• Journal of the Korean Society of Food Science and Nutrition
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• v.40 no.4
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• pp.500-508
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• 2011

This study was carried out to investigate the effects of jujube extracts on intestinal microflora, along with their antioxidant activities, according to extraction method. The antimicrobial activities of the extracts were measured using the agar diffusion method with a jujube extract concentration of 50 mg/mL. Neither the first nor second jujube extracts were inhibitory against the tested intestinal bacteria. However, water extracts of jujube significantly enhanced the growth of lactic acid bacteria, especially Bifidobacterium bifidum and Bifidobacterium adolescentis. Total phenol compounds and flavonoid compounds were higher in the 1st than in the 2nd water extracts. The EDA values of both water and ethanol extracts increased in proportion to the extract concentration. The 1st water extract showed the highest value among all the others, which was 85.60% at the concentration of 0.05 mg/mL. Furthermore, the 1st water extract showed stronger antioxidant activity than the other samples with an activity of 679.91 mg AA eq/g. These results support the potential use of jujube water extracts as a functional food component and a valuable resource for the development of nutraceutical foods, to increase the growth of Bifidobacterium spp. in the human intestine.

• Journal of Life Science
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• v.32 no.8
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• pp.622-632
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• 2022

The purpose of this study was to investigate activities as functional cosmetic materials, focusing on Rhododendron brachycarpum (RB) and Rhododendron fortunei (RF). The tyrosinase inhibitory effect, related to skin-whitening, was 32.6% and 39.3% respectively at the concentration of 1,000 ㎍/ml. The elastase inhibitory effect, related to skin anti-wrinkling activity, was 30% and 36.2% at 1,000 ㎍/ml concentration. Collagenase inhibitory activity showed 77.7%, and 80.2% respectively at 1,000 ㎍/ml concentration, which demonstrated excellent inhibitory activity. For a cell viability test, that measured on fibroblast cells by RB and RF extracts. Furthermore, the cell viability test showed 100.9% and 98.9% with cell viability at 100 ㎍/ml concentration in CCD-986Sk. The protein expression inhibitory effect of RB and RF extracts was measured by western blot at 25, 50, and 100 ㎍/ml concentrations, and the β-actin was used as a positive control. As a result, western blot of RB and RF extracts was measured by the expression inhibition rate of the MMP-1, MMP-2, MMP-3 protein, and was decreased by 67.2%, 65.5%, 13.6%, and 89.1%, 85.0%, and 62.7% at 100 ㎍/ml concentration. The mRNA expression inhibitory effect of RB and RF extracts was measured by RT-PCR at 25, 50, and 100 ㎍/ml concentrations, and the GAPDH was used as a positive control. According to the results of RT-PCR of RB and RF extracts, the expression inhibition rate of the MMP-1, MMP-2, and MMP-3 mRNA was decreased by 70.1%, 9.1%, 37.9%, and 38.2%, 8.3%, 57.3% at 100 ㎍/ml concentrations. So, RB and RF extracts showed the anti-wrinkle effectiveness as a functional cosmetic material.

• Journal of Life Science
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• v.10 no.3
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• pp.241-246
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• 2000

This study was carried out to investigate the antioxidant activity of the water extract from Coptis chinensis Franch. Coptis chinensis Franch. exhibited antioxidative activity at all concentration tested. The extract was as good as antioxidative action of the synthetic antioxidant, butylated hydroxytoluene and ascorbic acid; Also, the one was superior to that of natural antioxidant, $\alpha$ -tocopherol. With heavy metal ions (Fe3+, Zn2+) present, Coptis chinensis Franch. showed strong antioxidative effect.

