• Journal of the Korean Society of Radiology
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• v.85 no.1
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• pp.184-196
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• 2024

Purpose We investigated potentially promising imaging findings and their combinations in the evaluation of cognitive decline. Materials and Methods This retrospective study included 138 patients with subjective cognitive impairments, who underwent brain MRI. We classified the same group of patients into Alzheimer's disease (AD) and non-AD groups, based on the neuropsychiatric evaluation. We analyzed imaging findings, including white matter hyperintensity (WMH) and cerebral microbleeds (CMBs), using the Kruskal-Wallis test for group comparison, and receiver operating characteristic (ROC) curve analysis for assessing the diagnostic performance of imaging findings. Results CMBs in the lobar or deep locations demonstrated higher prevalence in the patients with AD compared to those in the non-AD group. The presence of lobar CMBs combined with periventricular WMH (area under the ROC curve [AUC] = 0.702 [95% confidence interval: 0.599-0.806], p < 0.001) showed the highest performance in differentiation of AD from non-AD group. Conclusion Combinations of imaging findings can serve as useful additive diagnostic tools in the assessment of cognitive decline.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2012.06a
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• pp.469-471
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• 2012

선박운항을 위해 선원들이 수행하는 인지작업은 다양한 요인에 의해 영향을 받는다. 개인의 능력 뿐만 아니라, 주어진 작업, 항해장비, 해양환경 그리고 조직의 특성/문화와 관련 제 규정 등이 밀접한 연관관계를 갖고 있으며 이러한 요인들이 선원의 인지작업에 영향을 주고 있다. 본 연구는 이러한 복잡한 요인들을 고려하면서, 선원들을 인지작업을 분석할 수 있는 인지작업분석 프레임�p을 개발하였다.

• The Journal of the Korea Contents Association
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• v.20 no.10
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• pp.458-469
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• 2020

Geriatric depression is associated with pathological changes in the brain and increases the risk of cognitive impairment or dementia. However, high cognitive reserve, such as high education, can delay or minimize clinical manifestations of pathologies involving the brain, so the effect of geriatric depression on cognitive impairment or dementia may vary depending on the education level. In this study, the author analyzed data from the Korean Longitudinal Study of Aging (KLoSA) to examine whether the effect of geriatric depression on cognitive function differed depending on education level. Among the 10,254 subjects registered in the KLoSA, the 4,905 subjects who met the inclusion criteria were analyzed by stepwise regression analysis. The results were as follows: first, depressive symptoms predicted low cognitive function after 12 years; second, the negative effect of depressive symptoms on cognitive function after 12 years was higher in the old adult group than in the young adult group; and third, the effect of age was significant only in the low-educated group. These results suggest that depressive symptoms in low-educated old adults may increase the risk of development of dementia in the long term.

• 한국노년학
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• v.40 no.1
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• pp.147-161
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• 2020

The purpose of this research is to investigates 10-year trajectories of cognitive functions among older adults in their 70s to understand changes in cognitive functions as a continuum until very late life. This study also examines differences in trajectories of cognitive functions by gender and by changes in marital status, especially widowhood. Among participants of the Korean Longitudinal Study of Ageing(KLoSA), the sample of this study includes 800 older adults in their 70s during the first study wave (2006) and those who reported their cognitive functions for six consecutive study waves (2006, 2008, 2010, 2012, 2014, and 2016). The analyses were conducted in two steps. First, we conducted Latent Class Growth Analyses(LCGA) to investigated heterogeneous trajectories of cognitive functions in 10 years. Then, we performed multinomial logistic regression. Three heterogeneous trajectories of cognitive functions were identified. One group of 48.7% of older adults showed high cognitive function at baseline and maintained it over 10 years. Second group of 14.7% of older adults reported low cognitive function scores at baseline and showed continuous decline over time. Third group of 36.6% were showed mid-level cognitive functions and maintained their functions over time. We also found significant gender differences but not significant differences in marital status when we consider both in our model; however, the we found significant differences in changes in marital status when we did not consider gender in the model. The results suggest that the importance of considering dynamics of gender and changes in marital status to understand changes in cognitive functions in later life.

• 한국HCI학회:학술대회논문집
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• 2007.02a
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• pp.423-428
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• 2007

본 연구는 기존의 프레젠터의 단순한 포인터 및 클릭 기능을 넘어선 다기능 제스처 인식 포인터의 구현이 주 목적이다. 주된 연구 내용으로는 적외선 발광 다이오드에서 나오는 빛을 인지하여 포인터의 궤적 인식을 하는 기술과 이를 응용한 어플리케이션의 개발에 있다. 본 하드웨어에는 기본적인 마우스 클릭 기능 외에도 적외선 발광 다이오드를 탑재하여 PC와 연결된 카메라가 이를 인지하도록 한다. 장점으로는 카메라가 항상 PC와 가까이 있을 필요가 없으므로 어느 장소이든 관계없이 적외선 투과 필터가 장착된 카메라 하나만 설치할 수 있는 곳이면 구현이 가능하며 적외선을 이용하므로 가시광선의 영향을 적게 받아 효율적으로 영상 처리를 할 수 있다는 데에 있다. 제스처 인식을 통하여 수많은 여러 가지 기능을 실행할 수 있으며, 보다 사용자와 인터랙티브한 작업이 가능해진다. 구현된 하드웨어와 소프트웨어 시스템은 프레젠테이션 및 게임 컨트롤에 사용되었다.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2000.06a
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• pp.41-47
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• 2000

