• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.6
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• pp.299-308
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• 2020

This study aimed to evaluate the effects of Chuna therapy for Sciatica. We searched the following 16 online databases without a language restriction (Pubmed, Cochrane, Embase, CINAHL, Ovid, Kmbase, RISS, NDSL, OASIS, KISS, KNAL, KTKP, DBpia, CNKI, Wangfang, J-stage) to find randomized controlled clinical trials that used Chuna therapy for Sciatica. The methodological quality of randomized controlled clinical trials (RCTs) were assessed using the Cochrane risk of bias tool and meta-analysis were performed. Among 496 articles that were searched, 15 RCTs were finally selected for systematic review. 14 studies showed that Chuna therapy has positive effect on sciatica. Two studies noted that there were side effects, and the difference between the intervention group and the control group was statistically insignificant. One study noted no side effects and the rest of the study, there was no mention of side effects. Meta-analysis showed positive results for Chuna single therapy in terms of efficiency rate compared to painkiller, herb medicine excepting acupuncture. When comparing Chuna therapy plus acupuncture and acupuncture, Chuna therapy plus acupuncture had a more positive result than acupuncture in terms of efficiency rate. Cochrane Risk of Bias (RoB)evaluation method, most of the studies's selection, performance, detection and reporting bias were unclear. The studies showed that Chuna therapy can significantly effective on sciatica. However, most of the studies's Risk of Bias included in the analysis were not low enough. In the future, to prove the level of evidence of Chuna therapy, more high-quality studies will be needed.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.3
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• pp.87-96
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• 2021

The purpose of this study was to investigate the effect of single herbal medicines and Korean herbal medicine complex prescriptions for osteoporosis in Korea. We targeted studies published in domestic journals from January 1, 2013 to April 1, 2021. For domestic databases, RISS, NDSL, OASIS, DBpia, KISS, KISTI, and Korean Traditional Knowledge Portal were used. Words such as "osteoporosis", "herbal medicine", "herbal combination prescription" and "herbal" were combined and searched. A total of 32 studies were selected. Among them, 8 studies were conducted exclusively for animal studies, 18 studies were conducted on cell experiments, and 6 studies were conducted on both animal and cell experiments. There were 18 studies using a single herb and 14 studies using a combination of Herbal medicine. As a result of the investigation of a single herb, it was found that 補陽藥 was most widely used, and it was found that it was mainly used in the herbal combination prescription, mainly for 補陽藥, 補氣藥, and 補陰藥. Studies in animal experiments revealed significant results mainly in bone mineral density, serological indicators, and morphological indicators of bone tissue. In the study of cell experiments, the effects were found in factors related to the differentiation of osteoclasts and inhibitors of inflammation. Through the results of this study, we are able to confirm the effective single herbal medicines and herbal medicine complex prescriptions for the treatment of osteoporosis, and it is expected that they will contribute to clinical treatment.

• Journal of the KSME
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• v.25 no.4
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• pp.327-329
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• 1985

생체역학(biomechanics)은 생물(bio)과 역학(mechanics)의 합성어로서 글자 그대로 생명체에 관 련된 역학을 다루는 학문이다. 생체역학의 역사는 레오나르드 다빈치가 혈액순환에 대하여 관 심있게 관찰한 것이 효시가 되겠지만 본격적인 생체역학은 Alfonso Borelli가 1680년에 "동물의 동작에 관하여"(De motu animalium)라는 책을 출판한 것이다. 생체역학은 공학의 발달 및 인 류의 건강복지 향상에 대한 관심의 증가로 장족의 발전을 하고 있으며 정형외과학, 재활의학, 체육학, 산업공학, 상해예방, 생리학, 외과학등 다방면에 응용되고 있다.에 응용되고 있다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.35 no.1
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• pp.1-7
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• 2021

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting side effects of neurotoxic chemotherapeutic agents that lead to decreased quality of life and dose reduction, delay or even cessation of treatment. The purpose of this systematic review is to evaluate the effect and the underlying mechanisms of bee venom (BV) pharmacopuncture therapy for CIPN in animal models. We searched for the available experimental literature using BV for CIPN through the Pubmed databases. Ten experimental studies were finally included in this review. In the oxaliplatin or paclitaxel-induced CIPN animal model, BV significantly relieved pain caused both mechanical and cold stimulation. It was suggested that the effect of BV is mediated by the stimulation effect of spinal α1- and α2-adrenergic receptors as a potential mechanism. In the future, more experimental studies are needed.

