• Sleep Medicine and Psychophysiology
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• v.12 no.1
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• pp.68-71
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• 2005

We report a case of obstructive sleep apnea syndrome, which occurred primarily during the REM sleep stage. A 55-year-old female patient who complained of chronic insomnia on the initial visit turned out to have obstructive sleep apnea syndrome of a mild degree (respiratory disturbance index (RDI) of 13.8/hour, %time spent below 90% of SaO2=5.0%) on nocturnal polysomnography. Interestingly, apnea episodes and desaturations mainly occurred during REM sleep stage. And RDI and destaturations during REM sleep stage were found to be severe enough to classify as a severe degree of obstructive sleep apnea syndrome. These findings suggest that severe obstructive sleep apnea syndrome might be masked under the symptom of chronic insomnia and that apneas can be predominantly localized within REM sleep epochs. In terms of treatment, "REM sleep-dependent" apneas may call for different methods of treatment, especially REM sleep-specific pharmacological intervention.

• Journal of the Society of Naval Architects of Korea
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• v.28 no.2
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• pp.195-206
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• 1991

This paper is concerned with comparison of the first-order reliability methods applied to the assessment of structural safety. For convenience the reliability methods are divided into two categories : the One can explicitly consider the effects of uncertainties in material and geometric variables on those of load effects, say stresses and displacement in the structural analysis procedure and the other one does not. The first method is commonly termed as the stochastic finite element method(SFEM) or probabilistic finite element method(PFEM) and the second method is termed heroin as the ordinary reliability method to distinct it from the stochastic finite element method in which the structural analysis is carried out just once and the load effects are directly input into the reliability analysis procedure. This is based on the reasonable assumption that the level of uncertainties of load effects is the same as those of load itself. In this paper the above two different reliability method have been applied to the safety assessment of plane frame structures and compared thier results from the view point of their efficiency and usefulness. As lear as results of the present structure models are concerned, it can be said that the ordinary reliability method can give reasonable results when the uncertainties of material and geometric variables are comparatively small, say when less than about 15% and the stochastic finite element method is desired to be applied to the structure in which the COV's are comparatively great, say when greater than about 15%.

• The Korea Journal of Herbology
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• v.30 no.6
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• pp.63-68
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• 2015

Objectives : Gastric lesions affect many people around the world and their development are results of the imbalance between destructive and protective factors in the gastric mucosa. Lycium chinense has been widely used as a traditional Korean medicine, it was recently reported that they have potent anti-inflammatory effects in chronic hepatitis models. Therefore, this study aimed to investigate the anti-inflammatory activity of Lycium chinense extract (LCE) on HCl-Ethanol induced gastric lesion mice.Methods : The ICR mice were divided randomly into five groups of six animals each. Group A was normal mice, and group B was treated orally with 0.5 ml 150 mM HCl-60% Ethanol. Mice in group C and D were pre-treatment of LCE (100 mg/kg and 200 mg/kg bodyweight, p.o before HCl/ethanol treatment) and group E was orally administered sucralfate (10 mg/kg).Results : 150mM HCl/60% ethanol-induced gastric mucosal injury mice were ameliorated mucosal damage upon histological evaluation by treatment of LCE. Pre-treatment of LCE attenuated reactive oxidative species (ROS) and produces peroxynitrite (ONOO^-) in stomach tissues. As results of stomach protein analyses, LCE effectively reduce inflammatory-related factors such as cyclooxygenase-2 (COX-2), tumor necrosis factor alpha (TNF-α), inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6) in gastric lesion mice. In addition, nuclear factor kappa B (NF-κB) and inhibitor of phosphorylation of nuclear factor kappa B (p-IκB) were down-regulated in LCE-administrated gastric lesion mice.Conclusions : Our discovery supports that the therapeutic activity of LCE ameliorate the development of gastric lesion via suppressing the oxidative stress and gastric partial inflammation induced by 150 mM HCl/60% ethanol.

