• Journal of Scientific & Technological Knowledge Infrastructure
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• s.12
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• pp.52-57
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• 2003

바이오인포매틱스 시스템은 생명공학, 의학, 약학 등의 바이오인포매틱스 관련 산.학.연 연구자들의 연구개발의 기반이 되는 대용량의 생물정보를 효율적으로 저장하는 데이터베이스 구축 및 운영에 필요한 검색 처리 및 분석 시스템을 구축하는 정보인프라로서 21세기 가장 각광 받는 분야로 자리잡고있다. 최근 기하급수적으로 증가하고 있는 유전정보와 특정그룹이나 개인별 유전자 변화와 질병 감수성과의 관계 및 특정 질병과 관련된 유전자에 대한 생물학적 2차, 3차 분석정보 등 바이오인포매틱스 연구의 확대 필요성이 증가하고 있으나, 대부분의 생명공학 관련 산.학.연 연구자들은 연구분야에 적합한 IT기술을 적용할 수 있는 적절한 방법을 보유하고 있지못한 실정이다.

• Journal of the Korean Society for Library and Information Science
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• v.46 no.3
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• pp.233-250
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• 2012

The purpose of this study is to assess the development, current states, and problems of MEDLIS document delivery service. With the analysis of MEDLIS transaction data from 2001 to 2011, we identified continuous usage decrease, unbalanced contribution by type of institution, high dependence on back issues, use differences among subfields of medicine, relatively low success rate, and various reasons for failure. Based on the results, recommendations for the maintenance of union catalog database, technical support for search capability enhancements, establishment of back issue archiving policy, user training and publicity, and membership expansion are suggested to promote the service.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.17 no.5
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• pp.137-142
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• 2017

The development of medical devices based on the theory of tranditional Korean medicine is increasing due to population aging and emerging demand for medical services. Various clinical trials are being conducted to ensure the clinical effectiveness of the developed medical devices, and the importance of systematic management of variously collected information in this process is increasing. In this paper, we designed and constructed the database that can systematically manage the medical information of the patient and the pulse measurement information in conducting clinical trials by using pulse analysis system which is a representative diagnostic method of traditional Korean medicine. The constructed database can be efficiently used for the verification of existing algorithms or developing new algorithms through the quality control of various information and measured data on clinical trials. It also has several advantages in the control of clinical data. The results of this study can contribute to the establishment of Korean medical device data standard for the construction of integrated database management system that can share information with different kind of pulse analysis system and other bio-signal measuring devices.

• Bioinformatics and Biosystems
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• v.2 no.2
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• pp.37-45
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• 2007

생물정보학은 컴퓨터를 이용하여 방대한 양의 생물학적 데이터를 처리하고 그 결과를 분석하는 학문으로서 IT의 고속성장과 맞물려 점차 그 활용도를 넓혀가고 있다. 특히 의학, 생명과학 연구에 사용되는 데이터는 그 종류도 다양하고 크기가 매우 큰 것이 일반적인데, 이의 처리를 위해서는 고속 네트워크가 바탕이 된 그리드-컴퓨팅(Grid-Computing) 기술 접목이 필연적이다. 고속 네트워크 기술의 발전은 슈퍼컴퓨터를 대체해 컴퓨터 풀 내에 분산된 시스템들을 하나로 묶을 수 있는 그리드-컴퓨팅 분야를 선도하고 있다. 최근 생물정보학 분야에서도 이처럼 발전된 고성능 분산 컴퓨팅 기술을 이용하여 데이터의 신속한 처리와 관리의 효율성을 증대시키고 있는 추세이다. 그리드-컴퓨팅 기술은 크게 데이터 가공을 위한 응용 프로그램 개발과 데이터 관리를 위한 데이터베이스 구축으로 구분 지을 수 있다. 전자에 해당하는 생물정보 연구용 프로그램들은 mpiBLAST, ClustalW-MPI와 같은 MSA서열정렬 프로그램들을 꼽을 수 있으며, BioSimGrid, Taverna와 같은 프로젝트는 그리드-데이터베이스 (Grid-Database)기술을 바탕으로 개발되었다. 본 고에서는 미지의 생명현상을 탐구하고 연구하기 위하여 현재까지 개발된 그리드-컴퓨팅 환경과 의생명과학 연구를 위한 응용 프로그램들, 그리고 그리드-데이터베이스 기술 등을 소개한다.

• Journal of KIISE:Software and Applications
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• v.31 no.2
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• pp.137-152
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• 2004

Assesment of 30 nutritional minerals and 8 toxic elements in hair are very important not only for determining adequacy, deficiencies and unbalance, but also for assessing their relative relationships in the body. A test has been developed that serves this purpose exceedingly well. This test is known as tissue mineral analysis(TMA). TMA is very popular method in hair mineral analysis for health care professionals in over 46 countries' medical center. However, there are some problems. First, they do not have database which is suitable for korean to do analyze. Second, as the TMA results from TEI-USA is composed of english documents and graphic files prohibited to open, its usability is very low. Third, some of them has low level database which is related to TMA, so hairs are sent to TEI-USA for analyzing and medical services. it bring about an severe outflow of dollars. Finally, TMA results are based on the database of american health and mineral standards, it is possibly mislead korean mineral standards. The purposes of this research is to develope the first Intelligent Medical Expert System(IMES) of TMA, in Korea, which makes clear the problems mentioned earlier IMES can analyze the tissue mineral data with multiple stage decision tree classifier. It is also constructed with multiple fuzzy rule base and hence analyze the complex data from Korean database by fuzzy inference methods. Pilot test of this systems are increased of business efficiency and business satisfaction 86% and 92% respectively.

