• Journal of Pharmaceutical Investigation
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• 제4권1_2호
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• pp.31-38
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• 1974

The effort of proteolytic enzyme on the absorption and excretion of sulfadimethoxine are investigated in this paper. The rat small intestinal absortion of sulfadimethoxine in the presence of proteolytic enzymes such as chymotrypsin and trypsin are increasingly absorbed more than 20% during 3 hours. Blood levels of sulfadimethoxine following oral administration are not effected by proteolytic enzyme, but both on the high concentration of chymotrypsin and the low concentration of trypsin at only 3 and 4 hours are increased(P<0.05) from that of the control . Blood levels of sulfadimethoxine after duodenum injection are remakably enhensed to correspand to 18.5-25.0% (P<0.01) by the proteolytic enzyme concentration respectively. Proteolytic enzymes did not give influence on excretions of sulfadimethoxine after duodenum and oral administration.

• Journal of Pharmaceutical Investigation
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• 제14권4호
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• pp.156-160
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• 1984

The pharmacokinetics of acetaminophen administered intravenously(20mg/kg) was investigated in the rabbits of carbon tetrachloride induced hepatic failure. The blood level, the total AUC and the biological half life of acetaminophen were increased significantly in hepatic failure rabbits compared with those of normal rabbits. The urinary excretion and the overall elimination rate of acetaminophen were decreased significantly in hepatic failure rabbits. There was significant relationship between GOT value and AUC or biological half life of acetaminophen.

• 대한지리학회지
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• 제38권
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• pp.61-74
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• 1988

Changing patterns of population densities in urban centers are different between Western countries and non-Western countries. Although Seoul is located in a non-Western country, the result of this study shows that its pattern of population density falls into the category of Western cities. Through the examination of three population density gradient models, it is clear that no model can precisely explain the population distribution of Seoul over time. Some of the models partly indicate the actual population distrisbution. The Clark model is appropriate to denote population distribution in the center of Seoul at an early stage in development. The Sherratt model cannot adequately explain the population distribution of Seoul.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 B
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• pp.575-577
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• 1998

In this paper, we propose a hybrid target tracking algorithm which combine the conventional Kalman filter algorithm and the fuzzy neural network. Conventional methods are degraded in the presence of uncertanties and the environmental noise. These problems can be resolved by the proposed method. The training data for the proposed target tracker is obtained by the off-line simulation. Unlike other target trackers usging fuzzy inference system, our method can be easily integrated into the existing system. A numerical simulation is included to show the effectiveness and the feasibility of the proposed method.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2015년도 추계학술대회
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• pp.239-241
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• 2015

본 논문에서는 클러스터 개수를 동적으로 생성하는 개선된 FCM을 적용하여 초음파 영상에서 충수염을 추출하는 방법을 제안한다. 초음파 영상에서 ROI 영역을 추출한 후, Max-Min 기반 이진화 기법을 적용한다. 이진화된 영상에서 근막 영역의 크기가 ROI 영역의 1/3이상을 차지한다는 정보를 이용하여 Labelling 기법을 적용하여 근막 영역을 추출한다. 근막의 최하단 좌표를 이용하여 근막의 하단 영역을 추출한 후, 근막의 하단 영역에서 객체들의 선명도를 높이기 위해 Blurring 기법과 Sharpening 기법을 적용한다. 충수염의 후보 영역을 추출하기 위해 FCM 알고리즘을 개선하여 양자화를 수행한다. 개선된 FCM 알고리즘으로 양자화를 수행하여 충수염의 후보 영역을 추출한다. 추출된 충수염의 후보 영역에서 8방향 윤곽선 추적 기법을 적용하여 객체들을 추출한다. 추출된 객체들 중에서 낮은 명암도를 가지고 초음파 전체 영상 크기의 1/3이하 되는 객체를 충수염으로 추출한다. 초음파 영상을 대상으로 제안된 방법을 적용하여 실험한 결과, 기존의 방법보다 충수염 영역의 추출률이 개선된 것을 확인하였다.