한국어 형태소 분석에서 가장 중요한 부분 중 하나가 바로 용언구(서술어)를 분석하는 것이다. 형태소 분석 뿐만 아니라 구문 분석, 의미 분석 단계에서도 정확한 용언구 분석은 매우 중요한 작업 중의 하나이다. 또한, 용언구에는 [체언+지정사+어미] 패턴도 포함되므로, 정보 검색기의 핵심 모듈인 명사 추출기(색인기)의 성능에도 용언구의 분석은 높은 비중을 차지한다. 본 논문에서는 용언구 분석의 정확성을 높이고, 견고하면서 속도도 향상시킬 수 있는 방법으로 새로운 어미 분류를 제안하고자 한다.

• Journal of Applied Biological Chemistry
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• v.64 no.3
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• pp.299-307
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• 2021

Accumulation of amyloid beta (Aβ) and oxidative stress are the most common reason of Alzheimer's disease (AD). In the present study, we investigated the cognitive improvement effects of butanol (BuOH) fraction from Momordica charantia in Aβ_25-35-induced AD mouse model. To develop an AD mouse model, mice were received injection of Aβ_25-35, and then orally administered BuOH fraction from M. charantia at doses of 100 and 200 mg/kg/day during 14 days. In the T-maze and novel object recognition test, administration of BuOH fraction from M. charantia L. at doses of 100 and 200 mg/kg/day improved spatial ability and novel object recognition by increased explorations of novel route and new object. In addition, BuOH fraction of M. charantia-administered groups improved learning and memory abilities by decreased time to reach hidden platform in Morris water maze test. Oral administration of BuOH fraction from M. charantia significantly inhibited lipid peroxidation and nitric oxide levels in the brain, liver, and kidney compared with Aβ_25-35-induced control group. These results indicated that BuOH fraction of M. charantia improved Aβ_25-35-induced cognitive impairment by attenuating oxidative stress. Therefore, M. charantia could be useful for protection from Aβ_25-35-induced cognitive impairment.

• 대한예방의학회:학술대회논문집
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• 2004.10a
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• pp.41.2-42
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• 2004

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.10
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• pp.1395-1401
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• 2012

This study investigated the cognition-related effects on antioxidant activities, ${\gamma}$-aminobutyric acid (GABA) contents, and AChE inhibitory activities in ethanol extracts from Zingiber officinale Rosc. (Korea), Curcuma longa L. (Korea), Curcuma longa L. (Myanmar), and Curcuma aromatica Salisb. (India). These extracts were investigated to determine the relationships among total polyphenols as well as DPPH and ABTS radical scavenging activities, GABA contents, and acetylcholinestrase (AChE) inhibitory activity. For the results, C. longa L. from Myanmar exhibited the highest contents of curcumin (97.1 ${\mu}g/mg$), total polyphenols (98.4 ${\mu}g/mg$), and GABA (1.31 ${\mu}g/mg$), as well as the strongest radical scavenging activities and AChE inhibitory activity. In addition, C. aromatica Salisb from India, which had the highest total polyphenol content (98.4 ${\mu}g/mg$) and strongest radical scavenging activities, exhibited relatively high AChE inhibitory activity similar to that of C. longa L. from Myanmar. On the other hand, Z. officinale Rosc. and C. longa L. from Korea showed low contents of curcumin (12.2 ${\mu}g/mg$) and polyphenols (85.7 ${\mu}g/mg$), as well as low AChE inhibitory activities. However, we could detect 1.11 ${\mu}g/mg$ of GABA in these extracts, which was similar to that of C. longa L. from Myanmar. Therefore, GABA content was not correlated with AChE inhibitory activity. Based on the results, AChE inhibitory activity is highly correlated with polyphenol contents in Zingibearceae family. Overall, among the Zingiberaceae tested, C. longa L. from Myanmar might be a strong candidate as a cognitive-enhancing ingredient.

• Journal of Korean Academic Society of Home Health Care Nursing
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• v.23 no.2
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• pp.121-128
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• 2016

Purpose: This study was aimed at constructing and examining the effects of a laughter therapy program for elderly patients in long-term care hospitals. Methods: A prospective, two-group quasi-experimental design was used and 50 patients (25 experimental and 25 control group patients) from two long-term care hospitals in Gyeonggido province, South Korea, were study participants. The experimental group received 24 laughter therapy sessions twice a week for 12 weeks, and the control group received laughter therapy after data collection. Data were collected between May 26 and August 17, 2014. Results: The level of cognitive function for the experimental group increased(t=3.27, p=.002). The level of forced vital capacity (t=2.78, p=.008) and forced expiratory volume in 1 second (t=4.94, p<.001) increased among members of the experimental group. Conclusion: These results indicated that the laughter program was effective in improving cognitive and pulmonary functions among older patients who were receiving long-term care in hospitals. This program could be used for community-based elderly patients.