• Title/Summary/Keyword: 재허가

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Ion Exchange of Glutamic Acid Coupled with Crystallization (결정화 반응이 결합된 글루탐산의 이온교환)

  • 이기세
    • KSBB Journal
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    • v.11 no.5
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    • pp.606-612
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    • 1996
  • A specific ammino auid in a mixture can be crystallized inside an ion exchange column when displacer concentration is high enough to concentrate the amino acid in a pure band beyond its solubility limit. Glutamic acid formpd a discrete crystal layer in a cation exchanger column by operating displacement development mode and using a high concentration of displacer NaOH. The glutamic acid crystal formed was eluded from the column with the effluent stream and collected in a fraction collector. When 1.0 M of NaOH was used as a displacer, more than 60% of the loaded glutamic acid was recovered as crystal. The continuous crystallization and dissolution of crystal occurred, resulting in apparent movement of the crystal along the column without clogging or pressure increase. NaOH was proved a better displacer than NaCl because hydroxide ions neutralized hydrogen ions released from the resin and thus reduced the number of hydrogen ion competing with sodium ion for re-adsorption. The displacement development process coupled with crystallization provided higher concentration and recovery of glutamic acrid than conventional chromatography.

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A Basic Study on the Establishment of Designated Area for Conservation plan of Traditional Landscape - Focus on the Designation Status of Linear Scenic Sites - (전통경관 보존계획을 위한 지정구역 설정에 대한 기초연구 - 선형(線形) 명승의 지정 현황을 중심으로 -)

  • Lee, Chang-Hun
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.38 no.1
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    • pp.67-76
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    • 2020
  • This study aims to elicit criteria regarding reassessment and designation of linear scenic sites henceforth. The results are as follows; First, based on the documents from the Cultural Properties Protection Committee of Korea, 23 out of 113 scenic sites in Korea were drawn, and their linear characteristics were categorized into four types including valleys, paths, rivers, and ridges. The linear scenic sites provide certain features in terms of sequence and direction, which results in the similar utilization among the sites which share the linear similarity. Second, the 23 sites mentioned above were intensely examined on the basis of six criteria for linear scenic sites through FGI, focus group interview. The criteria consist of six elements involving core resource(12), lot number(8), unclear(8), management path(5), ridge(4), basin(3). Third, the Cultural Heritage Administration has prioritized core resource since 2010, when designating a scenic site, whereas it tended to consider lot number as priority prior to 2010. It is thought that the authority gave consideration to issues related to private ownership of property in the scenic sites and the purpose of designation. Fourth, scenic sites are generally designated in accordance with the boundary of core resource, and in most cases, there are buffer zones alongside the core resource.

A Study on Evaluation of the Ancient Historic District for the Preservation and Development of Ancient Capital - Focus on the Pilot Project Districts in Ancient Capital Gyoengju - (고도(古都)보존 및 육성을 위한 고도지구 가치평가 - 경주시 고도시범사업지구를 대상으로 -)

  • Pan, Xiang;Kang, Tai-Ho
    • Journal of the Korean Institute of Landscape Architecture
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    • v.41 no.4
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    • pp.1-9
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    • 2013
  • The "Historic city Preservative law" was legislated for the preservation of cultural properties and enacting regulations of managing the environment around them in 2004. This law was revised to "Historic city Preservative and Development law" in 2012, and specified the criteria for permissible behaviors in the preservative district. Therefore, this paper focused on the ancient capital Gyeongju and developed a comprehensive system for evaluating the value of the ancient historic district based on Analytic Hierarchy Process (AHP). Through the evaluation of the ancient historic districts, which are the pilot project districts in the "Gyeongju Ancient Capital Preservation Plan", some preferential projects were objectively proposed. As a result, according to the evaluation among 10 ancient historic districts in Gyeongju, Daereungwon got a score of 78.34, which is the highest among 7 special preservation districts. On the other side, the Gyo-dong area got a score of 76.14, the highest among 3 historic and cultural environmental districts. Finally, for the preservation and development of Gyeongju, some efficient preservation and development plans were objectively proposed for the pilot project districts in the "Gyeongju Ancient Capital Preservation Plan".

Optimization of biomass production of Acetobacter pasteurianus SRCM101388 (Acetobacter pasteurianus SRCM101388 바이오매스 생산 최적화)

