budget of expense. According to the TEM (Traditional Eastern Medicine), on the other hand, the 'Guan' position of the right wrist is related to a stomach. Thus we can diagnosis chronic gastritis by analyzing of pulse signal. However, pulse signal diagnosis is depended on oriental doctor's knowledge and experience. In this study, a systematic approach is proposed to analyze the computerized pulse signal. The pulse signals are firstly pre-processed, Gaussian model is adopted to fit the pulse signal, and then some related parameters are extracted from the model. Consequently, disease-sensitive parameters are selected by T-test and statistical difference. Finally, the selected parameters are entered into a Fuzzy C-Means (FCM) algorithm for classification. Classification results show that healthy persons and chronic gastritis patients are 95% and 87%, respectively.

• The Korea Journal of Herbology
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• v.39 no.2
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• pp.11-18
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• 2024

Objectives : High blood pressure (also called Hypertension), which is the blood pressure that is higher than normal, is a chronic disease and causes various complications. Historically, Traditional Herbal Prescriptions (THP) have treated many diseases. However, there are not many studies on the treatment of hypertension with THP, very few studies have investigated the interactions between the co-administration of synthetic anti-hypertensives and THP. Therefore, the objective of the present study was to investigate the vasorelaxant activities of 10 THP in rat thoracic aortas pre-contracted with potassium chloride (KCl). Methods : An electric extractor was used to extract THP in distilled water for 2h. Rat thoracic aortas were isolated and pre-contracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. THP extracts were added in increasing concentrations (10-1000 ㎍/mL) to investigate vasorelaxant activities. The vasorelaxant activities induced by THP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 THP, Dangguisu-san, Mahwang-tang, Bulwhangeumjeonggi-san, Jakyakgamcho-tang, and Hyangsapyeongwi-san showed significant vasorelaxant activities. Maekmundong-tang, Bojungikgi-tang, Samryeongbaekchul-san, Yukmijihwang-tang, and Insampaedok-san showed no significant effect. Also, in co-administration with amlodipine, Mahwang-tang showed higher vasorelaxant activities than amlodipine alone, and Hyangsapyeongwi-san showed greater vasorelaxant activities at low concentrations but inhibited amlodipine's vasorelaxant activities at high concentrations. Conclusion : The results of these experiments are expected to provide useful data to establish guidelines for THPs and co-administration with western antihypertensive drugs to treat hypertension.

• Journal of Ginseng Culture
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• v.4
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• pp.103-127
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• 2022

The influx of modern culture in the early 20th century in Korea led to numerous changes in the country's ginseng industry. With the development of ginseng cultivation technology and commerce, the production and consumption of ginseng increased, and various ginseng products were developed using modern manufacturing technology. Consequently, competition for the sales of these products became fierce. At that time, newspaper advertisements showed detailed trends in the development and sales competition of ginseng products. Before 1920, however, there were few advertisements of ginseng in newspapers. This is thought to be because newspapers had not yet been generalized, and the ginseng industry had not developed that much. Ginseng advertisements started to revitalize in the early 1920s after the launch of the Korean daily newspapers Dong-A Ilbo and Chosun Ilbo. Such advertisements in this period focused on emphasizing the traditional efficacy of Oriental medicine and the mysterious effects of ginseng. There were many advertisements for products that prescribed the combination of ginseng and deer antler, indicating the great popularity of this prescription at the time. Furthermore, advertisements showed many personal experience stories about taking such products. Mail order and telemarketing sales were already widely used in the 1920s . In 1925, there were advertisements that ginseng products were delivered every day. The advertisements revealed that ginseng roots were classified more elaborately than they are now according to size and quality. Ginseng products in the 1920s did not deviate significantly from the scope of traditional Oriental medicine formulations such as liquid medicine, pill, and concentrated extract. In the 1930s, ginseng advertisements became more active. At this time, experts such as university professors and doctors in medicine or in pharmacy appeared in the advertisements. They recommended ginseng products or explained the ingredients and medicinal effects of the products. Even their experimental notes based on scientific research results appeared in the advertisements to enhance the reliability of the ginseng products. In 1931, modern tablet advertisements appeared. Ginseng products supplemented with vitamins and other specific ingredients as well as ginseng thin rice gruel for the sick appeared at this time. In 1938, ginseng advertisements became more popular, and advertisements using talents as models, such as dancer Choi Seunghee or famous movie stars, models appeared. Ginseng advertisements in the 1920s and 1930s clearly show a side of our rapidly changing society at the time.