• Science of Emotion and Sensibility
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• v.12 no.2
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• pp.181-192
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• 2009

The purpose of this study was to explain the attitudes and acceptance toward the smart clothing adopted by the TAM(Technology Acceptance Model). A theoretical model on consumer acceptance of the commercialized smart clothing was constructed on the basis of previous studies and a review of literature and tested the path analysis. For the data analysis, statistical methods of confirmatory factor analysis, correlation, and covariance structural analysis using AMOS 5.0 package were employed. The results from a web-based survey of 557 online consumers indicate that the TAM by Davis(1989) adopted by perceived value according to market price was able to explain consumer acceptance of smart clothing substantially well. Using structural equation modeling, eight of the six hypotheses investigated in this study were supported. The results of the testing of the hypothesis were as fellows: First, perceived ease of use had a side effect on attitude through perceived usefulness. In addition, the attitude was found to affect consumer acceptance. Second, perceived usefulness was found to affect consumer attitude on perceived value, however, had not significant effect on consumer acceptance toward smart clothing. Third, perceived value was found to affect both consumer acceptance and attitude toward smart clothing. Finally, the attitude toward smart clothing had a direct effect on the consumer acceptance.

• Journal of Applied Biological Chemistry
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• v.59 no.2
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• pp.113-124
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• 2016

Red ginseng is known to have many beneficial effects. Cisplatin, an effective antineoplastic drug, can cause many side effects like irreversible sensorineural hearing loss and serious tinnitus in humans. This study is aimed to reduce a cisplatin's side effect, nephrotoxicity by fermentated korean red ginseng. Korea ginseng was produced by steaming and dring and fermentation. And mice were divided into 4 groups- (A) normal mice, (B) Vehicle treated cisplatin mice, (C) RG0F0-treated cisplatin mice, (D) RG8F3-treated cisplatin mice. C and D groups were feed each material 200 mg/kg/day during 4 days. And cisplatin 20 mg/kg injected to B, C, and D groups as abdominal injection. After 24 h, blood sample was collected. The kidneys were harvested for histological, immuno histochemical and western blot analysis. 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity was depended on steaming hours. RG0F0 and RG8F3 (ginseng-8 h steamed and fermented by Saccharomyces cerevisiae) were showed antioxidants effect in DPPH and ABTS radical scavenging activity. Component amounts according to steaming hours. 8 h steamed red ginseng had the most ingredients of ginsenoside. Treatments with RG8F3 reduced cisplatin-induced nephrotoxicity in the mice resulting in increase of GSH and decrease of ROS, BUN, creatinine, and inflammatory mediators. This result seems to be involved with the restriction of the inflammation in the kidney. Therefore, fermented red ginseng might have therapeutic efficacy in reduce kidney injury induced by cisplatin treatment.

• Journal of the Korean Institute of Gas
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• v.24 no.1
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• pp.17-22
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• 2020

Light Naphtha is distillated from crude oil unit and separated into the methane, ethylene and propylene by boiling point difference in sequence. This separation is conducted using a series of binary-like columns. This separation method is known that the energy consumed in the reboiler is used to separate the heaviest components and most of this energy is discarded as vapor condensation in the overhead cooler. In this study, the first two columns of the separation process are replaced with the Petlyuk column. A structural design was exercised by the stage computation with ideal tray efficiency in equilibrium condition. Compared with the performance of a conventional system of 3-column model, The design outcome shows that the procedure is simple and efficient because the composition of the liquid component in the column tray was designed to be similar to the equilibrium distillation curve. The performance of the new process indicates that an energy saving of 12.1% is obtained and the cost savings of 44 million won per day based on gross domestic product is reduced under same total number of trays and the initial investment cost is saved.

• Korean Journal of Remote Sensing
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• v.37 no.6_3
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• pp.2027-2034
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• 2021

Using multi-temporal KOMPSAT-3/3A high-resolution satellite images, the Normalized Difference Vegetation Index (NDVI) for the area around the Fukushima daiichi nuclear power plant was determined, and the pattern of vegetation changes was analyzed. To calculate the NDVI, surface reflectance from the KOMPSAT-3/3A satellite image was used. Satellite images from four years were used, and the zones where the images overlap was designated as the area of interest (AOI) for the study, and by setting a profile passing through highly vegetated area as a data analysis method, the changes by year were examined. In addition, random points were extracted within the AOI and displayed as a box plot to quantitatively indicate change of NDVI distribution pattern. The main results of this study showed that the NDVI in 2014 was low within AOI in the vicinity of the nuclear power plant, but vegetated area continued to expand until 2021. These results were also confirmed in the change monitoring results shown in a profile or box plot. In disaster areas where access is restricted, such as the Fukushima nuclear power plant area, where it is difficult to collect field data, obtaining land cover classification products with high accuracy using satellite images is challenging, so it is appropriate to analyze them using primary outputs such as vegetation indices obtained from high-resolution satellite imagery. It is necessary to establish an international cooperation system for jointly utilizing satellite images. Meanwhile, to periodically monitor environmental changes in neighboring countries that may affect the Korean peninsula, it is necessary to establish utilization models and systems using high-resolution satellite images.