• Journal of Korea Water Resources Association
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• v.52 no.10
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• pp.671-680
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• 2019

Many researches illustrated that the magnitude and frequency of hydrological event would increase in the future due to changes of hydrological cycle components according to climate change. However, few studies performed quantitative analysis and evaluation of future rainfall in North Korea, where the damage caused by extreme precipitation is expected to occur as in South Korea. Therefore, this study predicted the extreme precipitation change of North Korea in the future (2020-2060) compared to the current (1981-2017) using stationary and nonstationary frequency analysis. This study conducted nonstationary frequency analysis considering the external factors (mean precipitation of JFM (Jan.-Mar.), AMJ (Apr.-Jun.), JAS (Jul.-Sept.), OND (Oct.-Dec.)) of the HadGEM2-AO model simulated according to the Representative Concentration Pathway (RCP) climate change scenarios. In order to select external factors that have a similar tendency with extreme rainfall events in North Korea, the maximum annual rainfall data was obtained by using the ensemble empirical mode decomposition (EEMD) method. Correlation analysis was performed between the extracted residue and the external factors. Considering selected external factors, nonstationary GEV model was constructed. In RCP4.5, four of the eight stations tended to decrease in future extreme precipitation compared to the present climate while three stations increased. On the other hand, in RCP8.5, two stations decreased while five stations increased.

• Journal of the Korea Convergence Society
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• v.10 no.3
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• pp.127-133
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• 2019

The ami of our study was on the anti-obesity effect of ethanol extract from Trichosanthes kirilowii Maxim root (TKM) in murine adipocytes, 3T3-L1 cells. This study focused on anti-adipogenic activity through inhibition of cell differentiation in 3T3-L1 cells treated TKM. 100 ug/ml of non-cytotoxic TEM remarkablely inhibited content of triglycerol and suppressed expressions of $C/EBP{\alpha}$, $PPAR{\gamma}a$ and SREBP-1c related with lipogenic transcription factors in theres 3T3-L1 cells compared to (-)control cells. As phosphorylations of AMPK and ACC were incerased, HSL and CPT-1 mRNA expression increased upon TKM treatment, which involved in inhibition of fatty acid synthase expression. In conclusion, these results indicate that TKM can inhibit mRNA and protein expression of lipogenic genes in 3T3-L1 adipocytes. Our study suggests that TKM has potential anti-obesity effects and is a convergence therapeutic functional agent with anti-adipogenic activity via hypolipogenesis.

• KIPS Transactions on Software and Data Engineering
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• v.3 no.6
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• pp.231-236
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• 2014

The transit time of contrast agents and the parameters of time-intensity curves in ultrasonography are important factors to diagnose various diseases of a digestive organ. We have implemented an automatic parametric imaging method to overcome the difficulty of the diagnosis by naked eyes. However, the micro-bubble noise and the respiratory motions may degrade the reliability of the parameter images. In this paper, we introduce an optimization technique based on MRF(Markov Random Field) model to enhance the quality of the parameter images, and present an image tracking algorithm to compensate the image distortion by respiratory motions. A method to extract the respiration periods from the ultrasound image sequence has been developed. We have implemented the ROI(Region of Interest) tracking algorithm using the dynamic weights and a momentum factor based on these periods. An energy function is defined for the Gibbs sampler of the image enhancement method. Through the experiments using the data to diagnose liver lesions, we have shown that the proposed method improves the quality of the parametric images.

• Journal of Korean Society for Geospatial Information Science
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• v.23 no.1
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• pp.39-45
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• 2015

The housing market is transformed by a variety of socio-economic characteristics, also appeared differently according to regional characteristics. This study aims to draw out the change factors influencing on the housing market structure and to analyze the drawn factors' distribution pattern by area. For this purpose, First, targeting 251 areas in the units of city, county and districts nationwide, this study drew out demographic, socio-economic variables influencing on the housing market structure for 5 years ranging 2005 to 2010. For that, the factor analysis was conducted. Second, this study grasped the change factors of the housing market structure's spatial patterns using the kriging method, a spatial statistical method. Third, this study used the Moran I, one of spatial autocorrelation analysis methods in order to grasp whether the factors had statistically significant concentration or dispersion or showed a random distribution pattern.

