• Journal of Veterinary Clinics
• /
• v.13 no.2
• /
• pp.212-215
• /
• 1996

Chemotherapy of transmissible venereal tumor (TVT) in a dog has been tried, using vincritstine, cyclophosphamide, and methotrexate. The dog was hiven an combination chemotherapy and underwent complete regression of the tumors with on recurrence. The result of our clinical trial indicates that combination chemotherapy is an effective modality for dogs with TVT.

• Journal of Veterinary Clinics
• /
• v.17 no.1
• /
• pp.293-294
• /
• 2000

6개월령의 숫 낙타와 29세의 남성 낙타 관리인에서 발생한 Trichophyton verrucosum에 의한 진균감염증에 대해 보고하였다. 이 감염증은 피부 병변으로부터 KOH 기술에 의해 균 요소를 증명하고, 또한 감염된 피부의 소파물로부터 Trichophyton verrucosum을 분리하여 확진하였다. 낙타에서는 안면에 국한하여 병변이 발생하고, 관리인에서는 손에 발생하였다. 화학요법으로서 낙타에게는 2% 옥도정기를 사용하고, 관리인에게는 2% miconazole 연고를 사용하였다. 이 보고는 인도에 사는 단봉낙타로부터 Trichophyton verrucosum이 직접 사람에게 전염된 최초의 보고로 생각된다. 이 보고에서 단봉낙타의 피부염 감별진단에 Trichophyton verrucosum도 고려해야 한다는 사실을 제시하였다.

• Journal of Veterinary Clinics
• /
• v.31 no.5
• /
• pp.407-411
• /
• 2014

A 12-year-old castrated male Pekingese dog was presented with weakness, exercise intolerance, and an episode of coughing started 2 weeks earlier upon presentation. Physical examination revealed a grade II/VI left systolic heart murmur. Echocardiographic examination revealed a pericardial effusion and a mass at the heart base located beside the left atrium. The mass beside the left atrium was also visible on the thoracic radiograph after drainage of the pericardial effusion. An aortic body tumor was definitely diagnosed based on postmortem histopathological examination and immunohistochemical staining for specific markers. The dog lived 234 days after diagnosis with only medical management and without recurrence of the pericardial effusion.

• Journal of the Korean Applied Science and Technology
• /
• v.36 no.1
• /
• pp.299-304
• /
• 2019

This study was conducted to investigate the effects of skin surface temperature on transdermal absorption of active substances and changes in skin condition. A transdermal absorption test was conducted using an emulsion containing 10% heat-resistant niacinamide, and the same emulsion was used in a clinical trial to test the thermal effects. As a result, absorption was found to be 2 times greater at 10 minutes and 3 times greater at 15 minutes after application at $42^{\circ}C$ than that of compared to normal skin temperature. During the clinical evaluation on skin, no clinical subjects showed any specific adverse reactions, while moisture and oiliness showed statistically significant effects at higher temperatures. Based on these results, it was confirmed that thermal warmer improves the absorption of active substances and had a positive effect on skin condition. It is deemed that this study will provide a preliminary data to support the development of various beauty devices using heat.

• Journal of Yeungnam Medical Science
• /
• v.13 no.1
• /
• pp.11-21
• /
• 1996

항암치료에 있어 내성기전은 암세포의 종류에 따라 다양하며 동일세포라도 내성이 생긴 항암제에 따라 그 기능이 다른 것으로 보고되고 있으며 세포종류 및 항암제에 따른 각각의 내성기전을 완전히 알기란 그리 쉬운 일이 아니다. 그러나 임상치료에 있어서 항암제의 적용은 대개 내성 생성이 잘 안되는 즉 교차내성이 적게 일어나는 약제끼리의 선택이 화학요법에 유리하며 재발방지의 지표가 될 수 있으며 내성억제가 가능한 약제의 개발이 중요하다. 또 암에 따른 정확한 내성기전을 잘 밝힘으로서 내성을 방지할 수 있는 target 약제를 함께 병용 개발하는 것이 암의 치료의 지름길이 될 수 있다.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.2
• /
• pp.294-299
• /
• 2019

Korean hospitals implement external quality assessment (EQA) schemes to improve the quality of clinical tests. However, smaller hospital do not implement EQA due to lack of appreciation and cost burdens. The purpose of this study was to analyze the results of EQA from the perspective of clinical chemistry carried out at a small-to-medium sized hospital (SMH) and to investigate factors influencing quality control. The medical institution concerned had performed EQA on 21 items annually for three years and had analyzed measurement methods, variation coefficients, and anomalous results as defined by the SMH. No significant change in test methods or variation coefficients, which exhibited a high level of variation, were observed for any test item over the 3-year period. The results obtained showed that anomalous test results were significantly more frequent when EQA was not conducted (p<0.05), internal quality control was not conducted daily (p<0.01), and when tests were less frequently performed (p<0.01). Small-to-medium sized hospitals need to be more aware of the benefits of EQA and provide tailored education to staff.

