• Proceedings of the Korea Information Processing Society Conference
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• 2019.05a
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• pp.346-347
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• 2019

의료영상은 환자의 질병을 진단하고 치료방침을 결정하는데 중요한 도구로 자리매김하고 있다. 최근 의료영상을 인공지능 연구가 국내외에서 활발하게 진행되고 있다. 특히 대규모의 의료영상들을 학습시켜 질병과 상태를 정밀 진단할 뿐만 아니라 예측하는 소프트웨어를 개발 하는 상황이다. 그러나 의료영상은 DICOM 표준에 따르고 있지만 태그정보의 사용은 의료기기와 의료기관마다 상이하다. 따라서 의료영상에 대한 메타 데이터의 표준화에 어려움이 있다. 본 논문은 이러한 의료영상 데이터를 표준화 할 수 있는 방법을 제안한다. 그리고 제안한 표준화 데이터로 변환할 수 있는 ETL 소프트웨어의 수행결과를 보이고, 조건에 따라 머신러닝 학습 데이터셋을 생성하는 결과를 제공한다. 향후 제안한 의료영상 표준화와 ETL 소프트웨어는 다양한 수요자 중심의 표준화된 데이터셋을 제공할 수 있는 플랫폼의 주요기능으로 활용 될 것으로 기대한다.

• Proceedings of the KSCN Conference
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• 2003.05a
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• pp.138-138
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• 2003

흡연은 각종 암의 발병율을 높이고 동맥경화증, 혈전증과 같은 관상심장질환의 주요 발병요인이 되는 것으로 알려져 있다. 흡연자에게 보여지는 지질과산화작용에 의한 LDL의 산화는 구리나 철과 같은 항산과 관련 무기질에 의해 촉진되며, 특히 구리는 매우 연관성이 높은 물질로 보고되었다. 따라서 흡연자의 혈중 무기질 함량의 측정은 항산화 능력과 심혈관계 질병의 진단 및 예후 판정에 민감한 지표로 사용할 수 있을 것으로 사료된다. (중략)

• Korean Journal of Psychosomatic Medicine
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• v.24 no.1
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• pp.74-82
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• 2016

Objectives : Suicide attempters have impaired decision making and are at high risk of reattempt. Therefore it is important to refer them to psychiatric treatment. Especially, People with medical comorbidity are at higher risk of suicidal attempt and mortality. The aim of this study was to investigate the characteristics of suicidal attempters and to analyze the influence of the medical comorbidity on decision to receive psychiatric treatment after visit to an emergency department. Methods : One hundred and thirty two patients, who visited the emergency room of a general hospital in Gyeonggi-do between January, 2012 and December, 2012 were enrolled as the subjects of this study. After reviewing each subject's medical records retrospectively, demographic and clinical factors were analyzed. Results : Regardless of the engagement type, either via admission or outpatient clinic, the determinant factors of psychiatric treatment engagement were psychiatric diagnosis, employment status, previous psychiatric treatment history, and previous attempt history. Comparison of severity of medical comorbidity(Charlson Comorbidity Index) showed that suicide attempters who received psychiatric treatment via admission or refused the treatment tended to have higher level of medical comorbidity than who received psychiatric treatment via outpatient department. Conclusions : Our findings showed that medical comorbidity of suicide attempters affected the decision to accept psychiatric treatment. All psychiatrists should evaluate the presence and the severity of medical comorbidity of the suicide attempters and consider implementing more intervention for the medically ill attempters who are willing to discharge against advice.

• Korean Journal of Microbiology
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• v.50 no.4
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• pp.265-274
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• 2014

Gut microbiota is a group of microorganisms that resides in the intestine and serves many important functions in human health. Using 16S ribosomal RNA sequencing analysis, a wide variety of bacteria in human gastrointestinal tract has been identified along with intriguing findings that there is a different bacterial composition among individuals. Fecal microbiota transplantation (FMT) is a procedure of stool transplantation from healthy donors to patients suffering from various diseases. Specifically, FMT is able to alter the composition of gut microbiota of recipients and therefore could be an effective treatment for the patients with gastrointestinal diseases including recurrent Clostridium difficile infection, inflammatory bowel disease, and irritable bowel syndrome. Here we review a list of human diseases related to gut microbiota disturbance and the case studies of FMT. We also summarize medicines and diagnostic tools that are under development. Therefore, gut microbiota can be a next generation's biotherapy for promotion of health and treatment of chronic diseases.