• Journal of Veterinary Clinics
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• v.24 no.4
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• pp.608-612
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• 2007

A 4-year-old castrated male Cocker spaniel was referred with chief complaint of pelvic limbs paralysis and trembling. This dog was diagnosed as a case of myelomalacia complicated with intervertebral disc disease(IVDD) by radiography and magnetic resonance imaging(MRI). This patient was treated by injection-AP with apitoxin, herbal medicine and moxibustion. The acupoints such as GV02-1, GV04, GV11, GV12, GV13, GV14, BL11, BL18, BL23, BL25, BL28, GB21, HT07, KI03, LI04, LU07, SI03, SI06, ST36, ST38, ST39, ST40, ST41, GB30, GB31, GB34, Liv03, SP06 and trigger points($T1{\sim}T4\;and\;T9{\sim}L1$) were used for treatment. At the session 1, the dog could not stand and move the limbs. However, gradual improvement of clinical signs was observed after 7, 14 and 21 session of treatment. Although the clinical signs related to pelvic paralysis were not completely abolished with TVM methods, this case showed the marked improvement of clinical signs after 21 sessions of treatment. In conclusion, the present patient was a case with canine myelomalacia complicated with IVDD which showed not so complete but somewhat improvement by TVM method.

• Journal of the Korean Applied Science and Technology
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• v.32 no.2
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• pp.260-274
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• 2015

This paper has shown the experimental results about the physiological activities of water-, ethanol-, ethyl acetate-soluble fractions from ethanolic extracts of leaves, stems and roots of Cudrania tricuspidata on the skin, which has been used for a long time as a traditional herb medicine in Korea and China. The effects of these fractions on the secretion of nitric oxide and cytokines from macrophage(RAW 264.7 cell) exhibited that the ethyl acetate and water fractions from leaves inhibited the release of nitric oxide, all fractions inhibited thoses of inflammatory cytokine $IL-1{\alpha}$, and the ethyl acetate fractions of leaves, stems and roots inhibited thoses of inflammatory cytokine IL-6. The only ethylacetate fraction of leaves demonstrated significantly the reduction of melanin synthesis in melanoma cells. In order to evaluate the efficacy of collagen synthesis, the treatment with extracts on the human normal fibroblast cell(CCD-986sk cell) resulted in finding that the water fractions of leaves, stems and roots and the ethanol fractions of leaves and stems showed the increased synthesis of collagen.

• Journal of Applied Biological Chemistry
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• v.56 no.3
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• pp.131-135
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• 2013

Jaeumganghwa-tang (JGT) is a traditional herbal medicine used for chronic bronchitis and inflammatory diseases. The variation in the amount of bioactive components of JGT and its fermentation JGT with ten species of microorganism was investigated via high performance liquid chromatography coupled with diode array detection (HPLC-DAD). Simultaneous qualitative and quantitative analysis of eight bioactive compounds; 5- hydroxymethylfurfural (5-HMF), paeoniflorin, nodakenin, hesperidin, nodakenetin, palmatine, berberine and glycyrrhizin were achieved by comparing their retention times ($t_R$) and UV spectra with those of the standard compounds. In the result, the paeoniflorin amount was 6.95 mg/g that as a main compound in JGT. The amount of nodakenetin was the highest in the fermented-JGT with Lactobacillus fermentum KFRI 145 ($0.47{\pm}0.01mg/g$), which was increased by 2,250% compared to that in non-fermented JGT ($0.02{\pm}0.00mg/g$). In the fermented JGT using Lactobacillus acidophilus KFRI 162, most components were increased than non-fermented JGT, except paeoniflorin and hesperidin.

• THE JOURNAL OF KOREAN ORIENTAL ONCOLOGY
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• v.3 no.1
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• pp.85-98
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• 1997

Oriental medicine as a candidate for effective cancer treatment recently gain positive concerns in fields of therapeutic oncology. that is why some herbal medicines have been empirically safer in toxicity than anticancer drugs used in western medicine, and to show excellent therapeutic efficacy in human trial. Thus, these effects by clinically applied-herbs have not yet fully demonstrated in experimental tumor model. This study was initiated to evaluate the antitumor effect of Insambaekhaptang as candidate of antitumor-herbal agent against B16 melanoma metastasized into C57BL/6 mice lung. In experiment to test whether Insambaekhaptang can directly kill cancer cells in vitro or not, Insambaekhaptang showed direct killing action in concentration or higher against B16 melanoma cells using MTT assay, and showed lower IC50. Another experiment to know whether Insambaekhaptang can inhibit growth and metastasis of cancer cell or not, Insambaekhaptang significantly inhibited Solid tumor by intraperiperal injected-melanoma and lung metastasis induced by intravenous injected-melanoma in inbred C57BL/6 mice. When quantitative survival time increasing, we could obtain results that increased 113% in treated by Insambaekhaptang. These results show that Insambaekhaptang can inhibit growth of B16 melanoma cells through various biological mechanisms.