• Journal of Korean Medicine Rehabilitation
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• v.29 no.2
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• pp.101-113
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• 2019

Objectives Bogol-tang has clinically been used to protect joint cartilage and to treat osteoarthritis. Our objective was to study the protective effect of Bogol-tang extract (BGT) in functional impairment, behavioral disorders, cartilage loss and pathological changes in a monoiodoacetate (MIA)-induced murine osteoarthritis (OA) model and interleukin (IL)-$1{\beta}$ -treated primary rat chondrocytes. Methods Mouse knee joints were injected with MIA, a chemical that inhibits glycolysis and causes joint inflammation and matrix loss. MIA-OA induced mice orally administered BGT or acetaminophen (AAP) for 18 days by daily. Primary rat chondrocytes were pretreated with BGT or dexamethasone (DEX) and followed by co-incubation with IL-$1{\beta}$ (10 ng/mL). Results In MIA-OA mice model, BGT led to delayed response on hot plate analysis, and suppressed the cartilage loss and damages in joint tissues. BGT suppressed the elevated levels of inflammatory mediators, nitrite and $PGE_2$, the gene expression of matrix degrading enzymes, and extracellular-signal-regulated kinases 1/2 and c-JunN-terminal kinase phosphorylation in IL-$1{\beta}$-treated primary rat chondrocytes. Conclusions Our results suggest that BGT improve the knee joint function and delay the cartilage damages by anti-nociceptive, anti-inflammatory and ant-catabolic effects, which indicate BGT could be a potential candidate for osteoarthritis treatment.

• The Journal of Internal Korean Medicine
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• v.1 no.1
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• pp.7-19
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• 1976

소화계질환(消化系疾患)이라고 하면 그 범위(範圍)가 매우 넓으나 대체로 크게 두가지로 구분(區分)할 수 있다. 하나는 소화기계통장기(消火器系統臟器)의 기질적(器質的) 질환(疾患)이고 다른 하나는 음식물(飮食物)의 섭취(攝取) 소화(消火) 흡수(吸收) 및 영양화(營養化)에 관계(關係)되는 기능적(機能的)인 질환(疾患)이다. 한의학상(韓醫學上) 소화계질환(消化系疾患)은 다분(多分)히 후자(後者) 즉(卽) 기능적(機能的) 질환(疾患)쪽을 많이 연구(硏究)한 경향(傾向)이 있으며 이것을 [비위내상(脾胃內傷)]위장병(胃腸病)이라고 부르고 있다. 한의학상(韓醫學上) 음식물(飮食物)과 질병(疾病)에 관(關)한 관찰(觀察)은 일찍이 상고시대(上古時代)로부터 매우 고조(高潮)되였던 것으로 생각된다. 내경(內經)(B. C200)에 의(依)하면 인간(人間)이 그 수명(壽命)을 다함에 있어 무엇보다도 음식(飮食)의 절제(節制)를 잘해야 한다는 설명(說明)이 있고, 천금방(千金方)(AD682)에는 신체(身體)를 강건(强健)케 하는 기본(基本)은 음식(飮食)에 있으며 의자(醫者)가 질병(疾病)을 치료(治療)함에 있어 마땅히 먼저 식치(食治)(식이요법(食餌療法))를 하되 식치(食治)로 낫지 않거던 용약(用藥)하라고 하였고, 삼인방(三因方)(AD1174)는 질병(疾病)의 삼대원인(三大原因) 중(中) 음식(飮食)으로 일어나는 원인(原因)을 가장 중요(重要)한 것으로 보았고 1250년대(年代) 이동원(李東垣)은 [비위론(脾胃論)]을 저술(著述)하여 소화계(消化系)에 관(關)한 이론(理論)을 특별(特別)히 천명(闡明)하였다. 이와 같이 한의학(韓醫學)은 음식(飮食)과 양생(養生), 영양(榮養)과 질병(疾病), 그리고 소화기능(消火機能)에 관(關)하여 고대(古代)로부터 중요시(重要視)해온 것이다. 그러나 그 이론(理論)들이 다분(多分)히 현상적관찰(現象的觀察)과 경험적추리(經驗的推理)로서 설명(說明)되었기 때문에 현대의학(現代醫學)(서양의학(西洋醫學))과 같은 조직해부학(組織解剖學) 및 생화학적(生化學的)인 이론(理論)과는 상위(相違)한 점(點)이 많다. 더욱이 음양오행설(陰陽五行說)이라는 다분(多分)히 형이상적(形而上的)인 학(學) 사유(思惟)로서 관찰추리(觀察推理)되였기 때문에 현대의학(現代醫學)과의 비교설명(比較說明)이 거의 불가능(不可能)하며 또한 한의학이론(韓醫學理論)의 과학적근거제시(科學的根據提示)도 현재(現在)로서는 어려운 형편(形便)이다. 그러나 이 의학(醫學)은 이미 2,000여년간(餘年間) 동양(東洋)에서 전래(傳來)한 경험의학(經驗醫學)으로서 동양인(東洋人)들은 이 의학(醫學)으로 소화계질환(消化系疾患)을 포함(包含)한 여러 가지 인간(人間)의 질병(疾病)을 치료(治療)해 왔고 현재(現在)도 이 의학(醫學)으로 치료(治療)를 하고 있고 실제적(實際的)으로 많은 치효(治效)를 보고 있는 것이다. 그러므로 이 의학(醫學)속에는 아직도 현대과학(現代科學)으로서 해명(解明)되지 못하는 어떤 요소(要素)들이 깃들여 있는 것이 확실(確實)하며 이것을 밝혀내기 위해서 우리 의학자(醫學者)들은 이 의학(醫學)에 관(關)한 모든 것을 연구(硏究)해 보아야 한다. 이런 뜻에서 본고찰(本考察)은 한방(漢方)의 역대제문헌(歷代諸文獻)을 섭렵(涉獵)하여 소화계질환(消化系疾患)에 관(關)한 제이론(諸理論)들을 발췌(拔萃), 한방(漢方)에서 보는 (1) 소화기관(消化器官)의 생리(生理) (2) 병리(病理), 증후(證候) (3) 치법원리(治法原理)을 조사고찰(調査考察)해 본 것이다.