• Journal of Digital Convergence
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• v.17 no.7
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• pp.131-138
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• 2019

The world's electricity production ratio is 40% for coal, 20% for natural gas, 16% for hydroelectric power, 15% for nuclear power and 6% for petroleum. Fossil fuels also cause serious problems in terms of price and supply because of the high concentration of resources on the earth. Solar energy is attracting attention as a next-generation eco-friendly energy that will replace fossil fuels with these problems. In this study, we test the charge-operation plan and the discharge operation plan for peak-cut operation by applying the maximum power demand reduction simulation. To do this, we selected the electricity usage from November to February, which has the largest amount of power usage, and applied charge / discharge logic. Simulation results show that the contract power decreases as the peak demand power after the ESS Peak-cut service is reduced to 50% of the peak-target power. As a result, the contract power reduction can reduce the basic power value of the customer and not only the economic superiority can be expected, but also contribute to the improvement of the electric quality and stabilization of the power supply system.

• Journal of Life Science
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• v.29 no.1
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• pp.37-44
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• 2019

Leaves of Sasa quelpaertensis Nakai are used in folk medicine for their anti-inflammatory, antipyretic, and diuretic properties. To ensure efficient utilization of S. quelpaertensis leaf, we previously reported a preparation method for phytochemical-rich extract (PRE) using the leaf residue, which was produced after hot water extraction. This study was undertaken to evaluate the hypouricemic potential of S. quelpaertensis leaf PRE in potassium oxonate (PO)-induced hyperuricemic mice. The administration of PRE significantly reduced serum uric acid (UA), blood urea nitrogen (BUN), and serum creatinine levels and increased urine UA and creatinine levels in the PO-induced hyperuricemic mice. It also reduced liver UA levels and xanthine oxidase (XA) activity. A histological analysis revealed that PRE administration protected against PO-induced liver damage, pointing to anti-inflammatory and cytoprotective effects in PO-induced hyperuricemic mice. We analyzed the transcriptome response to PRE administration in PO-induced hyperuricemic mice using RNA sequencing (RNA-Seq) in kidney tissues. The administration of PRE mainly enriched genes involved in mediating immune and inflammatory responses and the metabolic pathway. A Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the metabolic pathway, purine metabolism, and antibody biosynthesis were the major pathways altered in the PRE and PO groups. These results suggest a potential role for PRE in the prevention and treatment of hyperuricemia with inflammation.

• Journal of Ginseng Culture
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• v.3
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• pp.1-10
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• 2021

Panax ginseng (Ginseng or Korean ginseng) is one of the most important medicinal herbs in the world. We made a high-quality whole genome sequence of P. ginseng using 'Chunpoong' cultivar, which is the first cultivar registered in Korea Seed and Variety Service (KSVS) with relatively similar genotypes and superior phenotypes, representing approximately 3 Gbp and 60,000 genes. Genome sequence analyses of P. ginseng and related speciesrevealed the origin of Korean ginseng and the ecological adaptation of 18 Panax species around the world. Korean ginseng and American ginseng (P. quinquefolius) are tetraploid species having 24 chromosome pairs, while the other 16 species are diploid species with 12 chromosome pairs. Panax and Aralia are the closest genera belonging to the Araliaceae family that diverged approximately 8 million years ago (MYA). All Panax species evolved as shade plants adapting to cool climates and low light conditions under the canopy of deep forests from Southeast Asia such as Vietnam to Northeast Asia such as Russia approximately 6 MYA. However, through recurrent ice ages and global warming, most diploid Panax species disappeared due to the freezing winter, while tetraploid P. ginseng may have appeared by allotetraploidization, which contributed to the adaptation to cold temperaturesin Northeast Asian countries including the Korea peninsula approximately 2 MYA. American ginseng evolved by the adaptation of P. ginseng in Northeast America after the intercontinental migration 1 MYA. Meanwhile, most of diploid Panax species survived in high-altitude mountains over 1,600 meters in Southeast Asia because they could not endure the hot temperature and freezing cold. The genome sequence provides good basisto unveil the origin and evolution of ginseng and also supports practical gene chips which is useful for breeding and the ginseng industry.