• 제목/요약/키워드: 이형성증

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Ultrasonography in Developmental Dysplasia of Hip Part I: Technical Introduction (고관절 이형성증에서의 초음파의 사용 1부: 기술적 소개)

  • Lee, Soon Hyuck
    • The Journal of Korean Orthopaedic Ultrasound Society
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    • v.1 no.1
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    • pp.31-39
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    • 2008
  • After the introduction of ultrasound enabling a detailed view of both neonatal hip instability and morphology, two different streams have developed: one arguing that neonatal hip instability is the major pathology warranting treatment, the other including acetabular dysplasia as an important feature. Graf's method including the acetabular dysplasia led to higher treatment and follow-up rate than that based upon neonatal hip instability only. Recent report suggested that improved examination techniques and a better understanding of the findings have enabled a more tailored approach, and no differences in treatment rates exist due to different ultrasound techniques. I'd like to emphasize that enough experiences and the understanding enabling standardized examination and high repeatbility is more important than the choice of different techniques. Here the mothods and meanings of different techniques of ultrasound and its usefulness in the diagnosis and treatment of DDH is discussed.

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A Case of Dysplastic Epiglottis in Elderly Patient (노령 환자에서 발견된 후두개 이형성증 1예)

  • Lim, Sung Hwan;Kim, Seung Woo
    • Korean Journal of Head & Neck Oncology
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    • v.33 no.2
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    • pp.71-73
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    • 2017
  • Dysplastic epiglottis is extremely rare congenital malformation, which usually occurs in association with other laryngeal anomalies. Hypoplasia is the most common type in epiglottic malfomations. Other abnormalities include rudimentary, aplasia and bifid etc. Mostly, they are found in infancy and early childhood, and diagnosis at adulthood is extremely rare. A 69-year-old man with chronic cough and globus sense visited our clinic. Laryngoscopic findings revealed a unique form of epiglottis. He had no history of laryngeal trauma, tumors, head and neck surgery, and radiation. There was no another anomaly in the laryngo-pharynx. Because of a mass-like lesion at the apex of epiglottis, we performed the laryngeal microsurgery. The pathology revealed as granulation tissue. We report a rare and unique case of dysplastic epiglottis in elderly patient with a brief literature review.

Expression of c-fos Protein in Fibrous Dysplasia and Osteofibrous Dysplasia (섬유성 이형성증 및 골섬유성 이형성증에서의 c-fos 단백 발현)

  • Park, Hye-Rim;Park, Yong-Koo;Kim, Duck-Whan
    • The Journal of the Korean bone and joint tumor society
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    • v.5 no.4
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    • pp.216-220
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    • 1999
  • The purpose of this study was to evaluate the role of c-fos oncogenes in the development of fibrous dysplasia and osteofibrous dysplasia. The immunohistochemical expression of c-fos protein was evaluated in 15 cases of fibrous dysplasia and 8 cases of osteofibrous dysplasia. Ten cases of fibrous dysplasia were weakly positive with c-fos. Six cases of osteofibrous dysplasia were weakly positive and the remaining two cases were strongly positive. The overall expression of c-fos protein is weaker than high-grade osteosarcoma, thus the implication of c-fos protein is little in the development of these tumors. Fibrous dysplasia and osteofibrous dysplasia share some features of characteristic histology and c-fos expression.

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The effect of restricted fluid intakes in the first week of life on the risk of bronchopulmonary dysplasia and patent ductus arteriosus in very low birth weight infants (극소저출생체중아에서 생후 첫 주의 제한적 수액투여가 기관지폐이형성증과 동맥관개존증 발생에 미치는 영향)

  • Koo, Hoe Kyoung;Choi, Eun Na;Namgung, Ran;Park, Min Soo;Park, Kook In;Lee, Chul
    • Clinical and Experimental Pediatrics
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    • v.50 no.6
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    • pp.536-542
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    • 2007
  • Purpose : We investigated the effects of restricted fluid in the first 7 days of life on the risk of bronchopulmonary dysplasia (BPD) or patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants. Methods : Eighty three VLBW infants who lived more than 28 days were selected. The amount of daily maintenance fluid was determined by calculation of insensible water loss (IWL) and urine output (UO). Seventy to 80 percent of calculated amount was given to the ventilated infants. Subjects were grouped into low (<25th%), moderate (25-75th%), and high (>75th%) fluid groups for the first 24 hours, 3 days and 7 days. Chi square tests analyzed proportions of subjects with or without morbidities across fluid groups. Multivariate logistic regression was used to analyze the effect of fluid intake on BPD or PDA, controlling for factors that are significantly associated with BPD or PDA by univariate analysis. Results : Rates of BPD and PDA were not significantly associated with fluid groups on each time period. The result was the same after controlling for factors that are significantly associated with BPD or PDA by univariate analysis. For the first 3 and 7 days, fluid intakes were positively related with maximal weight loss, urine output and mechanical ventilation duration. Conclusion : In VLBW infants, when given based on needs reflected from IWL and UO versus intake, relatively low fluid intakes in the first week of life do not decrease the risk of BPD or PDA, and vice versa. We suggest that calculation of daily fluid based on IWL and UO is appropriate for VLBW infants.

