• Journal of Korean Orthopaedic Sports Medicine
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• v.8 no.1
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• pp.60-63
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• 2009

Trevor's disease, also known as dysplasia epiphysealis hemimelica, is rare abnormality characterized by aberrant cartilaginous overgrowth forming one half of epiphysis. Typically the patient is 2 to 14 years of age. Until now only six cases, including a case recurred after surgery, have been reported in Korea. A seven year-old boy complained pain of the left knee. However, any deformity of the knee was not seen. The plain radiographic findings showed multiple ossifications asymmetrically on the medial epiphysis of distal femur. The magnetic resonance imaging (MRI) clearly demonstrated the epiphyseal mass which contained low signal spots corresponding to calcified foci and abnormal cartilaginous overgrowth. We report one additional case with a brief review of literature with the MRI findings.

• Korean Journal of Cognitive Science
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• v.17 no.1
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• pp.1-13
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• 2006

We applied fMRI to examine brain activation at intentionality detection (ID) task. The main purpose of this study was to explore whether brain activation regions involved in intentionality detection (known as the basic mechanism of theory of mind) differ or not, according to prior instruction. Left uncus, superior temporal gyrus and right inferior occipital gyrus, supramarginal gyrus, inferior parietal lobule, thalamus (medial dorsal nucleus), and precuneus were activated with prior instruction. In contrast, ID task with no instruction activated merely inferior parietal lobule and superior parietal lobule. Common activated area between the two instruction conditions was inferiordparietal lobule. Our results suggest thar prior instruction activated ID-related brain regions more explicitly. furtherdinvestigations would be loused on spontaneity of intentionality detector and characteristic of participants.

• The Journal of the Korean bone and joint tumor society
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• v.6 no.2
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• pp.61-68
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• 2000

Purpose : We examined the patients to evaluate the radiologic findings of solitary plasmacytoma of the bone. Materials and Methods : We retrospectively reviewed radiologic findings of 9 cases with solitary plasmacytoma of the bone (SPB) for recent 5 years, but 2 cases were not included this study due to an abnormal finding of bone marrow and another 2 cases were not included due to an abnormal manifestations of computed tomography (n=1) and MRI (n=1). Results : Among 5 cases, 4 cases had an osteolytic bone destruction and 1 case had an osteosclerotic bone destruction on the plain radiograph. Computed tomography and MRI showed more informations about trabeculated bone destruction and the soft-tissue extension of the lesion comparing to plain radiographs. The MRI finding of SPB in 4 cases showed a relatively high signal intensity on T1-weighted image and intermediate signal intensity on T2-weighted image, on which the signal intensity of the lesion is slightly higher than that of the muscle. One case had an extensive soft-tissue involvement and multiple necrosis, which presented iso to low signal intensity on T1-weighted image and high heterogeneous signal intensity on T2-weighted image. The Gadolinium-enhanced T1-weighted images of 5 cases showed diffusely strong enhancement of the lesion except on the necrosis areas. Conclusion : Computed tomography and MRI may present some characteristics of SPB and demonstrate another foci of plasma cell infiltrates, so these can be helpful for the diagnosis and treatment of SPB.

• The Korean Journal of Nuclear Medicine
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• v.36 no.4
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• pp.232-243
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• 2002

Purpose: We studied whether brain perfusion SPECT is useful in the psychiatric disability evaluation of patients with chronic traumatic brain injury (TBI). Materials and Methods: Sixty-nine patients (M:F=58:11, age $39{\pm}14$ years) who underwent Tc-99m HMPAO brain SPECT, brain MRI and neuropsychological (NP) tests during hospitalization in psychiatric wards for the psychiatric disability evaluation were included; the severity of injury was mild in 31, moderate in 17 and severe in 21. SPECT, MRI, NP tests were peformed $6{\sim}61$ months (mean 23 months) post-injury. Diagnostic accuracy of SPECT and MRI to show hypoperfusion or abnormal signal intensity in patients with cognitive impairment represented by NP test results were compared. Results: Forty-two patients were considered to have cognitive impairment on NP tests and 27 not. Brain SPECT showed 71% sensitivity and 85% specificity, while brain MRI showed 62% sensitivity and 93% specificity (p>0.05, McNemar test). SPECT found more cortical lesions and MRI was superior in detecting white matter lesions. Sensitivity and specificity of 31 mild TBI patients were 45%, 90% for SPECT and 27%, 100% for MRI (p>0.05, McNemar test). Among 41 patients with normal brain MRI, SPECT showed 63% sensitivity (50% for mild TBI) and 88% specificity (85% for malingerers). Conclusion: Brain SPECT has a supplementary role to neuropsychological tests in the psychiatric disability evaluation of chronic TBI patients by detecting more cortical lesions than MRI.

• Journal of the Korean Society of Radiology
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• v.83 no.3
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• pp.473-485
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• 2022

The incidence of neurodegenerative diseases in the older population has increased in recent years. A considerable number of studies have been performed to characterize these diseases. Imaging analysis is an important biomarker for the diagnosis of neurodegenerative disease. Objective and reliable assessment and precise detection are important for the early diagnosis of neurodegenerative diseases. Artificial intelligence (AI) using brain MRI applied to the study of neurodegenerative diseases could promote early diagnosis and optimal decisions for treatment plans. MRI-based AI software have been developed and studied worldwide. Representatively, there are MRI-based volumetry and segmentation software. In this review, we present the development process of brain volumetry analysis software in neurodegenerative diseases, currently used and developed AI software for neurodegenerative disease in the Republic of Korea, probable uses of AI in the future, and AI software limitations.

