• Radiation Oncology Journal
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• v.20 no.2
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• pp.172-178
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• 2002

Purpose : X-ray film over responds to low-energy photons in relative photon beam dosimetry because its sensor is based on silver bromide crystals, which are high-Z molecules. This over-response becomes a significant problem in clinical photon beam dosimetry particularly in regions outside the penumbra. In intensity modulated radiation therapy (IMRT), the radiation field is characterized by multiple small fields and their outside-penumbra regions. Therefore, in order to use film dosimetry for IMRT, the nature the source of the over-response in its radiation field need to be known. This study is aimed to verify and possibly improve film dosimetry for IMRT. Materials and Method : Modulated beams were constructed by a combination of five or seven different static radiation fields using 6 MeV X-rays. In order to verify film dosimetry, we used X-ray film and an ion chamber were used to measure the dose profiles at various depths in a phantom. In addition, in order to reduce the over-response, 0.01 inch thick lead filters were placed on both sides of the film. Results : The measured dose profiles showed a film over-response at the outside-penumbra and low dose regions. The error increased with depths and approached 15% at a maximum for the field size of $15{\times}15cm^2$ at 10 cm depth. The use of filters reduced the error to 3%, but caused an under-response of the dose in a perpendicular set-up. Conclusion : This study demonstrated that film dosimetry for IMRT involves sources of error due to its over-response to low-energy Photons. The use of filers can enhance the accuracy in film dosimetry for IMRT. In this regard, the use of optimal filter conditions is recommended.

• Radiation Oncology Journal
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• v.22 no.4
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• pp.237-246
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• 2004

Purpose: To investigate the effects of radiation dose-escalation on the treatment outcome, complications and the other prognostic variables for glioblastoma patients treated with 3D-conformal radiotherapy (3D-CRT). Materials and Methods: Between Jan 1997 and July 2002, a total of 75 patients with histologically proven diagnosis of glioblastoma were analyzed. The patients who had a Karnofsky Performance Score (KPS) of 60 or higher, and received at least 50 Gy of radiation to the tumor bed were eligible. All the patients were divided into two arms; Arm 1, the high-dose group was enrolled prospectively, and Arm 2, the low-dose group served as a retrospective control. Arm 1 patients received $63\~70$ Gy (Median 66 Gy, fraction size $1.8\~2$ Gy) with 3D-conformal radiotherapy, and Arm 2 received 59.4 Gy or less (Median 59.4 Gy, fraction size 1.8 Gy) with 2D-conventional radiotherapy. The Gross Tumor Volume (GTV) was defined by the surgical margin and the residual gross tumor on a contrast enhanced MRI. Surrounding edema was not included in the Clinical Target Volume (CTV) in Arm 1, so as to reduce the risk of late radiation associated complications; whereas as in Arm 2 it was included. The overall survival and progression free survival times were calculated from the date of surgery using the Kaplan-Meier method. The time to progression was measured with serial neurologic examinations and MRI or CT scans after RT completion. Acute and late toxicities were evaluated using the Radiation Therapy Oncology Group neurotoxicity scores. Results: During the relatively short follow up period of 14 months, the median overall survival and progression free survival times were $15{\pm}1.65$ and $11{\pm}0.95$ months, respectively. The was a significantly longer survival time for the Arm 1 patients compared to those in Arm 2 (p=0.028). For Arm 1 patients, the median survival and progression free survival times were $21{\pm}5.03$ and $12{\pm}1.59$ months, respectively, while for Arm 2 patients they were $14{\pm}0.94$ and $10{\pm}1.63$ months, respectively. Especially in terms of the 2-year survival rate, the high-dose group showed a much better survival time than the low-dose group; $44.7\%$ versus $19.2\%$. Upon univariate analyses, age, performance status, location of tumor, extent of surgery, tumor volume and radiation dose group were significant factors for survival. Multivariate analyses confirmed that the impact of radiation dose on survival was independent of age, performance status, extent of surgery and target volume. During the follow-up period, complications related directly with radiation, such as radionecrosis, has not been identified. Conclusion: Using 3D-conformal radiotherapy, which is able to reduce the radiation dose to normal tissues compared to 2D-conventional treatment, up to 70 Gy of radiation could be delivered to the GTV without significant toxicity. As an approach to intensify local treatment, the radiation dose escalation through 3D-CRT can be expected to increase the overall and progression free survival times for patients with glioblastomas.