• Journal of Medicine and Life Science
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• v.15 no.1
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• pp.6-11
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• 2018

Previous studies have suggested that Citrus fruits might suppress the proliferation of various cancer cells. However, little is known about any specific ingredients in the extract of Citrus fruits to exert its anti-proliferative activity in cancer cells. The present study aimed to identify the active ingredients in Citrus fruits to suppress the proliferation of rat hepatocellular carcinoma cells. Among tested compounds, two polymethoxylated flavones (nobiletin and tangeritin) showed significant anti-proliferative activity whereas other compounds (synephrine, rutin, hesperidin) did not. Interestingly, nobiletin as well as tangeritin also decreased the protein amount of gluconeogenic enzymes, PEPCK and G6Pase. The possible involvement of gluconeogenic activity in the proliferation of hepatocellulacarcinoma cells are further to be investigated.

• Journal of the Korean Society of Radiology
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• v.82 no.6
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• pp.1355-1365
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• 2021

Adhesive capsulitis, the so-called 'frozen shoulder', is one of the common causes of pain with a limited range of motion in the shoulder joint. The condition is usually diagnosed through the clinical course and physical examinations; however, several studies on imaging findings of adhesive capsulitis using sonography, MRI, and MR angiography have been reported. In this article, various imaging findings for the diagnosis of adhesive capsulitis-related anatomy are reviewed.

• Journal of Haehwa Medicine
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• v.14 no.2
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• pp.87-91
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• 2005

Hepatitis B virus (HBV)는 전 세계적으로 약 3억 5천만 명이 만성적으로 보균하고 있으며, 한국에서도 보건의학적으로 가장 중요하여 높은 간암의 발병율과도 밀접한 관련이 있다. 최근에 와서 HBV가 유도하는 임상적 위험질환의 병태생리에 대해서 면역학적 지식의 발전을 바탕으로 이해가 깊어졌는데, 바이러스 자체보다는 인체의 다양한 면역반응이 질병의 경과에 더욱 중요하다. 이러한 사실로 한의학적 치료법의 과학적 연구는 만성 HBV 보균자들에게 효과적인 치료방법으로 적용될 것으로 기대될 수 있는데, 우선 여기서는 전형적으로 HBV와 관련해서 의학적 문제를 모두 가지고 있는 한 가족을 통해서 HBV에 대한 폭넓은 이해에 도움을 얻고자한다.

• Journal of Physiology & Pathology in Korean Medicine
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• v.36 no.5
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• pp.193-208
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• 2022

In this study, we proposed a mathematical model that can explain the source of the observed variability of repeated measurement data collected in Korean medicine clinical practice, and conducted a pilot analysis to infer the source of these variability based on our model. Mathematical model was constructed by dividing the observed variations into three components: common time-dependent variations, signal shift, and measurement error. To show the applicability of our model in real data, we analyzed 20 repeated measurement data of Korean clinical indicators in graduate students of Pusan National University Graduate School of Korean Medicine. We showed how to infer each source of variations based on our model and also showed the limitation of inference given the acquired the dataset. On the basis of objective recognition of these source of the variability, we hope that quantitative investigations on these sources for each Korean medicine clinical indicator are made in the future, so that they can be used in the clinical and educational areas of Korean medicine.