• Proceedings of the Korea Information Processing Society Conference
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• 2017.11a
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• pp.1097-1099
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• 2017

본 논문은 대뇌 활성화 상태 변화와 혈액형간의 상관성 분석을 목적으로 한다. 혈액은 인체의 혈관을 통하여 몸 전체로 순환하는 액체 성 물질이다. 이 혈액을 구성하는 물질의 이질적 차이를 나타내는 차별적 유형을 혈액형이라 하며, 혈액형은 멘델의 법칙에 따라 부모에서 자식으로 유전된다. [1] 최근 들어 혈액형이 가지는 유전적 특징을 통한 질병 진단 및 치료, 예방을 위한 연구가 진행되고 있으나, 대부분의 연구는 육체적인 질병과 관련되어 있는 실정이다. 그러나, 혈액형의 경우 유전적 특성을 가지고 있으며, 신경 전달 망에 영향을 끼칠 것으로 추정 되는바 육체적 질병뿐만 아닌 정신적인 질환에도 혈액형에 따른 치료 및 예방방법을 차별화 하여, 보다 효율적인 치료 및 예방을 수행 할 수 있을 것으로 판단된다. 본 논문에서는 이를 위하여, 외부자극에 따른 대뇌 활성화 상태 변화를 분석하며, 특히 혈액형에 따른 상태변화의 상관성을 분석하고자 한다. 본 논문에서 활용하는 외부 자극은 청각 자극을 활용하며, 먼저 혈액형에 따른 피험자 군의 분류를 수행하여 동일 군 내 공통반응 및 상이한 군 간의 특이반응을 분석하여, 혈액형이 대뇌 활성화 상태 변화 및 정신질환에 따른 증상발현 등과 유관함을 검증하고자 한다.

• The Journal of the Korea institute of electronic communication sciences
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• v.15 no.3
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• pp.611-616
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• 2020

In order to prevent the further spread of the COVID-19 virus in big cities, this paper proposes a semantic diagnosis and tracking system based on Linked Data through the cluster analysis of the infection situation in Seoul, South Korea. This paper is mainly composed of three sections, information of infected people in Seoul is collected for the cluster analysis, important infected patient attributes are extracted to establish a diagnostic model based on random forest, and a tracking system based on Linked Data is designed and implemented. Experimental results show that the accuracy of our diagnostic model is more than 80%. Moreover, our tracking system is more flexible and open than existing systems and supports semantic queries.

• Korean Journal of Psychosomatic Medicine
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• v.27 no.2
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• pp.77-84
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• 2019

Objectives : The Illness Intrusiveness Rating Scale (IIRS) is a well-validated self-report instrument for assessing negative impact of chronic illness and/or adverse effects of its treatment on everyday life domains. Although extensive literature probed its psychometric properties in medical illness, little attention was paid for its validity for psychiatric population. This study aimed to test factorial structure of the Korean Version of the IIRS (IIRS-K) in a consecutive sample of psychiatric outpatients. Methods : Data set of 307 first-visit patients of psychiatric clinic at Guri Hanyang univ. Hospital were used. Exploratory and confirmatory factor analysis, internal consistency were tested in IIRS-K. We also checked Spearman's correlation analysis between IIRS-K, Zung's self-report anxiety scale and Zung's self-report depression scale. Results : 76.9% of the patients were with anxiety disorder and depressive disorder. The principal component factor analysis of the IIRS-K extracted three-factor structure accounted for 63.2% of total variance that was contextually similar to the original English version. This three-factor solution showed the best fit when tested confirmatory factor analysis compared to the original IIRS, two-factor model of IIRS-K suggested from medical outpatients, and one-factor solution. The IIRS-K also showed good internal consistency (Cronbach's α=0.90) and good convergent validity with anxiety and depression scales. Conclusions : The IIRS-K showed the three-factor structure that was similar but not identical to original version. Overall, this study proved factorial validity of the IIRS-K and it can be used for Korean clinical population.