• Journal of radiological science and technology
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• v.39 no.4
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• pp.493-499
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• 2016

In this study, C-Arm equipment is being used as we intend to verify the exposure dose on the operator by the scattering rays during the operation of the C-Arm equipment and to provide an effective method of reducing the exposure dose. Exposure dose is less than the Over Tube method utilizes the C-arm equipment Under Tube the scheme, The result showed that the exposure dose on the operator decreased with a thicker shield, and as the operator moved away from the center line. Moreover, as the research time prolongated, the exposure dose increased, and among the three affixed location of the dosimeter, the most exposure dose was measured at gonadal, then followed by chest and thyroid. However, in consideration of the relationship between the operator and the patient, the distance cannot be increased infinitely and the research time cannot be decreased infinitely in order to reduce the exposure dose. Therefore, by changing the thickness of the radiation shield, the exposure dose on the operator was able to be reduced. If you are using a C-Arm equipment discomfort during surgery because the grounds that the procedure is neglected and close to the dose of radiation shielding made can only increase. Because a separate control room cannot be used for the C-Arm equipment due to its characteristic, the exposure dose on the operator needs to be reduced by reinforcing the shield through an appropriate thickness of radiation shield devices, such as apron, etc. during a treatment.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.1
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• pp.53-57
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• 2010

This study proposes the algorithm which drives the powerless without battery. The exiting wire or RF type dosimeter, which is the computation of the real time with battery on the dose radiation exposure, In the Wired dosimeter, it is trouble to need the maintenance and management by periods. Besides, the case of the RF typed dosimeter with battery, it is requested to size bigger and to replace battery frequently and so on. Especially RF typed dosimeter has trouble to need for the embody with large power consumption on the contactless typed dosimeter. As the method for the low power, the study designed to be down the operating clock of the MPC, to improve the efficiency of the rectifier, to eliminate the external memory and the DC-DC converter for the simplification of the circuit We convince our research contributes not only to understand the simplified circuit and miniaturization, but also to help the design and application technology of the powerless dosimeter.

• FLOWER RESEARCH JOURNAL
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• v.19 no.2
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• pp.119-125
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• 2011

Acorus calamus is an indigenous hydrophyte used as phytoremediation and water purification as well as medicinal herb. Irradiation of gamma ray was performed to investigate the effect on radioresistance of A. calamus on in vitro. Various doses (20-500 Gy) of gamma rays were irradiated to in vitro plantlets. The effect of irradiation was studied on survival rate, shoot formation and growth rate. The survival and multiplication rate was remarkably decreased with the increase of radiation dose. The growth of plantlets was significantly increased in comparison to the control at low doses. The hermetic effect of radiation was appeared in A. calamus. It was significantly decreased or interrupted above 250 Gy. The mean 50% lethal dose ($LD_{50}$) was extremely high as 240 Gy. We conclude that A. calamus had remarkably high radioresistance compared with other plant species.

• Proceedings of the Korean Nuclear Society Conference
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• 1995.05b
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• pp.875-881
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• 1995

원자력 연구소는 국제원자력기구(IAEA/RCA) 주관하에 1990년부터 1993년 사이 3차에 걸쳐 실시한 개인선량계에 대한 국제상호비교에 참여하였다. 국제 상호비교에 참여하여 사용된 개인선량계는 방사선작업종사자에 대한 외부방사선으로부터 피폭관리를 위하여 기 사용중인 Taedyne Isotope 사의 PB-3타입의 열형광선량계이며 선량계판독용으로 Tdedyne 9150자동판독기를 사용하였다. 본 논문에는 3차에 걸쳐 국제상호비교결과를 요약하였으며 저 에너지의 엑스선에 경우를 제외하고 모든 조사방사선에 대해 0.78에서 1.07사이에 상대비율로 결과를 나타내었다. 또한 미국기준 ANSI Nl 3.11에 의해 성능을 시험한 결과 모든 조사방사선장에 대해서 허용기준 0.5이하를 나타내었다.