Three-Dimensional Brain Surface Rendering Imaging of Cortical Dysplasia (뇌피질 이형성증의 3차원 뇌표면 연출영상)

  • Hwang, Seung-Bae;Kwak, Hyo-Sung;Lee, Sang-Yong;Jin, Gong-Yong;Han, Young-Min;Chung, Gyung-Ho
    • Investigative Magnetic Resonance Imaging
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    • v.14 no.2
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    • pp.126-133
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    • 2010
  • Purpose : The study was to evaluate the localization of the abnormal gyral and sulcal patterns obtained by means of brain surface rendering imaging. Materials and Methods : Nineteen patients with cortical dysplasia who underwent brain surface rendering MR imaging were included in this study. We acquired MP-RAGE sequence and created the 3-D surface rendering MR images by using $VoxelPlus^{(R)}$. Anatomical locations and configurations of abnormal gyri and sulci were reviewed. Results : Abnormal gyral and sulcal patterns were seen 18 in 19 patients. The configuration and orientation of affected gyri and sulci were clearly evaluated in the brain surface rendering images. In a lissencephaly, the a cortex was not delineated and showed markedly thick and smooth gyral pattern. In a schizencephaly, there were wheel shaped broad gyral pattern around the cleft. In a hemimegalencephaly, an affected hemisphere were enlarged and displayed thick and wide gyral pattern. In CBPS, the insular cortex was exposed and the gyri of the lesion were thickened. In focal cortical dysplasia, there were irregular serrated or thick and enlarged gyri. Conclusion : Brain surface rendering MR imaging is useful for the evaluation of a detailed gyral pattern and accurate involvement site of abnormal gyri.

HPV, 음부사마귀와 자궁경부암 유발

  • 이용은
    • RED RIBBON
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    • s.65
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    • pp.8-11
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    • 2005
  • HPV(human papilloma virus ; 인유두종 바이러스)감염은 HIV감염 여성에서 더 흔히 일어나는데 HPV는 음부사마귀와 자궁경부암을 일으킬 수 있다. HPV와 연관된 자궁경부 이형성증(cervical dysplasia)이라고 불리는 자궁경부암의 전구질환 또한 HIN감염 여성에서 더 흔하고 치료 후 재발이 쉽게 일어난다.

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A Novel RUNX2 Mutation in a Korean Family with Cleidocranial Dysplasia (한국인 쇄골 두개 이형성증 가족에서의 RUNX2 유전자 돌연변이)

  • Lee, Ji Won;Song, Jisoo;Shin, Teo Jeon;Hyun, Hong-Keun;Kim, Young-Jae;Lee, Sang-Hoon;Kim, Jongbin;Kim, Jung-Wook
    • Journal of the korean academy of Pediatric Dentistry
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    • v.46 no.4
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    • pp.409-415
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    • 2019
  • Cleidocranial dysplasia (CCD) is an autosomal-dominant disease characterized by the delayed closure of cranial sutures, defects in clavicle formation, supernumerary teeth, and delayed tooth eruption. Defects in the Runt-related transcription factor 2 (RUNX2), a master regulator of bone formation, have been identified in CCD patients. The aim of this study was to identify the molecular genetic causes in a CCD family with delayed tooth eruption. The 23-year-old female proband and her mother underwent clinical and radiographic examinations, and all coding exons of the RUNX2 were sequenced. Mutational analysis revealed a single nucleotide deletion mutation (NM_001024630.4 : c.357delC) in exon 3 in the proband and her mother. The single C deletion would result in a frameshift in translation and introduce a premature stop codon [p.(Asn120Thrfs*24)]. This would result in the impaired function of RUNX2 protein, which may be the cause of delayed eruption of permanent teeth in the family.