• The Microorganisms and Industry
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• v.17 no.1
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• pp.51-55
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• 1991

쥐의 단일클론항체는 기초연구에 뿐만 아니라 질병의 진단시약으로서도 광범위하게 유용되어 왔다. 반면, 쥐의 단일클론항체를 인체에 임상적으로 사용하는 것은 인체에 면역반응을 유발시킨다는 근본적인 문제점 때문에 어려운 일이라 인식되어 왔다. 그러나, 최근 2-3년간 유전자 기술과 단백질공학적인 방법에 의하여 쥐의 단일클론항체를 인간화시키거나 항체절편의 생산을 시도하게 되어, 단일클론항체의 임상적인 이용에 대한 가능성이 긍정적으로 진단되고 있다. 본 난에서는 항체의 구조와 기능을 간략히 살펴보고, 최근 항체의 단백질공학에 대한 경향과 방법 및 engineered 항체의 특성들에 관하여 논의하고자 한다.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.1
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• pp.1-8
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• 2023

The purpose of this study is to find terms that can give identity to the major and occupation of clinical laboratory technologist (also known as medical technologist). The term clinical pathology includes all branches of pathology, namely anatomical pathology, chemical pathology, hematology, microbiology, and all respective subspecialties. Unfortunately, several countries exclude anatomical pathology from the term clinical pathology, a problem that gets compounded when the title is translated into languages other than English. Clinical pathology (US, UK) is a medical specialty. Similar terms are laboratory medicine (Germany, Poland), medical/clinical biology (France, Netherlands) or clinical analysis (Spain). Depending on the person questioned, medical technology is defined slightly differently by individuals, companies, and institutions. The definition also depends on the language in which the question is asked. Medical technology can be translated to define clinical laboratory technology, allied health sciences, medical equipment, biomedical engineering, and health technology. The terms 'clinical pathology technology and pathological technology' are not used in allied health sciences. The names of 'medical technology·medical technologist' can be replaced by 'biomedical laboratory science·biomedical laboratory technologist' or 'clinical laboratory analysis·clinical laboratory analyst'. In this study, it is proposed to change the name of academic and occupation to 'medical biology·medical biology technologist' that combines the term biomedical.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.1
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• pp.105-121
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• 2021

To investigate and accommodate opinions on the revision of the official occupational title of the medical technologist, the Korean Association of Medical Technologists (KAMT) requested 22,638 people registered as its regular members to participate in an online survey and select their two preferred options from the alternative job titles presented. Survey responses were collected from 3,999 people (17.66%). To examine job title preferences among the KAMT members, each respondent was asked to choose two terms from the choice set. As a result, 6,958 responses were obtained, and out of the total responses, 5,555 (79.83%) indicated a choice for a job title that included the word 'analyst' as the preferred alternative. The survey results showed that "Diagnostic Laboratory Analyst" was the most preferred alternative selected by the largest proportion of respondents (2,417 responses, 34.73%), followed by "Clinical Laboratory Analyst" (1,710 responses, 24.57%), "Biomedical Pathology Technologist" (758 responses, 10.89%), "Biomedical Analyst" (730 responses, 10.49%), "Biomedical Laboratory Analyst" (730 responses, 10.03%), and "Clinical Laboratory Scientist" (646 responses, 9.26%). Therefore, based on the responses of the surveyed members, results of consultation and literature review, the Standard Classification of Occupations (SCO), and the current status of the job titles used in major countries, it is suggested that the occupational title of medical technologists should be changed by adopting "Diagnostic Laboratory Analyst", "Biomedical Laboratory Analyst", or "Biomedical Analyst" as their new official job title.

• Journal of IKEEE
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• v.22 no.4
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• pp.1093-1098
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• 2018

In this paper, we proposed a methodology for portable disease diagnosis platform using high performance computing. The proposed methodology consists of gathering clinical data, diagnosis and feature selection algorithm, implementation of diagnosis platform. For the algorithm verification, a clinical data which is obtained from 401 people(314 normal subjects and 87 liver cancer patients) using a microarray consists of 1,146 aptamers were used. As the result, we could diagnosis liver cancer with 97.5% accuracy using the 32 selected aptamers. Based on these results, we designed and implemented a portable disease diagnosis platform which has 32 bio-signals as inputs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.8 no.2
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• pp.420-429
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• 2004

It has been needed diagnosis technology of the EFG(Electro Functio Gram) measurement concept which is incorporated characteristic of modern science and biomedical engineering, because function abnormality diagnosis can't diagnose with visualization instruments or clinical pathology. The general diagnosis system(EFG system) has been developed to use basic diagnosis instrument that has reappearance, reliance and convenience using the functio diagnosis technology, in the field of western/oriental medicine. Also, we improved sticking electrode and simultaneous measurement method of the limbs 8CH, head 2CH to diagnose body circulation of Qi and acupoints for Oriental Medicine diagnosis/therapy. The result of clinical for adult man 20 persons, the EFG system can diagnose state of 12 meridians and autonomic nervous system. Therefore, in this paper, we designed of oriental medicine diagnosis system by bio-electric response with materialized H/W and S/W for 12 meridians state diagnosis of human body and system construction of the EFG.