  • Jun-Tae Kim;Sung-Ho Cho;Do-Youn Jeong;Young-Soo Kim
    • Food Science and Preservation
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    • v.30 no.1
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    • pp.132-145
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    • 2023
  • In this study, culture conditions were optimized to confirm the feasibility of Acetobacter pasteurianus as a starter for fermentation vinegar. Acetobacter pasteurianus strain can be used as a food ingredient. The optimal temperature and pH conditions of the selected Acetobacter pasteurianus SRCM101388 were 28℃ and pH 6.00, respectively. The response surface methodology (RSM) was used to optimize the composition of the medium, and Plackett-Burman design (PBD) was used to obtain the effective selection of culture medium, resulting in that glucose, sucrose, and yeast extract had the highest effect on increasing biomass. The optimal concentration, which was performed by central composite design (CCD), were determined to be 10.73 g/L of glucose, 3.98 g/L of sucrose, and 18.73 g/L of yeast extract, respectively. The optimal concentrations of trace elements for the production of biomass were found to be 1 g/L of ammonium sulfate, 0.5 g/L of magnesium sulfate, 2 g/L of sodium phosphate monobasic, 2 g/L of sodium phosphate dibasic, and the final optimized medium was pH 6.10. When incubated in a 5 L jar fermenter, the SRCM101388 strain showed a faster-dissolved oxygen (DO) reduction at a lower agitation rate (rpm), and it was able to grow even at reduced DO level when aeration was maintained. The amount of final biomass produced was 2.53±0.12×109 CFU/mL (9.40±0.02 log CFU/mL) when incubated for 18 hours at 150 rpm, 0.5 vvm, pH 6.0, and 28℃.

Reservation based Multichannel CSMA Protocol for Improvement of Energy Consumption and QoS in Wireless Sensor Networks (무선 센서 네트워크 환경에서 에너지 소비 및 QoS를 고려한 예약기반 Multichannel CSMA 프로토콜)

  • Han, Jung-Ahn;Kim, Yun-Hyung;Lee, Moon-Ho;Kim, Byung-Gi
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.32 no.2A
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    • pp.143-151
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    • 2007
  • One of the consideration things to design protocol in wireless sensor networks is to maximize lifetime of sensor node as reducing energy consumption. In this paper propose reserve based multichannel CSMA mac protocol for minimizing energy consumption which arise from collision and waiting retransmission at channel access process in mac layer Each sensor node which constitute sensor networks has data channel and control channel. And as sensor node reserve channel for data transmission by using control channel and receipt node allow reservation node to use data channel, sending node can abbreviate try of retransmission after random interval time. Also, When sending node delivers selects option channel in available channels to receipt node, the receipt node decide whether the channel is available to oneself and through the result select transmission channel ultimately. Performance evaluation compare with previous simple multichannel CSMA.

A Design of Permission Management System Based on Group Key in Hadoop Distributed File System (하둡 분산 파일 시스템에서 그룹키 기반 Permission Management 시스템 설계)

  • Kim, Hyungjoo;Kang, Jungho;You, Hanna;Jun, Moonseog
    • KIPS Transactions on Computer and Communication Systems
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    • v.4 no.4
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    • pp.141-146
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    • 2015
  • Data have been increased enormously due to the development of IT technology such as recent smart equipments, social network services and streaming services. To meet these environments the technologies that can treat mass data have received attention, and the typical one is Hadoop. Hadoop is on the basis of open source, and it has been designed to be used at general purpose computers on the basis of Linux. To initial Hadoop nearly no security was introduced, but as the number of users increased data that need security increased and there appeared new version that introduced Kerberos and Token system in 2009. But in this method there was a problem that only one secret key can be used and access permission to blocks cannot be authenticated to each user, and there were weak points that replay attack and spoofing attack were possible. Hence, to supplement these weak points and to maintain efficiency a protocol on the basis of group key, in which users are authenticated in logical group and then this is reflected to token, is proposed in this paper. The result shows that it has solved the weak points and there is no big overhead in terms of efficiency.

Investigation of New Drug Submission Documents for the Safety and Efficacy Evaluation of Stereoisomeric Drugs (광학이성질체 의약품의 안전성과 유효성 측면에서 의약품 허가신청 자료에 대한 비교연구)

  • Kim, Kwang Joon;Choi, In;Lee, Beom-Gyu;Moon, Hong Seop;Han, Hyo Kyung;Choi, Eun Joo;Lee, Wonjae
    • Journal of Integrative Natural Science
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    • v.4 no.4
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    • pp.315-322
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    • 2011
  • This study was performed to investigate the current regulatory guidances of safety and efficacy evaluation for the approval of stereoisomeric drugs in Korea and US. According to the regulatory guidelines in major countries (EU, Canada, US), the important categories for the development of stereoisomeric drugs are classified as 1) development of a single enantiomer as a new active substances 2) development of a racemate as a new active substance 3) development of a new single enantiomer from an approved racemate. For this study, domestic regulatory documents for current guidelines of stereoisomeric drugs were investigated. Also four typical stereoisomeric drugs for three categories were chosen to investigate the new drug submission documents of KFDA and FDA for the safety and efficacy evaluation of stereoisomeric drugs. It is expected that these comparative results between KFDA and FDA will be useful for the safety and efficacy for the regulatory approval of stereoisomeric drugs in Korea.