• Journal of Korean Medical classics
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• v.20 no.2
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• pp.231-268
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• 2007

재일본규주황한의학적전통의학지전신취시중국전통의학적지식(在日本叫做皇漢醫學的傳統醫學之前身就是中國傳統醫學的知識). 16세기이래(16世記以來), 일본불단수도이개조중국의학적최신성과(日本不斷收到而改造中國醫學的最新成果), 동양원류우부동홍류적한방의학체계점점형성적과정전후(同樣源流又不同洪流的漢方醫學體系점점形成的過程前后), 출현료4개학문유파(出現了4個學問流派). 저취시(저就是)"후세파(后世派)"."고방파(古方派)"."절충파(折衷派)"."고증파(考證派)". 소우호세파(소于호世派), 논자이경재대한한의학원전학회지적제19권3호상보고료(논者已경在大한한의학原典학회紙的第19卷3호上보告了), 본논문시연속적연구성과(本논文是연속的硏究成果). 종이재본논문상(종而在本논文上), 이한국적이정환(以한국的李政桓), 백유상(白裕相), 정창현등적연구여중국양영적연구위기초(丁彰炫等的硏究與中國梁嶸的硏九爲基礎), 요개략지보고일본의학방면상적‘고방파’(要槪略地報告日本의학方面上的'古方派'). "고방파"지칭부정근세송명의학이지지지한대장중경적"상한잡병론"지일본의가("古方派"指稱否定近世宋明醫學而只支持漢代張仲景的"傷寒雜病論"之日本醫家). 일반"상한론"전파우일본적실정시대(一般"傷寒論"傳播于日本的室町時代), 명응년간(明應年間)(1492${\sim}$1500)판정운재명유학후(阪淨運在明留학후), 타회도일본적시후(他回到日本的시候), 종명수입(종明수入)"상한잡병론(傷寒雜病論)", 이후일본후세한의칭송료이관동지역적영전덕본(以후日本후世漢醫칭송了以關東地域的永田德本)(1513-1603)위(爲)"고방파적선구자(古方派的先구者)". 도강호시대재일본학술계출현료복고사조(到江戶時代在日本學術係出現了復古思潮). 이등인제(伊藤仁劑)(1627${\sim}$1705)앙망료유학적경전(仰望了儒學的經典), 이차적극지주장료의학적복고(而且積極地主張了醫學的復古), 이후적생조래(以후荻生組徠)(1666${\sim}$1728)대우복여성인적학문부단노력(對于復與聖人的學問不斷努力). 인차복고적학문재덕천시대성위일대학파(因此復古的學問在德川時代成爲一代學派), 18세기상반기시전성시기(18世紀上半期是全盛시期). 주요의가시명고옥현의(主要醫家是名古屋玄議)(1628${\sim}$1696), 후등양산(後藤양山)(1659${\sim}$1733), 산협동양(山脅東洋), 병하천민(병河天民)(1679${\sim}$1719), 송원유악(松原維嶽)(1689${\sim}$1765), 향천수암(香川修庵)(1683${\sim}$1755), 타문복고적유학영향도흔다의학방면(他문復古的儒學影향到흔多의학方面). 중요의가길익동동(重要醫家吉益東洞)(1702${\sim}$1773)도후대피평위고방적'태두'(到后代被평위古方的'泰斗'), 동시'마귀'(同시'魔鬼'). 인차본논문소우황한의학지중"후세파"여반대후세파적"고방파"(因此本論文소于皇漢醫學之中"后世派"與反대后世派的"古方派"), 통과학파명칭여역사지위(通過學派名稱與歷史地位), 주요의가적생애(主要醫家的生涯), 학술적요지(學術的要旨), 저서등(著書等), 이연구병보고타문적학문주장(以硏究병報告他們的學問主張). 이차진저차궤회(而且진저次机회), 상회고아문한의학연착여하역사적궤적(想回고我문韓醫學沿着如何歷史的軌跡).

• Journal of the Society of Cosmetic Scientists of Korea
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• v.30 no.4 s.48
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• pp.509-514
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• 2004

The fruit or root of Ulmus davidiana var. Japonica and its extract has traditionally been used as anti inflammatation medicines as well as a remedy of the digestive ulcer for a long time. Ulmus davidiana var. Japonica has also been used to cure palliative and diuresis, because it contains lot of mucus and tannin. In this study, we examined the moisturizing effect and anti-inflammation effect of polysaccharides extracted from Ulmus davidiana var. Japonica to investigated whether it can be used as a cosmetic ingredient or not. The polysaccharides were extracted from Ulmus davidiana var. Japonica. Then the hydrolyzed was obtained through the hydrolysis. It has been ascertained that the polysaccharides we mainly composed of rhamnose, galactose, and glucose through HPLC experiments, and it has 20,000 of the molecular weight and 89.3 dL/g of intrinsic viscosity In a moisturizing test of measuring water loss in a desiccator and moisture content by Comeometer CM820, Ulmus davidiana root extract showed a similar moisturizing effect as hyaluronic acid. And its anti-inflammation effect on carrageenin-induced edema evaluated by measuring the thickness of swelling over paw induced by carrageenin (25 uL of $2\%$ carrageenin saline injection), the $\%$ swelling over paw treated with Ulmus davidiana root extract was much less than that of paw treated with carrageenin only. The anti-inflammatory effect of Ulmus davidiana root extract was almost similar to that of ketoprofen. These results can say that Ulmus davidiana root extract can be effectively used as a cosmetic ingredient.