• Proceedings of the Korea Information Processing Society Conference
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• 2024.05a
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• pp.652-655
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• 2024

COPD(Chronic Obstructive Pulmonary Disease)는 장기간에 걸쳐 기도가 좁아지는 폐질환으로, 규칙적 운동은 호흡을 용이하게 하고 증상을 개선할 수 있는 주요 자가관리 중재법 중 하나이다. 건강정보 데이터와 인공지능을 사용하여 규직적 운동 이행군과 불이행군을 선별하여 자가관리 취약 집단을 파악하는 것은 질병관리 측면에서 비용효과적인 전략이다. 하지만 많은 양의 데이터를 확보하기 어렵고, 규칙적 운동군과 그렇지 않은 환자의 비율이 상이하기 때문에 인공지능 모델의 전체적인 선별 능력을 향상시키기 어렵다는 한계가 있다. 이러한 한계를 극복하기 위해 본 연구에서는 국민건강영양조사 데이터를 사용하여 머신러닝 모델인 XGBoost와 딥러닝 모델인 MLP에 오버샘플링, 언더샘플링, 가중치 부여 등 불균형 데이터 처리 기법을 적용 후 성능을 비교하여 가장 효과적인 불균형 데이터 처리 기법을 제시한다.

• Pediatric Infection and Vaccine
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• v.31 no.1
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• pp.113-121
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• 2024

Purpose: In response to the surge in coronavirus disease 2019 (COVID-19) omicron variant cases, we have implemented preemptive testing for preschool and school. The purpose is to quickly detect COVID-19 cases using a rapid antigen test (RAT) kit so that normal school activities can continue. Methods: The results entered in The Healthcare Self-Test App were merged with the information on the status of confirmed cases in the COVID-19 Information Management System by Korea Disease Control and Prevention Agency (KDCA) for preschool and school of students and staffs March 2 to May 1, 2022 to analyze the RAT positive rate and positive predictive value of RAT. Results: In preschool and school 19,458,575 people were tested, weekly RAT positive rate ranged from 1.10% to 5.90%, positive predictive value of RAT ranged from 86.42% to 93.18%. By status, RAT positive rate ranged from 1.13% to 6.16% for students, 0.99% to 3.93% for staffs, positive predictive value of RAT ranged from 87.19% to 94.03% for students, 77.55% to 83.10% for staffs. RAT positive rate by symptoms ranged from 76.32% to 88.02% for those with symptoms and 0.34% to 1.11% for those without symptoms. As a result of preschool and school RAT, 943,342 confirmed cases were preemptively detected, before infection spread in preschool and school. Conclusions: RAT was well utilized to detect confirmed cases at an early stage, reducing the risk of transmission to minimize the educational gap in preschool and school. To compensate for the limitations of RAT, further research should continue to reevaluate the performance of RAT as new strains of viruses continue to emerge. We will have to come up with various ways to utilize it, such as performing periodic and repeated RAT and parallel polymerase chain reaction.

• Journal of Chest Surgery
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• v.36 no.1
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• pp.15-20
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• 2003

Myasthenia gravis is a rare autoimmune disease involving acetylcholine receptor and its autoantibody on neuromuscular junction. The methods of treatment are medical treatment and surgical thymectomy. In this paper we analyzed the result of thymectomy and the factors affecting the postoperative symptom improvement. Material and method : This study obtained medical records of 37 patients who received the thymectomy for myasthenia gravis from March 1986 to December 1998. Result Out of 37 cases, 21 cases(57%) showed improvement, of which 8 cases (50%) in the group of thymoma(n=16), and 13 cases (62%) in the group of thymic hyperplasia(n=21) showed the improvement of symptoms. Postoperative complications were respiratory insufficiency due to aggravation of symptoms after operation, including tracheal intubation for ventilator support in 9 cases, pneumonia in 3 cases, pneumothorax in 2 cases and left vocal cord palsy in 1 case. There was one postoperative mortality. The relation between postoperative improvement and sex(P=0.3222), age(P=0.7642), thymic pathologic variants,(P=0.4335) and classification of thymoma(P=0.20) showed no statistically significant correlation. However, the lower grade of preoperative symptoms can predict the lower grade of postoperative symptoms significantly(P=0.0032). Follow up study to 36 postoperative survivors was performed in October 2002 based on the out-patient records and call with patients. Out of 36 cases, 33 cases(91.7%) could be investigated and 3 cases could not. Mean follow up period was 83.2 months. Out of 33 cases, 25 cases(75.8%) showed symptomatic improvement, of which 8 cases(53.3%) in the group of thymoma(n=15) and 17 cases(94.4%) in the group of thymic hyperplasia(n=18) showed the improvement of$\boxUl$ symptoms. Conclusion : In myasthenia gravis, thymectomy showed the good improvement, and more important factor affecting the improvement of symptoms was the grdae of preoperative symptoms. Also midterm and long term follow up results showed good symptomatic improvement.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.05a
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• pp.93-96
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• 2011