• 반도체디스플레이기술학회지
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• 제7권4호
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• pp.23-28
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• 2008

A high speed automated pitch variation unit (HAPU) related to semiconductor category sorting movement of the test handler system was developed. In the design process, 'DMADOV' step of 6-Sigma method has been applied. The design result for the desirable pitch variation was a 3:1 reduction rack-pinion and a linkage which are operated by servomotors. The realization and reliability of the mechanism was obtained at the design stage by FEM analysis, and by robust design using Taguchi orthogonal array against weight and deformation. Finally, the validity of the high speed variation mechanism was confirmed via inspection using a high speed camera while performing pitch variation.

• Journal of Pharmaceutical Investigation
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• 제12권1호
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• pp.23-30
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• 1982

The effect of various surfactants on the absorption of antipyrine was studied using goldfish and rat. The results are as follows. The threshold concentration of antipyrine was reduced by various surfactants. Overturn time and death time of goldfish, in solution containing different concentration of antipyrine was reduced by the presence of various surfactants. Plots of reciprocal death time versus antipyrine concentration were linear with a positive concentration intercept such as minimum effective concentration. The absorption of antipyrine from rat small intestine was increased by administration with surfactants. As results, is believed to be one of rendering the goldfish membrane or rat small intestine more permeable to antipyrine.

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2008년도 추계학술대회
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• pp.123-126
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• 2008

외국 IT선진 기업들은 비용절감, 우수인력 활용, 전락 시장에의 접근 등의 목적으로 해외 IT 아웃소싱은 물론, Business Process Outsourcing(BPO)도 활용하고 있다. 선진 글로발 기업들은 이미 우수인력을 선점하여 글로발 차원에서 경쟁력을 유지하고 있다. 비롯 늦었지만 최근 우리나라 IT 서비스 기업들도 해외에 개발센터를 설립하여 중국인력을 활용하기 시작하였다. 개발 인건비 절감이 주 목적이나 분산 원격개발의 프로세스를 정립하고 훈련하는 것도 부수적으로 기대하고 있다. 중국시장을 접근한다는 장기적 전략으로 현지회사와의 M&A, 교육 및 보상체계 제공, 사용 언어의 다변화 등을 통하여 우수인력의 적극 확보하는 것이 요구된다.

• 약학회지
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• 제31권4호
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• pp.204-212
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• 1987

Rifampicin is an indispensable drug along with isoniazid for the control of tuberculosis and is usually prescribed as the combination of rifampicin and isoniazid. This paper is attemtped to investigate the interaction of rifampicin and isoniazid. Isoniazid was administered orally at a dose of 30mg/kg of rabbits pretreated with rifampicin 7.5mg/kg, 15mg/kg, and 30mg/kg, respectively twice daily for 9 days. The results are as follows: The blood level and relative bioavailability of isoniazid were decreased significantly (p<0.05) by rifampicin at a dose of 15mg/kg and 30mg/kg. The renal clearance of total isoniazid and ratio of its metabolites to isoniazid were increased significantly (p<0.05) by rifampicin at a dose of 15mg/kg and 30mg/kg. It seemed to be due to enzyme induction by rifampicin. Elimination rate constant ($\beta$) of isoniazid was increased and half life ($t_{1/2$\beta}$) was decreased by rifampicin pretreatment. Dosage regimen of isoniazid after long term administration of rifampicin should be adjusted carefully.

• 약학회지
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• 제29권6호
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• pp.362-366
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• 1985

These paper was attempted to investigate the mechanism of increased blood level of sulfisomidine by cimetidine pretreatment pharmacokinetically. Especially, effect of cimetidine pretreatment on both renal clearance and biliary clearance of sulfisomidine was studied in rabbits. The results are as follows. The blood level of sulfisomidine administered intravenously in dose of 25mg/kg was elevated significantly by cimetidine pretreatment. Relative bioavailability and biological half-life were increased significantly by cimetidine pretreatment. Overall elimination rate constant ($betha$) and distribution rate constant ($K_{13}$) of sulfisomidine were decreased significantly by cimetidine pretreatment. The renal and biliary clearance of sulfisomidine were decreased significantly compared with those of control rabbits by cimetidine pretreatment. The results may be also related to the inhibition of sulfisomidine metabolism enzyme activity or reduction of blood flow in the liver.