• Journal of the Korean Society for Library and Information Science
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• v.40 no.2
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• pp.457-480
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• 2006

It is essential to conduct an analysis of superior journals, facilitate the international distribution of domestic journals, and determine an effective way to promote a journal's international distribution. This study seeks to determine an effective approach to the international distribution of Korean medical and life science journals and investigates the bibliographies, home pages, and databases about four international distribution factors with regard to 90 journals arranged into three categories. For the effective way of distributing domestic journals internationally, we should develope Korean journals with international standards, record the journals' articles in international and domestic databases, raise the rate of international subscription and holding journals. and publish electronic journals linking their electronic files with many databases.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.5
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• pp.205-212
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• 2016

Recently, researches for the integration and standardization of clinical data in the Western medicine and Korean medicine is in progress. If an integration of similar clinical data as well as heterogeneous clinical data is possible based on one standardization, we can able to derive implicit medical knowledge from integrated clinical data. In this paper, we implemented Korean clinical database based on internationally known CDISC standardization to efficiently store Korean clinical data and constructed E-CRF system for convenient data input in clinical sites. Furthermore, we showed example of an integration of Korean clinical data from 4 clinical sites. The results of our study will help to establish the foundation for the extraction of implicit medical knowledge from integrated clinical data. Also, our results may support efficient management through data integration, prevention of repetitive or unnecessary clinical trials, facilitation of collaborative study and convenient research through the distribution of refined clinical data.

• Journal of Korean Library and Information Science Society
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• v.33 no.1
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• pp.291-322
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• 2002

Korean medical libraries have made interlibrary loan active under the korean medical library association since 1969, the sharing acquisition of journals has not been peformed efficiently in the absence of a bibliographic control institute. The medical library of seoul national medical university which is designated to a medical professional information center by korea education academy information developed MEDLIS linking the union catalog and interlibrary loan system and has been operating it in cooperation with the korean medical library association. Two types of questionaries were sent to 350 medical researchers and 160 medical librarians to investigate the realities of domestic and foreign medical information institutes, develop sharing systems and find a solution for sharing systems. Also, some analyses for the recent state of duplicate subscriptions, interlibrary loan, demands for system operations un the basis of the statistics of MEDLIS users were made. The result showed that medical researchers and medical librarians are affirmative for MEDLIS, users need a convenient interlibrary loan system and medical librarians agree to activate interlibrary loan. It also showed that sharing acquisition of journals seemed to be realizable for medical librarians, although there was no intention to improve the centralization of interlibrary loan among them. From the findings, a plan for sharing acquisition of journals established by the sharing acquisition committee under korea medical libraries society and national 8 local centers to play a key role in it was made. Also, a proposal for the establishment of an information center for controlling korean medical bibliographies was suggested. This system will be expected to contribute to make users to acquire materials more effectively and save the national budget.

• Korean Journal of Poultry Science
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• v.37 no.3
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• pp.275-282
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• 2010

Chicken is an important livestock as a valuable biomedical model as well as food for human, and there is a strong rationale for improving our understanding on metabolism and physiology of this organism. The first draft of chicken genome assembly was released in 2004, which enables elaboration on the linkage between genetic and metabolic traits of chicken. The objectives of this study were thus to reconstruct metabolic pathway of the chicken genome and to construct a chicken specific pathway genome database (PGDB). We developed a comprehensive genome database for chicken by integrating all the known annotations for chicken genes and proteins using a pipeline written in Perl. Based on the comprehensive genome annotations, metabolic pathways of the chicken genome were reconstructed using the PathoLogic algorithm in Pathway Tools software. We identified a total of 212 metabolic pathways, 2,709 enzymes, 71 transporters, 1,698 enzymatic reactions, 8 transport reactions, and 1,360 compounds in the current chicken genome build, Gallus_gallus-2.1. Comparative metabolic analysis with the human, mouse and cattle genomes revealed that core metabolic pathways are highly conserved in the chicken genome. It was indicated the quality of assembly and annotations of the chicken genome need to be improved and more researches are required for improving our understanding on function of genes and metabolic pathways of avian species. We conclude that the chicken PGDB is useful for studies on avian and chicken metabolism and provides a platform for comparative genomic and metabolic analysis of animal biology and biomedicine.

• Progress in Medical Physics
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• v.14 no.3
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• pp.175-183
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• 2003

Absorbed dose dosimetry protocols of high energy photon and electron beams, which are widely used and based on an air kerma (or exposure) calibration factors, have somewhat complex formalism and limitations for improving dosimetric accuracy due to the uncertainty of the physical parameters used. Recently, the IAEA and the AAPM published the absorbed dose to water-based dosimetry protocols(IAEA TRS-398 and AAPM TG-51). The dose calibration programs for these two protocols were developed. This program for high energy photon and electron beams was also developed for users to use in a window environment using the Visual C++ language. The formalism and physical parameters of these two protocols were strictly applied to the program. The tables and graphs of the physical data, and the information of ion chambers were numericalized for their incorporation into a database. This program can be useful in developing new dosimetry protocols in Korea.