• KIPS Transactions on Software and Data Engineering
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• v.7 no.7
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• pp.267-274
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• 2018

This paper describes a head pose estimation method using PTZ(Pan-Tilt-Zoom) camera. When the external parameters of a camera is changed by rotation and translation, the estimated face pose for the same head also varies. In this paper, we propose a new method to estimate the head pose independently on varying the parameters of PTZ camera. The proposed method consists of 3 steps: face detection, feature extraction, and pose estimation. For each step, we respectively use MCT(Modified Census Transform) feature, the facial regression tree method, and the POSIT(Pose from Orthography and Scaling with ITeration) algorithm. The existing POSIT algorithm does not consider the rotation of a camera, but this paper improves the POSIT based on perspective projection in order to estimate the head pose robustly even when the external parameters of a camera are changed. Through experiments, we confirmed that RMSE(Root Mean Square Error) of the proposed method improve $0.6^{\circ}$ less then the conventional method.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.169-169
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• 2016

농업 유역 내 수문 순환 및 비점오염원의 발생 및 거동에 대해서 유역단위로서의 많은 연구가 진행되어 왔다. 하지만 유역단위로서의 모의를 통해서는 필지 별 발생되는 농업 비점오염물질을 평가하고 대책을 세우기에는 한계가 있다. 따라서 농업 유역의 농경지를 대상으로 유역단위 모의가 아닌 필지단위 모의를 진행함으로써 농업 비점오염물질에 대한 관리를 해야 할 필요성이 있다. 그리하여 본 연구에서는 필지단위로 상세한 모의가 가능한 ArcAPEX 모형을 사용하였으며 모형 내 임계값 조정을 통한 유역 구분 시 우리나라 지형 및 농업특성 상 지형인자 추출의 어려움으로 Pre-defined Streams and Watersheds 기능을 활용하는 것이 농경지를 대상으로 정확한 필지 분할 및 필지 특성 반영이 될 것이라 판단하였다. 하지만 Pre-defined Streams and Watersheds 기능에 필요한 자료를 구축하는데 시간과 노력이 많이 소모되고 어려움이 있었다. 따라서 본 연구에서는 입력 자료 구축의 편의를 도모하고자 Subarea-Stream 자동 연결 모듈을 개발하여 그 활용성을 평가하고자 하였다. 이를 위해 지형적 특성으로 인해 집약적인 농업이 행해지고 있는 강원도 양구군에 위치한 해안면 유역의 농경지 경계와 하천 및 수로에 대한 자료를 Subarea-Stream 자동 연결 모듈에 입력하여 최종적으로 Pre-defined Streams and Watersheds 기능에 필요한 입력 자료를 변환시켜 모형에 적용하였다. 본 연구결과 Pre-defined Streams and Watersheds 기능에 필요한 입력 자료를 단시간에 편리하게 구축할 수 있었으며, 농경지를 대상으로 필지 단위로 분할이 된 것을 확인 할 수 있었다. 최종적으로 본 연구를 통해 지형인자 추출 오류로 인해 수계 추출 시 나타날 수 있는 문제점에 대한 해결을 할 수 있었으며 모형 내 Pre-defined Streams and Watersheds 입력 자료 구축 시 Subarea-Stream 자동 연결 모듈을 활용한다면 농업 유역 내 농경지에 대해서 편리하게 유역단위에서의 모의가 아닌 필지단위에서의 상세한 모의를 하는데 큰 기여를 할 것이라 판단된다.

• Microbiology and Biotechnology Letters
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• v.50 no.2
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• pp.277-282
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• 2022

Whitening effect of the extract of Phaseolus angularis (PA) shell was investigated for its potential application as a functional ingredient for cosmetic products. The tyrosinase inhibitory effect, which is related to whitening, was 76.4% at a concentration of 1,000 ㎍/ml. Cell viability of melanoma cells was measured to test toxicity of the PA shell extract at concentrations showing at least 90% viability. In addition, western blot and RT-PCR assays of the PA shell extract showed concentration-dependent decreases of MITF, TRP-1, TRP-2 and tyrosinase protein and inhibitory effect of mRNA expression. These findings suggested that extract from PA shell has great potential as a cosmeceutical ingredient with whitening effect.