본 논문에서는 개선된 FCM 알고리즘을 적용하여 통계청에서 제공하는 한국 표준 질병 사인 분류표(K.C.D)를 기초로 질병을 분류한 후, 질병을 도출하고 애매한 증상의 차이의 정도를 퍼지 추론기법을 사용하여 정확한 질병 상세를 도출할 수 있는 한방 질병 분류 시스템을 제시한다. 기존의 FCM 알고리즘은 입력 벡터들과 각 군집 중심과의 거리를 이용하여 측정된 유사도에 기초한 목적 함수의 최적화 방식을 사용한다. 하지만 측정된 패턴과 군집 공간상의 패턴들의 분포에 따라 바람직하지 못한 군집화 결과를 보일 수 있다. 따라서 본 논문에서는 군집들의 대칭성 측도에 퍼지 이론을 적용하여 기존의 FCM 알고리즘으로 군집화 한 결과를 재 군집화 하여 군집화의 정확성을 개선시킨 후, 증상의 차이를 구분하기 위해서 애매한 증상의 정도를 퍼지 추론 방법을 적용하여 정확한 질병 상세를 도출할 수 있는 방법을 제시한다. 본 논문에서는 개선된 FCM 알고리즘을 적용하여 질병을 분류한 후, 퍼지 제어 기법으로 질병을 추출함으로써 기존의 한방 자가진단 시스템 보다 정확하게 질병을 도출한 것을 확인하였다.

• Korean Journal of Psychosomatic Medicine
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• v.29 no.2
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• pp.207-212
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• 2021

Anti-N-methyl-D-aspartate receptor (Anti-NMDAR) encephalitis is a neuroinflammatory disease mediated by autoantibodies to NMDAR. In the initial clinical stages of anti-NMDAR encephalitis, psychiatric symptoms like delusions, perceptual disturbances, and disorganized speech or behaviors are pronounced even without obvious neurological symptoms. Early treatments like immunotherapy and/or tumor removal are central to good clinical outcomes. Hence, it is important to diagnose early anti-NMDAR encephalitis, distinguishing it from mental disorder. In the present case study, the authors described psychiatric symptoms assessed with Positive and Negative Syndrome Scale (PANSS) of Ms. A, a 26-year-old woman, in the early phase of anti-NMDAR encephalitis. We will discuss the characteristic psychopathology of anti-NMDAR encephalitis toward prompt diagnosis and treatment. Ms. A showed a higher negative subscale score than positive one on the PANSS. Compared with mental disorder, negative symptoms and cognitive impairment would be more prominent in the early stage of anti-NMDAR encephalitis. Rituximab and teratoma removal were effective, and quetiapine showed good tolerability. It is recommended to evaluate anti-NMDAR encephalitis when negative symptoms, cognitive impairment, catatonia, changes in consciousness level, and neurological symptoms are observed, especially in young women.

• Korean Journal of Psychosomatic Medicine
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• v.31 no.2
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• pp.72-78
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• 2023

Objectives : This study aims to identify various psychiatric symptoms and psychosomatic symptoms caused by COVID-19 infection and investigate their long-term impact. Methods : A systematic literature review was conducted, selecting papers from domestic and international databases using keywords such as "COVID-19" and "psychosomatic." A total of 16 papers, including those using structured measurement tools for psychosomatic symptoms, were included in the final analysis. Results : Psychiatric symptoms such as anxiety, depression, and somatic symptoms have been reported in acute COVID-19 infection, while long-term post-COVID symptoms include chest pain and fatigue. The frequency of long-term psychosomatic symptoms has been estimated to be 10%-20%. Factors contributing to these symptoms include psychological and social stress related to infectious diseases, gender, elderly age, a history of psychiatric disorders, and comorbid mental illnesses. It is suggested that systemic inflammation, autoimmune responses, and dysregulation of the autonomic nervous system may be involved. Conclusions : Psychosomatic symptoms arising after COVID-19 infection have a negative impact on quality of life and psychosocial functioning. Understanding and addressing psychiatric aspects are crucial for symptom prevention and treatment.