• Journal of agricultural medicine and community health
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• v.18 no.2
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• pp.141-151
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• 1993

This study was done about 371 tuberculosis(TB) patients composed 195 newly registered at Kyungju Gun Health Center from May 1989 to April 1990 (Group A) and 176 being treated at hospitals or private clinics from January 1988 to November 1989(Group B). When Group A patients visited and newly registered at Health Center, data was obtained by interviewing with a prepared questionnaire paper. And well trained inquirer visited Group B patients and obtained data by the same method from February 1990 to April 1990. The results are as follows ; Group A was generally lower than Group B in socioeconomic status and in family history of TB, the rate of Group A was 24.1% and higher than 11.9% in Group B(p<0.05). Knowledge about TB was improved more than past, but those who answered that TB is 'a communicable disease' were 59.5% in Group A and 51.7% in Group B(p<0.05). Those answered that TB is 'a inherited disease' were 9.2% and 11.4% each. And 1.7% of Group B answered that TB is 'a incurable disease'. Knowledge about TB treatment also was improved more than past, but in the rate of those who answered that TB is a curable disease provided by well treatment Group B(77.8%) was worse than Group A(91.3%). The rate of those who answered that TB were been able to cure by regularly anti-TB medication were 98.0% in Group A and 89.8% in Group B. Its difference was statistically significant. The rate that patients took the first diagnosis and wanted to receive treatments at the same organ were 34.9% of Group A at Health Center and 72.2% of Group B at hospitals or private clinics. And its difference was statistically significant. In the reasons that Group B knew Health Center treated pulmonary TB but they was treated at hospitals or private clinics, unreliability to Health Center was 48.1%. The reasons that Group A was treated at Health Center were 'because of trust' 63.1%, 'because of low cost' 50.3%, 'because of low cost except trust' 9.3%, 'no specific reasons' 27.7%. In the courses of knowing that TB was controlled at Health Center, 'by neighborhood, health worker and doctors' were 84.9% in Group A and 69.0% in Group B. But 'by TV or radio' were 8.2% in Group A and 14.7% in Group B, 'by school education' 2.5% in Group A and 6.2% in Group B. Conclusively, Group A patients were lower than Group B in socioeconomic status, but better than in knowledge about TB. Its reasons was suggested that Health Center had controlled TB patients better than hospitals and private clinics. But considering, that difference in the rate of the same organ for the first diagnosis and treatment, that the only 63.0% of Group A have treated due to 'reliability to Health Center', and that 48.1% of Group B knew that Health Center treated pulmonary TB but didn't visit it due to 'unreliability to Health Center', that public relations(PR) about use Health Center for pulmonary TB and health education for TB was thought to have to strengthened.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.907-910
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• 2018

오늘날 보행 분석은 여러 하지 관절, 뼈 및 근육, 신경 등의 이상을 판단할 수 있는 매우 중요한 지표로 사용되고 있다. 하지만 비정상 보행, 비대칭 보행을 하고 있는 사람들은 자신이 인지 할 수 있을 만큼 그 문제의 정도가 심각하지 않은 상태라면, 그 사실을 모른 채 살아간다. 결국 이런 문제가 지속된다면 향후 큰 질병이 발생하는 요인이 될 수 있다. 본 논문에서는 40개의 압력센서를 내장한 인솔을 통해 각 발의 압력 데이터를 수집하여 미리 정의한 정상 보행 시 나타나는 압력 분포를 기준으로 비정상 보행 여부를 판단하고 보행 시 나타나는 부분별 압력분포 데이터를 이용하여 보행 시 사용자 발의 과내전(over pronation)과 과외전(over supination) 경향도 분석하였다. 스마트 인솔을 사용하여 시간과 공간의 제약이 없는 사용자 친화적이면서 비정상 보행 판단 및 발의 과내 외전 경향 분석에 대해 자가 진단을 보조할 수 있을 것으로 기대한다.

• Journal of Genetic Medicine
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• v.6 no.2
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• pp.146-154
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• 2009

Multiplex ligation dependent probe amplification (MLPA) is a PCR-based method to detect gene dosage. Since its introduction, MLPA has been used to test a large number of genes for major deletions or duplications. Genetic testing, as a diagnostic tool for genetic disease, has been used primarily to identify point mutations, including base substitutions and small insertions/deletions, using PCR and sequence analysis. However, it is difficult to identify large deletions or duplications using routine PCR- gel based assays, especially in heterozygotes. The MLPA is a more feasible method for identification of gene dosage than another routine PCR-based methods, and better able to detect deleterious deletions or duplications. In addition to detection of gene dosage, MLPA can be applied to identify methylation patterns of target genes, aneuploidy during prenatal diagnoses, and large deletions or duplications that may be associated with various cancers. The MLPA method offers numerous advantages, as it requires only a small amount of template DNA, is applicable to a wide variety of applications, and is high-throughput. On the other hand, this method suffers from disadvantages including the possibility of false positive results affected by template DNA quality, difficulties identifying SNPs located in probe sequences, and analytical complications in quantitative aspects.