• Journal of Sasang Constitutional Medicine
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• v.11 no.2
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• pp.95-117
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• 1999

1. Purpose of study There are many Constitution theories. But, In the Sasang Constitutional medicine, the theory and the practice are connected systematically. So it has been used in Korea popularly. Lee Je-Ma suggested that the external form, the mind, the symptom are the criteria of Sasang constitution diagnosis at the Discourse on the Four Principle and the Discourse on the Identifying Four Constitutions. But The clinical importance study of three diagnostic criteria - the external form, the mind, the symptom - has never been studied. Therefore, there are many obstacles of using the three diagnostic criteria totally. And I think that it needs a study which we apply the three diagnostic criteria to practice and approve the clinical importance of one another. I classify and investigate the previous methods of Sasang constitution diagnosis by the three diagnostic criteria in this study. 2. Method of study I investigate the previous methods of Sasang constitution diagnosis bibliographically by Dongyi Soose Bowon, Journal of Constitutional medicine and other books. 3. Result of study (1) Study of the external form The Study of Ki-sang(氣像) and Sa-ki(詞氣) by experience and intuition was done previously, and study of imaginay formulation of each constitution by measuring Chae-hyung(體形) and yong-mo(容貌) has being done recently. (2) Study of the mind For the objectification of study and diagnosis, self-reporting questionnaire has been used. The ideal choice to determine an indivisual constitution, as far as questionnaire go, is to take results from both the modified version Sasang Pattern Identification Questionnaire and QSCCII. (3) Study of the symptom For the study of the symptom - constitution symptom and constitution symptom of disease - the study of principles, the clinical study of the type of disease and symptom, the study which the pathologic view of Oriental medicine apply the view of Sasang Constitutional medicine have been done. We must try to objectfy Sasang Constitutional disease.

• The Journal of the Korean dental association
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• v.21 no.7 s.170
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• pp.525-528
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• 1983

치수가 어떤 병적상태에 있는지 정확히 구분해 내는 것은 매우 어려운 일이다. 한 병적상태에서 다른 질환으로 쉽게 이행되고 염증상태에 있는 치수는 위촉되어 질환을 분류하는데 중첩되고 또한 병리조직학적 관점에서 진단해 내야 하기 때문에 임상에서 정확한 진단을 내리는데는 난점이 많다. 그러나 환자가 호소하는 주증상과 기왕증은 진단에 매우 중용한 부분을 찾이 하고 술자가 관찰하는 여러 가지 시험들을 토대로 하여 종합관찰한 후에 진단을 내려야 할 것이다.

• Journal of the korean veterinary medical association
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• v.47 no.3
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• pp.260-267
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• 2011

소의 피부병에 대한 적절한 예방조치, 치료, 도태에는 정확한 질병진단이 필수 불가결하며, 그 진단을 기본으로 하는 방역대책을 실시하는 것에 의해 피부병에 따른 경제적 손실을 최소화할 수가 있을 것이다. 그러나, 현재까지 국내 외에서 소 피부병에 관한 보고는 단편적인 것이 대부분이고, 피부병의 진단지침으로 되어야 할 연구논문이나 자료가 태부족한 실정이다. 또한 피부병은 원인이 복잡하기 때문에 병변만으로 확정진단을 할 수 있는 경우는 그다지 많지 않다. 이는 피부가 가축 개체의 최대기관이며, 다양한 기능을 갖고 있기 때문이다. 본고에서는 세계 각국에서 문제되고 있는 소의 주요 피부질환을 중심으로 관련 논문이나 보고자료 등을 정리하여 대동물 임상수의사들에게 소개하고 자 한다.

• Tuberculosis and Respiratory Diseases
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• v.59 no.1
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• pp.77-85
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• 2005

Background : According to the 2002 consensus report of the American Thoracic Society/European Respiratory Society (ATS/ERS), idiopathic pulmonary fibrosis (IPF) was classified as biopsy proven or probable IPF. Probable IPF is defined as those with distinctive features that allow for a confident diagnosis of IPF/usual interstitial pneumonia (UIP) within an appropriate clinical setting. The determination of the clinical course of probable IPF, as diagnosed by the ATS/ERS criteria, was studied. Methods : Between March 1995 and August 2002, 36 patients with probable IPF, from two tertiary referral hospitals, were enrolled in this study. The clinical characteristics, prognostic factors and treatment efficacy of these patients were retrospectively evaluated. Results : The mean age of the subjects was $65{\pm}6$ years. The one and 3 year survival rates were 82.4 and 50.3%, respectively, and a median survival period of 42.0 months. The total cell count of bronchoalveolar lavage was higher in the death than the survival group (p<0.05). No survival benefits were found in the cytoxan and steroid treatment groups compared with other treatment groups. Conclusion : These results suggest that the clinical course of probable IPF may be similar to that of biopsy-proven UIP. However, atypical patients must undergo an open lung biopsy for confirmation of the diagnosis.

• Journal of Chest Surgery
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• v.32 no.4
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• pp.394-398
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• 1999

Background: According to the changes in the Environmental factors, traumatic diaphragmic rupture is seen in increasing frequency. Many reports described the early diagnostic methods and treatment modalities. In our institution, a study was retrospectively performed to obtain the early diagnostic and treatment methods of diaphragmic ruptures. Material and Method: From January 1994 to April 1998, 20 patients with traumatic rupture of the diaphragm were treated in our institution and We analyzed the patients in preoperative clinical presentations, diagnostic accuracies, associated injuries and postoperative complications. Result: Socially active male patients were affected most. 75% of patients had blunt trauma and 25% had penetrating injury. There were 16 cases of ruptured right diaphragm, 3 cases of left diaphragm and 1 case on both. Preoperative diagnosis were possible in 10 patients (50%) and 6 patients(30%) were diagnosed intraoperatively, but 4 patients (20%) were diagnosed in the late stages. Most common postoperative complication was wound infection, and two died of associated injuries. Conclusion: We conclude that if there is suspicion of diaphragmic rupture after a trauma, careful study and examination is essential and interdepartmental collaboration is very important.