• Clinical and Experimental Pediatrics
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• v.50 no.9
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• pp.891-895
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• 2007

Purpose : Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease of the central nervous system and mostly develops after viral illness or vaccinations. We investigated the clinical differences and neurologic outcomes according to the distribution of the lesions on brain MRI. Methods : The study group was composed of 21 patients from January 1995 to August 2003 in Kyunghee University hospital. We grouped the patients according to the MRI findings as follows. Group I (14 cases): Multi- or unifocal lesions only in the cerebral white matter. Group II (7 cases): lesions in the gray matter with or without white matter involvement. Results : 1. Preceding events were as follows: no defined prodrome (38.1%), upper respiratory tract infection (28.6%), nonspecific febrile illness (19.0%), gastointestinal disturbance and vaccination. 2. Presenting symptoms were as follows: seizures (76.2%), headache/vomiting (47.6%), altered consciousness (38.1%), hemiparesis, cerebellar ataxia, visual disturbance and facial nerve palsy. 3. Laboratory findings were as follows: CSF pleocytosis (76.2%), leucocytosis (38.1%) and elevated CSF protein (28.6%). 4. Fifteen patients were recovered completely without neurological sequelae. Three patients in group I and 1 patient in group II had intractable seizures. Two patients in group I and 2 patients in group II had motor disturbance. Conclusion : There were no statistically significant differences in preceding events, presenting symptoms, and neurological outcomes according to the distribution of the lesions on brain MRI. However, the ADEM have quite diverse clinical manifestations and neuroimage findings. MRI plays an important role in making diagnosis of the patients who are suspected of ADEM.

• Korean Journal of Psychosomatic Medicine
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• v.26 no.2
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• pp.194-200
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• 2018

Objectives : The significance of leukoaraiosis on brain magnetic resonance imaging (MRI) is uncertain, but it is often seen with vascular risk factors or in the context of cognitive impairment. We aimed to investigate the effect of leukoaraiosis on the severity and course of delirium. Methods : Periventricular hyperintensity and deep white matter hyperintensity on brain MRI were rated in 42 patients with delirium by semiquantative visual rating scale. Correlations between their grades and the scores of Korean version of Delirium Rating Scale-Revised-98 (K-DRS-R-98) were analyzed, and the interaction effects between the groups according to the levels of leukoaraiosis and two evaluation points were also analyzed. Results : The grade of deep white matter hyperintensity in the occipital lobe was positively correlated with the scores on the total, severity items, cognitive items, and non-cognitive items of K-DRS-R-98. The cognitive items scores of K-DRS-R-98 in the low grade group of periventricular hyperintensity showed significantly steeper decrease than the high grade group. Conclusions : A difference in severity or recovery speed of delirium according to the level of leukoaraiosis may result from disruption in brain functional connectivity. Our results have a clinical implication in that the severity and course of delirium can be possibly predicted using the level of leukoaraiosis.

• Journal of Biomedical Engineering Research
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• v.22 no.5
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• pp.377-384
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• 2001

Generally. there have been limitations to investigate structural brain abnormalities with MR images for psychiatric patients. such as schizophrenia. depression and autism, since the brain abnormalities of psychiatric Patients are too small to be detected easily. It has been suggested to exploit the result of size-comparison or analysis of specified Part in various brain tissues. Results of brain analysis highly depend on accuracy of the brain segmentation because it is hard to segment image that the boundary between tissues in the brain MRI is inherently value. In this Paper. we improve the quality of brain segmentation so that we increase the credit of brain analysis. In addition, we Provide the improved images for studying brain abnormalities through left-right insular volume measure using handy software tool .

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.11 no.6
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• pp.42-47
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• 2012

Followed by a paper on the Pig and Bone orthopedic prosthetic, this experiment using Phantom and Bone MRI imaging I, II of orthopedic prosthetic metal effect combines magnetic resonance imaging on metal signal-to-noise ratio(Signal to noise : SNR) and CNR(Contrast to noise: CNR), fat signal suppression(Fat-suppression) images was compared. Specimen trees to measure the reliability of the experimental reproducibility tests and statistical analysis using the SPSS statistical package was applied program SPSS(IBM SPSS Statistice 19) by * P = 0.000 < significance level $({\alpha})$ = 0.01 as a significant there was a correlation(** P < 0.01). SNR and CNR results did not directly proportional to the Titanium, Stainless, Clip CNR and fat signal suppression of the order of images of blood specimens was found to be close to the image. The impact of orthopedic prosthetic metals on magnetic resonance imaging in the diagnostic value of Titanium is relatively high and are meant more.

• Investigative Magnetic Resonance Imaging
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• v.11 no.1
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• pp.10-19
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• 2007

Conventional MRI methods using T1-, T2-, diffusion-, perfusion-weighting, and functional imaging rely on characterizing the physical and functional properties of the tissue. In this review, we introduce an imaging modality based on measured the mechanical properties of soft tissue, namely magnetic resonance elastography (MRE). The use of palpation to identify the stiffness of tissue remains a fundamental diagnostic tool. MRE can quantify the stiffness of the tissue thereby providing a objective means to measure the mechanical properties. To accomplish a successful clinical setting using MRE, hardware and software techniques in the area of transducer, pulse sequence, and imaging processing algorithm need to be developed. Transducer, a mechanical vibrator, is the core of MRE application to make wave propagate invivo. For this reason, considerations of the frame of human body, pressure and friction of the interface, and high magnetic field of a MRI system needs to be taken into account when designing a transducer. Given that the wave propagates through human body effectively, developing an appropriate pulse sequence is another important issue in obtaining an optimal image. In this review paper, we introduce the technical aspects needed for MRE experiments and introduce several applications of this new field.