• Korean Journal of Head & Neck Oncology
• /
• v.28 no.2
• /
• pp.107-113
• /
• 2012

배 경 편평상피암은 두경부의 악성종양 중 가장 흔하며, 임상적인 경과가 불량하다. 따라서 나쁜 예후를 가지는 환자군을 조기에 선별하여 더 적극적인 치료의 시행을 결정짓는 표지자의 필요성이 대두된다. 우리는 일련의 두경부 편평세포암 검체에서 몇몇 분자 표지자의 예후적 유용성을 평가하고자 하였다. 방 법 23예의 두경부 편평세포암 검체를 대상으로 VEGF, p53, Apaf-1, caspase-9의 발현과 몇몇 임상병리학적 지표들간의 연관성을 면역조직화학염색을 통해 조사하였다. 결 과 환자군은 남성이 더 많았으며 평균연령은 63.7세였다. 1기가 5예, 2기가 2예, 3기가 8예, 4기가 8예였다. 평균생존기간은 37.3개월이었다. VEGF단백 발현은 종양의 크기와 통계적으로 유의한 연관성을 보였다. 이와 더불어 VEGF단백 발현은 병기, 그리고 림프관 침습과 연관적인 경향성을 보였다. 그러나 VEGF단백 발현과 생존기간과는 관련성이 없었다. 또한, Apaf-1과 caspase-9의 단백발현은 다른 임상지표, 환자의 생존기간과는 관련이 없었다. 결 론 VEGF단백 발현은 두경부 편평세포암 환자에서 나쁜 임상경과를 예측할 수 있게 하는 표지자로서의 역할을 할 수 있다. 또한 본 연구는 두경부 편평세포암에서 별로 연구되지 않은 Apaf-1과 caspase-9의 발현상태를 밝힌 점에서 의의가 있다.

• Biomedical Science Letters
• /
• v.3 no.2
• /
• pp.161-168
• /
• 1997

The measurement of many biochemical changes that could be appeared as aging will be resulted in the very useful and basal marker to maintain healthy life and to predict the health condition and the retardation of the aging. We classified the geriatrics into the normal and same aged dementia on the based of clinical diagnostic as well as MMSE evaluation. And then we were collected blood samples from both groups and examined 13 biochemical assays to screen any valuable biochemical index for dementia. Among 13 assays, several assay data showed the statistically significant differences between two groups. The values of serum albumin, APase, and GOT were significantly decreased in demented group compared to control. On the other hand, the values of glucose and LDH were increased in dementia compared to control. Additionally, the value of Pi was increased but the values of calcium and GPT were decreased, without significant difference (p＞0.05). The values of other assays such as bilirubin, BUN, cholesterol, creatinine and total protein did not show any statistically significant differences. Conclusively it may be suggested that dementia might be resulted in the variable biochemical changes which could be affected by many environmental factors as well as dementia itself.

• Journal of the Korean Applied Science and Technology
• /
• v.41 no.2
• /
• pp.172-187
• /
• 2024

In good laboratory practice (GLP), analytical method validation prior to toxicity testing is important in terms of concentration setting and sample preparation. The testing agency performed validation of the two requested test substances using high-performance liquid chromatography (HPLC), and as a result, the analysis satisfied the criteria for specificity, system suitability, linearity, intra-day reproducibility, homogeneity, stability, concentration analysis, and quality control. The method was established and validated. However, the content of standard substances in the test report of the requesting institution was found to be 1.34 and 1.17 times higher than the results of the testing institution, confirming that deriving results through validation of analysis methods suitable for GLP is important in terms of securing reliability and stability.

• Korean Journal of Clinical Laboratory Science
• /
• v.55 no.2
• /
• pp.71-81
• /
• 2023

This study examined the transition process of clinical laboratory technologists' national examination and job definition in Korea and compared the differences in the national examination between Korea and neighboring countries, such as Japan and Taiwan. In Korea, the number of questions made for it was 200 (1965), 200 (1977), 300 (1982), 250 (1992), 330 (2006), and 280 (2015). The practice of clinical physiology is important for real-time monitoring, given the characteristics of physiological testing. On the other hand, there are conflicts between other occupations in the working area. Clinical molecular biology needs to be established as a new major subject considering the diagnostic importance of molecular biological tests and the speed of science and technology development. Clinical laboratory operations provide policy and guidance recommendations to technologist staff. The proposed clinical laboratory technologists' national examination comprises major subjects: clinical biochemistry, clinical hematology, clinical transfusionology, clinical immunology, clinical microbiology, clinical molecular biology, clinical histology, clinical cytology, clinical physiology, and clinical laboratory operations. In addition, this study proposes the job definition of clinical laboratory technologists, revising various chemical or physiological testing to biomedical or physiological testing required for medical practice.