PKI-based Distribution System of the User's Permission about Broadcast Program (PKI를 통한 방송프로그램 사용자 권한 유통시스템)

  • Im, Dae-Myung;Park, Ki-Chul;Lee, Joo-Young;Nam, Je-ho;Jung, Hoe-Kyung
    • Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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    • 2009.05a
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    • pp.649-652
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    • 2009
  • Now Broadcasting system of TV has been developed from analogue to digital we call that IPTV(Internet Protocol Television) or DCATV(Digital Cable Television). But, The characteristics of digital broadcasting is the high-quality contents of easily and almost no damage piracy, and Copyright loss is increasing by Internet, P2P(Peer to Peer) and personal path. Nevertheless user's permissions that recorded and reuse of broadcasting can't restraint, And Training Materials etc. use of fair program needs to be separated from illegality. In this paper using a digital certificate permit the use of stored program to authorized user and user of fair purpose, And illegal distribution of restriction design and implement a distribution system.

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A Longitudinal Study on the Supply & Demand-side Diversity of Digital Media : TV Channel & VOD Data of 2012-2017 (디지털미디어 콘텐츠 공급과 수요측면의 다양성 구현 종단 연구: 2012-2017년의 TV채널과 VOD 데이터를 중심으로)

  • Lee, Sang-Ho
    • Journal of the Korea Convergence Society
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    • v.10 no.8
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    • pp.137-144
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    • 2019
  • This paper deals with the longitudinal study on the supply & demand-side diversity of digital media service. The purpose of this study is to measure the diversity of contents supply and demand-side of digital media platform providers by longitudinal data and discuss the implication. In the approval and re-authorization of pay-TV broadcasters, there were attempts to measure diversity indicators as items to evaluate the publicness and public interest of broadcasting, but they are mainly limited to the method of measuring diversity in the short-term supply side. Thus researcher wants to confirm the evaluation of two aspects through this study. First, researcher proposes a demand-side measurement methodology that utilizes actual audience data from users, and second, a longitudinal evaluation methodology that evaluates long-term trends of diversity change. Researcher has secured the actual supply and demand data of the platform player and confirmed trends of longitudinal diversification indexing for 50 months from 2012 to 2017. Through this research, researcher expects that the supply and demand-side and the longitudinal diversity evaluation will be utilized in a balanced way of publicness and public interest evaluation of broadcasting.

Drought Analysis Using the Low Flow Frequency and Computation Model of Maintenance Flow (갈수빈도와 정상유량산정 모델을 활용한 가뭄상황 분석)

  • Son, Kyung-Hwan;Oh, Sung-Ryul;Choi, Kyu-Hyun
    • Proceedings of the Korea Water Resources Association Conference
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    • 2017.05a
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    • pp.356-356
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    • 2017
  • 최근 국토교통부 홍수통제소에서는 가뭄대응을 위해 1, 3개월 갈수예보를 시범적으로 운영하고 있다. 국가재난 위기경보단계(관심, 주의, 경계, 심각)에 따라 분류된 기준유량과 예측유량의 비교를 통해 갈수상황을 판단하며, 그 중 기준유량은 일본의 정상유량 산정 기법에 의해 계산된다. 그러나 우기 건기에 따라 상이한 유입량 및 물 사용량이 정상유량 산정에 고려되지 않았고, 각 위기단계별 물 부족상황이 재현되지 못하였다. 또한, 하천유량 부족은 가뭄과 관계가 밀접함에도 불구하고, 가뭄상황과의 연계분석이 이뤄지지 않았다. 본 연구에서는 갈수빈도와 정상유량산정 모델을 이용하여 기준유량을 재설정하고 가뭄상황을 분석하였다. 대상유역은 영산강유역으로 선정하였고, 보고된 하천수사용허가량, 댐 용수 공급량 및 10년 이상 장기간 관측된 관측소별 일 유량자료를 활용하였다. 일 관측유량을 7일 이동평균으로 변환한 후, 유황분석을 통해 $Q_{90}$을 산정하였으며, 빈도별 $Q_{90}$을 계산하였다. 정상유량 산정 모델에서 입력 자료(자연유량, 댐 공급량 및 하천수 허가량)에 가중치를 두어 양을 조절하고 각 빈도에 맞는 관개기 및 비관개기 기준유량을 산정 하였다. 가뭄지수로는 국내 활용성이 높은 Standardized Precipitaion Index (SPI) 및 Standardized Runoff Index (SRI)를 선정하였고, 이를 지속기간 1, 3, 6, 12개월에 따라 일별로 계산하였다. 7일 평균 관측유량이 기준유량 이하일 때, 이시점을 전 후로 가뭄지수의 시공간적 특성과 가뭄의 지속기간 및 심도를 분석하여 가뭄상황을 제시하였다. 본 연구의 결과는 갈수예보 시 하천유량 부족에 따른 물수지 및 가뭄상황에 대한 직관적인 판단과 갈수기 효율적인 하천수 조정 협의에 기여할 것으로 본다.

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