• Journal of Preventive Medicine and Public Health
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• v.26 no.2 s.42
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• pp.251-267
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• 1993

The relationship between lead related subject symptoms and lead exposure indices was studied in 435 male lead workers in thirteen lead using industries. 212 male office workers who were not exposed to lead occupationally were also studied as a control group. Fourteen lead related symptoms were selected. They were further subdivied into 4 sub-symptom groups such as 1) gastrointestinal, 2) neuromuscular and joint 3) constitutional, and 4) psychological symptoms. Symptom questionnaires were provided to the workers and filled up by themselves and reconfirmed by interviewer(doctor). The test used fer the evaluation of lead exposure were blood lead(PbB), zinc protoporphyrin in whole blood(ZPP), hemoglobin(Hb), hematocrit (Hct), delta-aminolevulinic acid in urine(DALA). The results obtained were as follows; 1. The higher prevalence rate in the sub-group of neuromuscular and joint symptoms was observed in occupationally lead exposed subjects than non-exposed subjects. Among the sub-groups, the most frequent symptom was 'numbness of finger, hands or feet', and the prevalence of the symptom of 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia' were higher in order. 2. While the symptom which showed the biggest difference of prevalence rate among the 14 symptoms between exposed and non-exposed subjects was 'numbness of fingers, hands or feet', the symptom which showed the highest prevalence rate was 'feeling tired generally' in exposed and non-exposed subjects, but no statistical difference of symptom prevalence were observed. 3. In total study population, PbB and ZPP had dose-response relationship with 4 symtoms of neuromuscular and joint symptoms ('numbness of finger, hands or feet', 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia') and one symptom of gastrointestinal group('intermittent pains in lower abdomen'). 4. In lead exposed workers, only neuromuscular and joint symptoms group showed dose-response relationship with PbB and ZPP, 5. In lead exposed workers, the prevalance rate of overall symptoms of lead workers with age below 39 years was higher than that of lead workers with age above 40. While neuromuscular and joint symptoms group had a dose-response relationship with PbB in former group, it had a dose-response relationship with ZPP in latter group. 6. Age adjusted odds ratios of symptoms of non-exposed with exposed and odds ratios of low exposed with high exposed workers showed the dose-response relationship of lead exposure with neuromuscular and joint symptoms group('numbness of fingers, hands or feet', 'arthralgia', 'weakness of fingers, hands or feet' and 'myalgia') and gastrointestinal symptoms group('intermittent pains in lower abdoman').

• The Journal of the Korean dental association
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• v.21 no.7 s.170
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• pp.525-528
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• 1983

치수가 어떤 병적상태에 있는지 정확히 구분해 내는 것은 매우 어려운 일이다. 한 병적상태에서 다른 질환으로 쉽게 이행되고 염증상태에 있는 치수는 위촉되어 질환을 분류하는데 중첩되고 또한 병리조직학적 관점에서 진단해 내야 하기 때문에 임상에서 정확한 진단을 내리는데는 난점이 많다. 그러나 환자가 호소하는 주증상과 기왕증은 진단에 매우 중용한 부분을 찾이 하고 술자가 관찰하는 여러 가지 시험들을 토대로 하여 종합관찰한 후에 진단을 내려야 할 것이다.

• Journal of Haehwa Medicine
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• v.17 no.2
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• pp.17-21
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• 2008

화침은 오행 침법 중의 하나로써 다양한 질환에서 매우 효과적으로 작용하며, 최근 한의학계에서 많은 주목을 받고 있기도 하다. 본 연구의 목적은 화침의 중추신경질환 유래의 보행 장애에 미치는 효과를 평가하기 위한 것으로, 몇가지 임상증례를 통하여 분석하였다. 환자를 맥의 형태에 따라 5가지 유형으로 나누어 치료하였고, 치료 후 대부분 증상이 빠른 속도로 회복되었으며 다른 사람의 도움이 필요 없이 자가 보행이 가능하게 되었다. 이러한 결과들은 화침이 중추신경계질환의 보행 장애 환자에게 좋은 효과와 아울러 보행 장애에 대한 화침의 잠재적 가능성을 보여준다.

• The Monthly Diabetes
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• s.129
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• pp.26-28
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• 2000

소아 당뇨병은 일반적으로 인슐린의존성과 비의존성으로 구분된다. 인슐린의존성은 체내에서 혈당을 조절하는 인슐린이 분비되지 않아 인슐린주사에 의존해야 하는 경우, 비의존성은 비만 등으로 인슐린 작용이 감소하는 것으로 체중을 줄이거나 식이요법 등으로 조절이 가능하다. 19세미만 소아당뇨병의 90%는 인슐린의존성으로 바이러스 감염 후 자가항체가 생기거나 아황산가스 질소 등 공해물질에 의해 췌장이 파괴해 발생한다. 주로 10$\~$13세 또는 6$\~$8세에 많이 생기며, 한 번 발병하면 췌장이 재생되지 않아 평생 인슐린주사를 맞아야 한다. 우리나라는 인구 10만명당 1.2명으로 서구보다 발병률이 낮은 편이나 5년전에 비해 2배 가량 급증하고 있다.