• Proceedings of the Korean Nuclear Society Conference
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• 1995.05b
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• pp.889-894
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• 1995

본 연구에서는 ANSI N13.32(1995)에서 제시한 손가락, 손목/발목 기준 팬텀(1)을 설계 제작하여 Teledye사의 말단선량계(finger와 wrist dosimeter)에 대한 방향의존성 실험을 수행하였다. 방사선원으로는 PTB 2차 베타표준선원 $^{204}$Tl(0.24 MeV), $^{90}$ sr/Y(0.8 MeV) 그리고 $^{l37}$ Cs(0.66 MeV) 표준 감마선원을 사용하였으며, 말단선량계로는 LiF Teflon(D-LiF-7-0.13)을 사용하였다. 90$^{\circ}$ 에서 $10^{\circ}$ 까지 20$^{\circ}$ 씩 수직과 수평으로 팬텀을 회전하여 정상각과 비정상각에 대한 상대응답을 제시하였다. 실험결과 90$^{\circ}$에서 모든 선량계는 잘 일치하였다. $^{90}$ Sr/Y은 50$^{\circ}$ 정도에서 다소 방향의존성이 적은 결과를 보였으며, $^{204}$ TI는 20$^{\circ}$에서 최소 13% 정도의 심한 방향의존성이 나타났다. 또한 $^{137}$Cs은 $10^{\circ}$에서도 최대 10.6% 정도의 적은 방향의존성을 나타냈다. 본 실험의 결과로부터 말단선량계는 저에너지와 낮은 투과 방사선[2]에서 심하게 방향의존성이 나타남을 알 수 있었다.

• Journal of radiological science and technology
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• v.37 no.1
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• pp.21-28
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• 2014

Cultured pancreatic beta cells and nerve cells, it is given normal condition of 10% FBS (fetal bovine serum), 11.1 mM glucose and hyperglycemia codition of 1% FBS, 30 mM glucose. For low LET X-ray irradiated with 0.5 Gy/hr dose-rate(total dose: 0.5 to 5 Gy). Survival rates were measured by MTT assay. When non irradiated, differentiated in the pancreatic beta cells experiment is hyperglycemia conditions survival rate compared to normal conditions survival rate seemed a small reduction. However increasing the total dose of X-ray, the survival rate of normal conditions decreased slightly compared to the survival rate of hyperglycemia conditions, the synergistic effect was drastically reduced. When non irradiated, undifferentiated in the nerve cells experiment is hyperglycemia conditions survival rate compared to normal conditions survival rate seemed a large reduction. As the cumulative dose of X-ray normal conditions and hyperglycemia were all relatively rapid cell death. But the rate of decreased survivals by almost parallel to the reduction proceed and it didn't show synergistic effect.

• Korean Journal of Environmental Agriculture
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• v.18 no.3
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• pp.245-249
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• 1999

This study was carried out to investigate the influence of artificial acid rain on the growth of soybean irradiated with the low dose gamma radiation. The growth patterns of Hwangkumkong and Bangsakong were not dependent on the acid rain treatment and the period of seed storage but the radiation dose. In Hwangkumkong, the optimal irradiation dose for the growth promotion was lower in the acid rain treatment group than the control group. The symptom of acid rain damage appeared broadly around pH 2.20, were higher in Hwangkumkong than in Bangsakong, and were more effective in the seeds of 1997 than 1995. But the damage symptom of Bangsakong was not dependent on the acid rain treatment and the irradiation of gamma radiaiton.

• The Korean Journal of Nuclear Medicine
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• v.35 no.5
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• pp.313-323
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• 2001

Purpose: The purpose of this study was to search activated genes that could be related to radiation adaptive response (RAR) induced by low-level radiation from $^{99m}Tc$ in human cell lines. Methods: We used gene discovery array (GDA) and representational difference analysis (RDA) methods. $^{99m}Tc$-pertechnetate was added to $2{\times}106/mL$ NC-37 cells (human lymphoblastic cells) to make concentrations ranging from 148 MBq/mL to 148 Bq/mL by serial 10 fold dilutions. After 44 hours, 2 Gy gamma irradiation was given to them using a Cs-137 cell irradiator. Results: As compared to the control (Con) group to which no $^{99m}Tc$ was added, those cells to which 148 and 14.8 KBq of $^{99m}Tc$ were added showed significantly lower damage to chromosomes, which was evaluated by metaphase analysis. Cells with 148 KBq $^{99m}Tc$ (T148 group) showed most significant protection. Activated genes in the T148 group as compared to Con group were evaluated by GDA and GDA methods. GDA revealed genes of casein kinase 2 (CK2) beta chain, immunoglobulins (lg), human leukocyte antigen (HLA)-B, and two novel genes. Twenty RAR related clones were selected by RDA method. The size of those genes was from 234 to 603 base pairs. Conclusions: RAR was induced by low dose irradiation from $^{99m}Tc$ in NC-37 cell lines. Genes related to the response included CK2, lg, HLA-B in human lymphoblastic cell lines.